Cited by 411Nerve injury and regenerationNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

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Brain-Derived Neurotrophic Factor Is Required for the Maintenance of Cortical Dendrites

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Gorski, Jessica A., Zeiler, Steven R., Tamowski, Susan, Jones, Kevin R.·2003·The Journal of Neuroscience

DOI 10.1523/jneurosci.23-17-06856.2003PMC PMC6740724

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Abstract

Brain-derived neurotrophic factor (BDNF) is thought to be involved in neuronal survival, migration, morphological and biochemical differentiation, and modulation of synaptic function in the CNS. In the rodent cortex, postnatal BDNF expression is initially low but subsequently increases to reach maximal levels around weaning. Thus, BDNF expression peaks at a time when both structural and functional maturation of cortical circuitry occurs. Although the function of BDNF has been probed using many approaches, its requirements during this phase of life have not previously been examined genetically. To test the in vivo requirements for BDNF during this important phase of development we generated early-onset forebrain-specific BDNF mutant mice. Although these mice undergo forebrain-restricted deletion of BDNF by Cre-mediated recombination during embryogenesis, they are healthy, and we did not detect the loss of specific cortical excitatory or inhibitory neurons. However, the neocortex of 5-week-old mice was thinner, attributable at least partly to neuronal shrinkage. Importantly, although visual cortical layer 2/3 neurons in the mutants initially developed normal dendrite structure, dendritic retraction became apparent by 3 weeks of age. Thus, our observations suggest that cortically expressed BDNF functions to support the maintenance of cortical neuron size and dendrite structure rather than the initial development of these features. This is consistent with a role for BDNF in stabilizing the "survival" of circuitry during the phase of activity-dependent reorganization of cortical connectivity.

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Authors: Gorski, J. A., Zeiler, S. R., Tamowski, S., & Jones, K. R.
Affiliations: University of Colorado Boulder (US)
ORCID: Zeiler, Steven R.
Jones, Kevin R.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2003-07-30
Volume: 23
Issue: 17
Pages: 6856-6865
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.23-17-06856.2003
PMC: PMC6740724
OpenAlex: W2110442840
Cited by: 411
References: 79
Citations by year: 2026: 3 · 2025: 3 · 2024: 13 · 2023: 13 · 2022: 9 · 2021: 13 · 2020: 16 · 2019: 12 · 2018: 25 · 2017: 16 · 2016: 21 · 2015: 28 · 2014: 28 · 2013: 20 · 2012: 30
FWCI: 6.92
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Cancer Society
Muscular Dystrophy Association
Wellcome Trust
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: brain-derived neurotrophic factor, dendritic retraction, neocortex development, neuronal survival, neuronal shrinkage, postnatal development
MeSH terms: Age Factors, Animals, Behavior, Animal, Cell Count, Cell Survival, Cerebral Cortex, Dendrites, Female, Lysine, Male, Mice, Mutant Strains, Neurons, Organ Specificity, Prosencephalon, Pyramidal Cells, Gene Targeting, Gene Expression Regulation, Developmental, Brain-Derived Neurotrophic Factor, Neurodegenerative Diseases, Cell Size, Mice

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Brain-Derived Neurotrophic Factor Is Required for the Maintenance of Cortical Dendrites

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