Cited by 411Nerve injury and regenerationNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

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Brain-Derived Neurotrophic Factor Is Required for the Maintenance of Cortical Dendrites

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Gorski, Jessica A., Zeiler, Steven R., Tamowski, Susan, Jones, Kevin R.·2003·The Journal of Neuroscience

DOI 10.1523/jneurosci.23-17-06856.2003PMC PMC6740724

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Abstract

Brain-derived neurotrophic factor (BDNF) is thought to be involved in neuronal survival, migration, morphological and biochemical differentiation, and modulation of synaptic function in the CNS. In the rodent cortex, postnatal BDNF expression is initially low but subsequently increases to reach maximal levels around weaning. Thus, BDNF expression peaks at a time when both structural and functional maturation of cortical circuitry occurs. Although the function of BDNF has been probed using many approaches, its requirements during this phase of life have not previously been examined genetically. To test the in vivo requirements for BDNF during this important phase of development we generated early-onset forebrain-specific BDNF mutant mice. Although these mice undergo forebrain-restricted deletion of BDNF by Cre-mediated recombination during embryogenesis, they are healthy, and we did not detect the loss of specific cortical excitatory or inhibitory neurons. However, the neocortex of 5-week-old mice was thinner, attributable at least partly to neuronal shrinkage. Importantly, although visual cortical layer 2/3 neurons in the mutants initially developed normal dendrite structure, dendritic retraction became apparent by 3 weeks of age. Thus, our observations suggest that cortically expressed BDNF functions to support the maintenance of cortical neuron size and dendrite structure rather than the initial development of these features. This is consistent with a role for BDNF in stabilizing the "survival" of circuitry during the phase of activity-dependent reorganization of cortical connectivity.

