Dopamine action in the nucleus accumbens
Abstract
The action of dopamine was studied in the nucleus accumbens of acutely prepared rabbits. Dopamine was applied iontophoretically to those cells and cell populations that responded in a monosynaptic excitatory manner to ipsilateral fimbrial stimulation. This strategy was adopted to isolate the effects of dopamine on postsynaptic receptors thus avoiding the bias resulting from activation of presynaptic dopamine receptors on dopaminergic afferents. Dopamine was found to have a suppressive effect on the excitatory (N) component of the field response and on driven extracellular unitary discharges. The specificity of dopamine's effect with receptors was indicated by the facts that fluphenazine effectively antagonized dopamine's effect, whereas bicuculline did not. The effect of dopamine was dependent on the rate of fimbrial stimulation. Dopamine has a marked suppressive effect on the fimbria-induced response at 0.5 Hz of stimulation but not at 6.0 Hz. This frequency specificity could not be linked directly to a cyclic adenosine 3',5'-cyclic monophosphate (cyclic AMP) mechanism because the iontophoresis cyclic AMP and dibutyryl cyclic AMP had suppressive effects at both 0.5 and 6.0 Hz rates of stimulation. It is suggested that dopamine acts in the nucleus accumbens to increase the "signal-to-noise" ratio. This might be a form of "contrast enhancement" of an incoming hippocampal message.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Accumbens neurons require activation from more than one source to reach threshold, integrating limbic and cortical innervations depending on the intensity and timing of inputs.
“Accumbens neurons require activation from more than one source to reach threshold [87, 88] - integrating limbic and cortical innervations depending on the intensity and timing of inputs [89].”
Cites
Still being checked.
Cited by
Sorted by citations
The principal features and mechanisms of dopamine modulation in the prefrontal cortex
Seamans, J. K., & Yang, C. R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.006 · Cited by 1,592 · see citing works
Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens
Nicola, S. M., Surmeier, D. J., & Malenka, R. C. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.185 · Cited by 931 · see citing works
Groenewegen, H. J., Vermeulen‐Vanderzee, E., Kortschot, A. T., & Witter, M. P. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90275-2 · Cited by 867 · see citing works
Alcaro, A., Huber, R., & Panksepp, J. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.07.014 · Cited by 614 · see citing works
Floresco, S., Todd, C. L., & Grace, A. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04915.2001 · Cited by 556 · see citing works
Gating of information flow within the limbic system and the pathophysiology of schizophrenia.
Grace, A. (2000) · Brain research. Brain research reviews · doi:10.1016/s0165-0173(99)00049-1 · Cited by 532 · see citing works
Sesack, S. R., & Pickel, V. M. (1990) · Brain Research · doi:10.1016/0006-8993(90)91146-8 · Cited by 439 · see citing works
Lisman, J. E., & Otmakhova, N. A. (2001) · Hippocampus · doi:10.1002/hipo.1071 · Cited by 402 · see citing works
Dopamine gating of forebrain neural ensembles
O’Donnell, P. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02463.x · Cited by 253 · see citing works
Floresco, S., Blaha, C. D., Yang, C. R., & Phillips, A. G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02851.2001 · Cited by 242 · see citing works
Nicola, S. M., Kombian, S. B., & Malenka, R. C. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-05-01591.1996 · Cited by 212 · see citing works
Blaha, C. D., Yang, C. R., Floresco, S., Barr, A. M., & Phillips, A. G. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01441.x · Cited by 207 · see citing works
Modulation of Cell Firing in the Nucleus Accumbens
O’Donnell, P., GREENE, J., Pabello, N. G., LEWIS, B. L., & Grace, A. A. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09267.x · Cited by 204 · see citing works
Horvitz, J. C. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00285-1 · Cited by 201 · see citing works
Chapter 1 The cellular framework for chemical signalling in the nucleus accumbens
Meredith, G. E., Pennartz, C. M. A., & Groenewegen, H. J. (1993) · Progress in brain research · doi:10.1016/s0079-6123(08)61335-7 · Cited by 189 · see citing works
Nicola, S. M., & Malenka, R. C. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05697.1997 · Cited by 185 · see citing works
Baclofen Inhibits Heroin Self-Administration Behavior and Mesolimbic Dopamine Release
Xi, Z.-X., & Stein, E. A. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35044-x · Cited by 177 · see citing works
Has dopamine a physiological role in the control of sexual behavior?
