The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Vascular Endothelial Growth Factor Has Neurotrophic Activity and Stimulates Axonal Outgrowth, Enhancing Cell Survival and Schwann Cell Proliferation in the Peripheral Nervous System
Open accessAbstract
Vascular endothelial growth factor (VEGF) is a mitogen for endothelial cells, and it promotes angiogenesis in vivo. Here we report that VEGF 165 has neurotrophic actions on cultured adult mouse superior cervical ganglia (SCG) and dorsal root ganglia (DRG), measured as axonal outgrowth. Maximal effect was observed at 10–50 ng/ml for SCG and 100 ng/ml for DRG. VEGF-induced axonal outgrowth was inhibited by the mitogen-activated protein kinase kinase inhibitor PD 98059 but not by the protein kinase inhibitor K252a. VEGF also increased survival of both neurons and satellite cells and the number of proliferating Schwann cells. Immunocytochemistry and immunoblotting revealed that VEGF was expressed in virtually all nerve cells in the SCG but only in a population of small-diameter (<35 μm) neurons representing ∼30% of the neurons in DRG. Immunostaining showed that the VEGF receptor fetal liver kinase receptor (flk-1) was found on nerve cell bodies in DRG and to a lesser extent on neurons in SCG. Growth cones of regenerating axons from both types of ganglia exhibited flk-1 immunoreactivity, as did Schwann cells. We conclude that VEGF has both neurotrophic and mitogenic activity on cells in the peripheral nervous system.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Vascular endothelial growth factor (VEGF) is known to promote revascularization, axonal outgrowth, and Schwann cell proliferation.58”
From Regenerative Electrode Interfaces for Neural Prostheses. (2016) · cites this paper as [58]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · cited 2×
“The samples were electrophoresed according to Laemmli (1970).”
MethodRaza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,311
The Biology of Vascular Endothelial Growth Factor
Ferrara, N., & Davis-Smyth, T. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.1.0287 · Cited by 4,585
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., & Schuh, A. C. (1995) · Nature · doi:10.1038/376062a0 · Cited by 3,931 · cited 2×
“Both receptor types are essential for development and organization of endothelial cells and the disruption of the genes encoding flk-1 and flt-1 results in defects of blood vessel formation and an early death of homozygous mice embryo (Fong et al., 1995; Shalaby et al., 1995 ).”
BackgroundRole of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
Fong, G.-H., Rossant, J., Gertsenstein, M., & Breitman, M. L. (1995) · Nature · doi:10.1038/376066a0 · Cited by 2,606 · cited 1×
“Both receptor types are essential for development and organization of endothelial cells and the disruption of the genes encoding flk-1 and flt-1 results in defects of blood vessel formation and an early death of homozygous mice embryo (Fong et al., 1995; Shalaby et al., 1995).”
BackgroundSöker, S., Takashima, S., Miao, H. Q., Neufeld, G., & Klagsbrun, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81402-6 · Cited by 2,493 · cited 2×
“It has also been reported that VEGF165 binds to neurophilin-1 ( Soker et al., 1998 ), a neuronal cell surface molecule that is important for chemorepulsive signaling during peripheral axonal outgrowth in the developing mice (Kitsukawa et al., 1997).”
BackgroundVascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF
Keck, P. J., Hauser, S. D., Krivi, G. G., Sanzo, K., Warren, T. G., Feder, J., & Connolly, D. T. (1989) · Science · doi:10.1126/science.2479987 · Cited by 2,058 · cited 2×
“However, other angiogenic factors, including basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF), have been shown to be neurotrophic or exert growthpromoting activity (Rydel and Greene, 1987; Davis and Stroobant, 1990; Smits et al., 1991; Fujimoto et al., 1997).”
