The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Repetitive Transcranial Magnetic Stimulation of the Human Prefrontal Cortex Induces Dopamine Release in the Caudate Nucleus
Open accessAbstract
Dopamine is implicated in movement, learning, and motivation, and in illnesses such as Parkinson's disease, schizophrenia, and drug addiction. Little is known about the control of dopamine release in humans, but research in experimental animals suggests that the prefrontal cortex plays an important role in regulating the release of dopamine in subcortical structures. Here we used [(11)C]raclopride and positron emission tomography to measure changes in extracellular dopamine concentration in vivo after repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex in healthy human subjects. Repetitive TMS of the left dorsolateral prefrontal cortex caused a reduction in [(11)C]raclopride binding in the left dorsal caudate nucleus compared with rTMS of the left occipital cortex. There were no changes in binding in the putamen, nucleus accumbens, or right caudate. This shows that rTMS of the prefrontal cortex induces the release of endogenous dopamine in the ipsilateral caudate nucleus. This finding has implications for the therapeutic and research use of rTMS in neurological and psychiatric disorders.
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“In the early 2000s, two influential studies demonstrated a causal relationship between the application of transcranial magnetic stimulation (TMS) on the prefrontal cortex and dopamine binding in the caudate nucleus, leading to an increase in extracellular dopamine and glutamate in the ventral striatum by TMS”
From A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder (2024) · cites this paper as [106]
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“Another study by the same group, using the same tracer, demonstrated that rTMS of the left dlPFC induced dopamine release specifically in the head of the ipsilateral caudate nucleus, but not the NAcc, putamen or contralateral caudate nucleus (Strafella et al., 2001).”
From Cortico-striatal-thalamic loop circuits of the salience network: A central pathway in psychiatric disease and treatment (2016) · cites this paper as Strafella et al., 2001
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Cites
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MethodDepression of motor cortex excitability by low-frequency transcranial magnetic stimulation
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“…of direct stimulation of the corticostriatal axons (Rothwell, 1997), indirect trans-synaptic activation of corticostriatal neurons caused by a reduction in GABA-mediated intracortical inhibition (Chen et al., 1997; Nakamura et al., 1997; Rothwell, 1997; Pascual-Leone et al., 1998), or both.”
BackgroundSimplified Reference Tissue Model for PET Receptor Studies
Lammertsma, A. A., & Hume, S. P. (1996) · NeuroImage · doi:10.1006/nimg.1996.0066 · Cited by 2,025
Uneven Pattern of Dopamine Loss in the Striatum of Patients with Idiopathic Parkinson's Disease
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Evidence for striatal dopamine release during a video game
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- Breier A, Su TP, Saunders R, Carson RE, Kolachana BS, De Bartolomeis A, Weinberger DR, Weisenfeld N, Malhotra AK, Eckelman WC, Pickar D (1998) Effects of NMDA antagonism on striatal dopamine release in healthy subjects: application of a novel PET approach. Syn- apse 29:142-147.
- Endres CJ, Kolachana BS, Saunders RC, Su T, Weinberger D, Breier A, Eckelman WC, Carson RE (1997) Kinetic modelling of [ 11 C]raclo- pride: combined PET-microdialysis studies. J Cereb Blood Flow Metab 9:932-942.
Cited by
Sorted by citations
Rossi, S., Hallett, M., Rossini, P. M., & Pascual-Leone, A. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.08.016 · Cited by 5,367
Lefaucheur, J.-P., André-Obadia, N., Antal, A., Ayache, S. S., Baeken, C., Benninger, D. H., Cantello, R. M., Cincotta, M., de Carvalho, M., De Ridder, D., et al. (2014) · Clinical Neurophysiology · doi:10.1016/j.clinph.2014.05.021 · Cited by 2,119
Chambers, R. A., Taylor, J. R., & Potenza, M. N. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.6.1041 · Cited by 1,719
Transcranial magnetic stimulation in neurology
Kobayashi, M., & Pascual‐Leone, Á. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00321-1 · Cited by 1,299
The role of dopamine in the pathophysiology of depression
Dunlop, B. W., & Nemeroff, C. B. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.3.327 · Cited by 1,244
Metadata
- Authors
- Strafella, A. P., Paus, T., Barrett, J., & Dagher, A.
- Affiliations
- Montreal Neurological Institute and Hospital (CA)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-08-01
- Volume
- 21
- Issue
- 15
- Pages
- RC157-RC157
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6762641
- OpenAlex
- W2118266586
- Cited by
- 1,058
- References
- 39
- Citations by year
- 2026: 29 · 2025: 38 · 2024: 44 · 2023: 53 · 2022: 49 · 2021: 57 · 2020: 55 · 2019: 52 · 2018: 51 · 2017: 51 · 2016: 45 · 2015: 54 · 2014: 48 · 2013: 45 · 2012: 35
- FWCI
- 19.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- repetitive transcranial magnetic stimulation, dopamine release, caudate nucleus, dorsolateral prefrontal cortex, dopamine transporter binding, extracellular dopamine, putamen, nucleus accumbens
- MeSH terms
- Adult, Autonomic Nervous System, Behavior, Carbon Isotopes, Caudate Nucleus, Dopamine, Electric Stimulation, Electromagnetic Fields, Female, Humans, Male, Nucleus Accumbens, Occipital Lobe, Putamen, Receptors, Dopamine, Reference Values, Tomography, Emission-Computed, Prefrontal Cortex, Dopamine Antagonists, Raclopride, Transcranial Magnetic Stimulation
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