ORGANELLES AND TRAFFICKING MACHINERY FOR POSTSYNAPTIC PLASTICITY
Open accessAbstract
Neurons are among the largest and most complex cells in the body. Their immense size and intricate geometry pose many unique cell-biological problems. How is dendritic architecture established and maintained? How do neurons traffic newly synthesized integral membrane proteins over such long distances to synapses? Functionally, protein trafficking to and from the postsynaptic membrane has emerged as a key mechanism underlying various forms of synaptic plasticity. Which organelles are involved in postsynaptic trafficking, and how do they integrate and respond to activity at individual synapses? Here we review what is currently known about long-range trafficking of newly synthesized postsynaptic proteins as well as the local rules that govern postsynaptic trafficking at individual synapses.
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In response to changes in synaptic activity, neurons can alter both pre- and postsynaptic elements of the synapse, including the number, size, and shape of dendritic spines.
“In response to changes in synaptic activity, neurons can alter both pre-and postsynaptic elements of the synapse, including the number, size, and shape of dendritic spines (Kennedy and Ehlers, 2006;Alvarez and Sabatini, 2007;Bourne and Harris, 2007;Hanus and Ehlers, 2008;Newpher and Ehlers, 2009;Kasai et al, 2010).”
From Ral mediates activity‐dependent growth of postsynaptic membranes via recruitment of the exocyst (2013) · cites this paper as Kennedy and Ehlers, 2006
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- Authors
- Kennedy, M. J., & Ehlers, M. D.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2006-07-21
- Volume
- 29
- Issue
- 1
- Pages
- 325-362
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- PMC
- PMC1876664
- OpenAlex
- W2138435892
- Cited by
- 346
- References
- 21
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 3 · 2023: 2 · 2022: 11 · 2021: 14 · 2020: 15 · 2019: 7 · 2018: 9 · 2017: 10 · 2016: 11 · 2015: 17 · 2014: 12 · 2013: 24 · 2012: 25
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS047574)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- postsynaptic plasticity, synaptic plasticity, organelles, protein trafficking, dendritic morphology, postsynaptic membrane, synapses
- MeSH terms
- Animals, Brain, Dendrites, Endocytosis, Exocytosis, Models, Biological, Neuronal Plasticity, Synapses, Organelles, Excitatory Postsynaptic Potentials, Protein Transport
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