The DOI matches its Crossref record; 85 of the 86 references it cites were found in a registry or an index.
ATP-Mediated Glia Signaling
Open accessAbstract
Glia calcium signaling has recently been identified as a potent modulator of synaptic transmission. We show here that the spatial expansion of calcium waves is mediated by ATP and subsequent activation of purinergic receptors. Ectopic expression of gap junction proteins, connexins (Cxs), leads to an increase in both ATP release and the radius of calcium wave propagation. Cx expression was also associated with a phenotypic transformation, and cortical neurons extended longer neurites when co-cultured with Cx-expressing than with Cx-deficient cells. Purinergic receptor activation mediated both these effects, because treatment with receptor antagonists restored the glia phenotype and slowed neurite outgrowth. These results identify a key role of ATP in both short-term calcium signaling events and in long-term differentiation regulated by glia.
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“Astrocytes reside in close proximity to neuronal synapses and express glutamate receptors that regulate CA 2+ influx (Cornell-Bell et al, 1990) to influence ATP signaling (Cotrina et al, 2000).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Cotrina et al, 2000
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Cites
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Glutamate-mediated astrocyte–neuron signalling
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Differentiated Rat Glial Cell Strain in Tissue Culture
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Prostaglandins stimulate calcium-dependent glutamate release in astrocytes
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Regulation and Kinetics of the Actin-Myosin-ATP Interaction
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Self-citationAstrocyte-mediated potentiation of inhibitory synaptic transmission
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Research works printed but not linked: 1
- 10.1002/(SICI)1098-1136(199809)24:1<141::AID-GLIA13>3.0.CO;2-R · DOI
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ATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913
Molecular Physiology of P2X Receptors
North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Self-citationNeuroinflammation and Central Sensitization in Chronic and Widespread Pain
Ji, R.-R., Nackley, A., Huh, Y., Terrando, N., & Maixner, W. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002130 · Cited by 1,630
Physiology and Pathophysiology of Purinergic Neurotransmission
Burnstock, G. (2007) · Physiological Reviews · doi:10.1152/physrev.00043.2006 · Cited by 1,609
Metadata
- Authors
- Cotrina, M. L., Lin, J. H.-C., López-Garcı́a, J. C., Naus, C. C. G., & Nedergaard, M.
- Affiliations
- New York Medical College (US)
- Western University (CA)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-04-15
- Volume
- 20
- Issue
- 8
- Pages
- 2835-2844
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6772203
- OpenAlex
- W1901485302
- Cited by
- 388
- References
- 86
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 7 · 2018: 12 · 2017: 13 · 2016: 15 · 2015: 14 · 2014: 12 · 2013: 15 · 2012: 20
- FWCI
- 15.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS135011, NS130007)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- ATP release, purinergic receptors, connexins, gap junctions, calcium waves, neurite outgrowth, cortical neurons, neuron-glia interactions, glial differentiation, synaptic transmission
- MeSH terms
- Adenosine Triphosphate, Animals, Cells, Cultured, Neuroglia, Tumor Cells, Cultured, Gap Junctions, Connexins, Calcium Signaling, Rats, Purinergic Antagonists
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