Cited by 931Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeurological disorders and treatments

Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens

Nicola, Saleem M., Surmeier, D. James, Malenka, Robert C.·2000·Annual Review of Neuroscience

Abstract

The striatum and its ventral extension, the nucleus accumbens, are involved in behaviors as diverse as motor planning, drug seeking, and learning. Invariably, these striatally mediated behaviors depend on intact dopaminergic innervation. However, the mechanisms by which dopamine modulates neuronal function in the striatum and nucleus accumbens have been difficult to elucidate. Recent electrophysiological studies have revealed that dopamine alters both voltage-dependent conductances and synaptic transmission, resulting in state-dependent modulation of target cells. These studies make clear predictions about how dopamine, particularly via D1 receptor activation, should alter the responsiveness of striatal neurons to extrinsic excitatory synaptic activity.

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Crossref · 10.1146/annurev.neuro.23.1.185

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216 of 216 references verified0 citation errors · 0 not checkable

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Authors
Nicola, S. M., Surmeier, D. J., & Malenka, R. C.
Affiliations
Northwestern University (US)
Venue
Annual Review of Neuroscience
Published
2000-03
Volume
23
Issue
1
Pages
185-215
ISSN
  • 0147-006X (ISSN-L)
  • 1545-4126
OpenAlex
W2145594774
Cited by
931
References
216
Citations by year
2026: 12 · 2025: 24 · 2024: 17 · 2023: 15 · 2022: 21 · 2021: 17 · 2020: 17 · 2019: 27 · 2018: 21 · 2017: 22 · 2016: 32 · 2015: 36 · 2014: 48 · 2013: 35 · 2012: 26
FWCI
4.02
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (F31MH010568)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
dopamine, striatum, nucleus accumbens, neuronal excitability, dopamine D1 receptor, voltage-dependent conductance, synaptic transmission, state-dependent modulation, striatal neurons
MeSH terms
Anesthesia, Animals, Corpus Striatum, Dopamine, Electric Conductivity, Humans, Ions, Synaptic Transmission, Neurons, Nucleus Accumbens, Receptors, Dopamine, Wakefulness

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