The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Identification of the Kv2.1 K+Channel as a Major Component of the Delayed Rectifier K+Current in Rat Hippocampal Neurons
Open accessAbstract
Molecular cloning studies have revealed the existence of a large family of voltage-gated K+channel genes expressed in mammalian brain. This molecular diversity underlies the vast repertoire of neuronal K+channels that regulate action potential conduction and neurotransmitter release and that are essential to the control of neuronal excitability. However, the specific contribution of individual K+channel gene products to these neuronal K+currents is poorly understood. We have shown previously, using an antibody, “KC,” specific for the Kv2.1 K+channel α-subunit, the high-level expression of Kv2.1 protein in hippocampal neurons in situ and in culture. Here we show that KC is a potent blocker of K+currents expressed in cells transfected with the Kv2.1 cDNA, but not of currents expressed in cells transfected with other highly related K+channel α-subunit cDNAs. KC also blocks the majority of the slowly inactivating outward current in cultured hippocampal neurons, although antibodies to two other K+channel α-subunits known to be expressed in these cells did not exhibit blocking effects. In all cases the blocking effects of KC were eliminated by previous incubation with a recombinant fusion protein containing the KC antigenic sequence. Together these studies show that Kv2.1, which is expressed at high levels in most mammalian central neurons, is a major contributor to the delayed rectifier K+current in hippocampal neurons and that the KC antibody is a powerful tool for the elucidation of the role of the Kv2.1 K+channel in regulating neuronal excitability.
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Trade-off between transcriptome plasticity and genome evolution in cephalopods
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A Novel Targeting Signal for Proximal Clustering of the Kv2.1 K+ Channel in Hippocampal Neurons
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Self-citationGraded Regulation of the Kv2.1 Potassium Channel by Variable Phosphorylation
Park, K.-S., Mohapatra, D. P., Misonou, H., & Trimmer, J. S. (2006) · Science · doi:10.1126/science.1124254 · Cited by 262
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Metadata
- Authors
- Murakoshi, H., & Trimmer, J. S.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-03-01
- Volume
- 19
- Issue
- 5
- Pages
- 1728-1735
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2099949778
- Cited by
- 301
- References
- 39
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Murakoshi, H., & Trimmer, J. S. (1999). Identification of the Kv2.1 K+Channel as a Major Component of the Delayed Rectifier K+Current in Rat Hippocampal Neurons. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.19-05-01728.1999
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