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Cited by 445

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Reduced Levels of Norepinephrine Transporters in the Locus Coeruleus in Major Depression

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Klimek, Violetta, Stockmeier, Craig, Overholser, James, Meltzer, Herbert Y., Kalka, Sheila, Dilley, Ginny, Ordway, Gregory A.·1997·The Journal of Neuroscience
DOI 10.1523/jneurosci.17-21-08451.1997
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Abstract

The norepinephrine transporter (NET) is a membrane protein responsible for termination of the action of synaptic norepinephrine and is a site of action of many drugs used to treat major depression. The present study determined whether the binding of [3 H]nisoxetine to the NET is altered in the locus coeruleus (LC) in major depression, using brain tissue collected postmortem from subjects diagnosed with major depression and from age-matched normal control subjects. Thirteen of the 15 major depressive subjects studied died by suicide. The distribution of [3 H]nisoxetine binding along the rostro-caudal axis of the nucleus was uneven and was paralleled by a similar uneven distribution of neuromelanin-containing cells in both major depressives and psychiatrically normal control subjects. The binding of [3 H]nisoxetine to NETs in the midcaudal portion of the LC from major depressive subjects was significantly lower than that from age-matched, normal control subjects. The binding of [3 H]nisoxetine to NETs in other regions of the LC was similar in major depressives and control subjects. In contrast to reductions in binding to NETs, there were no significant differences in the number of noradrenergic cells at any particular level of the LC between major depressives and normal control subjects. The decreased binding of [3 H]nisoxetine to NETs in the LC in major depression may reflect a compensatory downregulation of this transporter protein in response to an insufficient availability of its substrate (norepinephrine) at the synapse.

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Metadata

Authors
Klimek, V., Stockmeier, C., Overholser, J., Meltzer, H. Y., Kalka, S., Dilley, G., & Ordway, G. A.
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
1997-11-01
Volume
17
Issue
21
Pages
8451-8458
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.17-21-08451.1997
OpenAlex
W1588260775
Cited by
445
References
1
FWCI
10.61
Type
journal article
Language
en
Open access
hybrid
Licence
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)

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CoChat. (2026). Citation check: Reduced Levels of Norepinephrine Transporters in the Locus Coeruleus in Major Depression. https://app.cochat.ai/papers/10.1523/jneurosci.17-21-08451.1997
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Klimek, V., Stockmeier, C., Overholser, J., Meltzer, H. Y., Kalka, S., Dilley, G., & Ordway, G. A. (1997). Reduced Levels of Norepinephrine Transporters in the Locus Coeruleus in Major Depression. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.17-21-08451.1997

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