The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Vascular Endothelial Growth Factor Has Neurotrophic Activity and Stimulates Axonal Outgrowth, Enhancing Cell Survival and Schwann Cell Proliferation in the Peripheral Nervous System
Open accessAbstract
Vascular endothelial growth factor (VEGF) is a mitogen for endothelial cells, and it promotes angiogenesis in vivo. Here we report that VEGF 165 has neurotrophic actions on cultured adult mouse superior cervical ganglia (SCG) and dorsal root ganglia (DRG), measured as axonal outgrowth. Maximal effect was observed at 10–50 ng/ml for SCG and 100 ng/ml for DRG. VEGF-induced axonal outgrowth was inhibited by the mitogen-activated protein kinase kinase inhibitor PD 98059 but not by the protein kinase inhibitor K252a. VEGF also increased survival of both neurons and satellite cells and the number of proliferating Schwann cells. Immunocytochemistry and immunoblotting revealed that VEGF was expressed in virtually all nerve cells in the SCG but only in a population of small-diameter (<35 μm) neurons representing ∼30% of the neurons in DRG. Immunostaining showed that the VEGF receptor fetal liver kinase receptor (flk-1) was found on nerve cell bodies in DRG and to a lesser extent on neurons in SCG. Growth cones of regenerating axons from both types of ganglia exhibited flk-1 immunoreactivity, as did Schwann cells. We conclude that VEGF has both neurotrophic and mitogenic activity on cells in the peripheral nervous system.
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“Vascular endothelial growth factor (VEGF) is known to promote revascularization, axonal outgrowth, and Schwann cell proliferation.58”
From Regenerative Electrode Interfaces for Neural Prostheses. (2016) · cites this paper as [58]
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Citations
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Background
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Items 301–400 of 750
The role of the immune system in neurofibromatosis type 1-associated nervous system tumors
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BackgroundNeuropilin 1 and CD25 co-regulation during early murine thymic differentiation
Corbel, C., Lemarchandel, V., Thomas‐Vaslin, V., Pelus, A.-S., Agboton, C., & Roméo, P. (2007) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2007.01.009 · Cited by 44
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“VEGF is a pro-angiogenic (41, 63) neurotrophic factor (49, 51, 52) and is elevated in AD (30, 54).”
BackgroundAntivascular Endothelial Growth Factor Agents for Neovascular Age-Related Macular Degeneration
Zampros, I., Praidou, A., BRAZITIKOS, P. D., Ekonomidis, P., & Androudi, S. N. (2011) · Journal of Ophthalmology · doi:10.1155/2012/319728 · Cited by 44
“VEGF has neuroprotective properties [23] that may be attributed in part to its ability to increase the survival of neurons and proliferating Schwann cells [24].”
BackgroundFujimaki, H., Matsumine, H., Osaki, H., Ueta, Y., Kamei, W., Shimizu, M., Hashimoto, K., Fujii, K., Kazama, T., Matsumoto, T., et al. (2019) · Regenerative Therapy · doi:10.1016/j.reth.2019.08.004 · Cited by 43
“Axonal outgrowth is stimulated by the neurotrophic activity of VEGF in cervical ganglia or dorsal ganglia [25].”
BackgroundAqueous Humor Levels of Vascular Endothelial Growth Factor in Retinitis Pigmentosa
Salom, D., Díaz-Llopis, M., Delpech, S. G., Udaondo, P., Sancho‐Tello, M., & Romero, F. J. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1168 · Cited by 43
Chu, L., chen, J., Yu, K., Cheng, K., Chen, I. J., Wu, P., & Wu, B. (2012) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201202500124 · Cited by 43
“VEGF shows some neurotrophic and neuroprotective effects (20).”
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“Since other reports have shown VEGFR-2 expression by adult DRG sensory neurons detected by immunostaining (31, 32), we confirmed our immunohistochemistry results in embryonic DRG by comparing RTPCR of endothelial vs.”
