Microglial CD33-related Siglec-E inhibits neurotoxicity by preventing the phagocytosis-associated oxidative burst

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · cited 3× · see citing works

Siglecs and their roles in the immune system

Crocker, P. R., Paulson, J. C., & Varki, A. P. (2007) · Nature reviews. Immunology · doi:10.1038/nri2056 · Cited by 2,032 · see citing works

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

the Immunological Genome Consortium, Gautier, E. L., Shay, T., Miller, J., Greter, M., Jakubzick, C., Ivanov, S., Helft, J., Chow, A., Elpek, K. G., et al. (2012) · Nature Immunology · doi:10.1038/ni.2419 · Cited by 1,972 · cited 3× · see citing works

Debris clearance by microglia: an essential link between degeneration and regeneration

Neumann, H., Kotter, M. R., & Franklin, R. J. M. (2008) · Brain · doi:10.1093/brain/awn109 · Cited by 1,111 · see citing works

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

Mócsai, A., Abram, C. L., Jakus, Z., Hu, Y., Lanier, L. L., & Lowell, C. A. (2006) · Nature Immunology · doi:10.1038/ni1407 · Cited by 369 · see citing works

Developmental Neuronal Death in Hippocampus Requires the Microglial CD11b Integrin and DAP12 Immunoreceptor

Wakselman, S., Béchade, C., Roumier, A., Bernard, D., Triller, A., & Bessis, A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1006-08.2008 · Cited by 351 · see citing works

Eaten alive! Cell death by primary phagocytosis: ‘phagoptosis’

Brown, G. C., & Neher, J. J. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.05.002 · Cited by 320 · see citing works

Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

Varki, A. (2011) · Glycobiology · doi:10.1093/glycob/cwr087 · Cited by 263 · see citing works

The murine inhibitory receptor mSiglec‐E is expressed broadly on cells of the innate immune system whereas mSiglec‐F is restricted to eosinophils

Zhang, J. Q., Biedermann, B., Nitschke, L., & Crocker, P. R. (2004) · European Journal of Immunology · doi:10.1002/eji.200324723 · Cited by 195 · see citing works

Alleviation of Neurotoxicity by Microglial Human Siglec-11

Wang, Y., & Neumann, H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3940-09.2010 · Cited by 190 · see citing works

Accumulation of tau induced in neurites by microglial proinflammatory mediators

Gorlovoy, P., Larionov, S., Pham, T. T. H., & Neumann, H. (2009) · The FASEB Journal · doi:10.1096/fj.08-123877 · Cited by 156 · see citing works

Microglial activatory (immunoreceptor tyrosine‐based activation motif)‐ and inhibitory (immunoreceptor tyrosine‐based inhibition motif)‐signaling receptors for recognition of the neuronal glycocalyx

Linnartz‐Gerlach, B., & Neumann, H. (2012) · Glia · doi:10.1002/glia.22359 · Cited by 117 · see citing works

Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin–dependent signaling

McMillan, S. J., Sharma, R. S., McKenzie, E. J., Richards, H. E., Zhang, J., Prescott, A. R., & Crocker, P. R. (2013) · Blood · doi:10.1182/blood-2012-08-449983 · Cited by 109 · see citing works

Generation of microglial cells from mouse embryonic stem cells

Beutner, C., Roy, K., Linnartz, B., Napoli, I., & Neumann, H. (2010) · Nature Protocols · doi:10.1038/nprot.2010.90 · Cited by 85 · see citing works

Siglec-E Is Up-Regulated and Phosphorylated Following Lipopolysaccharide Stimulation in Order to Limit TLR-Driven Cytokine Production

Boyd, C. R., Orr, S. J., Spence, S., Burrows, J. F., Elliott, J., Carroll, H. P., Brennan, K., Gabhann, J. N., Coulter, W. A., Johnston, J. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902780 · Cited by 77 · see citing works

