The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
The Family of Na+/Cl− Neurotransmitter Transporters
Abstract
Abstract: The termination of neurotransmission is achieved by rapid uptake of the released neurotransmitter by specific high‐affinity neurotransmitter transporters. Most of these transporters are encoded by a family of genes (Na+/Cl− transporters) having a similar membrane topography of 12 transmembrane helices. An evolutionary tree revealed five distinct subfamilies: γ‐aminobutyric acid transporters, monoamine transporters, amino acid transporters, “orphan” transporters, and the recently discovered bacterial transporters. The bacterial transporters that belong to this family may help to develop heterologous expression systems with the aim of solving the three‐dimensional structure of these membrane proteins. Some of the neurotransmitter transporters have been implicated as important sites for drug action. Monoamine transporters, for example, are targeted by major classes of antidepressants, psychostimulants, and antihypertensive drugs. Localization of individual transporters in specific cells and brain areas is pertinent to understanding their contribution to neurotransmission and their potential as targets for drugs. The most important questions in the field include resolving the mechanism of neurotransmitter transport, the structure of the transporters, and the interaction of each transporter in complex neurological activities.
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Citations
Cites
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Cited by
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
Krishnamurthy, H., & Gouaux, E. (2012) · Nature · doi:10.1038/nature10737 · Cited by 503
Membrane Trafficking Regulates the Activity of the Human Dopamine Transporter
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Metadata
- Authors
- Nelson, N.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1998-11
- Volume
- 71
- Issue
- 5
- Pages
- 1785-1803
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2090493398
- Cited by
- 358
- References
- 101
- FWCI
- 8.35
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