ResultStorkebaum, E., de Almodóvar, C. R., Meens, M. J. P. M. T., Zacchigna, S., Mazzone, M., Vanhoutte, G., Vinckier, S., Miśkiewicz, K., Poesen, K., Lambrechts, D., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.929364 · Cited by 41
He, B., Liu, S., Chen, Q., Li, H., Ding, W.-J., & Deng, M. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.06.001 · Cited by 42
“In this study, we determined the dose dependence of PD98059 and wortmannin in inhibition of phosphorylated-ERK1/2 and Akt, our results confirmed a similar inhibitory effect of PD98059 and wortmannin in CMCS treated SCs proliferation as in SCs proliferation treated by IGF, VEGF and TMT (Campana et al., 1999; Seo, et al…”
MethodResultLee, J., Tae, H., Kim, I. H., Cho, J.-H., Lee, T.-K., Park, J. H., Ahn, J. H., Choi, S. Y., Bai, H. C., Shin, B.-N., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0219-2 · Cited by 41
“It has been reported that VEGF stimulates axonal outgrowth and increases the survival of mouse superior cervical and dorsal root ganglion cells [46] and that VEGF promotes the survival of rat mesencephalic neurons in culture [47].”
BackgroundRole of shortwave and microwave diathermy in peripheral neuropathy
Fu, T., Lineaweaver, W. C., Zhang, F., & Zhang, J. (2019) · Journal of International Medical Research · doi:10.1177/0300060519854905 · Cited by 42
Hormesis: A potential strategic approach to the treatment of neurodegenerative disease
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Engineered Schwann Cell-Based Therapies for Injury Peripheral Nerve Reconstruction
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The pattern of neurovascular development in the forelimb of the quail embryo.
Bates, D., Taylor, G., & Newgreen, D. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0771 · Cited by 40
VEGF-A and Semaphorin3A: Modulators of vascular sympathetic innervation
Long, J. B., Jay, S. M., Segal, S. S., & Madri, J. A. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.07.023 · Cited by 41
“Angiogenic factors exert neurotrophic and neuroprotective effects in-vivo and in-vitro (Cheng et al., 2004; Rosenstein and Krum, 2004; Schwarz et al., 2004; Sondell and Kanje, 2001; Sondell et al., 1999; Sondell et al., 2000; Storkebaum et al., 2005; Wingerd et al., 2002).”
BackgroundEvaluation of Sirtuin Role in Neuroprotection of Retinal Ganglion Cells in Hypoxia
Balaiya, S., Ferguson, L. R., & Chalam, K. V. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-9259 · Cited by 41
Postnatal expression of VEGF and its receptor flk-1 in peripheral ganglia
Sondell, M., & Kanje, M. (2001) · Neuroreport · doi:10.1097/00001756-200101220-00028 · Cited by 41
Self-citationNeuroprotection using gene therapy to induce vascular endothelial growth factor-A expression
Sakowski, S. A., Heavener, S. B., Lunn, J. S., Fung, K., Oh, S. S., Spratt, S. K., Hogikyan, N. D., & Feldman, E. L. (2009) · Gene Therapy · doi:10.1038/gt.2009.111 · Cited by 41
Reimers, D., Herranz, A. S., Díaz-Gil, J. J., Lobo, M. V. T., Paı́no, C. L., Alonso, R. L., Asensio, M. J., Gonzalo‐Gobernado, R., & Bazán, E. (2005) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.5a6805.2005 · Cited by 41
Chavez, J. C., & LaManna, J. C. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0205-0_55 · Cited by 41
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“The VEGF/VEGFR-2 signaling pathway has been shown to promote survival and growth of neurons in mesencephalic (16) and in superior cervical and dorsal root ganglia explant cultures (14, 15).”