An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells

Graham, D. B., Stephenson, L. M., Lam, S. K., Brim, K. L., Lee, H. M., Bautista, J. L., Gilfillan, S., Akilesh, S., Fujikawa, K., & Swat, W. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071283 · Cited by 67 · see citing works

Early Murine T-lymphocyte Activation Is Accompanied by a Switch from N-Glycolyl- to N-Acetyl-neuraminic Acid and Generation of Ligands for Siglec-E

Redelinghuys, P., Antonopoulos, A., Liu, Y., Campanero‐Rhodes, M. A., McKenzie, E. J., Haslam, S. M., Dell, A., Feizi, T., & Crocker, P. R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.243410 · Cited by 47 · see citing works

Chapter 23 Quantification of Superoxide Production by Mouse Brain and Skeletal Muscle Mitochondria

Malińska, D., Kudin, A. P., Dębska–Vielhaber, G., Vielhaber, S., & Kunz, W. S. (2009) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)04423-6 · Cited by 29 · see citing works

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

Simpson, D. S. A., & Oliver, P. L. (2020) · Antioxidants · doi:10.3390/antiox9080743 · Cited by 1,044 · see citing works

Microglial Phagocytosis of Live Neurons

Brown, G. C., & Neher, J. J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3710 · Cited by 853 · see citing works

How microglia kill neurons

Brown, G. C., & Vilalta, A. (2015) · Brain Research · doi:10.1016/j.brainres.2015.08.031 · Cited by 306 · see citing works

Microglial phagocytosis of neurons in neurodegeneration, and its regulation

Butler, C. A., Popescu, A. S., Kitchener, E. J. A., Allendorf, D. H., Puigdellívol, M., & Brown, G. C. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15327 · Cited by 293 · see citing works

The Pathophysiological Role of Microglia in Dynamic Surveillance, Phagocytosis and Structural Remodeling of the Developing CNS

Arcuri, C., Mecca, C., Bianchi, R., Giambanco, I., & Donato, R. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00191 · Cited by 279 · see citing works

Mitochondrial dysfunction and seizures: the neuronal energy crisis

Zsurka, G., & Kunz, W. S. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00148-9 · Cited by 246 · see citing works

Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease

Vilalta, A., & Brown, G. C. (2017) · FEBS Journal · doi:10.1111/febs.14323 · Cited by 174 · see citing works

Complex Roles of Microglial Cells in Ischemic Stroke Pathobiology: New Insights and Future Directions

Guruswamy, R., & ElAli, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030496 · Cited by 159 · see citing works

Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response

Cai, Q., Li, Y., & Pei, G. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0839-0 · Cited by 154 · see citing works

Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration

Puigdellívol, M., Allendorf, D. H., & Brown, G. C. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00162 · Cited by 145 · see citing works

Molecular Communication of a Dying Neuron in Stroke

Puig, B., Brenna, S., & Magnus, T. U. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092834 · Cited by 138 · see citing works

Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system

Lannes, N., Eppler, E., Etemad, S., Yotovski, P., & Filgueira, L. (2017) · Oncotarget · doi:10.18632/oncotarget.23106 · Cited by 139 · see citing works

Siglec‐H is a microglia‐specific marker that discriminates microglia from CNS‐associated macrophages and CNS‐infiltrating monocytes

Konishi, H., Kobayashi, M., Kunisawa, T., Imai, K., Sayo, A., MALISSEN, B., Crocker, P. R., Sato, K., & Kiyama, H. (2017) · Glia · doi:10.1002/glia.23204 · Cited by 138 · see citing works

Microglial phagocytosis in aging and Alzheimer's disease

Gabandé‐Rodríguez, E., Keane, L., & Capasso, M. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24419 · Cited by 127 · see citing works

The Phagocytic Code Regulating Phagocytosis of Mammalian Cells

Cockram, T. O. J., Dundee, J. M., Popescu, A. S., & Brown, G. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.629979 · Cited by 111 · see citing works

Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase

Nomura, K., Vilalta, A., Allendorf, D. H., Hornik, T. C., & Brown, G. C. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1502532 · Cited by 111 · see citing works

Microglia and inflammation: conspiracy, controversy or control?

