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ATP-Mediated Glia Signaling
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Glia calcium signaling has recently been identified as a potent modulator of synaptic transmission. We show here that the spatial expansion of calcium waves is mediated by ATP and subsequent activation of purinergic receptors. Ectopic expression of gap junction proteins, connexins (Cxs), leads to an increase in both ATP release and the radius of calcium wave propagation. Cx expression was also associated with a phenotypic transformation, and cortical neurons extended longer neurites when co-cultured with Cx-expressing than with Cx-deficient cells. Purinergic receptor activation mediated both these effects, because treatment with receptor antagonists restored the glia phenotype and slowed neurite outgrowth. These results identify a key role of ATP in both short-term calcium signaling events and in long-term differentiation regulated by glia.
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“Astrocytes reside in close proximity to neuronal synapses and express glutamate receptors that regulate CA 2+ influx (Cornell-Bell et al, 1990) to influence ATP signaling (Cotrina et al, 2000).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Cotrina et al, 2000
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Pankratov, Y. V., Lalo, U., Krishtal, O., & Verkhratsky, A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.076 · Cited by 161
Braet, K. (2003) · Cell Calcium · doi:10.1016/s0143-4160(02)00180-x · Cited by 155
ATP: a vasoactive signal in the pericyte-containing microvasculature of the rat retina
Kawamura, H., Sugiyama, T., Wu, D. M., Kobayashi, M., Yamanishi, S., Katsumura, K., & Puro, D. G. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00787.x · Cited by 156
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Metadata
- Authors
- Cotrina, M. L., Lin, J. H.-C., López-Garcı́a, J. C., Naus, C. C. G., & Nedergaard, M.
- Affiliations
- New York Medical College (US)
- Western University (CA)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-04-15
- Volume
- 20
- Issue
- 8
- Pages
- 2835-2844
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6772203
- OpenAlex
- W1901485302
- Cited by
- 388
- References
- 86
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 7 · 2018: 12 · 2017: 13 · 2016: 15 · 2015: 14 · 2014: 12 · 2013: 15 · 2012: 20
- FWCI
- 15.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS135011, NS130007)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- ATP release, purinergic receptors, connexins, gap junctions, calcium waves, neurite outgrowth, cortical neurons, neuron-glia interactions, glial differentiation, synaptic transmission
- MeSH terms
- Adenosine Triphosphate, Animals, Cells, Cultured, Neuroglia, Tumor Cells, Cultured, Gap Junctions, Connexins, Calcium Signaling, Rats, Purinergic Antagonists
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