BackgroundThe fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor
de Vries, C. J. M., Escobedo, J. A., Ueno, H., Houck, K. A., Ferrara, N., & Williams, L. T. (1992) · Science · doi:10.1126/science.1312256 · Cited by 2,019 · cited 2×
“VEGF exerts its action via high-affinity binding to two types of phosphotyrosine kinase receptors: fms-like tyrosine kinase (flt-1) and fetal liver kinase receptor (flk-1) (De Vries et al., 1992; Quinn et al., 1993).”
BackgroundWaltenberger, J. L., Claesson, L., Siegbahn, A., Shibuya, M., & Heldin, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47116-5 · Cited by 1,661 · cited 2×
“The human counterpart to the flk-1 receptor, which activates the mitogen-activated protein kinase (MAPK) pathway, is also known to induce reorganization of actin filaments, chemotaxis, and give rise to a mitogen response in endothelial cells (Waltenberger et al., 1994; Kroll and Waltenberger, 1997).”
BackgroundMolecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins
Ferrara, N., Houck, K. A., Jakeman, L. B., & LEUNG, D. W. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-1-18 · Cited by 1,655 · cited 1×
“In the nervous system, VEGF mRNA has been found in neurons in the capillary-rich areas of the brain, for instance in the pars distalis cells of the pituitary gland but also in glial cells in the retina after hypoxia (Ferrara et al., 1992; Stone et al., 1995).”
Background
Cited by
Sorted by citations
Items 601–700 of 750
Almeida‐Leite, C. M., & Arantes, R. M. E. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.09.015 · Cited by 5
Control of cellular motility by neuropilin-mediated physical interactions
Li, X., Parker, M. W., & Kooi, C. W. V. (2014) · BioMolecular Concepts · doi:10.1515/bmc-2013-0035 · Cited by 6
“For example, VEGF-A stimulates axon outgrowth (104, 105), whereas Sema3F blocks endothelial cell migration (106).”
BackgroundFactors Regulating Neurogenesis in the Adult Dentate Gyrus
Zhang, L., & Zhang, X. (2018) · InTech eBooks · doi:10.5772/intechopen.75631 · Cited by 7
Rao, M. S. R., & Abd‐El‐Basset, E. M. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00018 · Cited by 5
Rosenstein, J. M., Krum, J. M., & Ruhrberg, C. (2008) · Springer eBooks · doi:10.1007/978-0-387-78632-2_8 · Cited by 5
Vascular Endothelial Growth Factor and Its Receptors Expression in the Rat Eye.
Ueda, H., Kashiwagi, K., & Iizuka, Y. (2001) · ACTA HISTOCHEMICA ET CYTOCHEMICA · doi:10.1267/ahc.34.329 · Cited by 5
“These data are compatible with the previous study demonstrating that Flk-1 was localized in the cell body, axon and growth cone of the dorsal root ganglia and superior cervical ganglia in vitro [36].”
BackgroundResultKonstorum, A., Sprowl-Tanio, S., Waterman, M. L., Lander, A. D., & Lowengrub, J. S. (2013) · Journal of Coupled Systems and Multiscale Dynamics · doi:10.1166/jcsmd.2013.1028 · Cited by 6
Peripheral nerve repair: innovations and future directions
Aldali, F., 唐莉, Yang, Y., Huang, Y., Li, Y., Deng, C., & Chen, H. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-025-07567-z · Cited by 5
“In addition, VEGF expression after PNI is upregulated and contributes to both neovascularization and SC-guided axonal regeneration [37].”