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The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394
Synaptic Activity and the Construction of Cortical Circuits
Katz, L. C., & Shatz, C. J. (1996) · Science · doi:10.1126/science.274.5290.1133 · Cited by 3,048
The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium
Doetschman, T., Eistetter, H. R., Katz, M., Schmidt, W., & Kemler, R. (1985) · Development · doi:10.1242/dev.87.1.27 · Cited by 1,962
Neurotrophins as synaptic modulators
Poo, M.-M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049004 · Cited by 1,775
Simplified mammalian DNA isolation procedure
Laird, P. W., Zijderveld, A., Linders, K., Rudnicki, M. A., Jaenisch, R., & Berns, A. J. M. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.15.4293 · Cited by 1,497
Cortical Excitatory Neurons and Glia, But Not GABAergic Neurons, Are Produced in the Emx1-Expressing Lineage
Gorski, J. A., Talley, T., Qiu, M. S., Puelles, L., Rubenstein, J. L. R., & Jones, K. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06309.2002 · Cited by 1,403
Self-citation
The Trk family of neurotrophin receptors
Barbacid, M. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251107 · Cited by 1,281
NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression
Maisonpierre, P. C., Belluscio, L., Friedman, B., Alderson, R. F., Wiegand, S. J., Furth, M. E., Lindsay, R. M., & Yancopoulos, G. D. (1990) · Neuron · doi:10.1016/0896-6273(90)90089-x · Cited by 1,250
BDNF Regulates the Maturation of Inhibition and the Critical Period of Plasticity in Mouse Visual Cortex
Huang, Z. J., Kirkwood, A., Pizzorusso, T., Porciatti, V., Morales, B., Bear, M. F., Maffei, L., & Tonegawa, S. (1999) · Cell · doi:10.1016/s0092-8674(00)81509-3 · Cited by 1,198
Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family
Hohn, A., Leibrock, J., Bailey, K., & Barde, Y.-A. (1990) · Nature · doi:10.1038/344339a0 · Cited by 1,145
Trk receptors: mediators of neurotrophin action
Patapoutian, A., & Reichardt, L. F. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00208-7 · Cited by 1,070
Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous systemPreprint
Bibel, M., & Barde, Y. (2000) · Genes & Development · doi:10.1101/gad.841400 · Cited by 1,069
Mice lacking brain-derived neurotrophic factor develop with sensory deficits
Ernfors, P., Lee, K.-F., & Jaenisch, R. (1994) · Nature · doi:10.1038/368147a0 · Cited by 1,067
Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development
Jones, K. R., Fariñas, I., Backus, C., & Reichardt, L. F. (1994) · Cell · doi:10.1016/0092-8674(94)90377-8 · Cited by 1,041
Self-citation
Requirement for BDNF in activity-dependent survival of cortical neurons
Ghosh, A., Carnahan, J., & Greenberg, M. E. (1994) · Science · doi:10.1126/science.7907431 · Cited by 989
Neurotrophins regulate dendritic growth in developing visual cortex
McAllister, A. K., Lo, D. C., & Katz, L. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90171-x · Cited by 959
Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
Lyons, W. E., Mamounas, L. A., Ricaurte, G. A., Coppola, V., Reid, S. W., Bora, S. H., Wihler, C., Koliatsos, V. E., & Tessarollo, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15239 · Cited by 862
Multiple promoters direct tissue-specific expression of the rat BDNF gene
Timmusk, T., Palm, K., Metsis, M., Reintam, T., Paalme, V., Saarma, M., & Persson, H. (1993) · Neuron · doi:10.1016/0896-6273(93)90335-o · Cited by 858
Experience-Dependent Plasticity of Binocular Responses in the Primary Visual Cortex of the Mouse
Gordon, J. A., & Stryker, M. P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03274.1996 · Cited by 856
BDNF regulates eating behavior and locomotor activity in mice
Kernie, S. G., Liebl, D. J., & Parada, L. F. (2000) · The EMBO Journal · doi:10.1093/emboj/19.6.1290 · Cited by 806
Essential Role for TrkB Receptors in Hippocampus-Mediated Learning
Minichiello, L., Korte, M., Wolfer, D., Kühn, R., Unsicker, K., Cestari, V., Rossi-Arnaud, C., Lipp, H.-P., Bonhoeffer, T., & Klein, R. (1999) · Neuron · doi:10.1016/s0896-6273(00)80853-3 · Cited by 799
Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons
Nakayama, A. Y., Harms, M. B., & Luo, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05329.2000 · Cited by 708
Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death
Klein, R., Smeyne, R. J., Wurst, W., Long, L. K., Auerbach, B. A., Joyner, A. L., & Barbacid, M. (1993) · Cell · doi:10.1016/s0092-8674(05)80088-1 · Cited by 698
Actin Cytoskeleton Regulation in Neuronal Morphogenesis and Structural Plasticity
Luo, L. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.031802.150501 · Cited by 658
Activity-dependent regulation of dendritic growth and patterning
Wong, R. O. L., & Ghosh, A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn941 · Cited by 635
Opposing Roles for Endogenous BDNF and NT-3 in Regulating Cortical Dendritic Growth
McAllister, A. K., Katz, L. C., & Lo, D. C. (1997) · Neuron · doi:10.1016/s0896-6273(00)80316-5 · Cited by 570
Neurotrophin-evoked rapid excitation through TrkB receptors
Kafitz, K. W., Rose, C. R., Thoenen, H., & Konnerth, A. (1999) · Nature · doi:10.1038/44847 · Cited by 548
Neurotrophin Regulation of Cortical Dendritic Growth Requires Activity
McAllister, A. K., Katz, L. C., & Lo, D. C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80239-1 · Cited by 503
