The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Neonatal Infection-Induced Memory Impairment after Lipopolysaccharide in Adulthood Is Prevented via Caspase-1 Inhibition
Open accessAbstract
We have reported that neonatal infection leads to memory impairment after an immune challenge in adulthood. Here we explored whether events occurring as a result of early infection alter the response to a subsequent immune challenge in adult rats, which may then impair memory. In experiment 1, peripheral infection with Escherichia coli on postnatal day 4 increased cytokines and corticosterone in the periphery, and cytokine and microglial cell marker gene expression in the hippocampus of neonate pups. Next, rats treated neonatally with E. coli or PBS were injected in adulthood with lipopolysaccharide (LPS) or saline and killed 1-24 h later. Microglial cell marker mRNA was elevated in hippocampus in saline controls infected as neonates. Furthermore, LPS induced a greater increase in glial cell marker mRNA in hippocampus of neonatally infected rats, and this increase remained elevated at 24 h versus controls. After LPS, neonatally infected rats exhibited faster increases in interleukin-1beta (IL-1beta) within the hippocampus and cortex and a prolonged response within the cortex. There were no group differences in peripheral cytokines or corticosterone. In experiment 2, rats treated neonatally with E. coli or PBS received as adults either saline or a centrally administered caspase-1 inhibitor, which specifically prevents the synthesis of IL-1beta, 1 h before a learning event and subsequent LPS challenge. Caspase-1 inhibition completely prevented LPS-induced memory impairment in neonatally infected rats. These data implicate IL-1beta in the set of immune/inflammatory events that occur in the brain as a result of neonatal infection, which likely contribute to cognitive alterations in adulthood.
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“Bilbo et al. revealed that neonatal E. coli infection could impair memory in adult rats (394).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [394]
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Cites
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MethodAnalysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
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MethodA new mathematical model for relative quantification in real-time RT-PCR
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“Relative gene expression was determined using the 2 -⌬⌬Ct method (Livak and Schmittgen, 2001; Pfaffl, 2001).”
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Cited by
Sorted by citations
Immune modulation of learning, memory, neural plasticity and neurogenesis
Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483
“Specifically, peripheral infection with Escherichia coli on postnatal day 4 in rats resulted in markedly impaired learning and memory due to an inflammatory (LPS) challenge in adulthood (Bilbo et al., 2008, 2005a,b, 2007).”
Microbiota and neurodevelopmental windows: implications for brain disorders
Borre, Y. E., O’Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.002 · Cited by 1,089
Systemic inflammation and microglial activation: systematic review of animal experiments
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Early-life programming of later-life brain and behavior: a critical role for the immune system
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BackgroundResultInfluentialSelf-citation
Metadata
- Authors
- Bilbo, S. D., Biedenkapp, J. C., Der-Avakian, A., Watkins, L. R., Rudy, J. W., & Maier, S. F.
- Affiliations
- University of Colorado Boulder (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-08-31
- Volume
- 25
- Issue
- 35
- Pages
- 8000-8009
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6725459
- OpenAlex
- W2042311033
- Cited by
- 251
- References
- 71
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 9 · 2023: 9 · 2022: 6 · 2021: 18 · 2020: 10 · 2019: 15 · 2018: 10 · 2017: 28 · 2016: 9 · 2015: 17 · 2014: 20 · 2013: 24 · 2012: 12
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH065656, R01-MH065656-02)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- neonatal infection, lipopolysaccharide, memory impairment, caspase-1 inhibition, IL-1β, hippocampus, microglia, neuroinflammation, Escherichia coli, corticosterone, cytokines, learning, neuroimmune interactions
- MeSH terms
- Age Factors, Animals, Animals, Newborn, Enzyme Inhibitors, Escherichia coli Infections, Female, Hippocampus, Interleukin-1, Lipopolysaccharides, Male, Memory Disorders, Pregnancy, Rats, Sprague-Dawley, Caspase 1, Rats, Caspase Inhibitors
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