Fernandes, A. M. A., Miller‐Fleming, L., & Pais, T. F. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1670-8 · Cited by 110 · see citing works

TREM2 triggers microglial density and age-related neuronal loss

Linnartz‐Gerlach, B., Bodea, L., Klaus, C., Ginolhac, A., Halder, R., Sinkkonen, L., Walter, J., Colonna, M., & Neumann, H. (2019) · Glia · doi:10.1002/glia.23563 · Cited by 104 · see citing works

Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury <i>in vivo</i>

Herzog, C., Pons Garcia, L., Keatinge, M., Greenald, D., Moritz, C., Peri, F., & Herrgen, L. (2019) · Development · doi:10.1242/dev.174698 · Cited by 106 · see citing works

Siglecs in Brain Function and Neurological Disorders

Siddiqui, S. S., Matar, R., Merheb, M., Hodeify, R., Vazhappilly, C. G., Marton, J., Shamsuddin, S. A., & Al Zouabi, H. (2019) · Cells · doi:10.3390/cells8101125 · Cited by 100 · see citing works

Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages

Shahraz, A., Kopatz, J., Mathy, R., Kappler, J., Winter, D., Kapoor, S., Schütza, V., Scheper, T. H., Gieselmann, V., & Neumann, H. (2015) · Scientific Reports · doi:10.1038/srep16800 · Cited by 95 · see citing works

Microglia engulf viable newborn cells in the epileptic dentate gyrus

Luo, C., Koyama, R., & Ikegaya, Y. (2016) · Glia · doi:10.1002/glia.23018 · Cited by 94 · see citing works

Association of CD33 polymorphism rs3865444 with Alzheimer's disease pathology and CD33 expression in human cerebral cortex

Walker, D. G., Whetzel, A. M., Serrano, G., Sue, L. I., Beach, T. G., & Lue, L.-F. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.09.023 · Cited by 93 · see citing works

Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation

Secundino, I., Lizcano, A., Roupé, K. M., Wang, X., Cole, J. N., Olson, J., Ali, S. R., Dahesh, S., Amayreh, L. K., Henningham, A., et al. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1341-8 · Cited by 92 · see citing works

Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina

Karlstetter, M., Kopatz, J., Aslanidis, A., Shahraz, A., Caramoy, A., Linnartz‐Gerlach, B., Lin, Y., Lückoff, A., Fauser, S., Düker, K., et al. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606627 · Cited by 91 · see citing works

Deletion of Alzheimer's disease‐associated CD33 results in an inflammatory human microglia phenotype

Wißfeld, J., Nozaki, I., Mathews, M., Raschka, T., Ebeling, C., Hornung, V., Brüstle, O., & Neumann, H. (2021) · Glia · doi:10.1002/glia.23968 · Cited by 89 · see citing works

Paired Siglec receptors generate opposite inflammatory responses to a human‐specific pathogen

Schwarz, F., Landig, C. S., Siddiqui, S. S., Secundino, I., Olson, J., Varki, N. M., Nizet, V., & Varki, A. P. (2017) · The EMBO Journal · doi:10.15252/embj.201695581 · Cited by 84 · see citing works

Microglia as Therapeutic Target for Radiation-Induced Brain Injury

Liu, Q., Yan, H., Duan, M., Yang, Q., Ren, B., & Tang, F. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158286 · Cited by 83 · see citing works

Siglec functions of microglia

Linnartz‐Gerlach, B., Kopatz, J., & Neumann, H. (2014) · Glycobiology · doi:10.1093/glycob/cwu044 · Cited by 75 · see citing works

Activated microglia desialylate their surface, stimulating complement receptor 3‐mediated phagocytosis of neurons

Allendorf, D. H., Puigdellívol, M., & Brown, G. C. (2019) · Glia · doi:10.1002/glia.23757 · Cited by 76 · see citing works

