The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
A Novel Octopamine Receptor with Preferential Expression in Drosophila Mushroom Bodies
Open accessAbstract
Octopamine is a neuromodulator that mediates diverse physiological processes in invertebrates. In some insects, such as honeybees and fruit flies, octopamine has been shown to be a major stimulator of adenylyl cyclase and to function in associative learning. To identify an octopamine receptor mediating this function in Drosophila, putative biogenic amine receptors were cloned by a novel procedure using PCR and single-strand conformation polymorphism. One new receptor, octopamine receptor in mushroom bodies (OAMB), was identified as an octopamine receptor because human and Drosophila cell lines expressing OAMB showed increased cAMP and intracellular Ca 2+levels after octopamine application. Immunohistochemical analysis using an antibody made to the receptor revealed highly enriched expression in the mushroom body neuropil and the ellipsoid body of central complex, brain areas known to be crucial for olfactory learning and motor control, respectively. The preferential expression of OAMB in mushroom bodies and its capacity to produce cAMP accumulation suggest an important role in synaptic modulation underlying behavioral plasticity.
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Cites
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Cited by
Schwaerzel, M., Monastirioti, M., Scholz, H., Friggi-Grelin, F., Birman, S., & Heisenberg, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-33-10495.2003 · Cited by 871
Tyramine and octopamine: ruling behavior and metabolism
Roeder, T. (2005) · Annual Review of Entomology · doi:10.1146/annurev.ento.50.071803.130404 · Cited by 711
Layered reward signalling through octopamine and dopamine in Drosophila
Burke, C. J., Huetteroth, W., Owald, D., Perisse, E., Krashes, M. J., Das, G., Gohl, D., Silies, M., Certel, S., & Waddell, S. (2012) · Nature · doi:10.1038/nature11614 · Cited by 614
Localization of a Short-Term Memory in Drosophila
Zars, T., Fischer, †. M., Schulz, R., & Heisenberg, M. (2000) · Science · doi:10.1126/science.288.5466.672 · Cited by 600
OLFACTORY MEMORY FORMATION IN DROSOPHILA: From Molecular to Systems Neuroscience
Davis, R. L. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135651 · Cited by 543
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Metadata
- Authors
- Han, K.-A., Millar, N. S., & Davis, R. L.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1998-05-15
- Volume
- 18
- Issue
- 10
- Pages
- 3650-3658
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2113394141
- Cited by
- 288
- References
- 48
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Han, K.-A., Millar, N. S., & Davis, R. L. (1998). A Novel Octopamine Receptor with Preferential Expression in Drosophila Mushroom Bodies. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.18-10-03650.1998
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