Paredes, R. G., & Ågmo, A. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.001 · Cited by 163 · see citing works
Seamans, J. K., & Phillips, A. G. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.3.456 · Cited by 159 · see citing works
Dopaminergic Modulation of Prefrontal Cortical Input to Nucleus Accumbens NeuronsIn Vivo
Brady, A. M., & O’Donnell, P. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4178-03.2004 · Cited by 143 · see citing works
The nucleus accumbens and reward: neurophysiological investigations in behaving animals
Carelli, R. M. (2002) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582302238338 · Cited by 131 · see citing works
GABAergic MECHANISMS OF OPIATE REINFORCEMENT
Xi, Z. (2002) · Alcohol and Alcoholism · doi:10.1093/alcalc/37.5.485 · Cited by 124 · see citing works
Nicola, S. M., & Malenka, R. C. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.4.1768 · Cited by 123 · see citing works
Higashi, H., Inanaga, K., Nishi, S., & Uchimura, N. (1989) · The Journal of Physiology · doi:10.1113/jphysiol.1989.sp017478 · Cited by 109 · see citing works
Pralong, É. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00017-5 · Cited by 99 · see citing works
Mulder, A. B., Arts, M. P. M., & Lopes, F. H. D. S. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01518.x · Cited by 99 · see citing works
Inhibitory Control Deficits in Rats with Ventral Hippocampal Lesions
Abela, A. R., Dougherty, S. D., Fagen, E. D., Hill, C. J. R., & Chudasama, Y. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs121 · Cited by 94 · see citing works
Dopaminergic regulation of limbic-striatal interplay
Floresco, S. (2007) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0739 · Cited by 94 · see citing works
Pistis, M., Muntoni, A. L., Pillolla, G., & Gessa, G. L. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02019.x · Cited by 88 · see citing works
Dopaminergic Reduction of Excitability in Nucleus Accumbens Neurons Recorded in Vitro
O’Donnell, P. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00177-f · Cited by 80 · see citing works
Brodie, M. S., & Dunwiddie, T. V. (1990) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00175709 · Cited by 69 · see citing works
Contrast enhancement: a physiological effect of striatal dopamine?
Nicola, S. M., Hopf, F. W., & Hjelmstad, G. O. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0929-z · Cited by 68 · see citing works
Peoples, L. L., Uzwiak, A. J., Guyette, F. X., & West, M. O. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00116-x · Cited by 66 · see citing works
Neuronal firing in the nucleus accumbens is associated with the level of cortical arousal
Callaway, C. W., & Henriksen, S. J. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90294-c · Cited by 62 · see citing works
Floresco, S. B., Seamans, J. K., & Phillips, A. G. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00031-9 · Cited by 56 · see citing works
Altered short-term plasticity in the prefrontal cortex after early life seizures
Hernan, A. E., Holmes, G. L., Isaev, D., Scott, R. C., & Isaeva, E. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.10.007 · Cited by 49 · see citing works
Distribution of amygdala input to the nucleus accumbens septi: An electrophysiological investigation
Callaway, C. W., Hakan, R. L., & Henriksen, S. J. (1991) · Journal of Neural Transmission · doi:10.1007/bf01253391 · Cited by 47 · see citing works
Extracellular glutamate in the nucleus accumbens during a conditioned emotional response in the rat
Saulskaya, N. B., & Marsden, C. A. (1995) · Brain Research · doi:10.1016/0006-8993(95)00848-k · Cited by 46 · see citing works
Dopamine Modulation of the Prefrontal Cortex and Cognitive Function
Seamans, J. K., & Robbins, T. W. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-333-6_14 · Cited by 45 · see citing works
Boeijinga, P. H., Pennartz, C. M. A., & Lopes, F. H. D. S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90084-h · Cited by 43 · see citing works
EVOLUTIONARY MISMATCH, NEURAL REWARD CIRCUITS, AND PATHOLOGICAL GAMBLING
Spinella, M. (2003) · International Journal of Neuroscience · doi:10.1080/00207450390162254 · Cited by 38 · see citing works
Gill, K. M., & Grace, A. A. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000618 · Cited by 34 · see citing works
Dopamine-Dependent Periadolescent Maturation of Corticostriatal Functional Connectivity in Mouse
Galiñanes, G. L., Taravini, I. R. E., & Murer, M. G. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4421-08.2009 · Cited by 32 · see citing works