Molecular mechanisms underlying microglial sensing and phagocytosis in synaptic pruning

Huo, A., Wang, J., Li, Q., Li, M., Qi, Y., Yin, Q., Luo, W., Shi, J., & Cong, Q. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.385854 · Cited by 73 · see citing works

Microglia Ontology and Signaling

ElAli, A., & Rivest, S. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00072 · Cited by 73 · see citing works

CD33 isoforms in microglia and Alzheimer's disease: Friend and foe

Eskandari‐Sedighi, G., Jung, J., & Macauley, M. S. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101111 · Cited by 68 · see citing works

Sialylation acts as a checkpoint for innate immune responses in the central nervous system

Klaus, C., Liao, H., Allendorf, D. H., Brown, G. C., & Neumann, H. (2020) · Glia · doi:10.1002/glia.23945 · Cited by 67 · see citing works

Reactive Oxygen Species: Angels and Demons in the Life of a Neuron

Biswas, K., Alexander, K. D., & Francis, M. M. (2022) · NeuroSci · doi:10.3390/neurosci3010011 · Cited by 69 · see citing works

Siglec receptors impact mammalian lifespan by modulating oxidative stress

Schwarz, F., Pearce, O. M. T., Wang, X., Samraj, A. N., Laubli, H. P., Garcia, J. O., Lin, H., Fu, X., Garcia-Bingman, A., Secrest, P., et al. (2015) · eLife · doi:10.7554/elife.06184 · Cited by 65 · see citing works

Lectin Receptors Expressed on Myeloid Cells

Brown, G. D., & Crocker, P. R. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0036-2016 · Cited by 66 · see citing works

Is There Still Any Role for Oxidative Stress in Mitochondrial DNA-Dependent Aging?

Zsurka, G., Peeva, V., Kotlyar, A. B., & Kunz, W. S. (2018) · Genes · doi:10.3390/genes9040175 · Cited by 57 · see citing works

Microglial Lectins in Health and Neurological Diseases

Siew, J. J., & Chern, Y. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00158 · Cited by 61 · see citing works

Lipopolysaccharide activates microglia via neuraminidase 1 desialylation of Toll‐like Receptor 4

Allendorf, D. H., Franssen, E. H., & Brown, G. C. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15024 · Cited by 57 · see citing works

Sensing the neuronal glycocalyx by glial sialic acid binding immunoglobulin-like lectins

Linnartz-Gerlach, B., Mathews, M., & Neumann, H. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.061 · Cited by 54 · see citing works

Neuropathological signs of inflammation correlate with mitochondrial DNA deletions in mesial temporal lobe epilepsy

Volmering, E., Niehusmann, P., Peeva, V., Grote, A., Zsurka, G., Altmüller, J., Nürnberg, P., Becker, A. J., Schoch, S., Elger, C. E., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1561-1 · Cited by 52 · see citing works

Role of Microglia in Modulating Adult Neurogenesis in Health and Neurodegeneration

Al-Onaizi, M., Alkhalifah, A. B., Qasem, D., & ElAli, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186875 · Cited by 43 · see citing works

Control of Innate Immunity by Sialic Acids in the Nervous Tissue

Liao, H., Klaus, C., & Neumann, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155494 · Cited by 46 · see citing works

Apoptotic Cell Clearance in Development

Shklover, J., Levy‐Adam, F., & Kurant, E. (2015) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2015.07.024 · Cited by 42 · see citing works

Roles for Siglec-glycan interactions in regulating immune cells

Lin, S.-Y., Schmidt, E. N., Takahashi, K., & Macauley, M. S. (2024) · Seminars in Immunology · doi:10.1016/j.smim.2024.101925 · Cited by 40 · see citing works

Homozygous mutation in TXNRD1 is associated with genetic generalized epilepsy

Kudin, A. P., Baron, G., Zsurka, G., Hampel, K. G., Elger, C. E., Grote, A., Weber, Y. G., Lerche, H., Thiele, H., Nürnberg, P., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.02.040 · Cited by 39 · see citing works

