Cited by 206Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

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Sensitization of Midbrain Dopamine Neuron Reactivity Promotes the Pursuit of Amphetamine

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Vezina, Paul, Lorrain, Daniel S., Arnold, Gretchen M., Austin, Jennifer D., Suto, Nobuyoshi·2002·The Journal of Neuroscience

DOI 10.1523/jneurosci.22-11-04654.2002PMC PMC6758806

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Abstract

Stimulant drugs such as amphetamine are readily self-administered by humans and laboratory animals by virtue of their actions on dopamine (DA) neurons of the midbrain. Repeated exposure to this drug systemically or exclusively in the cell body region of these neurons in the ventral tegmental area (VTA) leads to long-lasting changes in dopaminergic function that can be assessed by increased locomotor activity and enhanced DA overflow in the nucleus accumbens (NAcc) after re-exposure to the drug. Three experiments were conducted to evaluate the possibility that this enduring sensitized reactivity underlies compulsive drug self-administration. In all experiments, rats were pre-exposed to amphetamine and, starting 10 d later, their intravenous self-administration of the drug was assessed. In the first experiment, rats previously exposed to amphetamine systemically or exclusively in the VTA subsequently worked harder than untreated animals to obtain the drug when the work required to obtain successive infusions was increased progressively. In the second experiment, this progressively increasing workload was found to decrease the magnitude of amphetamine-induced DA overflow observed with successive infusions until responding ceased. Rats previously exposed to amphetamine were more resistant to this decline and more apt to maintain responding. Finally, in experiment three, a noncontingent priming injection of the drug produced a greater NAcc DA response and a greater parallel increase in lever pressing in drug compared with saline pre-exposed rats. Together, these results demonstrate a direct relation between drug-induced sensitization of midbrain dopamine neuron reactivity and the excessive pursuit and self-administration of an abused substance.

