The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission
Abstract
Astrocytes provide metabolic substrates to neurons in an activity-dependent manner. However, the molecular mechanisms involved in this function, as well as its role in synaptic transmission, remain unclear. Here, we show that the gap-junction subunit proteins connexin 43 and 30 allow intercellular trafficking of glucose and its metabolites through astroglial networks. This trafficking is regulated by glutamatergic synaptic activity mediated by AMPA receptors. In the absence of extracellular glucose, the delivery of glucose or lactate to astrocytes sustains glutamatergic synaptic transmission and epileptiform activity only when they are connected by gap junctions. These results indicate that astroglial gap junctions provide an activity-dependent intercellular pathway for the delivery of energetic metabolites from blood vessels to distal neurons.
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Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
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Leng, F., & Edison, P. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-020-00435-y · Cited by 3,179
Molecular dissection of reactive astrogliosis and glial scar formation
Sofroniew, M. V. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.08.002 · Cited by 2,594
Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation
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Synaptic Energy Use and Supply
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Metadata
- Authors
- Rouach, N., Koulakoff, A., Abudara, V., Willecke, K., & Giaume, C.
- Venue
- Science
- Published
- 2008-12-05
- Volume
- 322
- Issue
- 5907
- Pages
- 1551-1555
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1974420316
- Cited by
- 871
- References
- 13
- FWCI
- 16.50
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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