Novel Blood-Derived Extracellular Vesicle-Based Biomarkers in Alzheimer’s Disease Identified by Proximity Extension Assay

Nielsen, J. E., Pedersen, K. S., Vestergård, K., Maltesen, R. G., Christiansen, G., Lundbye‐Christensen, S., Moos, T., Kristensen, S. R., & Pedersen, S. (2020) · Biomedicines · doi:10.3390/biomedicines8070199 · Cited by 39 · see citing works

Basic Concept of Microglia Biology and Neuroinflammation in Relation to Psychiatry

Mattei, D., & Notter, T. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2018_83 · Cited by 37 · see citing works

Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E

Siddiqui, S. S., Schwarz, F., Springer, S. A., Khedri, Z., Yu, H., Deng, L., Verhagen, A., Naito‐Matsui, Y., Jiang, W., Kim, D., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.738351 · Cited by 35 · see citing works

Inhibitory Siglec-sialic acid interactions in balancing immunological activation and tolerance during viral infections

Saini, P., Adeniji, O. S., & Abdel‐Mohsen, M. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104354 · Cited by 32 · see citing works

Microglia-Centered Combinatorial Strategies Against Glioblastoma

Martins, T. A., Schmassmann, P., Shekarian, T., Boulay, J., Ritz, M., Zanganeh, S., Berg, J. V., & Hütter, G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.571951 · Cited by 30 · see citing works

Siglec-9 is an inhibitory receptor on human mast cells in vitro

Miralda, I., Samanas, N. B., Seo, A. J., Foronda, J. S., Sachen, J., Hui, Y. Y., Morrison, S. D., Oskeritzian, C. A., & Piliponsky, A. M. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.04.007 · Cited by 29 · see citing works

Integration of lectin–glycan recognition systems and immune cell networks in CNS inflammation

Méndez‐Huergo, S. P., Maller, S. M., Farez, M., Mariño, K. V., Correale, J. D., & Rabinovich, G. A. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.02.003 · Cited by 26 · see citing works

The Neuro-Immune-Regulators (NIREGs) Promote Tissue Resilience; a Vital Component of the Host’s Defense Strategy against Neuroinflammation

Bedoui, Y., Neal, J. W., & Gasque, P. (2018) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9793-6 · Cited by 27 · see citing works

Low molecular weight polysialic acid prevents lipopolysaccharide‐induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice

Liao, H., Winkler, J., Wißfeld, J., Shahraz, A., Klaus, C., & Neumann, H. (2021) · Glia · doi:10.1002/glia.24073 · Cited by 26 · see citing works

A novel locus on mouse chromosome 7 that influences survival after infection with tick-borne encephalitis virus

Palus, M., Sohrabi, Y., Broman, K. W., Strnad, H., Šíma, M., Růžek, D., Volkova, V., Slapničková, M., Vojtíšková, J., Mrázková, L., et al. (2018) · BMC Neuroscience · doi:10.1186/s12868-018-0438-8 · Cited by 26 · see citing works

Microglia and neurogenesis in the epileptic dentate gyrus

Luo, C., Ikegaya, Y., & Koyama, R. (2016) · Neurogenesis · doi:10.1080/23262133.2016.1235525 · Cited by 26 · see citing works

Siglecs Modulate Activities of Immune Cells Through Positive and Negative Regulation of ROS Generation

Karmakar, J., Mukherjee, K., & Mandal, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.758588 · Cited by 24 · see citing works

Siglecs as modulators of macrophage phenotype and function

Kukan, E. N., Fabiano, G. L., & Cobb, B. A. (2024) · Seminars in Immunology · doi:10.1016/j.smim.2024.101887 · Cited by 24 · see citing works

Microglia-Mediated Phagocytosis in Alzheimer’s Disease: Mechanisms, Heterogeneity, and Therapeutic Insights

