VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate

Fremeau, Robert T; Voglmaier, Susan; Seal, Rebecca P; Edwards, Robert H

doi:10.1016/j.tins.2003.11.005

Cited by 745Neuroscience and Neuropharmacology ResearchCellular transport and secretionAmino Acid Enzymes and Metabolism

VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate

Fremeau, Robert T, Voglmaier, Susan, Seal, Rebecca P, Edwards, Robert H·2004·Trends in Neurosciences

DOI 10.1016/j.tins.2003.11.005

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Abstract

Exocytotic release of the excitatory neurotransmitter glutamate depends on transport of this amino acid into synaptic vesicles. Recent work has identified a distinct family of proteins responsible for vesicular glutamate transport (VGLUTs) that show no sequence similarity to the other two families of vesicular neurotransmitter transporters. The distribution of VGLUT1 and VGLUT2 accounts for the ability of most established excitatory neurons to release glutamate by exocytosis. Surprisingly, they show a striking complementary pattern of expression in adult brain that might reflect differences in membrane trafficking. By contrast, VGLUT3 is expressed by many cells traditionally considered to release a different classical transmitter, suggesting novel roles for glutamate as an extracellular signal. VGLUT3 also differs from VGLUT1 and VGLUT2 in its subcellular location, with somatodendritic as well as axonal expression.

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Authors: Fremeau, R. T., Voglmaier, S., Seal, R. P., & Edwards, R. H.
Affiliations: University of California, San Francisco (US)
Corresponding author: Edwards, Robert H
ORCID: Voglmaier, Susan
Seal, Rebecca P
Edwards, Robert H
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2004-02
Volume: 27
Issue: 2
Pages: 98-103
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2003.11.005
OpenAlex: W2050123488
Cited by: 745
References: 65
Citations by year: 2026: 16 · 2025: 18 · 2024: 26 · 2023: 27 · 2022: 35 · 2021: 36 · 2020: 31 · 2019: 26 · 2018: 31 · 2017: 26 · 2016: 34 · 2015: 28 · 2014: 36 · 2013: 35 · 2012: 35
FWCI: 3.06
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords: vesicular glutamate transporter, VGLUT1, VGLUT2, VGLUT3, glutamate release, excitatory neurons, synaptic vesicles, membrane trafficking
MeSH terms: Animals, Brain, Carrier Proteins, Exocytosis, Humans, Synaptic Transmission, Synaptic Vesicles, Tissue Distribution, Signal Transduction, Excitatory Postsynaptic Potentials, Membrane Transport Proteins, Amino Acid Transport Systems, Acidic, Amino Acid Transport System X-AG, Vesicular Transport Proteins, Vesicular Glutamate Transport Proteins, Vesicular Glutamate Transport Protein 1, Vesicular Glutamate Transport Protein 2

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VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate

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