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Tyro3, Axl, Mertk receptor-mediated efferocytosis and immune regulation in the tumor environment

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Neu1 Is Released From Activated Microglia, Stimulating Microglial Phagocytosis and Sensitizing Neurons to Glutamate

Allendorf, D. H., & Brown, G. C. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.917884 · Cited by 34 · see citing works

CD33M inhibits microglial phagocytosis, migration and proliferation, but the Alzheimer’s disease‐protective variant CD33m stimulates phagocytosis and proliferation, and inhibits adhesion

Butler, C. A., Thornton, P., & Brown, G. C. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15349 · Cited by 35 · see citing works

Mammalian Neuraminidases in Immune-Mediated Diseases: Mucins and Beyond

Lillehoj, E. P., Luzina, I. G., & Atamas, S. P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.883079 · Cited by 33 · see citing works

Galectin-3 (MAC-2) controls phagocytosis and macropinocytosis through intracellular and extracellular mechanisms

Rotshenker, S. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.949079 · Cited by 35 · see citing works

Galectins in the brain: advances in neuroinflammation, neuroprotection and therapeutic opportunities

Barake, F., Soza, A., & González, A. (2020) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000812 · Cited by 32 · see citing works

Evidence of the Cellular Senescence Stress Response in Mitotically Active Brain Cells—Implications for Cancer and Neurodegeneration

Gillispie, G. J., Sah, E., Krishnamurthy, S., Ahmidouch, M. Y., Zhang, B., & Orr, M. E. (2021) · Life · doi:10.3390/life11020153 · Cited by 32 · see citing works

Differential Cellular Expression of Galectin-1 and Galectin-3 After Intracerebral Hemorrhage

Bonsack, F., & Sukumari‐Ramesh, S. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00157 · Cited by 30 · see citing works

Role of immune inflammation regulated by macrophage in the pathogenesis of age-related macular degeneration

Zhao, Q., & Lai, K. (2023) · Experimental Eye Research · doi:10.1016/j.exer.2023.109770 · Cited by 29 · see citing works

Cellular translocation and secretion of sialidases

Aljohani, M. A., Sasaki, H., & Sun, X. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107671 · Cited by 29 · see citing works

Galectin-3 Involvement in Cognitive Processes for New Therapeutic Considerations

Mijailović, N. R., Vesić, K., Arsenijević, D., Milojević‐Rakić, M., & Borovčanin, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.923811 · Cited by 29 · see citing works

Galectin-3 in Microglia-Mediated Neuroinflammation: Implications for Central Nervous System Diseases

Tian, Y.-K., Ye, D.-W., Ge, M.-M., Chen, N., Zhou, Y.-Q., & Yang, H. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220201094547 · Cited by 31 · see citing works

TAM kinase inhibition and immune checkpoint blockade– a winning combination in cancer treatment?

Msaouel, P., Genovese, G., Gao, J., Sen, S., & Tannir, N. M. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1869212 · Cited by 28 · see citing works

The dual role of microglia in ischemic stroke and its modulation via extracellular vesicles and stem cells

Haupt, M., Gerner, S. T., & Doeppner, T. R. (2024) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.39 · Cited by 26 · see citing works

Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis

Pérez-Moreno, E., Oyanadel, C., de la Peña, A., Hernández, R., Pérez-Molina, F., Metz, C., González, A., & Soza, A. (2024) · Biological Research · doi:10.1186/s40659-024-00490-5 · Cited by 26 · see citing works

Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV

Liberto, G. D., Égervári, K., Kreutzfeldt, M., Schürch, C. M., Hewer, E., Wagner, I., Pasquier, R. D., & Merkler, D. (2022) · Brain · doi:10.1093/brain/awac102 · Cited by 26 · see citing works

Microglia Mediate Contact-Independent Neuronal Network Remodeling via Secreted Neuraminidase-3 Associated with Extracellular Vesicles

Delaveris, C. S., Wang, C. L., Riley, N. M., Li, S., Kulkarni, R. U., & Bertozzi, C. R. (2023) · ACS Central Science · doi:10.1021/acscentsci.3c01066 · Cited by 25 · see citing works