BackgroundYang, Z., Cai, X., Xu, A., Xu, F., & Qin, L. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2015.06.005 · Cited by 40
“VEGF is further involved in neurogenesis; it stimulates axonal outgrowth and improves the survival of cultured superior cervical and dorsal-route ganglion neurons [41,42] and enhances the survival of mesencephalic neurons in organotypic explant cultures [43].”
BackgroundVascular Endothelial Growth Factor Mediates the Sprouted Axonogenesis of Breast Cancer in Rat
Han, H., Yang, C., Zhang, Y., Han, C., & Zhang, G. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.12.006 · Cited by 43
Vascular-specific growth factor angiopoietin 1 is involved in the organization of neuronal processes
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“…neurotrophic and neuroprotective functions, including axonal growth and cell survival of various populations of neurons (Silverman et al., 1999; Sondell et al., 1999; Jin et al., 2000; Matsuzaki et al., 2001; Oosthuyse et al., 2001; Ogunshola et al., 2002) and inducing neurogenesis in cultured…”
BackgroundDifferential gene expression between human schwannoma and control Schwann cells
Hanemann, C. O., Bartelt‐Kirbach, B., Diebold, R., Kaempchen, K., Langmesser, S., & Utermark, T. (2006) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2006.00769.x · Cited by 40
“In addition to playing a role in angiogenesis also in peripheral nerves [43], VEGF influences differentiation of different cell types, which includes acting as a Schwann cell mitogen [ 44 ].”
BackgroundVascular endothelial growth factor (VEGF) isoform regulation of early forebrain development
Darland, D. C., Cain, J. T., Berosik, M. A., Saint‐Geniez, M., Odens, P. W., Schaubhut, G. J., Frisch, S., Stemmer-Rachamimov, A. O., Darland, T., & D'Amore, P. A. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.06.045 · Cited by 41
“…cells (Yang and Cepko, 1996) and has since been shown to promote neuronal survival and axon outgrowth in cultured peripheral neurons in vitro (Sondell et al., 1999; Sondell et al., 2000), cortical neurons in vitro and in vivo (Jin et al., 2002; Zhu et al., 2003) and retinal photoreceptors in…”
BackgroundPark, H. W., Moon, H.-E., Kim, H. R., Paek, S. L., Kim, Y., Chang, J. W., Yang, Y. S., Kim, K., 오원일, Hwang, J. H., et al. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23616 · Cited by 39
“For example, VEGF stimulates axonal outgrowth and improves the survival of cultured superior cervical and dorsal root ganglion neurons (Sondell et al., 1999, 2000).”
BackgroundCellular and molecular mechanisms involved in the neuroprotective effects of VEGF on motoneurons
Lladó, J., Tolosa, L., & Olmos, G. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00181 · Cited by 39
“In addition, direct effects of VEGF on Schwann cells have been described (Sondell et al., 1999).”
BackgroundInfluentialAdipocyte-Derived and Dedifferentiated Fat Cells Promoting Facial Nerve Regeneration in a Rat Model
Matsumine, H., Takeuchi, Y., Sasaki, R., Kazama, T., Kano, K., Matsumoto, T., Sakurai, H., Miyata, M., & Yamato, M. (2014) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000000537 · Cited by 39
Soheilian, M., Karimi, S., Montahae, T., Nikkhah, H., & Mosavi, S. A. (2017) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-017-3702-1 · Cited by 39
Friends Turned Foes: Angiogenic Growth Factors beyond Angiogenesis
Matkar, P. N., Ariyagunarajah, R., Leong-Poi, H. M., & Singh, K. K. (2017) · Biomolecules · doi:10.3390/biom7040074 · Cited by 39
“It is worthwhile to investigate these protective effects of VEGF in other neurodegenerative disorders, particularly due to the role of VEGF receptors in several neural cells [111,114,115] and the functional benefit offered by VEGF in different types of neurons [115,116], astrocytes [117], microglial cells [118] and Sc…”
BackgroundWang, W., Dong, J., Liu, X., Wang, Y., Ying, G. X., Ni, Z.-M., & Zhou, C. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.04.064 · Cited by 39
Gilson, J. M., & Blakemore, W. F. (2002) · Neuroreport · doi:10.1097/00001756-200207020-00027 · Cited by 39
Enhanced Vascularization and Survival of Neural Transplants with Ex Vivo Angiogenic Gene Transfer
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“, 2014) but both isoforms promote neuroprotection (Beazley-Long et al., 2013; Sondell and Kanje, 1999).”