Hassan, H., Rawlinson, C., Lan, Y., Jenkins, S. I., & Chen, R. (2025) · Biomolecules · doi:10.3390/biom15111629 · Cited by 24 · see citing works

Therapeutic potential to target sialylation and SIGLECs in neurodegenerative and psychiatric diseases

Wißfeld, J., Assale, T. A., Cuevas-Ríos, G., Liao, H., & Neumann, H. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1330874 · Cited by 23 · see citing works

Ablation of Siglec-E augments brain inflammation and ischemic injury

Li, L., Chen, Y., Sluter, M. N., Hou, R., Hao, J., Wu, Y., Chen, G., Yu, Y., & Jiang, J. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02556-1 · Cited by 22 · see citing works

Impaired peroxisomal beta-oxidation in microglia triggers oxidative stress and impacts neurons and oligodendrocytes

Tawbeh, A., Gondcaille, C., Saih, F.-E., Raas, Q., Loichot, D., Hamon, Y., Keime, C., Benani, A., Di Cara, F., Cherkaoui-Malki, M., et al. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1542938 · Cited by 21 · see citing works

Roles of Siglecs in neurodegenerative diseases.

Siew, J.-J., Chern, Y., Khoo, K., & Angata, T. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101141 · Cited by 17 · see citing works

Deficits in Monocyte Function in Age Related Macular Degeneration: A Novel Systemic Change Associated With the Disease

Gu, B., Huang, X., Avula, P. K., Caruso, E., Drysdale, C., Vessey, K. A., Ou, A., Fowler, C., Liu, T.-H., Lin, Y., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.634177 · Cited by 14 · see citing works

Siglec‐F is induced by granulocyte–macrophage colony‐stimulating factor and enhances interleukin‐4‐induced expression of arginase‐1 in mouse macrophages

Tateyama, H., Murase, Y., Higuchi, H., Inasaka, Y., Kaneoka, H., Iijima, S., & Nishijima, K. (2019) · Immunology · doi:10.1111/imm.13121 · Cited by 19 · see citing works

Parenchymal and non‐parenchymal immune cells in the brain: A critical role in regulating CNS functions

Arcuri, C., Mecca, C., Giambanco, I., & Donato, R. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.04.005 · Cited by 18 · see citing works

CD33/TREM2 Signaling Mediates Sleep Deprivation-Induced Memory Impairment by Regulating Microglial Phagocytosis

Tan, S., Gao, H., Sun, J., Li, N., Zhang, Y., Yang, L., Wang, M., Wang, Q., & Zhai, Q. (2023) · NeuroMolecular Medicine · doi:10.1007/s12017-023-08733-6 · Cited by 16 · see citing works

Activation of microglial Toll‐like receptor 3 promotes neuronal survival against cerebral ischemia

Jeong, S., Jeon, R., Choi, Y. K., Jung, J. E., Liang, A. C., Xing, C., Wang, X., Lo, E. H., & Song, Y. S. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13441 · Cited by 16 · see citing works

Low molecular weight polysialic acid binds to properdin and reduces the activity of the alternative complement pathway

Shahraz, A., Lin, Y.-C., Mbroh, J., Winkler, J., Liao, H., Lackmann, M., Bungartz, A., Zipfel, P. F., Skerka, C., & Neumann, H. (2022) · Scientific Reports · doi:10.1038/s41598-022-09407-2 · Cited by 15 · see citing works

RNA‐Seq analysis of knocking out the neuroprotective proton‐sensitive GPR68 on basal and acute ischemia‐induced transcriptome changes and signaling in mouse brain

Zhou, G., Wang, T., & Zha, X. (2021) · The FASEB Journal · doi:10.1096/fj.202002511r · Cited by 15 · see citing works

The Pivotal Immunoregulatory Functions of Microglia and Macrophages in Glioma Pathogenesis and Therapy

Richard, S. A. (2022) · Journal of Oncology · doi:10.1155/2022/8903482 · Cited by 14 · see citing works

