The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Type 1 Inositol 1,4,5-Trisphosphate Receptor Is Required for Induction of Long-Term Depression in Cerebellar Purkinje Neurons
Open accessAbstract
The inositol 1,4,5-trisphosphate receptor (InsP3R) is an intracellular Ca 2+channel that releases Ca 2+from internal Ca 2+stores in response to InsP3. Although InsP3R is highly expressed in various regions of the mammalian brain, the functional role of this receptor has not been clarified. We show here that cerebellar slices prepared from mice with a disrupted InsP3R type 1 gene, which is predominantly expressed in Purkinje cells, completely lack long-term depression (LTD), a model of synaptic plasticity in the cerebellum. Moreover, a specific antibody against InsP3R1, introduced into wild-type Purkinje cells through patch pipettes, blocked the induction of LTD. These data indicate that, in addition to Ca 2+influx through Ca 2+channels on the plasma membrane, Ca 2+release from InsP3R plays an essential role in the induction of LTD, suggesting a physiological importance for InsP3R in Purkinje cells.
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Cites
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1
Conquet, F., Bashir, Z. I., Davies, C. H., Daniel, H., Ferraguti, F., Bordi, F., Franz-Bacon, K., Reggiani, A., Matarese, V., Condé, F., et al. (1994) · Nature · doi:10.1038/372237a0 · Cited by 743
Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor
Matsumoto, M., Nakagawa, T., Inoue, T., Nagata, E., Tanaka, K., Takano, H., Kuno, J., Sakakibara, S., Yamada, M., Yoneshima, H., et al. (1996) · Nature · doi:10.1038/379168a0 · Cited by 485
Self-citation
Cited by
Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons
Verkhratsky, A. (2005) · Physiological Reviews · doi:10.1152/physrev.00004.2004 · Cited by 709
Calcium- and activity-dependent synaptic plasticity
Zucker, R. S. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80045-2 · Cited by 616
Endoplasmic reticulum of animal cells and its organization into structural and functional domains
Baumann, O., & Walz, B. (2001) · International Review of Cytology · doi:10.1016/s0074-7696(01)05004-5 · Cited by 458
Inositol 1,4,5-Trisphosphate Receptors as Signal Integrators
Patterson, R. L., Boehning, D., & Snyder, S. H. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.071403.161303 · Cited by 441
Higo, T., Hattori, M., Nakamura, T., Natsume, T., Michikawa, T., & Mikoshiba, K. (2005) · Cell · doi:10.1016/j.cell.2004.11.048 · Cited by 373
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Metadata
- Authors
- Inoue, T., Kato, K., Kohda, K., & Mikoshiba, K.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1998-07-15
- Volume
- 18
- Issue
- 14
- Pages
- 5366-5373
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2100688704
- Cited by
- 217
- References
- 3
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Type 1 Inositol 1,4,5-Trisphosphate Receptor Is Required for Induction of Long-Term Depression in Cerebellar Purkinje Neurons. https://app.cochat.ai/papers/10.1523/jneurosci.18-14-05366.1998
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- Inoue, T., Kato, K., Kohda, K., & Mikoshiba, K. (1998). Type 1 Inositol 1,4,5-Trisphosphate Receptor Is Required for Induction of Long-Term Depression in Cerebellar Purkinje Neurons. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.18-14-05366.1998
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