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GOLFα Mediates Dopamine D1 Receptor Signaling
Open accessAbstract
It is generally assumed that the coupling of dopamine D1 receptors to adenylyl cyclase is mediated by the stimulatory GTP-binding protein G(s). However, the striatum contains little G(s)alpha subunit, whereas it expresses high levels of G(olf)alpha, a close relative of G(s)alpha that is also expressed in olfactory receptor neurons. We used G(olf)alpha knockout mice to examine the functional coupling of D1 receptors. We found that these mice showed no hyperlocomotor response to either the D1 agonist SKF-81297 or the psychostimulant cocaine. Moreover, G(olf)alpha knockout mice did not display cocaine-induced c-fos expression in the striatum. Finally, in the absence of G(olf)alpha, striatal D1 receptors have a decreased affinity for dopamine. Thus coupling to G(olf)alpha appears to mediate D1 signaling in the striatum.
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Citations
Cited by
Roth, B. L. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.040 · Cited by 1,742
The principal features and mechanisms of dopamine modulation in the prefrontal cortex
Seamans, J. K., & Yang, C. R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.006 · Cited by 1,592
Neve, K. A., Seamans, J. K., & Trantham‐Davidson, H. (2004) · Journal of Receptors and Signal Transduction · doi:10.1081/lrst-200029981 · Cited by 837
Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons
Verkhratsky, A. (2005) · Physiological Reviews · doi:10.1152/physrev.00004.2004 · Cited by 709
Noradrenaline activation of hippocampal dopamine D 1 receptors promotes antidepressant effects
Kobayashi, K., Shikano, K., Kuroiwa, M., Horikawa, M., Ito, W., Nishi, A., Segi-Nishida, E., & Suzuki, H. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2117903119 · Cited by 34
Metadata
- Authors
- Zhuang, X., Belluscio, L., & Hen, R.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-08-15
- Volume
- 20
- Issue
- 16
- Pages
- RC91-RC91
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1496714476
- Cited by
- 219
- References
- 0
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhuang, X., Belluscio, L., & Hen, R. (2000). GOLFα Mediates Dopamine D1 Receptor Signaling. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.20-16-j0001.2000
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