Quigley, B. L., Wellington, N. J., Levenstein, J. M., Dutton, M., Bouças, A. P., Forsyth, G., Gallay, C. C., Hajishafiee, M., Treacy, C., Lagopoulos, J., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-91840-0 · Cited by 6
Increased Nerve Fibers in Placental Bed Myometrium in Women With Preeclampsia
Fan, R., Qiu, L., Huang, X., Chen, Z., Xu, H., Zhou, C., & Zhang, X. (2011) · Reproductive Sciences · doi:10.1177/1933719111411730 · Cited by 4
“Many angiogenic factors (eg, VEGF) have both neurogenic activity and angiogenic effects, whereas many neurogenic factors, such as neuropilin 1 and nerve growth factor (NGF), contribute to angiogenesis.(9-17) Recently, NGF, a neurotrophin that plays an important role in promoting neurotrophic and neurotropic effects in…”
BackgroundRegenerative effect of the polydeoxyribonucleotide after sciatic nerve transection in mouse
Park, J.-W., Kim, M.-S., Kim, S.-K., Lee, K.-C., & Lee, J.-W. (2015) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-015-0023-5 · Cited by 4
“Karagoz has noted that VEGF stimulates an Flk-1 receptor to promote growth of axons, increase cell viability, and accelerate Schwann cell proliferation [15,16].”
Vascular Endothelial Growth Factor and Its Receptors Are Expressed in Human Nerve Grafts
Ylä-Kotola, T. M., Kauhanen, S., Leivo, I. V. V., Haglund, C. H., & Tukiainen, E. J. (2010) · Journal of Reconstructive Microsurgery · doi:10.1055/s-0030-1270532 · Cited by 4
“In numerous studies, VEGF has been administered to neural structures in an attempt to influence nerve regeneration.(5,6,9,13)”
BackgroundInfluentialCui, H. Z., Yang, Z., Xiao, P., Shao, F., Zhao, S., & Tang, Z. (2020) · Shock · doi:10.1097/shk.0000000000001559 · Cited by 4
“The increased expression of ANG-1 and VEFG may also directly or indirectly contribute to the observed proliferative and protective effects in neurons (23, 26, 27).”
BackgroundBurn Injury-related Growth Factor Expressions and Their Potential Roles in Burn-related Neuropathies
Chaker, S. C., Saad, M., Mayes, T., & Lineaweaver, W. C. (2023) · Journal of Burn Care & Research · doi:10.1093/jbcr/irad184 · Cited by 4
Retinal Neovascularization and the Role of VEGF
Duh, E. J. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-563-3_15 · Cited by 4
“VEGF stimulated axonal outgrowth and increased survival of both neurons and satellite cells in experiments with cultured superior cervical ganglia and dorsal root ganglia ( 94 ).”
BackgroundExperimental therapeutic approaches to peripheral nerve tumors
Riley, J. R., Spiotta, A. M., & Boulis, N. M. (2007) · Neurosurgical FOCUS · doi:10.3171/foc.2007.22.6.3 · Cited by 4
Neuroimmune hypothesis of atherosclerosis
Chaldakov, G. N., Fiore, M., Stankulov, I. S., Triaca, V., Ghenev, P., & Aloe, L. (1999) · Biomedical Reviews · doi:10.14748/bmr.v10.6 · Cited by 4
Detection of extracellular signal-regulated kinase1/2 in the inner ear of guinea pigs
Heß, A., Michel, O., Kopeć, T., Wittekindt, C., Bloch, W., Stennert, E., & Addicks, K. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01266-0 · Cited by 4
Fujimaki, H., Matsumine, H., Osaki, H., Ueta, Y., Kamei, W., Shimizu, M., Hashimoto, K., Fujii, K., Kazama, T., Matsumoto, T., et al. (2020) · Regenerative Therapy · doi:10.1016/j.reth.2020.05.002 · Cited by 4
“Axonal outgrowth is stimulated by the neurotrophic activity of VEGF in cervical ganglia or dorsal ganglia [25].”
