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Multimodal Integration in Rostral Fastigial Nucleus Provides an Estimate of Body Movement
Open accessAbstract
The ability to accurately control posture and perceive self-motion and spatial orientation requires knowledge of the motion of both the head and body. However, whereas the vestibular sensors and nuclei directly encode head motion, no sensors directly encode body motion. Instead, the convergence of vestibular and neck proprioceptive inputs during self-motion is generally believed to underlie the ability to compute body motion. Here, we provide evidence that the brain explicitly computes an internal estimate of body motion at the level of single cerebellar neurons. Neuronal responses were recorded from the rostral fastigial nucleus, the most medial of the deep cerebellar nuclei, during whole-body, body-under-head, and head-on-body rotations. We found that approximately half of the neurons encoded the motion of the body in space, whereas the other half encoded the motion of the head in space in a manner similar to neurons in the vestibular nuclei. Notably, neurons encoding body motion responded to both vestibular and proprioceptive stimulation (accordingly termed bimodal neurons). In contrast, neurons encoding head motion were sensitive only to vestibular inputs (accordingly termed unimodal neurons). Comparison of the proprioceptive and vestibular responses of bimodal neurons further revealed similar tuning in response to changes in head-on-body position. We propose that the similarity in nonlinear processing of vestibular and proprioceptive signals underlies the accurate computation of body motion. Furthermore, the same neurons that encode body motion (i.e., bimodal neurons) most likely encode vestibular signals in a body-referenced coordinate frame, since the integration of proprioceptive and vestibular information is required for both computations.
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“Recent work by Cullen and colleagues on the cerebellar and vestibular mechanisms related to the control and appreciation of head and body movements has shown the important relationship between corollary discharge signals and reafferent signals associated with the resulting movement of the head or body.”
From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Brooks and Cullen 2009
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“Any discrepancy between the expected and reafferent signals represents a sensory conflict that potentially could be provocative (Brooks and Cullen 2009, 2013; Cullen 2012; Cullen et al. 2009; Saab and Willis 2001; Serra et al. 1998).”
From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Brooks and Cullen 2009
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Background
Metadata
- Authors
- Brooks, J. X., & Cullen, K. E.
- Affiliations
- McGill University (CA)
- ORCID
- Cullen, Kathleen E.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-08-26
- Volume
- 29
- Issue
- 34
- Pages
- 10499-10511
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3311469
- OpenAlex
- W2083680074
- Cited by
- 106
- References
- 56
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 6 · 2023: 7 · 2022: 1 · 2021: 10 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 3 · 2014: 17 · 2013: 8 · 2012: 3
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- National Institute on Deafness and Other Communication Disorders (R01DC002390)
- Topics
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Keywords
- neck proprioception, bimodal neurons, self-motion perception, deep cerebellar nuclei, vestibular nuclei
- MeSH terms
- Action Potentials, Animals, Macaca mulatta, Models, Neurological, Motion, Movement, Neck, Neurons, Orientation, Physical Stimulation, Posture, Predictive Value of Tests, Proprioception, Vestibule, Labyrinth, Vestibular Nuclei, Head Movements
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