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The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Experimental Design: Procedures for the Behavioral Sciences
Kirk, R. (2013) · doi:10.4135/9781483384733 · Cited by 8,539
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Experimental Design: Procedures for the Behavioral Sciences.
Addelman, S., & Kirk, R. E. (1969) · Journal of the American Statistical Association · doi:10.2307/2283497 · Cited by 5,233
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,514
A psychomotor stimulant theory of addiction.
Wise, R. A., & Bozarth, M. A. (1987) · Psychological Review · doi:10.1037/0033-295x.94.4.469 · Cited by 2,747
The metabotropic glutamate receptors: Structure and functions
Pin, J., & Duvoisin, R. M. (1995) · Neuropharmacology · doi:10.1016/0028-3908(94)00129-g · Cited by 2,273
Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity.
Kalivas, P., & Stewart, J. (1991) · Brain research. Brain research reviews · doi:10.1016/0165-0173(91)90007-u · Cited by 2,087
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070
Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy
Richardson, N. R., & Roberts, D. C. S. (1996) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(95)00153-0 · Cited by 1,373
Factors That Predict Individual Vulnerability to Amphetamine Self-Administration
Piazza, P. V., Deminière, J.-M., Moal, M. L., & Simon, H. (1989) · Science · doi:10.1126/science.2781295 · Cited by 1,355
Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants.
Stewart, J., de Wit, H., & Eikelboom, R. (1984) · Psychological Review · doi:10.1037/0033-295x.91.2.251 · Cited by 1,261
Incubation of cocaine craving after withdrawal
Grimm, J. W., Hope, B. T., Wise, R. A., & Shaham, Y. (2001) · Nature · doi:10.1038/35084134 · Cited by 1,031
Stress-induced relapse to heroin and cocaine seeking in rats: a review
Shaham, Y., Erb, S. M., & Stewart, J. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00024-2 · Cited by 704
Pathophysiological basis of vulnerability to drug abuse: role of an interaction between stress, glucocorticoids, and dopaminergic neurons
Piazza, P. V., & Le Moal, M. (1996) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.36.040196.002043 · Cited by 690
Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration
Piazza, P. V., Deminiere, J. M., le Moal, M., & Simon, H. (1990) · Brain Research · doi:10.1016/0006-8993(90)90431-a · Cited by 565
Behavioral functions of nucleus accumbens dopamine: Empirical and conceptual problems with the anhedonia hypothesis
Salamone, J. D., Cousins, M. S., & Snyder, B. J. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00017-6 · Cited by 522
Repeated exposures intensify rather than diminish the rewarding effects of amphetamine, morphine, and cocaine
Lett, B. T. (1989) · Psychopharmacology · doi:10.1007/bf00451687 · Cited by 479
Pathways to relapse: the neurobiology of drug- and stress-induced relapse to drug-taking.
Stewart, J. (2000) · PubMed Central · Cited by 361
Preexposure to amphetamine and nicotine predisposes rats to self-administer a low dose of cocaine
Horger, B. A., Giles, M. K., & Schenk, S. (1992) · Psychopharmacology · doi:10.1007/bf02245147 · Cited by 344
Drug‐induced reinstatement of heroin‐ and cocaine‐seeking behaviour following long‐term extinction is associated with expression of behavioural sensitization
Vries, T. J. D., Schoffelmeer, A. N. M., Binnekade, R., Mulder, A. H., & Vanderschuren, L. J. M. J. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00368.x · Cited by 332
Amphetamine injection into the ventral mesencephalon sensitizes rats to peripheral amphetamine and cocaine.
Kalivas, P. W., & Weber, B. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24103-9 · Cited by 329
Dopaminergic activity is reduced in the prefrontal cortex and increased in the nucleus accumbens of rats predisposed to develop amphetamine self-administration
Piazza, P. V., Rougé‐Pont, F., Deminière, J. M., Kharouby, M., Moal, M. L., & Simon, H. (1991) · Brain Research · doi:10.1016/0006-8993(91)91452-7 · Cited by 328
Extracellular dopamine in the medial preoptic area: implications for sexual motivation and hormonal control of copulation
Hull, E. M., Du, J., Lorrain, D., & Matuszewich, L. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07465.1995 · Cited by 321
Self-citation
Evidence of a complete independence of the neurobiological substrates for the induction and expression of behavioral sensitization to amphetamine
Cador, M., Bjijou, Y., & Stinus, L. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00524-9 · Cited by 296
Response to novelty predicts the locomotor and nucleus accumbens dopamine response to cocaine
Hooks, M. S., Jones, G. H., Smith, A. D., Neill, D. B., & Justice, J. B. (1991) · Synapse · doi:10.1002/syn.890090206 · Cited by 293
D1 dopamine receptor activation is necessary for the induction of sensitization by amphetamine in the ventral tegmental area
Vezina, P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02411.1996 · Cited by 283
Self-citation
Time-Dependent Changes in Cocaine-Seeking Behavior and Extracellular Dopamine Levels in the Amygdala during Cocaine Withdrawal
Tran-Nguyen, L. T. L. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00205-4 · Cited by 278
Preexposure sensitizes rats to the rewarding effects of cocaine
Horger, B. A., Shelton, K. L., & Schenk, S. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90552-s · Cited by 271
Sensitization to the conditioned rewarding effects of cocaine: pharmacological and temporal characteristics.
Shippenberg, T. S., & Heidbreder, C. A. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)09578-3 · Cited by 263
Enhanced Vulnerability to Cocaine Self-Administration Is Associated with Elevated Impulse Activity of Midbrain Dopamine Neurons
Marinelli, M., & White, F. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08876.2000 · Cited by 254
Predisposition to self-administer amphetamine: the contribution of response to novelty and prior exposure to the drug
Pierre, P. J., & Vezina, P. (1997) · Psychopharmacology · doi:10.1007/s002130050191 · Cited by 197
Self-citation
Individual differences in stress‐induced dopamine release in the nucleus accumbens are influenced by corticosterone
Rougé‐Pont, F., Deroche‐Gamonet, V., Moal, M. L., & Piazza, P. V. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00438.x · Cited by 184
Repeated Cocaine Modifies the Mechanism by which Amphetamine Releases Dopamine
Pierce, R. C., & Kalivas, P. W. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-09-03254.1997 · Cited by 179
Cocaine self‐administration increases the incentive motivational properties of the drug in rats
Deroche‐Gamonet, V., Moal, M. L., & Piazza, P. V. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00696.x · Cited by 178
Pre-exposure of rats to amphetamine sensitizes self-administration of this drug under a progressive ratio schedule