BackgroundLei, T., Jing, D., Xie, K., Jiang, M., Li, F., Cai, J., Wu, X., Tang, C., Xu, Q., Liu, J., et al. (2013) · PLoS ONE · doi:10.1371/annotation/b162aa26-6251-4db6-af5f-35b4d9ee5055 · Cited by 4
Epigenetic regulation of BDNF-TrkB signaling in the pathophysiology and treatment of mood disorders
Boulle, F. (2013) · Research Publications (Maastricht University) · doi:10.26481/dis.20131129fb · Cited by 4
Savage, A. M., Wagner, A. C., Kim, R. T., Gilbert, P., Singer, H. D., Chen, E., Kim, E. M., Lopez, N., Dooling, K. E., Paoli, J. C., et al. (2024) · Developmental Biology · doi:10.1016/j.ydbio.2025.05.030 · Cited by 3
Sonic Hedgehog Agonists Induce Repair Schwann Cells
Colchado, D., Schofield, J. B., Hunter, D. A., Xia, X., Yang, M., Sacks, J. M., Wood, M. D., & Li, X. (2025) · Biotechnology and Bioengineering · doi:10.1002/bit.70049 · Cited by 3
Vestibular Schwannoma Drug Development: Current State-of-the Art
Miller, C., Sudhoff, H. H., & Jacob, A. (2014) · Current Otorhinolaryngology Reports · doi:10.1007/s40136-014-0063-8 · Cited by 3
“This molecule promotes survival of various cell types, including Schwann cells [27] and correlates with vascularity and growth rate of several solid tumors [28].”
BackgroundVascular endothelial growth factor gene transfer for diabetic polyneuropathy
Kessler, J. A. (2009) · Annals of Neurology · doi:10.1002/ana.21686 · Cited by 3
Stem Cell Approaches for Treatment of Neurodegenerative Diseases
Anand, S. (2014) · Clinical Pharmacology & Biopharmaceutics · doi:10.4172/2167-065x.1000126 · Cited by 3
“have shown these to have neuroprotective effects [57-60].”
BackgroundChanges in the ganglion cell complex thickness after anti-VEGF treatment for diabetic macular edema
Çiloğlu, E., Ünal, F., & Doğan, N. Ç. (2020) · Arquivos Brasileiros de Oftalmologia · doi:10.5935/0004-2749.20200045 · Cited by 3
“VEGF is involved in the regulation of angiogenesis and neuroprotection in response to retinal ischemia and cell proliferation (4) .”
Vascular endothelial growth factor and neurodevelopment
Theis, V., & Theiß, C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817986-4.00021-3 · Cited by 3
Effect of Collagen Nerve Wrapping in a Rabbit Peripheral Neuropathy Model
Huddleston, H. P., Shah, N. V., Kurtzman, J. S., Dar, Q.-A., Wang, H., Carter, J., Hayes, W. T., Avoricani, A., Dua, K., & Koehler, S. M. (2021) · Plastic & Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000003919 · Cited by 3
The Association of Primary Open Angle Glaucoma and Ocular Hypertension with Anti-VEGF Injections
LoBue, S., Albear, S., Martin, C. R., Guagliardo, A., & Chang, T. (2024) · Clinical ophthalmology · doi:10.2147/opth.s482123 · Cited by 3
Growth factors and steroidogenesis in the bovine placenta
Sousa, L. M. M. D. C., Campos, D. B., Junior, J. B., Binelli, M., & Papa, P. D. C. (2008) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 3
Effect of primate bone marrow stromal cells on survival and neurite outgrowth
Kim, K. N., Guest, J. D., Oh, J. S., Pennant, W. A., Yoon, D. H., & Ha, Y. S. (2010) · Neuroreport · doi:10.1097/wnr.0b013e32833da3a6 · Cited by 3
Widerberg, A., & Dahlin, L. B. (2000) · Neuroreport · doi:10.1097/00001756-200008210-00020 · Cited by 3
Ranjbar, M., Kurz, M., Holzhey, A., Rades, D., & Grisanti, S. (2017) · Current Eye Research · doi:10.1080/02713683.2017.1355972 · Cited by 3
Increased angiogenesis by the rotational muscle flap is crucial for nerve regeneration
Pan, H.-C., Chang, M., Sheu, M., Chen, C., & Sheehan, J. P. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217402 · Cited by 3
Translational Challenges in Soft Tissue Regeneration
Liu, J., Ernst, J., Klingelhoefer, E., Saul, D., Lehmann, W., Felmerer, G., & Schilling, A. F. (2019) · Springer eBooks · doi:10.1007/978-3-030-19958-6_23 · Cited by 2
Chu, T., & Midha, R. (2022) · Muscle & Nerve · doi:10.1002/mus.27769 · Cited by 2
“The subtle differences may reflect the unique properties of Sk-SCs, such as higher VEGF release, which may influence axonal growth and SC migration.(5,11,12) Future studies may consider injuring the sciatic nerve proper to elicit a more severe injury to discern differences.”