BackgroundUpdate in the molecular mechanism and biomarkers of diabetic retinopathy
Zhu, H., Li, B., Huang, T., Wang, B., Li, S., Yu, K., Cai, L., Ye, Y., Chen, S., Zhu, H., et al. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167758 · Cited by 40
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“Deficiency in VEGF results in neurodegenerative disorders.(12,13)”
NISHIDA, Y., Yamada, Y., Kanemaru, H., Ohazama, A., Maeda, T., & Seo, K. (2018) · Biomedical Research · doi:10.2220/biomedres.39.287 · Cited by 37
“However, since they contained a lengthy observation after axotomy in vivo (7, 11, 16, 18), very few reports have been available describing on early changes after nerve injury (4, 6).”
BackgroundVEGF and ALS: the luckiest growth factor?
Greenberg, D. A., & Jin, K. (2003) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2003.11.006 · Cited by 37
VEGF 164 gene transfer by electroporation improves diabetic sensory neuropathy in mice
Murakami, T., Arai, M., Sunada, Y., & Nakamura, A. (2006) · The Journal of Gene Medicine · doi:10.1002/jgm.893 · Cited by 37
“VEGF 164 may restore the sensory functions of Aδ and C fibers through these receptors on small DRG neurons, thus resulting in improvement of the hypoalgesia.”
BackgroundInfluentialParacrine control of vascular innervation in health and disease
Storkebaum, E., & Carmeliet, P. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02333.x · Cited by 37
“Hydroporation of WT mice with a plasmid encoding soluble Flk1 (sFlk1 mice), which traps VEGF, indeed resulted in neuro-effector dysfunction as early as 10 days after hydroporation, whereas arterial SMC function was not affected.”
BackgroundInfluentialChoi, J., Kim, H.-Y., Cha, J., Choi, J.-Y., Park, S., Jeong, C. H., Jeun, S., & Lee, M. (2007) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.6a7139.2007 · Cited by 35
“Recent studies have shown that VEGF is also a possible direct neurotrophic and neuroprotective factor (Sondell et al. 1999; Oosthuyse et al. 2001; Jin et al. 2002; Rosenstein et al. 2003; Sun et al. 2003; Han et al. 2004).”
BackgroundBearden, S. E., & Segal, S. S. (2004) · Microcirculation · doi:10.1080/10739680490517659 · Cited by 36
Vascular endothelial growth factor promotion of neoangiogenesis in conventional nerve grafts
Wongtrakul, S., Bishop, A. T., & Friedrich, P. F. (2002) · The Journal Of Hand Surgery · doi:10.1053/jhsu.2002.31158 · Cited by 36
Shah, A. P., Carreno, F. R., Wu, H., Chung, Y. A., & Frazer, A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.02.024 · Cited by 37
“Further, K252a (Sondell et al., 1999) does not block the neurotrophic effects of vascular endothelial growth factor through its tyrosine kinase receptor.”
BackgroundDong, M., Di, G., Zhang, X., Zhou, Q., & Shi, W. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-20926 · Cited by 35
cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis
Yoon, Y., Tsai, W., de Velde, S. V., Chen, Z., Lee, K., Morgan, D. A., Rahmouni, K., Matsumura, S., Wiater, E., Song, Y., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805257115 · Cited by 36
“Addition of neutralizing antisera against NGF, BDNF, or the angiogenic factor VEGFA, which can also function as a neurotrophin (26, 27), reduced neurite outgrowth (Fig.”