Mendrek, A., Blaha, C. D., & Phillips, A. G. (1998) · Psychopharmacology · doi:10.1007/s002130050530 · Cited by 176
Individual locomotor response to novelty predicts selective alterations in D1 and D2 receptors and mRNAs
Hooks, M. S., Juncos, J., Justice, J. B., Meiergerd, S. M., Povlock, S., Schenk, J., & Kalivas, P. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-10-06144.1994 · Cited by 164
Previous exposure to amphetamine increases incentive to obtain the drug: long-lasting effects revealed by the progressive ratio schedule
Lorrain, D. S., Arnold, G. M., & Vezina, P. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00109-6 · Cited by 162
Self-citation
Protein kinase C inhibitors block amphetamine-mediated dopamine release in rat striatal slices.
Kantor, L., & Gnegy, M. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37287-8 · Cited by 153
Dopamine Fluctuations in the Nucleus Accumbens during Maintenance, Extinction, and Reinstatement of Intravenous d-Amphetamine Self-Administration
Ranaldi, R., Pocock, D., Zereik, R., & Wise, R. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-10-04102.1999 · Cited by 148
Amphetamine administered to the ventral tegmental area sensitizes rats to the locomotor effects of nucleus accumbens amphetamine.
Perugini, M., & Vezina, P. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22426-0 · Cited by 148
Self-citation
The K‐Opioid Agonist, U‐69593, Decreases Acute Amphetamine‐Evoked Behaviors and Calcium‐Dependent Dialysate Levels of Dopamine and Glutamate in the Ventral Striatum
Gray, A. M., Rawls, S. M., Shippenberg, T. S., & McGinty, J. F. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731066.x · Cited by 116
Sensitization and individual differences to IP amphetamine, cocaine, or caffeine following repeated intracranial amphetamine infusions
Hooks, M. S., Jones, G. H., Liem, B., & Justice, J. B. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90413-a · Cited by 112
Evidence for selective involvement of dopamine D1 receptors of the ventral tegmental area in the behavioral sensitization induced by intra-ventral tegmental area injections of D-amphetamine.
Bjijou, Y., Stinus, L., Moal, M. L., & Cador, M. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12906-6 · Cited by 111
Persistence of the ability of amphetamine preexposure to facilitate acquisition of cocaine self-administration
Valadez, A. A., & Schenk, S. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90132-5 · Cited by 102
Dynamics of behavioral sensitization induced by the dopamine agonist quinpirole and a proposed central energy control mechanism
Szechtman, H., Talangbayan, H., Canaran, G., Dai, H., & Eilam, D. (1994) · Psychopharmacology · doi:10.1007/bf02244757 · Cited by 99
Enhanced Amphetamine- and K+-Mediated Dopamine Release in Rat Striatum after Repeated Amphetamine: Differential Requirements for Ca2+- and Calmodulin-Dependent Phosphorylation and Synaptic Vesicles
Kantor, L., Hewlett, G. H. K., & Gnegy, M. E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-10-03801.1999 · Cited by 87
Individual differences in behavioral measures: Correlations with nucleus accumbens dopamine measured by microdialysis
Bradberry, C. W., Gruen, R. J., Berridge, C. W., & Roth, R. H. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90047-6 · Cited by 78
D 1 dopamine receptor blockade prevents the facilitation of amphetamine self-administration induced by prior exposure to the drug
Pierre, P. J., & Vezina, P. (1998) · Psychopharmacology · doi:10.1007/s002130050658 · Cited by 63
Self-citation
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Stewart, J., & Vezina, P. (1987) · Psychobiology · doi:10.3758/bf03333103 · Cited by 57
Self-citation
Injection of the protein kinase C inhibitor Ro31-8220 into the nucleus accumbens attenuates the acute response to amphetamine: tissue and behavioral studies.
Browman, K. E., Kantor, L., Richardson, S., Badiani, A., Robinson, T., & Gnegy, M. (1998) · Brain Research · doi:10.1016/s0006-8993(98)01040-3 · Cited by 55
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Vezina, P., Pierre, P. J., & Lorrain, D. S. (1999) · Psychopharmacology · doi:10.1007/s002130051152 · Cited by 53
Self-citation
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Hooks, M. S., JONES, G. H., Liem, B., & Justice, J. B. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb25993.x · Cited by 49
Pathophysiological Basis of Vulnerability to Drug Abuse: Role of an Interaction Between Stress, Glucocorticoids, and Dopaminergic Neurons
Piazza, P. V. (1996) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.36.1.359 · Cited by 41
A comparison of two behavioral measures of psychomotor activation following intravenous amphetamine or cocaine
Crombag, H. S., Mueller, H., Browman, K. E., Badiani, A., & Robinson, T. E. (1999) · Behavioural Pharmacology · doi:10.1097/00008877-199903000-00009 · Cited by 32
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Jolly, D. C., & Vezina, P. (1996) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(96)00089-1 · Cited by 28
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Szechtman, H., Talangbayan, H., Canaran, G., Dai, H., & Eilam, D. (1994) · Psychopharmacology · doi:10.1007/bf02244885 · Cited by 8
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Authors: Vezina, P., Lorrain, D. S., Arnold, G. M., Austin, J. D., & Suto, N.
Affiliations: University of Chicago (US)
Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
ORCID: Suto, Nobuyoshi
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2002-06-01
Volume: 22
Issue: 11
Pages: 4654-4662
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.22-11-04654.2002
PMC: PMC6758806
OpenAlex: W1556555813
Cited by: 206
References: 58
Citations by year: 2026: 1 · 2025: 2 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 7 · 2019: 3 · 2018: 11 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 4 · 2013: 10 · 2012: 6
FWCI: 5.47
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01da009860-04)
U.S. Public Health Service
National Institute on Drug Abuse (R01DA009397, T32DA007255)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: amphetamine, self-administration, midbrain dopaminergic neurons, ventral tegmental area, compulsive drug seeking, locomotor activity, stimulant abuse
MeSH terms: Amphetamine, Animals, Behavior, Animal, Disease Models, Animal, Dopamine, Drug Administration Routes, Drug Administration Schedule, Extracellular Space, Injections, Intraperitoneal, Male, Mesencephalon, Motor Activity, Neurons, Nucleus Accumbens, Self Administration, Microdialysis, Ventral Tegmental Area, Amphetamine-Related Disorders, Rats, Long-Evans, Rats

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Sensitization of Midbrain Dopamine Neuron Reactivity Promotes the Pursuit of Amphetamine

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