Cell type- and region-specific translatomes in an MPTP mouse model of Parkinson's disease

Huang, Q., Chen, C., Chen, W., Cai, C., Xing, H., Li, J., Li, M., & Ma, S. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106105 · Cited by 14 · see citing works

Neuroimmunomodulatory properties of polysialic acid

Gretenkort, L., Thiesler, H., & Hildebrandt, H. (2023) · Glycoconjugate Journal · doi:10.1007/s10719-023-10120-z · Cited by 15 · see citing works

Pharmacological Tools to Activate Microglia and their Possible use to Study Neural Network Patho-physiology

Peña‐Ortega, F. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160928151546 · Cited by 14 · see citing works

Polysialic acid production using Escherichia coli K1 in a disposable bag reactor

de Vries, I., Busse, C., Kopatz, J., Neumann, H., Beutel, S., & Scheper, T. H. (2017) · Engineering in Life Sciences · doi:10.1002/elsc.201600220 · Cited by 14 · see citing works

Maximum reproductive lifespan correlates with CD33rSIGLEC gene number: Implications for NADPH oxidase‐derived reactive oxygen species in aging

Khan, N., Kim, S. K., Gagneux, P., Dugan, L. L., & Varki, A. P. (2019) · The FASEB Journal · doi:10.1096/fj.201902116r · Cited by 13 · see citing works

Imaging Biomarkers for Monitoring the Inflammatory Redox Landscape in the Brain

Fernandes, E. F. A., & Özcelik, D. (2021) · Antioxidants · doi:10.3390/antiox10040528 · Cited by 13 · see citing works

The Fate of Oxidative Strand Breaks in Mitochondrial DNA

Trombly, G., Said, A. M., Kudin, A. P., Peeva, V., Altmüller, J., Becker, K., Köhrer, K., Zsurka, G., & Kunz, W. S. (2023) · Antioxidants · doi:10.3390/antiox12051087 · Cited by 10 · see citing works

Sialylation pattern in lung epithelial cell line and Siglecs expression in monocytic THP-1 cells as cellular indicators of cigarette smoke – induced pathology in vitro

Wielgat, P., Trofimiuk, E., Czarnomysy, R., Hołownia, A., & Braszko, J. J. (2018) · Experimental Lung Research · doi:10.1080/01902148.2018.1461959 · Cited by 7 · see citing works

Selective Response to Bacterial Infection by Regulating Siglec-E Expression

Wu, Y., Yang, D., Liu, R., Wang, L., & Chen, G. (2020) · iScience · doi:10.1016/j.isci.2020.101473 · Cited by 7 · see citing works

Sialylation as a checkpoint for inflammatory and complement-related retinal diseases

Min, Y., Cuevas-Ríos, G., Langmann, T., & Neumann, H. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1623755 · Cited by 6 · see citing works

Recent approaches for directly profiling cell surface sialoform

Zhang, X., Nie, H., Whited, J., Wang, D., Li, Y., & Sun, X. (2018) · Glycobiology · doi:10.1093/glycob/cwy046 · Cited by 5 · see citing works

Synaptic-immune interactions in neuropathic pain: complement-mediated remodeling of spinal dorsal horn microcircuits

Zhou, W.-M., Zhang, K., Ma, W.-W., Shi, Y.-Q., Dong, Y.-B., Yuan, Z.-Y., & Zhang, H. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1798053 · Cited by 3 · see citing works

Siglec-E Ligand Downregulation on Hippocampus Neurons Induced Inflammation in Sevoflurane-Associated Perioperative Neurocognitive Disorders in Aged Mice

Zhang, X., Wang, X., Xu, Z., Sun, F., Jia, Y., & Tian, Y. (2023) · Inflammation · doi:10.1007/s10753-023-01888-1 · Cited by 3 · see citing works

Lectin Receptors Expressed on Myeloid Cells

Brown, G. D., & Crocker, P. R. (2017) · ASM Press eBooks · doi:10.1128/9781555819194.ch25 · Cited by 3 · see citing works