Effects of CCK-8 in the nucleus accumbens
DeFrance, J. F., Sikes, R. W., & Chronister, R. B. (1984) · Peptides · doi:10.1016/0196-9781(84)90040-8 · Cited by 32 · see citing works
Self-citationD1–NMDA receptor interactions in the rat nucleus accumbens change during adolescence
Huppé‐Gourgues, F., & O’Donnell, P. (2012) · Synapse · doi:10.1002/syn.21544 · Cited by 31 · see citing works
Peoples, L. L., Kravitz, A. V., Lynch, K. G., & Cavanaugh, D. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301203 · Cited by 31 · see citing works
Young, C. E., & Yang, C. R. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04161.x · Cited by 27 · see citing works
Fabbricatore, A. T., Ghitza, U. E., Prokopenko, V. F., & West, M. O. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07033.x · Cited by 26 · see citing works
Floresco, S., & Phillips, A. G. (1999) · Psychobiology · doi:10.3758/bf03332121 · Cited by 24 · see citing works
Periadolescent changes of D2–AMPA interactions in the rat nucleus accumbens
Huppé‐Gourgues, F., & O’Donnell, P. (2011) · Synapse · doi:10.1002/syn.20976 · Cited by 23 · see citing works
Pennartz, C. M. A., & Lopes, F. H. D. S. (1994) · Brain Research · doi:10.1016/0006-8993(94)91656-x · Cited by 23 · see citing works
Mulder, A. B., Manshanden, I., Vos, P. E., Wolterink, G., van Ree, J. M., & Lopes, F. H. D. S. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00035-8 · Cited by 18 · see citing works
Haddon, J. E., Titherage, D., Heckenast, J. R., Carter, J., Owen, M. J., Hall, J., Wilkinson, L. S., & Jones, M. W. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02969-x · Cited by 6 · see citing works
“Accumbens neurons require activation from more than one source to reach threshold [87, 88] - integrating limbic and cortical innervations depending on the intensity and timing of inputs [89].”
BackgroundSorimachi, M., Moritoyo, T., & Yamagami, K. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02819-5 · Cited by 6 · see citing works
4.3 Postnatal Maturation of Dopamine Actions in the Prefrontal Cortex
O’Donnell, P., & Tseng, K. Y. (2009) · doi:10.1093/acprof:oso/9780195373035.003.0012 · Cited by 6 · see citing works
Buckby, L., & Lacey, M. (2001) · Experimental Brain Research · doi:10.1007/s00221-001-0927-2 · Cited by 4 · see citing works
Dopaminergic Modulation of Cortical and Striatal Up States
Tseng, K. Y., & O’Donnell, P. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-387-28066-9_44 · Cited by 4 · see citing works
MODULATION OF INTRACRANIAL SELF STIMULATION BY CHOLECYSTOKININ DEPENDS ON THE SITE OF ADMINISTRATION
Vanderhaeghen, J. J., Heidbreder, C. A., Schiffmann, S. N., Lotstra, F., Goldman, S., & Witte, P. D. (1987) · Elsevier eBooks · doi:10.1016/b978-0-08-035588-7.50035-2 · Cited by 1 · see citing works
Ultrastructural study of CCK and tyrosine hydroxylase immunoreactivity in the rat nucleus accumbens
Baali-Cherif, H., Roques, B. P., Tramu, G., & Thibault, J. (1994) · Peptides · doi:10.1016/0196-9781(94)90022-1 · Cited by 1 · see citing works
Cheong, J.-S., Kim, A.-Y., & Kim, K. (1996) · Archives of Pharmacal Research · doi:10.1007/bf02976240 · Cited by 1 · see citing works
Zhang, T. (2005) · Texas ScholarWorks (Texas Digital Library) · Cited by 1 · see citing works
Boeijinga, P. H., Lopes, F. H. D. S., & Pennartz, C. M. A. (1991) · Advances in behavioral biology · doi:10.1007/978-1-4684-5871-8_23
Carvalho, A. L., Caldeira, M. V., Gomes, A. R., Carvalho, A. P., & Duarte, C. B. (2008) · Springer eBooks · doi:10.1007/978-0-387-30382-6_12
Adli Toksikoloji Klinik, Nöropsikiyatrik ve Postmortem Değerlendirme
Işık, C., & Öztuna, Ş. (2024) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.3156
- Authors
- DeFrance, J. F., Sikes, R. W., & Chronister, R. B.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1985-12-01
- Volume
- 54
- Issue
- 6
- Pages
- 1568-1577
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2257076861
- Cited by
- 66
- References
- 0
- Citations by year
- 2024: 2 · 2013: 1 · 2012: 4
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R0-1MH31114)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- dopamine, nucleus accumbens, postsynaptic dopamine receptors, signal-to-noise ratio, contrast enhancement, fluphenazine, bicuculline, cyclic AMP, frequency dependence, excitatory postsynaptic potentials
- MeSH terms
- Cyclic AMP, Animals, Bucladesine, Dopamine, Electric Stimulation, Evoked Potentials, Hippocampus, Iontophoresis, Male, Neurons, Nucleus Accumbens, Rabbits, Reaction Time, Septal Nuclei
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review