BackgroundVascular endothelial growth factor mediates vasogenic edema in acute lead encephalopathy
Hossain, M. A., Russell, J. C., Miknyoczki, S. J., Ruggeri, B., Lal, B., & Laterra, J. (2004) · Annals of Neurology · doi:10.1002/ana.20065 · Cited by 36
Hypoxia Induces the Expression of Membrane-Type 1 Matrix Metalloproteinase in Retinal Glial Cells
Noda, K., Ishida, S., Shinoda, H., Koto, T., Aoki, T., Tsubota, K., Oguchi, Y., Okada, Y., & Ikeda, E. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-1528 · Cited by 35
“The target of VEGF was originally thought to be restricted to endothelial cells, but accumulating evidence has indicated that nonendothelial cells can be VEGF targets by expressing VEGF receptors.(40,41,55,56) In the present investigation, we analyzed the expression of VEGF receptors in cultured retinal glial cells.”
BackgroundUnderstanding the Biology of Compressive Neuropathies
Gupta, R., Rummler, L. S., & Steward, O. (2005) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000164354.61677.f5 · Cited by 35
“To further investigate the ischemic changes associated with CNC injury, we examined the expression of vascular endothelial growth factor (VEGF), a potent mitogen and chemotactic agent for endothelial and Schwann cells that stimulate angiogenesis and increase vascular permeability.(15,50,64,69,89,93) Jin et al suggeste…”
BackgroundNeuron differentiation and neuritogenesis stimulated by N-acetylcysteine (NAC)
Qian, H., & Yang, Y. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.72 · Cited by 34
VEGF receptor signaling in vertebrate development
Vieira, J. M., Ruhrberg, C., & Schwarz, Q. (2010) · Organogenesis · doi:10.4161/org.6.2.11686 · Cited by 37
Chauvet, S., Burk, K., & Mann, F. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1278-4 · Cited by 40
Dorafshar, A. H., Angle, N., Bryer‐Ash, M., Huang, D., Farooq, M. M., Gelabert, H. A., & Freischlag, J. A. (2003) · Journal of Surgical Research · doi:10.1016/s0022-4804(03)00254-3 · Cited by 34
“Evidence suggests that VEGF receptors, Flt-1 and Flk-1/KDR, are present not only on endothelial cells but are present on a number of other cell types [31–33].”
BackgroundShadad, O., Chaulagain, R., Luukko, K., & Kettunen, P. J. (2019) · Journal of Anatomy · doi:10.1111/joa.12950 · Cited by 33
“VEGF acts also as a chemoattractant to commissural axons and stimulates growth of peripheral axons through VEGFR2 (Sondell et al. 1999, Sondell et al. 2000, Ruiz de Almodovar et al. 2011).”
BackgroundNeuroprotective Effect of Vascular Endothelial Growth Factor on Motoneurons of the Oculomotor System
Silva-Hucha, S., Pastor, Á. M., & Morcuende, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020814 · Cited by 33
Osuka, K., Watanabe, Y., Usuda, N., Nakazawa, A., Tokuda, M., & Yoshida, J. (2004) · Stroke · doi:10.1161/01.str.0000143454.14159.28 · Cited by 33
Benvenuti, S., Deledda, C., Luciani, P., Modi, G., Bossio, A., Giuliani, C., Fibbi, B., & Peri, A. (2013) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8235-0 · Cited by 33
Bai, Y., Cui, M., Meng, Z., Shen, L., He, Q., Zhang, X., Chen, F., & Xiao, J. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.11.052 · Cited by 32
Human neural stem cells express extra-neural markers
Parati, E. A., Bez, A., Ponti, D., de Grazia, U., Corsini, E., Cova, L., Sala, S., Colombo, A., Alessandri, G., & Pagano, S. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03291-7 · Cited by 33
Beyond vessels: unraveling the impact of VEGFs on neuronal functions and structure
Aksan, B., & Mauceri, D. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01128-8 · Cited by 34
“For instance, VEGFA promotes neurite outgrowth in axoto-mized postnatal retinal RGCs, embryonic glial-reduced ventral mesencephalic neuronal cultures, and explants of adult mouse superior cervical ganglia (SCG) or DRG [231–233].”
