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Evidence That Increased Hippocampal Expression of the Cytokine Interleukin-1β Is a Common Trigger for Age- and Stress-Induced Impairments in Long-Term Potentiation
Open accessAbstract
Several cytokines and their receptors are identified in brain; one of these is the proinflammatory cytokine interleukin-1β that is synthesized and released from neurons and glia in response to stress or insult. Among the actions of interleukin-1β is its ability to inhibit long-term potentiation in the hippocampus in vitro, an action that mimics one of the consequences of stress and age. It has been shown that the concentration of interleukin-1β in brain tissue is increased in neurodegenerative conditions, and recent evidence from our laboratory has indicated an increase in the concentration of interleukin-1β in the hippocampus of aged rats. These observations led us to consider that the underlying common cause of impaired long-term potentiation in aged and stressed rats might be increased endogenous interleukin-1β concentration in hippocampus. The data presented here indicate that there was an inverse relationship between concentration of interleukin-1β in the dentate gyrus and long-term potentiation in perforant path→granule cell synapses in aged rats, stressed rats, and rats pretreated with interleukin-1β. The evidence suggested that the cytokine induces formation of reactive oxygen species that triggers lipid peroxidation in vivo, as well as in vitro, and that these changes lead to depletion of membrane arachidonic acid that correlates with impaired long-term potentiation. We propose that three theories of aging, the glucocorticoid theory, the membrane theory, and the free radical theory, constitute three facets of age with one underlying trigger: an increase in the endogenous concentration of interleukin-1β in hippocampus.
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“Early reports on aging showed increased IL-1β, reactive oxygen species, and lipid peroxidation levels that corresponded with impaired long-term potentiation (LTP) in the dentate gyrus of aged rats (Murray and Lynch, 1998).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Murray and Lynch, 1998
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Self-citation
Metadata
- Authors
- Murray, C. A., & Lynch, M. A.
- Affiliations
- Trinity College Dublin (IE)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1998-04-15
- Volume
- 18
- Issue
- 8
- Pages
- 2974-2981
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W4292340975
- Cited by
- 359
- References
- 51
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 9 · 2023: 7 · 2022: 7 · 2021: 13 · 2020: 18 · 2019: 19 · 2018: 14 · 2017: 16 · 2016: 15 · 2015: 8 · 2014: 16 · 2013: 12 · 2012: 12
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Funders
- Health Research Board
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- IL-1β, hippocampus, long-term potentiation, aging, stress, dentate gyrus, reactive oxygen species, lipid peroxidation, free radical theory of aging, neuroinflammation
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