Dendritic arbor development and synaptogenesis
Cline, H. T. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00182-3 · Cited by 499
Regulation of Dendritic Growth and Remodeling by Rho, Rac, and Cdc42
Threadgill, R., Bobb, K., & Ghosh, A. (1997) · Neuron · doi:10.1016/s0896-6273(00)80376-1 · Cited by 492
BDNF Has Opposite Effects on the Quantal Amplitude of Pyramidal Neuron and Interneuron Excitatory Synapses
Rutherford, L. C., Nelson, S. B., & Turrigiano, G. G. (1998) · Neuron · doi:10.1016/s0896-6273(00)80563-2 · Cited by 451
Regulation of Dendritic Spine Morphology by the Rho Family of Small GTPases: Antagonistic Roles of Rac and Rho
Tashiro, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.927 · Cited by 416
Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice.
Dymecki, S. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.6191 · Cited by 361
Control of cortical interneuron migration by neurotrophins and PI3-kinase signaling
Polleux, F., Whitford, K. L., Dijkhuizen, P. A., Vitalis, T., & Ghosh, A. (2002) · Development · doi:10.1242/dev.129.13.3147 · Cited by 361
Destabilization of Cortical Dendrites and Spines by BDNF
Horch, H. W., Krüttgen, A., Portbury, S. D., & Katz, L. C. (1999) · Neuron · doi:10.1016/s0896-6273(00)80785-0 · Cited by 345
Anatomical Correlates of Functional Plasticity in Mouse Visual Cortex
Antonini, A., Fagiolini, M., & Stryker, M. P. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04388.1999 · Cited by 337
Functionally Related Motor Neuron Pool and Muscle Sensory Afferent Subtypes Defined by Coordinate ETS Gene Expression
Lin, J. H., Saito, T., Anderson, D. J., Lance-Jones, C. C., Jessell, T. M., & Arber, S. (1998) · Cell · doi:10.1016/s0092-8674(00)81770-5 · Cited by 334
Multicolor “DiOlistic” Labeling of the Nervous System Using Lipophilic Dye Combinations
Gan, W., Grutzendler, J., Wong, W. T., Wong, R., & Lichtman, J. W. (2000) · Neuron · doi:10.1016/s0896-6273(00)00031-3 · Cited by 331
Neurotrophin signalling pathways regulating neuronal apoptosis
Miller, F. D., & Kaplan, D. R. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000919 · Cited by 316
Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo
Li, Z., Aelst, L. V., & Cline, H. T. (2000) · Nature Neuroscience · doi:10.1038/72920 · Cited by 293
SCIP: A glial POU domain gene regulated by cyclic AMP
Monuki, E. S., Weinmaster, G., Kuhn, R., & Lemke, G. (1989) · Neuron · doi:10.1016/0896-6273(89)90247-x · Cited by 292
Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K
Kozma, S. C., & Thomas, G. (2002) · BioEssays · doi:10.1002/bies.10031 · Cited by 289
Brain-Derived Neurotrophic Factor Enhances Long-Term Potentiation in Rat Visual Cortex
Akaneya, Y., Tsumoto, T., Kinoshita, S., & Hatanaka, H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-17-06707.1997 · Cited by 286
Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth
Yacoubian, T. A., & Lo, D. C. (2000) · Nature Neuroscience · doi:10.1038/73911 · Cited by 278
Cortical Degeneration in the Absence of Neurotrophin Signaling
Xu, B., Zang, K., Ruff, N. L., Zhang, Y. A., McConnell, S. K., Stryker, M. P., & Reichardt, L. F. (2000) · Neuron · doi:10.1016/s0896-6273(00)81153-8 · Cited by 275
Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems.
Frisén, J., Verge, V. M. K., Fried, K., Risling, M., Persson, H., Trotter, J., Hökfelt, T. G. M., & Lindholm, D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.4971 · Cited by 259
Development of Projection and Local Circuit Neurons in Neocortex
Miller, M. W. (1988) · Cerebral cortex · doi:10.1007/978-1-4615-6619-9_5 · Cited by 246
Rapid Dendritic Remodeling in the Developing Retina: Dependence on Neurotransmission and Reciprocal Regulation by Rac and Rho
Wong, W. T., Faulkner-Jones, B. E., Sanes, J. R., & Wong, R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-13-05024.2000 · Cited by 242
Neurotrophins and activity-dependent plasticity of cortical interneurons
Marty, S., da, M., & Berninger, B. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01026-0 · Cited by 227
Axon terminals immunolabeled for dopamine or tyrosine hydroxylase synapse on GABA‐immunoreactive dendrites in rat and monkey cortex
Sesack, S. R., Snyder, C. L., & Lewis, D. A. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903630208 · Cited by 226
Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice
Gorski, J. A., Balogh, S. A., Wehner, J. M., & Jones, K. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00426-3 · Cited by 220
Self-citation
A DNA cassette containing a trimerized SV40 polyadenylation signal which efficiently blocks spurious plasmid-initiated transcription.
Maxwell, I. H., Harrison, G. S., Wood, W. M., & Maxwell, F. (1989) · PubMed · Cited by 205
TrkB Signaling Is Required for Postnatal Survival of CNS Neurons and Protects Hippocampal and Motor Neurons from Axotomy-Induced Cell Death
Alcántara, S., Frisén, J., del Rı́o, J. A., Soriano, E., Barbacid, M., & Silos‐Santiago, I. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03623.1997 · Cited by 203
BDNF Regulates the Intrinsic Excitability of Cortical NeuronsPreprint
Desai, N. S., Rutherford, L. C., & Turrigiano, G. G. (1999) · Learning & Memory · doi:10.1101/lm.6.3.284 · Cited by 200
Insulin-Like Growth Factor I Stimulates Dendritic Growth in Primary Somatosensory Cortex
Niblock, M. M., Brunso‐Bechtold, J. K., & Riddle, D. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04165.2000 · Cited by 184