Reactive microglia partially envelop viable neurons in prion diseases

Makarava, N., Safadi, T., Bocharova, O. V., Mychko, O., Pandit, N. P., Molesworth, K., Baiardi, S., Zhang, L., Parchi, P., & Baskakov, I. V. (2024) · Journal of Clinical Investigation · doi:10.1172/jci181169 · Cited by 26 · see citing works

Efferocytosis: the resolution of inflammation in cardiovascular and cerebrovascular disease

Zhang, B., Zou, Y., Yuan, Z., Jiang, K., Zhang, Z., Chen, S., Zhou, X., Wu, Q., & Zhang, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1485222 · Cited by 27 · see citing works

Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models

Manich, G., Gómez‐López, A. R., Almolda, B., Villacampa, N., Recasens, M., Shrivastava, K., González, B., & Castellano, B. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.567404 · Cited by 26 · see citing works

Dopaminergic neurons lacking Caspase-3 avoid apoptosis but undergo necrosis after MPTP treatment inducing a Galectin-3-dependent selective microglial phagocytic response

García‐Revilla, J., Ruiz, R., Espinosa‐Oliva, A. M., Santiago, M., García-Domínguez, I., Camprubí-Ferrer, L., Bachiller, S., Deierborg, T., Joseph, B., de Pablos, R. M., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07014-9 · Cited by 25 · see citing works

Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis

Neel, D. V., Basu, H., Gunner, G., & Chiu, I. M. (2022) · Immunological Reviews · doi:10.1111/imr.13083 · Cited by 22 · see citing works

Galectin-3 Mediates Endotoxin Internalization and Caspase-4/11 Activation in Tubular Epithelials and Macrophages During Sepsis and Sepsis-Associated Acute Kidney Injury

Wang, F., Ye, J., Zhu, W., Ge, R., Hu, C., Qian, Y., Li, Y., & Peng, Z. (2023) · Inflammation · doi:10.1007/s10753-023-01928-w · Cited by 23 · see citing works

Galectin-3 Stimulates Tyro3 Receptor Tyrosine Kinase and Erk Signalling, Cell Survival and Migration in Human Cancer Cells

Kafri, N. A., & Hafizi, S. (2020) · Biomolecules · doi:10.3390/biom10071035 · Cited by 22 · see citing works

I’m Infected, Eat Me! Innate Immunity Mediated by Live, Infected Cells Signaling To Be Phagocytosed

Birkle, T. J. Y., & Brown, G. C. (2021) · Infection and Immunity · doi:10.1128/iai.00476-20 · Cited by 22 · see citing works

Post-stroke Delivery of Valproic Acid Promotes Functional Recovery and Differentially Modifies Responses of Peri-Infarct Microglia

Kuo, T., Chen, Y.-H., Wang, V., Wu, J., & Tseng, K.-Y. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.639145 · Cited by 21 · see citing works

Computational Interspecies Translation Between Alzheimer’s Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures, Distinct From Influences of Aging

Lee, M. J., Wang, C., Carroll, M. J., Brubaker, D. K., Hyman, B. T., & Lauffenburger, D. A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.727784 · Cited by 18 · see citing works

Potential Use of Nanomedicine for the Anti-inflammatory Treatment of Neurodegenerative Diseases

Otero, M. D. C., Espinosa‐Oliva, A. M., Herrera, A. J., García-Domínguez, I., Arévalo, M. F., Martín‐Banderas, L., & de Pablos, R. M. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612824666180403113015 · Cited by 17 · see citing works

Protein tyrosine kinase A modulates intracellular survival of mycobacteria through Galectin 3

Jaiswal, S., & Srivastava, K. K. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.03.075 · Cited by 14 · see citing works

Modulating Microglia/Macrophage Activation by CDNF Promotes Transplantation of Fetal Ventral Mesencephalic Graft Survival and Function in a Hemiparkinsonian Rat Model

Tseng, K.-Y., Wu, J., Chen, Y.-H., Airavaara, M., Cheng, C., & Ma, K. (2022) · Biomedicines · doi:10.3390/biomedicines10061446 · Cited by 13 · see citing works

Atrazine induces phagocytotic dysfunction of microglia depends on nucleocytoplasmic translocation of acetylated HMGB1

Shi, G., Zhang, C., Li, G., Wang, K., Cai, Q., & Huang, M. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114583 · Cited by 12 · see citing works

New Insights Regarding Diagnosis and Medication for Schizophrenia Based on Neuronal Synapse–Microglia Interaction