BackgroundLee, H., Jeong, S., Kim, H.-J., Chung, Y., & Kwon, Y. K. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.06.056 · Cited by 2
Perspectives et voies de recherche dans le traitement des lésions nerveuses périphériques
Chammas, M., Coulet, B., Lacombe, F., Lazergues, C., Bacou, F., & Micallef, J. P. (2007) · Elsevier eBooks · doi:10.1016/b978-2-84299-846-2.50016-3 · Cited by 2
The Neuronal Influence on Retinal Vascular Pathology
Barber, A. J., Guilder, H. D. V., & Gastinger, M. J. (2007) · Springer eBooks · doi:10.1007/978-3-540-29542-6_6 · Cited by 2
La neurogénèse dans le cerveau adulte : de l’effondrement des dogmes vers de nouvelles thérapies ?
Crespel, A., Baldy-Moulinier, M., & Lerner‐Natoli, M. (2004) · Revue Neurologique · doi:10.1016/s0035-3787(04)71159-5 · Cited by 2
Appukuttan, B., McFarland, T. J., Stempel, A. J., Kassem, J. B., Hartzell, M., Zhang, Y., Bond, D., West, K., Wilson, R. L., Stout, A. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031260 · Cited by 2
“[29–40] Inhibition of VEGF production in tumor cells may help in treatments for cancer.”
BackgroundVEGF Receptor Signalling in Vertebrate Development
Vieira, J. M., Ruhrberg, C., & Schwarz, Q. (2008) · Springer eBooks · doi:10.1007/978-0-387-78632-2_2 · Cited by 2
Jiang, B., Zhang, Y., Zhao, J., She, C., Zhou, X., Wang, P., & Dong, Q. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.08.034 · Cited by 2
Haigh, J. J. (2008) · Springer eBooks · doi:10.1007/978-0-387-78632-2_5 · Cited by 2
A Contemporary Overview of Peripheral Nerve Research from Cleveland Clinic Microsurgery Laboratory
Siemionow, M., & Sari, A. (2014) · Springer eBooks · doi:10.1007/978-1-4471-6335-0_50 · Cited by 2
Wiring the Vascular Circuitry: From Growth Factors to Guidance Cues
Urness, L. D., & Li, D. Y. (2004) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(04)62004-7 · Cited by 2
Neural gene therapy: Sensational finding
Greenberg, D. A., & Jin, K. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302560 · Cited by 2
Kärpänen, T. (2006) · Työväentutkimus Vuosikirja · Cited by 2
Tissue Engineering erektiler Nerven
May, F., Weidner, N., Matiasek, K., Vroemen, M., Mrva, T., Caspers, C., Henke, J., Brill, T., Lehmer, A., Blesch, A., et al. (2004) · Der Urologe · doi:10.1007/s00120-004-0692-5 · Cited by 2
“Neben der mitogenen Wirkung von VEGF auf das Gefäßendothel besitzt dieser Wachstumsfaktor auch muskulotrophe und neurotrophe Eigenschaften [20].”