Enhanced axon outgrowth and improved long‐distance axon regeneration in sprouty2 deficient mice
Marvaldi, L., Thongrong, S., Kozłowska, A., Irschick, R., Pritz, C. O., Bäumer, B. E., Ronchi, G., Geuna, S., Hausott, B., & Klimaschewski, L. P. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22224 · Cited by 32
“However, ERK inhibitors apparently exert no effect on spontaneous axon outgrowth of adult DRG explants, while neurotrophic factor induced growth is significantly impaired (Sondell et al., 1999; Sjogreen et al., 2000).”
BackgroundHeritability of circulating growth factors involved in the angiogenesis in healthy human population
Pantsulaia, I., Trofimov, S., Kobyliansky, E. D., & Livshits, G. (2004) · Cytokine · doi:10.1016/j.cyto.2004.04.005 · Cited by 32
Mani, N., Khaibullina, A., Krum, J. M., & Rosenstein, J. M. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000090620.86921.9c · Cited by 32
“At higher doses of VEGF, increased immunostaining for developmentally regulated mature neuronal and glial markers has been observed (Mani et al., 2000; Silverman et al., 1999; Sondell et al., 1999).”
BackgroundPhysiological Role of Vascular Endothelial Growth Factors as Homeostatic Regulators
Bates, D. O., Beazley‐Long, N., Benest, A. V., Ye, X., Ved, N., Hulse, R. P., Barratt, S. L., Machado, M. J. C., Donaldson, L. F., Harper, S. J., et al. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170015 · Cited by 36
Xu, A., Zhang, H., Zhang, Y., Wu, J., & Huang, Z. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.07.026 · Cited by 40
“A study using the MCAO mouse model revealed significant increase in the number of new blood vessels in the ischemic penumbra within 2 — 3 days of vascular occlusion 265 .”
Activation of cerebral recovery by matrix metalloproteinase-9 after intracerebral hemorrhage
Lei, C., Lin, S., Zhang, C., Wu, T., Dong, W., Hao, Z., Liu, M., & Wu, B. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.11.008 · Cited by 31
“In addition to acting in the ipsilateral brain, VEGF has been shown to exert neurotrophic and mitogenic effects on cells in the peripheral nervous system (Sondell et al., 1999).”
Pang, C.-J., Tong, L., Ji, L., Wang, Z., Zhang, X., Gao, H., Jia, H., Zhang, L., & Xiao-jie, T. (2013) · Synapse · doi:10.1002/syn.21669 · Cited by 31
“VEGF stimulates neurogenic, protective and neurotrophic activities, including proliferation of astrocytes (Silverman et al., 1999) and Schwann cells (Sondell et al., 1998, 1999).”
BackgroundSemaphorins in the development, homeostasis and disease of hormone systems
Giacobini, P., & Prévot, V. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.11.005 · Cited by 34
Giacobini, P. (2015) · Neuroendocrinology · doi:10.1159/000431021 · Cited by 32
Metallothionein-III induces HIF-1α-mediated VEGF expression in brain endothelial cells
Kim, H. G., Hwang, Y. P., & Jeong, H. G. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.02.059 · Cited by 31
Adipose-derived stem cells ameliorate erectile dysfunction after cavernous nerve cryoinjury
Yang, R., Fang, F., Wang, J., & Guo, H. (2015) · Andrology · doi:10.1111/andr.12047 · Cited by 30
“In a CN cryoinjury rat model, a significant decrease in nitric oxide synthase (NOS) containing nerves was noticed in the penis and main pelvic ganglia (MPG) (El-Sakka et al., 1998).”
