The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Reduced Hippocampal Neurogenesis in Adult Transgenic Mice with Chronic Astrocytic Production of Interleukin-6
Open accessAbstract
Postnatal neurogenesis can be modulated after brain injury, but the role of the attendant expression of inflammatory mediators in such responses remains to be determined. Here we report that transgenically directed production of interleukin-6 (IL-6) by astroglia decreased overall neurogenesis by 63% in the hippocampal dentate gyrus of young adult transgenic mice. The proliferation, survival, and differentiation of neural progenitor cells labeled with the thymidine analog bromodeoxyuridine were all reduced in the granule cell layer of these mice, whereas their distribution and gliogenesis appeared normal. These effects were not a consequence of general toxicity of the IL-6 transgene, because they were manifested in the absence of neuronal death and of major changes in glial cell number and morphology. These findings suggest that long-term exposure of the brain to proinflammatory mediators such as IL-6, as is seen in certain degenerative disorders and infections, can interfere with adult neurogenesis.
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Cites
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Cited by
Mechanisms and Functional Implications of Adult Neurogenesis
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Inflammation is detrimental for neurogenesis in adult brain
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Immune modulation of learning, memory, neural plasticity and neurogenesis
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Irradiation induces neural precursor-cell dysfunction
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Metadata
- Authors
- Vallières, L., Campbell, I. L., Gage, F. H., & Sawchenko, P. E.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-01-15
- Volume
- 22
- Issue
- 2
- Pages
- 486-492
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2099713879
- Cited by
- 600
- References
- 55
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vallières, L., Campbell, I. L., Gage, F. H., & Sawchenko, P. E. (2002). Reduced Hippocampal Neurogenesis in Adult Transgenic Mice with Chronic Astrocytic Production of Interleukin-6. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.22-02-00486.2002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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