The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Membrane Trafficking Regulates the Activity of the Human Dopamine Transporter
Open accessAbstract
The trafficking of synaptic proteins is unquestionably a major determinant of the properties of synaptic transmission. Here, we present a detailed analysis of the downregulation and intracellular trafficking of the cocaine- and amphetamine-sensitive dopamine transporter (DAT), a presynaptic plasma membrane protein responsible for the regulation of extracellular DA concentrations. Using PC12 cells stably transfected with human DAT cDNA, we observe that phorbol ester activation of protein kinase C (PKC) results in decreased transporter capacity and a parallel decrease in the amount of DAT on the cell surface that is attributable to intracellular transporter sequestration. After internalization, DAT diverges to the recycling, as opposed to the degradative, arm of the endocytic pathway. This study demonstrates, for the first time, DAT endocytosis, establishes the pathways through which DAT traffics both at steady state and in response to PKC activation, and suggests that DAT recycling is likely to occur.
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Cited by
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
Plasma membrane monoamine transporters: structure, regulation and function
Torres, G. E., Gainetdinov, R. R., & Caron, M. G. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1008 · Cited by 939
New Insights into the Mechanism of Action of Amphetamines
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Mechanisms of dopamine transporter regulation in normal and disease states
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Metadata
- Authors
- Melikian, H. E., & Buckley, K. M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-09-15
- Volume
- 19
- Issue
- 18
- Pages
- 7699-7710
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1920778929
- Cited by
- 374
- References
- 50
- FWCI
- 8.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Melikian, H. E., & Buckley, K. M. (1999). Membrane Trafficking Regulates the Activity of the Human Dopamine Transporter. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.19-18-07699.1999
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