RhoA Inhibits the Nerve Growth Factor-induced Rac1 Activation through Rho-associated Kinase-dependent Pathway
Yamaguchi, Y., Katoh, H., Yasui, H., Mori, K., & Negishi, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100254200 · Cited by 184
BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortex
Webster, M. J., Weickert, C. S., Herman, M. M., & Kleinman, J. E. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(02)00540-0 · Cited by 173
Brain‐Derived Neurotrophic Factor Increases the Stimulation‐Evoked Release of Glutamate and the Levels of Exocytosis‐Associated Proteins in Cultured Cortical Neurons from Embryonic Rats
Takei, N., Sasaoka, K., Inoue, K., Takahashi, M., Endo, Y., & Hatanaka, H. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68010370.x · Cited by 148
Severe Sensory Deficits but Normal CNS Development in Newborn Mice Lacking TrkB and TrkC Tyrosine Protein Kinase Receptors
Silos‐Santiago, I., Fagan, A. M., Garber, M., Fritzsch, B., & Barbacid, M. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01372.x · Cited by 134
Postsynaptic Depolarization Scales Quantal Amplitude in Cortical Pyramidal Neurons
Leslie, K. R., Nelson, S. B., & Turrigiano, G. G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-j0005.2001 · Cited by 128
Transgenic Activation of Ras in Neurons Promotes Hypertrophy and Protects from Lesion-Induced Degeneration
Heumann, R., Goemans, C. G., Bartsch, D., Lingenhöhl, K., Waldmeier, P. C., Hengerer, B., ALLEGRINI, P. R., Schellander, K., Wagner, E. F., Arendt, T., et al. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.7.1537 · Cited by 127
Enrichment of cholinergic synaptic terminals on GABAergic neurons and coexistence of immunoreactive GABA and choline acetyltransferase in the same synaptic terminals in the striate cortex of the cat
Beaulieu, C., & Somogyi, P. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903040412 · Cited by 125
Nerve Growth Factor Signals through TrkA, Phosphatidylinositol 3-Kinase, and Rac1 to Inactivate RhoA during the Initiation of Neuronal Differentiation of PC12 Cells
Nusser, N., Gosmanova, E. O., Zheng, Y., & Tigyi, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203617200 · Cited by 122
Brain-derived neurotrophic factor alters the synaptic modification threshold in visual cortex
Huber, K. M., Sawtell, N. B., & Bear, M. F. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00050-1 · Cited by 107
Calcium regulation of the brain-derived neurotrophic factor gene
Finkbeiner, S. M. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000701 · Cited by 102
Brain-derived neurotrophic factor blocks long-term depression in rat visual cortex
Akaneya, Y., Tsumoto, T., & Hatanaka, H. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.6.4198 · Cited by 99
Developmental regulation of brain-derived neurotrophic factor messenger RNAs transcribed from different promoters in the rat brain
Timmusk, T., Belluardo, N., Persson, H., & METSIS, M. L. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90242-9 · Cited by 95
Specific Neurotrophic Factors Support the Survival of Cortical Projection Neurons at Distinct Stages of Development
Catapano, L. A., Arnold, M. W., Perez, F. A., & Macklis, J. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-22-08863.2001 · Cited by 89
Pak1 Is Involved in Dendrite Initiation as a Downstream Effector of Rac1 in Cortical Neurons
Hayashi, K. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1144 · Cited by 72
Brain-Derived Neurotrophic Factor Prevents Low-Frequency Inputs from Inducing Long-Term Depression in the Developing Visual Cortex
Kinoshita, S., Yasuda, H., Taniguchi, N., Katoh‐Semba, R., Hatanaka, H., & Tsumoto, T. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02122.1999 · Cited by 69
Apoptotic Cell Death of Cultured Cerebral Cortical Neurons Induced by Withdrawal of Astroglial Trophic Support
Ohgoh, M., Kimura, M., Ogura, H., Katayama, K., & Nishizawa, Y. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6719 · Cited by 66
BDNF‐activated Sianal Transduction in Rat Cortical Glial Cells
Roback, J. D., Marsh, H. N., Downen, M., Palfrey, H. C., & Wainer, B. H. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01072.x · Cited by 62
Brain-derived neurotrophic factor requirement for activity-dependent maturation of glutamatergic synapse in developing mouse somatosensory cortex
Itami, C., Mizuno, K., Kohno, T., & Nakamura, S. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02352-5 · Cited by 46
Neocortical neurons lacking the protein-tyrosine kinase B receptor display abnormal differentiation and process elongation in vitro and in vivo
Gates, M. A., Tai, C. C., & Macklis, J. D. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00106-8 · Cited by 41
Expression of Full-Length trkB Receptors by Reactive Astrocytes after Chronic CNS Injury
McKeon, R. J., Silver, J., & Large, T. H. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6698 · Cited by 40
BIT/SHPS‐1 Enhances Brain‐Derived Neurotrophic Factor‐Promoted Neuronal Survival in Cultured Cerebral Cortical Neurons
Araki, T., Yamada, M., Ohnishi, H., Sano, S., & Hatanaka, H. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751502.x · Cited by 33
Noradrenergic Innervation of Peptidergic Interneurons in the Rat Visual Cortex
Paspalas, C. D. (1999) · Cerebral Cortex · doi:10.1093/cercor/9.8.844 · Cited by 24
Untitled work
(1953) · Europe PMC (PubMed Central)

