The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Segregated Expression of AMPA-Type Glutamate Receptors and Glutamate Transporters Defines Distinct Astrocyte Populations in the Mouse Hippocampus
Open accessAbstract
Recent data have suggested the existence of direct signaling pathways between glial cells and neurons. Here we report the coexistence of distinct types of cells expressing astrocyte-specific markers within the hippocampus that display diverse morphological, molecular, and functional profiles. Usage of transgenic mice with GFAP promoter-controlled enhanced green fluorescent protein (EGFP) expression allowed the identification of astroglial cells after fresh isolation or in brain slices. Combining patch-clamp recordings and single-cell reverse transcription-PCR, we distinguished two morphologically distinct types of EGFP-positive cells, one expressing glutamate transporters and the other expressing ionotropic glutamate receptors. None of the EGFP-positive cells coexpressed glutamate receptors and transporters. Subpopulations of glutamate receptor-bearing EGFP-positive cells expressed AN2, the mouse homolog of the rat NG2 proteoglycan or transcripts for excitatory amino acid carrier 1, a neuronal glutamate transporter. Our data demonstrate the presence of distinct, independent populations of cells with astroglial properties in the developing hippocampus that can differently modulate neuronal signaling pathways. The observed heterogeneity of cells with GFAP promoter-regulated EGFP expression and S100β/GFAP immunoreactivity challenges the hitherto accepted definition of astrocytes.
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Cited by
Astrocytes, from brain glue to communication elements: the revolution continues
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Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission
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Metadata
- Authors
- Matthias, K., Kirchhoff, F., Seifert, G., Hüttmann, K., Matyash, M., Kettenmann, H., & Steinhäuser, C.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-03-01
- Volume
- 23
- Issue
- 5
- Pages
- 1750-1758
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2162637085
- Cited by
- 431
- References
- 52
- FWCI
- 12.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Matthias, K., Kirchhoff, F., Seifert, G., Hüttmann, K., Matyash, M., Kettenmann, H., & Steinhäuser, C. (2003). Segregated Expression of AMPA-Type Glutamate Receptors and Glutamate Transporters Defines Distinct Astrocyte Populations in the Mouse Hippocampus. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.23-05-01750.2003
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