The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
EAT-4, a Homolog of a Mammalian Sodium-Dependent Inorganic Phosphate Cotransporter, Is Necessary for Glutamatergic Neurotransmission in Caenorhabditis elegans
Open accessAbstract
The Caenorhabditis elegans gene eat-4 affects multiple glutamatergic neurotransmission pathways. We find that eat-4 encodes a protein similar in sequence to a mammalian brain-specific sodium-dependent inorganic phosphate cotransporter I (BNPI). Like BNPI in the rat CNS,eat-4 is expressed predominantly in a specific subset of neurons, including several proposed to be glutamatergic. Loss-of-function mutations in eat-4 cause defective glutamatergic chemical transmission but appear to have little effect on other functions of neurons. Our data suggest that phosphate ions imported into glutamatergic neurons through transporters such as EAT-4 and BNPI are required specifically for glutamatergic neurotransmission.
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Cites
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589 · cited 3×
“The identification of the cells expressing -gal or GFP was based on their stereotypic locations and the morphologies of the cell bodies and, when possible, the neuronal process morphologies (Albertson and Thomson , 1976; Sulston et al., 1983; White et al., 1986).”
BackgroundThe embryonic cell lineage of the nematode Caenorhabditis elegans
Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199
The neural circuit for touch sensitivity in Caenorhabditis elegans
Chalfie, M., Sulston, J., White, J., Southgate, E., Thomson, J., & Brenner, S. (1985) · The Journal of Neuroscience · doi:10.1523/jneurosci.05-04-00956.1985 · Cited by 1,093
Self-citationBargmann, C. I., & Horvitz, H. R. (1991) · Neuron · doi:10.1016/0896-6273(91)90276-6 · Cited by 740
Self-citationThe pharynx of Caenorhabditis elegans
Albertson, D. G., & Thompson, J. N. (1976) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1976.0085 · Cited by 649 · cited 5×
“It is interesting to note that there are two types of vesicles (large and small) in the NSM neurons, suggesting that these neurons may use more than one neurotransmitter (Albertson and Thomson, 1976).”
BackgroundInfluential
Cited by
A circuit for navigation in Caenorhabditis elegans
Gray, J. M., Hill, J. J., & Bargmann, C. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409009101 · Cited by 811
Takamori, S., Rhee, J. S., Rosenmund, C., & Jahn, R. (2000) · Nature · doi:10.1038/35025070 · Cited by 862
VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate
Fremeau, R. T., Voglmaier, S., Seal, R. P., & Edwards, R. H. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2003.11.005 · Cited by 745
A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons
Gras, C., Herzog, E., Bellenchi, G. C., Bernard, V., Ravassard, P., Pohl, M., Gasnier, B., Giros, B., & El Mestikawy, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05442.2002 · Cited by 639
An elegant mind: Learning and memory in Caenorhabditis elegans
Ardiel, E. L., & Rankin, C. H. (2010) · Learning & Memory · doi:10.1101/lm.960510 · Cited by 323
Metadata
- Authors
- Lee, R. Y. N., Sawin, E. R., Chalfie, M., Horvitz, H. R., & Avery, L.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-01-01
- Volume
- 19
- Issue
- 1
- Pages
- 159-167
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2132957118
- Cited by
- 347
- References
- 5
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lee, R. Y. N., Sawin, E. R., Chalfie, M., Horvitz, H. R., & Avery, L. (1999). EAT-4, a Homolog of a Mammalian Sodium-Dependent Inorganic Phosphate Cotransporter, Is Necessary for Glutamatergic Neurotransmission in Caenorhabditis elegans. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.19-01-00159.1999
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