BackgroundBone and Nerve Response to Sciatic Compression Neuropathy in a Rabbit Model
Fringuello, A. R., Kurtzman, J. S., Hayes, W. T., Carter, J., & Koehler, S. M. (2025) · Journal of Orthopaedic Research® · doi:10.1002/jor.26045 · Cited by 1
Ma, Y. H. E., Putta, A. R., Chan, C. H. H., Vidman, S. R., Monje, P. V., & Plant, G. W. (2025) · Cells · doi:10.3390/cells14060461 · Cited by 1
Lee, S. Y., & Hwang, D. D.-J. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14228225 · Cited by 1
“A proposed mechanism is that VEGF acts as a neuroprotective factor for retinal ganglion cell survival and neuronal nutrition, and repeated VEGF inhibition may impair this function, resulting in RNFL loss [25–27].”
Ongun, G. T., & Yağcı, R. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15020449 · Cited by 1
“VEGF-A is known to exert neurotrophic and neuroprotective effects on glial cells [23], potentially mediated directly or indirectly through angiogenesis [24,25].”
Quigley, B. L., Orr, E., Kafka, S., Hajishafiee, M., Bouças, A. P., Wellington, N. J., Dutton, M., Jones, M., Randall, F., Lagopoulos, J., et al. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07043-6 · Cited by 1
“VEGF-A is best known for its roles in angiogenesis and blood vessel permeability but, like BDNF, it also has recognised neurotropic activity (Sondell et al. 1999).”
Manoonkitiwongsa, P. S., Schultz, R. L., & Lyden, P. D. (2010) · Springer eBooks · doi:10.1007/978-90-481-9495-7_8 · Cited by 1
A New Method of Nerve Bridging with a Collagen Mesothelial Tube
Ryoke, K., NSHIKAWA, U., Ochi, M., & UCHIO, Y. (2008) · Journal of Hand Surgery (European Volume) · doi:10.1177/1753193408090103 · Cited by 1
“…to directly and indirectly promote regeneration of nerves (Eben et al., 1996; Hamanoue et al., 1996; Hobson et al., 2000; Krasnoseisky et al., 1994; Maina et al., 1998; Siebert and Bruck, 2003; Sondell et al., 1999a, b; Wong et al., 1997) and produce favourable conditions for nerve regeneration.”
BackgroundLucena, D., & Yamane, R. (2008) · Revista Brasileira de Oftalmologia · doi:10.1590/s0034-72802008000600009 · Cited by 1
Gil‐Perotín, S., & Casaccia‐Bonnefil, P. (2006) · Springer eBooks · doi:10.1007/0-387-31389-3_2 · Cited by 1
“VEGF has neurotrophic and neuroprotective effects on distinct types of neurons (Silverman et al., 1999; Sondell et al., 1999, 2000; Jin et al., 2000a, 2000b; ; Matsuzaki et al., 2001) and its receptor VEGFR2/flk-1 is expressed in neural progenitor cells (Yang and Cepko, 1996; Jin et al., 2002b),…”
Cartilage oligomeric matrix protein enhances the vascularization of acellular nerves
Hu, J. X., Cui, W., Qiu, L., Lian, J., Li, J., & Liu, X. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.179078 · Cited by 1
“Thus, the blood supply may directly or indirectly affect nerve regeneration (Sondell et al., 1999; Mompeo et al., 2003; Skold et al., 2011).”