Izuo, N., & Nitta, A. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11050371 · Cited by 12 · see citing works

Diurnal Photoreceptor Outer Segment Renewal in Mice Is Independent of Galectin-3

Esposito, N. J., Mazzoni, F., Vargas, J. A., & Finnemann, S. C. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.2.7 · Cited by 9 · see citing works

Galectins in the Pathogenesis of Common Retinal Disease

Caridi, B., Doncheva, D., Sivaprasad, S., & Turowski, P. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.687495 · Cited by 8 · see citing works

TAM Receptors in the Pathophysiology of Liver Disease

Flint, E., Triantafyllou, E., & Bernsmeier, C. (2022) · Livers · doi:10.3390/livers2010002 · Cited by 8 · see citing works

Roles of Microglia in Synaptogenesis, Synaptic Pruning, and Synaptic Plasticity in Physiological Conditions and Central Nervous System Disorders

Xie, M., Wang, T., Feng, J., Ma, D., Feng, L., & Hao, Y. (2025) · Current Neuropharmacology · doi:10.2174/1570159x23666250225091729 · Cited by 7 · see citing works

MERTK in the rat trigeminal system: a potential novel target for cluster headache?

Edvinsson, J. C. A., Ran, C., Olofsgård, F. J., Steinberg, A., Edvinsson, L. I., & Belin, A. C. (2024) · The Journal of Headache and Pain · doi:10.1186/s10194-024-01791-6 · Cited by 6 · see citing works

Microglial galectin-3 increases with aging in the mouse hippocampus

Shin, H. J., Lee, S. J., An, H. S., Choi, H. N., Jeong, E. A., Lee, J. W., Kim, K. E., Choi, B.-H., Yun, S. P., Kang, D., et al. (2025) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.24.196 · Cited by 7 · see citing works

Sweet Aging: Glycocalyx and Galectins in CNS Aging and Neurodegenerative Disorders

Légrádi, Á., & Mir, M. Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104699 · Cited by 5 · see citing works

Unique Glycans in Synaptic Glycoproteins in Mouse Brain

Noël, M., Suttapitugsakul, S., Wei, M., Tilton, C. A., Mehta, A. Y., Matsumoto, Y., Heimburg‐Molinaro, J., Mealer, R. G., & Cummings, R. D. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00399 · Cited by 5 · see citing works

Microglia mediate contact-independent neuronal pruning via secreted Neuraminidase-3 associated with extracellular vesiclesPreprint

Delaveris, C. S., Wang, C. L., Riley, N. M., Li, S., Kulkarni, R. U., & Bertozzi, C. R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.21.554214 · Cited by 5 · see citing works

Exploring galectin-3’s role in predicting mild cognitive impairment in type 2 diabetes and its regulation by miRNAs

Zhou, X., Dai, N., Yu, D., Niu, T., & Wang, S. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1443133 · Cited by 4 · see citing works

Oseltamivir (Tamiflu), a commonly prescribed antiviral drug, mitigates hearing loss in mice

Sailor‐Longsworth, E. J., Lutze, R. D., Ingersoll, M. A., Kelmann, R. G., Ly, K., Currier, D. G., Chen, T., Zuo, J., & Teitz, T. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1803 · Cited by 4 · see citing works

A network pharmacology and in silico approach to target NEU1-mediated microglial activation in neuroinflammation: Validation in an LPS-induced mouse model

Alzarea, S. I., Alsaidan, O. A., Qasim, S., Alhassan, H. H., Alzarea, A. I., Alsahli, T. G., Alharbi, M., & Almutairi, M. (2025) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2025.111318 · Cited by 3 · see citing works

Synaptic-immune interactions in neuropathic pain: complement-mediated remodeling of spinal dorsal horn microcircuits

Zhou, W.-M., Zhang, K., Ma, W.-W., Shi, Y.-Q., Dong, Y.-B., Yuan, Z.-Y., & Zhang, H. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1798053 · Cited by 3 · see citing works

Galectins as stress-integrating regulators of neuroimmune signaling and proteinopathy in the central nervous system

Siew, J. J., & Chern, Y. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107410 · Cited by 2 · see citing works

Impaired Efferocytosis of Pericytes and Vascular Smooth Muscle Cells in Diabetic Retinopathy

