The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Dual Modes of Endoplasmic Reticulum-to-Golgi Transport in Dendrites Revealed by Live-Cell Imaging
Open accessAbstract
Organelles of the neuronal secretory pathway are critical for the addition of membrane that accompanies neuronal development, as well as for the proper localization of plasma membrane proteins necessary for polarity, synaptic transmission, and plasticity. Here, we demonstrate that two organizations of the secretory pathway exist in neurons: one requiring processing of membrane and lipids in the Golgi complex of the cell body and one in which endoplasmic reticulum (ER)-to-Golgi trafficking is localized to dendrites. Using time-lapse imaging of green fluorescent protein-tagged cargo proteins and compartment markers, we show that organelles of the secretory pathway, including ER, ER exit sites, and Golgi, are present and engage in trafficking in neuronal dendrites. We find that ER-to-Golgi trafficking involves highly mobile vesicular carriers that traffic in both the anterograde and retrograde directions throughout the dendritic arbor. Dendritic Golgi outposts, which appear developmentally during the phase of process outgrowth, are involved in the trafficking of both integral membrane proteins and the secreted neuronal growth factor BDNF. This distributed dendritic Golgi represents an organization of the secretory pathway unique among mammalian cells.
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Cites
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Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement
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ER-to-Golgi transport visualized in living cells
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Cited by
Cajigas, I. J., Tushev, G., Will, T. J., tom Dieck, S., Fuerst, N., & Schuman, E. M. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.036 · Cited by 709
Sutton, M. A., Ito, H. T., Cressy, P., Kempf, C., Woo, J. C., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.03.040 · Cited by 633
Organization of the ER–Golgi interface for membrane traffic control
Brandizzi, F., & Barlowe, C. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3588 · Cited by 522
ORGANELLES AND TRAFFICKING MACHINERY FOR POSTSYNAPTIC PLASTICITY
Kennedy, M. J., & Ehlers, M. D. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112808 · Cited by 346
Self-citationOri-McKenney, K. M., Jan, L. Y., & Jan, Y.-N. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.008 · Cited by 323
Metadata
- Authors
- Horton, A. C., & Ehlers, M. D.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-07-16
- Volume
- 23
- Issue
- 15
- Pages
- 6188-6199
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2039005185
- Cited by
- 320
- References
- 68
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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