Axonal transport proteins: What they are and how they relate to depressive behaviors
Nahavandi, A., & Mehrabi, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817935-2.00018-0 · Cited by 1
Semela, D., & Dufour, J. (2009) · Springer eBooks · doi:10.1007/978-3-642-00150-5_28 · Cited by 1
Regeneration and Experimental Nerve Repair
(2004) · Elsevier eBooks · doi:10.1016/b978-0-443-06711-2.50009-3 · Cited by 1
Roslavtceva, V., Salmina, A. B., Prokopenko, S. V., Пожиленкова, Е. А., Кобаненко, И. В., & Rezvitskaya, G. G. (2016) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750816040053 · Cited by 1
Karakulova, Y., & Филимонова, Т. А. (2022) · Biomarkers in disease · doi:10.1007/978-3-030-81303-1_60-1 · Cited by 1
Zhai, G., Su, Y., Wang, S. W., Lu, H., & Liu, N. (2024) · BMC Ophthalmology · doi:10.1186/s12886-024-03344-6 · Cited by 1
“During the embryonic development of the eyeball, VEGF plays key roles in the formation of blood vessels, in the proliferation of endothelial cells, and in the permeability of blood vessels [10].”
BackgroundFathi, M., & Hassanpour-Ezatti, M. (2024) · Caspian Journal of Neurological Sciences · doi:10.32598/cjns.10.37.48.1 · Cited by 1
Bone Marrow Mesenchymal Stromal Cell Transplantation: A Neurorestorative Therapy for Stroke
Chen, J., Venkat, P., & Chopp, M. (2014) · Springer eBooks · doi:10.1007/978-3-319-11481-1_4 · Cited by 1
“VEGF promotes angiogenesis and is also capable of exerting neuroprotective effects (Sondell et al. 1999).”
BackgroundAl-Timmemi, H. A. K., Ibrahim, R., Karim, A.-J., Zuki, A., & Azmi, T. (2011) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb10.2421 · Cited by 1
Potentiality of Graphene-Based Materials for Neural Repair
Portolés, M. T., & Serrano, M. C. (2016) · Carbon nanostructures · doi:10.1007/978-3-319-45639-3_6 · Cited by 1
The Role of Angiogenesis in Neuroblastoma
Katzenstein, H. M. (2003) · American Journal of Cancer · doi:10.2165/00024669-200302040-00002 · Cited by 1
Ersoy, B. (2015) · The Sydney eScholarship Repository (The University of Sydney) · Cited by 1
Prospects for Vascular Endothelial Growth Factor Neurotherapeutics
Pleasure, D. (2002) · Archives of Neurology · doi:10.1001/archneur.59.5.692 · Cited by 1
Ruhanya, V., Jacobs, G. B., Paul, R. H., Joska, J. A., Seedat, S., Nyandoro, G., Engelbrecht, S., & Glashoff, R. H. (2021) · Preprints.org · doi:10.20944/preprints202105.0501.v1 · Cited by 1
“The growth factor has been shown to have neurotrophic effect and enhances survival of neurones in some brain regions [58] and higher levels have been detected in HIV associated CNS diseases [59-61].”
BackgroundMa, Y. H. E., Putta, A. R., Chan, C. H. H., Vidman, S. R., Monje, P. V., & Plant, G. W. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.23.634338 · Cited by 1
Mechanisms and Modification of the Radiation Response of the Central Nervous System
Nieder, C., Andratschke, N. H., & Ang, K. K. (2003) · Medical radiology · doi:10.1007/978-3-642-55613-5_6 · Cited by 1
“It also protected neuronal cell lines from hypoxia and glucose deprivation (Jin et al. 2000) and showed proliferation- and survival-promoting effects on neural cells in the peripheral nervous system ( Sondell et al. 1999 ).”
BackgroundVascular and Neuronal Effects of VEGF in the Nervous System
Moons, L., Carmeliet, P., & Dewerchin, M. A. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-021-8_19
Role of Nerve Fibres in Endometriosis
Tokushige, N. (2014) · Springer eBooks · doi:10.1007/978-4-431-54421-0_13
Epineural Patch Applications in Dorsal Root Ganglion Decompression Model
Siemionow, K. B. (2014) · Springer eBooks · doi:10.1007/978-1-4471-6335-0_61
Modulation of the neuroinflammatory response after spinal cord injury
van Neerven, S. G. A. (2011) · doi:10.26481/dis.20110420sn
Vascular Endothelial Growth Factor and Retinal Diseases
Dahr, S. S., & Csaky, K. G. (2006) · Humana Press eBooks · doi:10.1007/978-1-59745-047-8_11
“Multiple studies have demonstrated that VEGF may be involved in this process through the activity of VEGFR-2 (34–37) 7 . Specifically, VEGF may play a role in the differentiation and protection of cortical neurons, astrocytes (34,36) 6 , and Schwann cells ( 35 ).”
