Lynch, Marina A.

Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 1,973

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice

Dempsey, C., Rubio Araiz, A., Bryson, K. J., Finucane, O., Larkin, C., Mills, E. L., Robertson, A. A. B., Cooper, M. A., O'Neill, L. A. J., & Lynch, M. A. (2017) · Brain Behavior and Immunity

Inflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 571

Interleukin-1β (IL-1β) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro

Cunningham, A. J., Murray, C. A., O'Neill, L. A. J., Lynch, M. A., & O'Connor, J. J. (1996) · Neuroscience Letters

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 433

Evidence That Increased Hippocampal Expression of the Cytokine Interleukin-1β Is a Common Trigger for Age- and Stress-Induced Impairments in Long-Term Potentiation

Murray, C. A., & Lynch, M. A. (1998) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 359

The age-related attenuation in long-term potentiation is associated with microglial activation

Griffin, R., Nally, R., Nolan, Y., McCartney, Y., Linden, J., & Lynch, M. A. (2006) · Journal of Neurochemistry

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 282

CD200 Ligand–Receptor Interaction Modulates Microglial Activation In Vivo and In Vitro: A Role for IL-4

Lyons, A., Downer, E. J., Crotty, S., Nolan, Y. M., Mills, K. H. G., & Lynch, M. A. (2007) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 258

Modulation of Intestinal Microbiota by the Probiotic VSL#3 Resets Brain Gene Expression and Ameliorates the Age-Related Deficit in LTP

Distrutti, E., O’Reilly, J.-A., McDonald, C., Cipriani, S., Renga, B., Lynch, M. A., & Fiorucci, S. (2014) · PLoS ONE

Gut microbiota and healthProbiotics and Fermented Foods

Cited by 237

Fractalkine‐induced activation of the phosphatidylinositol‐3 kinase pathway attentuates microglial activation in vivo and in vitro

Lyons, A., Lynch, A. M., Downer, E. J., Hanley, R., O’Sullivan, J. B., Smith, A., & Lynch, M. A. (2009) · Journal of Neurochemistry

Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Cited by 202

Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer's disease

Guillot-Sestier, M.-V., Araiz, A. R., Mela, V., Gaban, A. S., O’Neill, E., Joshi, L., Chouchani, E. T., Mills, E. L., & Lynch, M. A. (2021) · Communications Biology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 182

Amyloid-β-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE

Jones, R. S., Minogue, A. M., Connor, T. J., & Lynch, M. A. (2013) · Journal of Neuroimmune Pharmacology

Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Cited by 147

Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine

Lynch, M. A. (2022) · Frontiers in Aging Neuroscience

Neuroinflammation and Neurodegeneration MechanismsSex and Gender in Healthcare

Cited by 146

Targeting innate immunity for neurodegenerative disorders of the central nervous system

Andreasson, K. I., Bachstetter, A. D., Colonna, M., Ginhoux, F., Holmes, C., Lamb, B., Landreth, G., Lee, D. C., Low, D., Lynch, M. A., et al. (2016) · Journal of Neurochemistry

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 126

Neuroinflammatory changes negatively impact on LTP: A focus on IL-1β

Lynch, M. A. (2015) · Brain Research

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 115

Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer’s disease

McDonald, C. L., Hennessy, E., Rubio-Araiz, A., Keogh, B., McCormack, W., McGuirk, P., Reilly, M., & Lynch, M. A. (2016) · Brain, Behavior, and Immunity

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 108

Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide

Lyons, A., McQuillan, K., Deighan, B. F., O’Reilly, J.-A., Downer, E. J., Murphy, A. C., Watson, M., Piazza, A., O’Connell, F., Griffin, R., et al. (2009) · Brain, Behavior, and Immunity

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 98

The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability

Blau, C. W., Cowley, T. R., O'Sullivan, J., Grehan, B., Browne, T. C., Kelly, L., Birch, A., Murphy, N., Kelly, A. M., Kerskens, C. M., et al. (2012) · Neurobiology of Aging

Neuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function Studies

Cited by 92

Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli

Barrett, J. P., Costello, D. A., O’Sullivan, J., Cowley, T. R., & Lynch, M. A. (2015) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsImmune cells in cancer

Cited by 76

Increased IL-1β in cortex of aged rats is accompanied by downregulation of ERK and PI-3 kinase

Maher, F. O., Martin, D. S. D., & Lynch, M. A. (2004) · Neurobiology of Aging

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 73

The role of the immune system in driving neuroinflammation

Ní Chasaide, C., & Lynch, M. A. (2020) · Brain and Neuroscience Advances

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 72

The Effects of IL-1 Receptor Antagonist on Beta Amyloid Mediated Depression of LTP in the Rat CA1 in Vivo

Schmid, A. W., Lynch, M. A., & Herron, C. E. (2009) · Hippocampus

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 64

Involvement of IGF-1 and Akt in M1/M2 activation state in bone marrow-derived macrophages

Barrett, J. P., Minogue, A. M., Falvey, A., & Lynch, M. A. (2015) · Experimental Cell Research

Immune cells in cancerCytokine Signaling Pathways and Interactions

Cited by 59

What is the biological significance of an age-related increase in IL-1β in hippocampus?

Lynch, M. A. (1999) · Molecular Psychiatry

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 10