Sialic Acid-Binding Ig-Like Lectins (Siglecs)

Kim, C. (2022) · Springer eBooks · doi:10.1007/978-981-16-9081-5_7 · Cited by 2 · see citing works

Phagocytosis and neuroinflammation: orchestrating central nervous system homeostasis, repair, and the resolution of inflammation

Gaudet, A. D., & Fonken, L. K. (2026) · Trends in Neurosciences · doi:10.1016/j.tins.2026.01.002 · Cited by 2 · see citing works

Microglial state transitions are constrained by developmental and metabolic checkpoints

Mesaoudi, A. E., & Kim, D. W. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1852176 · Cited by 1 · see citing works

Microglial State Mismatch in Autism Spectrum Disorder: Timing, Circuit Specificity and Glycan-Mediated Recognition

Osterne, V. J. S., Oliveira, M. V., Pinto‐Junior, V. R., Mota, F. S. B., Leal, R. B., Cavada, B. S., & Nascimento, K. S. (2026) · Neuroglia · doi:10.3390/neuroglia7020017 · Cited by 1 · see citing works

Glycans in Nervous System

Sato, C., Gu, J., Fukuda, T., Kadomatsu, K., & Ikenaka, K. (2019) · Springer eBooks · doi:10.1007/978-981-13-5856-2_12

養液土耕法によるスプレーギク栽培 : (第1報)養水分管理プログラムの検討

鈴木, 智., 落合, 悦., 峯岸, 長., & 古口, 光. (1996) · 園芸学会雑誌. 別冊, 園芸学会大会研究発表

Proteomics- and Metabolomics-Based Molecular Signatures of Alzheimer's Disease - From Blood to Extracellular Vesicles

Nielsen, J. E. (2021) · doi:10.54337/aau455017331

Targeting Microglial Phagocytosis for Alzheimer's Disease Management: Natural, Pharmacological, Nanoparticle, and Gene Therapy Approaches

Raghuvanshi, S., Mazumder, A., & Das, S. (2025) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273378092250623064748

Microglia at the Forefront: New Insights From the Glial Club South Cone Meeting 2025

Giambartolomei, G. H., Iribarren, P., Pasquini, L. A., & Peluffo, H. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70384

Rôle de la protéine C3 du système du complément dans les déficits mnésiques précoces sur un modèle expérimental de sclérose en plaques

Bourel, J. (2019) · theses.fr (ABES) · doi:10.70675/41880720z6bdez4e9czb821z3fe69fd6e016

Reactive oxygen species alter ex vivo dopaminergic and purinergic signaling and microglia physiology in the nucleus accumbensPreprint

Wadsworth, H. A., Webb, J. A., Taylor, E. B., White, E. R., Ford, L. H., Hawley, L. R., Parker, B. J., Jones, S. T., Linderman, S., Galbraith, C. J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.01.722235

The implication of microglial sialic acid-binding immunoglobulin-like lectin-E (Siglec-E) in neuroinflammation

Claude, J. (2014) · bonndoc (University of Bonn)

Siglec functions of microglia

Linnartz‐Gerlach, B., Kopatz, J., & Neumann, H. (2014) · Glycobiology · doi:10.1093/glycob/cwu044 · Cited by 75 · see citing works

Alleviation of Neurotoxicity by Microglial Human Siglec-11

Wang, Y., & Neumann, H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3940-09.2010 · Cited by 190 · see citing works

Sensing the neuronal glycocalyx by glial sialic acid binding immunoglobulin-like lectins

Linnartz-Gerlach, B., Mathews, M., & Neumann, H. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.061 · Cited by 54 · see citing works

Ablation of Siglec-E augments brain inflammation and ischemic injury

Li, L., Chen, Y., Sluter, M. N., Hou, R., Hao, J., Wu, Y., Chen, G., Yu, Y., & Jiang, J. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02556-1 · Cited by 22 · see citing works