BackgroundOn VEGF and related factors in neurotrauma
Sköld, M. K. (2004) · Figshare
Mechanisms of malignant and non-malignant angiogenesis using zebrafish models
Jensen, L. D. (2010) · Figshare
Lenzer, J. (2014) · CUNY Academic Works (City University of New York)
Erdağ, B., Balcıoğlu, B. K., Kumbasar, A., & Çırakoğlu, B. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0063-6_24
Die Rolle des VEGF im Ovarialkarzinom
Bremert, A. (2011) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-9496
Martín, C., & del Pilar, M. (2003) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Cell-matrix interactions in neuronal regeneration : Focus on integrins and laminins
Plantman, S. (2008) · Figshare
The novel sumoylation enhancer RSUME is implicated in pituitary tumour pathogenesis
Shan, B. (2010) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0030-1266992
Vascular Endothelial Growth Factor Antagonists as Anticancer Agents
Hasan, J., & Jayson, G. C. (2004) · American Journal of Cancer · doi:10.2165/00024669-200403040-00003
Vascular and Neuronal Development: Intersecting Parallelisms and rossroads
Zacchigna, S., de Almodóvar, C. R., Lafuste, P., & Carmeliet, P. (2007) · Springer eBooks · doi:10.1007/1-4020-5955-8_9
Lee, H. M., Nam, S., & Kim, Y. S. (2013) · 대한침구학회지 · doi:10.13045/acupunct.2013001
The use of adipose derived stem cells in spinal cord and peripheral nerve repair
Kolar, M. K. (2014) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Expression and Neuroprotection of Vascular Endothelial Growth Factor in an in vitro Ischemia
Han, M., Kim, M.-H., Rha, J.-H., Lee, Y., Kim, S. U., & Roh, J. (2002) · Journal of the Korean Neurological Association
Шаймарданова, Г. Ф., Mukhamedshina, Y. O., Arkhipova, S. S., Salafutdinov, I. I., Rizvanov, A. A., & Chelyshev, Y. A. (2012) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-012-9671-2
“It maintains the survival of sensory [17] and motor [11] neurons.”
Background
Metadata
- Authors
- Sondell, M., Lundborg, G., & Kanje, M.
- Affiliations
- Lund University (SE)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-07-15
- Volume
- 19
- Issue
- 14
- Pages
- 5731-5740
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6783109
- OpenAlex
- W1962154683
- Cited by
- 750
- References
- 44
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 8 · 2023: 11 · 2022: 16 · 2021: 19 · 2020: 26 · 2019: 25 · 2018: 26 · 2017: 28 · 2016: 33 · 2015: 22 · 2014: 44 · 2013: 42 · 2012: 37
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- vascular endothelial growth factor, VEGF165, neurotrophic activity, axon growth, Schwann cell proliferation, satellite cells, superior cervical ganglion, dorsal root ganglia, MEK, PD98059, K252a, axon regeneration, peripheral nervous system, small-diameter neurons, cell survival
- MeSH terms
- Animals, Axons, Carbazoles, Cell Survival, Cells, Cultured, Enzyme Inhibitors, Flavonoids, Ganglia, Spinal, Humans, Lymphokines, Male, Mice, Inbred Strains, Nerve Growth Factors, Recombinant Proteins, Schwann Cells, Time Factors, Endothelial Growth Factors, Superior Cervical Ganglion, Indole Alkaloids, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Protein Kinase Inhibitors, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