BackgroundHubbell, M. C., Semotiuk, A., Thorpe, R. B., Adeoye, O. O., Butler, S. M., Williams, J. M., Khorram, O., & Pearce, W. J. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00408.2011 · Cited by 30
Pharmacogenetics of Erectile Dysfunction: Navigating into Uncharted Waters
Lacchini, R., & Tanus-Santos, J. E. (2014) · Pharmacogenomics · doi:10.2217/pgs.14.110 · Cited by 30
Pasin, T., ATAOĞLU, S., PASİN, Ö., & Ankaralı, H. Ç. (2019) · Archives of Rheumatology · doi:10.5606/archrheumatol.2019.7225 · Cited by 30
Pro- and Antiangiogenic Factors in Gliomas: Implications for Novel Therapeutic Possibilities
Groblewska, M., & Mroczko, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116126 · Cited by 35
Chen, J. R., Zacharek, A., Li, A., Zhang, C., Ding, J., Roberts, C., Lü, M., Kapke, A., & Chopp, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.042 · Cited by 31
“VEGF, an angiogenic factor, not only induces angiogenesis, but also stimulates neurogenesis and axonal outgrowth (Sondell et al., 1999).”
BackgroundCisplatin induced sensory neuropathy is prevented by vascular endothelial growth factor-A.
Vencappa, S., Donaldson, L. F., & Hulse, R. P. (2015) · PubMed Central · Cited by 29
Feng, Y., Rhodes, P. G., Liu, H., & Bhatt, A. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.024 · Cited by 29
Kim, B.-K., Kim, S. E., Shim, J.-H., Woo, D., Gil, J.-E., Kim, S., & Kim, J. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.09.053 · Cited by 29
“of their own growth and differentiation during embryonic development [8–14].”
BackgroundCanavese, M., & Spaccapelo, R. (2014) · Pathogens and Global Health · doi:10.1179/2047773214y.0000000130 · Cited by 28
Mukhamedshina, Y. O., Garanina, E. E., Masgutova, G. A., Galieva, L. R., Sanatova, E. R., Chelyshev, Y. A., & Rizvanov, A. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151745 · Cited by 28
“GDNF has been demonstrated to increase the number and size of regenerating axons and to stimulate neurite outgrowth in cultures of spinal ganglion neurons [24], whereas VEGF, a typical neurotrophic factor, supports survival motor [13] and sensitive [25] neurons stimulating neurogenesis and axonal growth [14].”
BackgroundMotawi, T. K., Rizk, S. M., Ibrahim, I. A., & El‐Emady, Y. F. (2013) · Cell Biochemistry and Function · doi:10.1002/cbf.2987 · Cited by 29
“Vascular factors are thought to be central in the development of diabetic neuropathy,(32,33) and VEGF has neuroprotective effects.(34,35) The relationship between VEGF and neural development and repair (i.”
BackgroundSundberg, L. M., Herrera, J. J., & Narayana, P. A. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2010.1533 · Cited by 28
“The observed reduction in hypointense lesion volume may be attributed to the neuroprotective effect of VEGF, resulting in tissue sparing, and/or its ability to stimulate proliferation of neurons and axonal sprouting (Brockington et al., 2004; Sondell et al., 1999, 2000).”
Zhang, Y.-G., Huang, J., Hu, X., Sheng, Q., Zhao, W. G., & Luo, Z.-J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029184 · Cited by 28
Vascular endothelial growth factor-B expression in postischemic rat brain
Xie, L., Mao, X., Jin, K., & Greenberg, D. A. (2013) · Vascular Cell · doi:10.1186/2045-824x-5-8 · Cited by 29
“Vascular endothelial growth factor (VEGF-A), identified originally as an angiogenic [1] and vascular permeability [2] factor, also exhibits direct neurotrophic [3] and neuroprotective [4] effects.”
