The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Thyroid Hormone Regulates reelin and dab1 Expression During Brain Development
Open accessAbstract
The reelin and dab1 genes are necessary for appropriate neuronal migration and lamination during brain development. Since these processes are controlled by thyroid hormone, we studied the effect of thyroid hormone deprivation and administration on the expression of reelin and dab1. As shown by Northern analysis, in situ hybridization, and immunohistochemistry studies, hypothyroid rats expressed decreased levels of reelin RNA and protein during the perinatal period [embryonic day 18 (E18) and postnatal day 0 (P0)]. The effect was evident in Cajal-Retzius cells of cortex layer I, as well as in layers V/VI, hippocampus, and granular neurons of the cerebellum. At later ages, however, Reelin was more abundant in the cortex, hippocampus, cerebellum, and olfactory bulb of hypothyroid rats (P5), and no differences were detected at P15. Conversely, Dab1 levels were higher at P0, and lower at P5 in hypothyroid animals. In line with these results, reelin RNA and protein levels were higher in cultured hippocampal slices from P0 control rats compared to those from hypothyroid animals. Significantly, thyroid-dependent regulation of reelin and dab1 was confirmed in vivo and in vitro by hormone treatment of hypothyroid rats and organotypic cultures, respectively. In both cases, thyroid hormone led to an increase in reelin expression. Our data suggest that the effects of thyroid hormone on neuronal migration may be in part mediated through the control of reelin and dab1 expression during brain ontogenesis.
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Citations
Cites
Specification of Cerebral Cortical Areas
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“Neuronal migration is an essential step in the genesis of the nervous system, particularly in laminated brain regions (Mari ´n-Padilla, 1971, 1998; Rakic, 1988, 1990; Hatten, 1993).”
BackgroundA protein related to extracellular matrix proteins deleted in the mouse mutant reeler
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“…of Reelin immunoreactivity in the cerebral cortex of hypothyroid rats To investigate whether Reelin distribution was also altered in hypothyroid rats, brain sections were immunostained with the CR50 mAb that recognizes the N-terminal region of Reelin (Ogawa et al., 1995; D’Arcangelo et al., 1997).”
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Scrambler and yotari disrupt the disabled gene and produce a reeler -like phenotype in mice
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Self-citationA role for Cajal–Retzius cells and reelin in the development of hippocampal connections
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Self-citationCortical development: View from neurological mutants two decades later
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Differential survival of Cajal-Retzius cells in organotypic cultures of hippocampus and neocortex
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Self-citation
Cited by
Physiological and Molecular Basis of Thyroid Hormone Action
Yen, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1097 · Cited by 2,011
Morreale de Escobar, G., Jesús Obregón, M., & Escobar del Rey, F. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.11.6961 · Cited by 538
Influence of maternal thyroid hormones during gestation on fetal brain development
Moog, N. K., Entringer, S., Heim, C., Wadhwa, P. D., Kathmann, N., & Buss, C. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.070 · Cited by 474
Action of thyroid hormone in brain
Bernal, J. (2002) · Journal of Endocrinological Investigation · doi:10.1007/bf03344003 · Cited by 358
Self-citationThyroid Hormone Action and Brain Development
Koibuchi, N., & Chin, W. W. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00238-1 · Cited by 329
Metadata
- Authors
- Alvarez-Dolado, M., Ruiz, M., Del Rı́o, J. A., Alcántara, S., Burgaya, F., Sheldon, M., Nakajima, K., Bernal, J., Howell, B. W., Curran, T., Soriano, E., & Muñoz, A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-08-15
- Volume
- 19
- Issue
- 16
- Pages
- 6979-6993
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2118749411
- Cited by
- 171
- References
- 10
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Alvarez-Dolado, M., Ruiz, M., Del Rı́o, J. A., Alcántara, S., Burgaya, F., Sheldon, M., Nakajima, K., Bernal, J., Howell, B. W., Curran, T., Soriano, E., & Muñoz, A. (1999). Thyroid Hormone Regulates reelin and dab1 Expression During Brain Development. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.19-16-06979.1999
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