Research works printed but not linked: 4

1985, J Embryol Exp Morphol, 87, 27
Gorski JA, Balogh SA, Wehner JM, Jones KR ( 2003) Learning deficits in forebrain-restricted BDNF mutant mice. Neuroscience (in press).
1989, Biotechniques, 7, 276
1953, J Anat, 87, 387

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Authors: Gorski, J. A., Zeiler, S. R., Tamowski, S., & Jones, K. R.
Affiliations: University of Colorado Boulder (US)
ORCID: Zeiler, Steven R.
Jones, Kevin R.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2003-07-30
Volume: 23
Issue: 17
Pages: 6856-6865
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.23-17-06856.2003
PMC: PMC6740724
OpenAlex: W2110442840
Cited by: 411
References: 79
Citations by year: 2026: 3 · 2025: 3 · 2024: 13 · 2023: 13 · 2022: 9 · 2021: 13 · 2020: 16 · 2019: 12 · 2018: 25 · 2017: 16 · 2016: 21 · 2015: 28 · 2014: 28 · 2013: 20 · 2012: 30
FWCI: 6.92
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Cancer Society
Muscular Dystrophy Association
Wellcome Trust
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: brain-derived neurotrophic factor, dendritic retraction, neocortex development, neuronal survival, neuronal shrinkage, postnatal development
MeSH terms: Age Factors, Animals, Behavior, Animal, Cell Count, Cell Survival, Cerebral Cortex, Dendrites, Female, Lysine, Male, Mice, Mutant Strains, Neurons, Organ Specificity, Prosencephalon, Pyramidal Cells, Gene Targeting, Gene Expression Regulation, Developmental, Brain-Derived Neurotrophic Factor, Neurodegenerative Diseases, Cell Size, Mice

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Brain-Derived Neurotrophic Factor Is Required for the Maintenance of Cortical Dendrites

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