BackgroundJo, Y. J., Kim, W., Shin, I.-H., & Kim, J. (2016) · Korean Journal of Ophthalmology · doi:10.3341/kjo.2016.30.2.114 · Cited by 28
“Considering that VEGF is involved in the survival of neuronal cells and has neuroprotective and neurotrophic actions in addition to its angiogenesis role [16,17], anti-VEGF treatment can affect the neurophysiologic role of VEGF and cause damage to optic nerves.”
BackgroundÉgervári, K., Potter, G., Guzmán-Hernández, M. L., Salmon, P., Soto-Ribeiro, M., Kastberger, B., Balla, T., Wehrle‐Haller, B., & Kiss, J. Z. (2015) · Glia · doi:10.1002/glia.22939 · Cited by 27
“After hypoxic/ischemic damage, astrocyte-derived VEGF not only stimulates angiogenesis as well as endothelial cell proliferation, but also has a protective and trophic effect on neurons (Sondell et al., 1999; Zachary, 2005).”
BackgroundBaumann, J., Tsao, C.-C., Patkar, S., Huang, S., Francia, S., Magnussen, S. N., Gassmann, M., Vogel, J., Köster-Hegmann, C., & Ogunshola, O. O. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-021-00302-y · Cited by 28
“For example, endogenous VEGF secretion during injury increased astrocyte survival and proliferation per se, as well as provided neuroprotection [48, 50].”
BackgroundLei, T., Jing, D., Xie, K., Jiang, M., Li, F., Cai, J., Wu, X., Tang, C., Xu, Q., Liu, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061414 · Cited by 29
Foxton, R. H., Osborne, A., Martin, K. R. G., Ng, Y., & Shima, D. T. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.110 · Cited by 27
Physiological hypoxia promotes survival of cultured cortical neurons
Li, D., Marks, J. D., Schumacker, P. T., Young, R. M., & Brorson, J. R. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04335.x · Cited by 27
“Neurotrophic effects of VEGF have been linked to the MAP kinase pathway (Sondell et al., 1999) and to the phosphatidylinositol 3-kinase–Akt pathway (Li et al., 2003).”
BackgroundResultInfluentialOlmarker, K. (2005) · Spine · doi:10.1097/01.brs.0000167823.17687.ec · Cited by 27
A conditioning lesion enhances sympathetic neurite outgrowth
Shoemaker, S. E., Sachs, H. H., Vaccariello, S. A., & Zigmond, R. E. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.02.023 · Cited by 26
Metadata
- Authors
- Sondell, M., Lundborg, G., & Kanje, M.
- Affiliations
- Lund University (SE)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-07-15
- Volume
- 19
- Issue
- 14
- Pages
- 5731-5740
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6783109
- OpenAlex
- W1962154683
- Cited by
- 750
- References
- 44
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 8 · 2023: 11 · 2022: 16 · 2021: 19 · 2020: 26 · 2019: 25 · 2018: 26 · 2017: 28 · 2016: 33 · 2015: 22 · 2014: 44 · 2013: 42 · 2012: 37
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- vascular endothelial growth factor, VEGF165, neurotrophic activity, axon growth, Schwann cell proliferation, satellite cells, superior cervical ganglion, dorsal root ganglia, MEK, PD98059, K252a, axon regeneration, peripheral nervous system, small-diameter neurons, cell survival
- MeSH terms
- Animals, Axons, Carbazoles, Cell Survival, Cells, Cultured, Enzyme Inhibitors, Flavonoids, Ganglia, Spinal, Humans, Lymphokines, Male, Mice, Inbred Strains, Nerve Growth Factors, Recombinant Proteins, Schwann Cells, Time Factors, Endothelial Growth Factors, Superior Cervical Ganglion, Indole Alkaloids, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Protein Kinase Inhibitors, Mice
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