Gardiner, T. A., Little, K., & Stitt, A. W. (2025) · Cells · doi:10.3390/cells14171349 · Cited by 2 · see citing works

Analysis of gene expression in microglial apoptotic cell clearance following spinal cord injury based on machine learning algorithms

Yan, L., Chen, C., Wang, L., Hong, H., Wu, C., Huang, J., Jiang, J., Chen, J., Xu, G., & Cui, Z. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12581 · Cited by 2 · see citing works

Galectin-8 drives ERK-dependent mitochondrial fragmentation, perinuclear relocation and mitophagy, with metabolic adaptations for cell proliferation

de la Peña, A., Retamal, C., Pérez-Molina, F., Díaz-Valdivia, N., Veloso-Bahamondes, F., Tapia, D., Cancino, J., Randow, F., González, A., Oyanadel, C., et al. (2025) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2025.151488 · Cited by 1 · see citing works

Galectin-3 in Alzheimer’s disease: pathological roles, biomarker potential, and therapeutic implications

Akash, A., Ahamed, M., Porel, P., & Aran, K. R. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149949 · Cited by 2 · see citing works

Identification of a reactive astrocyte subpopulation during HIV-associated pain pathogenesis in mouse models

Zheng, J., Spurgat, M. S., Maurelli, M., Watson, Z., Hossain, S., DiBua, A., Yuan, S., Liu, X., Gelman, B. B., & Tang, S. (2025) · Nature Communications · doi:10.1038/s41467-025-67368-2 · Cited by 1 · see citing works

Exploring the role of sialidases in Galectin-1-associated resistance to cancer therapies

Scheidegger, M. A., Merlo, J. P., Villarreal, S. N., Schattner, M. A., Croci, D. O., Dalotto‐Moreno, T., Mariño, K. V., & Rabinovich, G. A. (2026) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2026.130931 · Cited by 1 · see citing works

The role of galectins in modulating the tumor microenvironment and driving metastasis in skin cancers

Dabagh, M., Ciceu, A., Baltă, C., Trotta, M. C., Ferraro, B., D’Amico, G., Hermenean, A. O., & Voiculescu, V. M. (2026) · Biological Research · doi:10.1186/s40659-026-00695-w · Cited by 1 · see citing works

Flavonoid-rich dietary patterns and incident hospital-recorded Parkinson's disease: a prospective UK Biobank study

Yang, W., Chen, Z., Zhang, Y., Peng, C., & Chen, B. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1893517 · Cited by 1 · see citing works

Roles in Innate Immunity

Church, K. A., Cardona, A. E., & Hopp, S. C. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_15 · Cited by 1 · see citing works

Identification of a new mechanism for preserving lysosomal functional integrity upon oxidative stress

Maestro, R. P. (2018) · doi:10.35376/10324/33119 · Cited by 1 · see citing works

Engulfment of viable neurons by reactive microglia in prion diseasesPreprint

Makarava, N., Safadi, T., Mychko, O., Pandit, N. P., Molesworth, K., Baiardi, S., Zhang, L., Parchi, P., & Baskakov, I. V. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.06.583759 · Cited by 1 · see citing works

Expression and role of Galectin-3 in the postnatal development of the cerebellumPreprint

González-Calvo, I., & Selimi, F. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/364760

Activated microglia desialylate their surface, stimulating complement receptor 3‐mediated phagocytosis of neurons

Allendorf, D. H., Puigdellívol, M., & Brown, G. C. (2019) · Glia · doi:10.1002/glia.23757 · Cited by 76 · see citing works

Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration

Puigdellívol, M., Allendorf, D. H., & Brown, G. C. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00162 · Cited by 145 · see citing works

Neu1 Is Released From Activated Microglia, Stimulating Microglial Phagocytosis and Sensitizing Neurons to Glutamate

Allendorf, D. H., & Brown, G. C. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.917884 · Cited by 34 · see citing works

Lipopolysaccharide activates microglia via neuraminidase 1 desialylation of Toll‐like Receptor 4

Allendorf, D. H., Franssen, E. H., & Brown, G. C. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15024 · Cited by 57 · see citing works

Role of Neuraminidase-mediated Desialylation in Microglial Activation

Allendorf, D. H. (2021) · Apollo (University of Cambridge) · doi:10.17863/cam.76902 · Cited by 1 · see citing works