Caregiver maltreatment causes altered neuronal DNA methylation in female rodents

Blaze, Jennifer; Roth, Tania L.

doi:10.1017/s0954579417000128

Cited by 48Child Abuse and TraumaEpigenetics and DNA MethylationStress Responses and Cortisol

Caregiver maltreatment causes altered neuronal DNA methylation in female rodents

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Blaze, Jennifer, Roth, Tania L.·2017·Development and Psychopathology

DOI 10.1017/s0954579417000128PMC PMC5508559

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Abstract

Negative experiences with a caregiver during infancy can result in long-term changes in brain function and behavior, but underlying mechanisms are not well understood. It is our central hypothesis that brain and behavior changes are conferred by early childhood adversity through epigenetic changes involving DNA methylation. Using a rodent model of early-life caregiver maltreatment (involving exposure to an adverse caregiving environment for postnatal days 1–7), we have previously demonstrated abnormal methylation of DNA associated with the brain-derived neurotrophic factor(Bdnf) gene in the medial prefrontal cortex (mPFC) of adult rats. The aim of the current study was to characterize Bdnf DNA methylation in specific cell populations within the mPFC. In the prefrontal cortex, there is approximately twice as many neurons as glia, and studies have recently shown differential and distinctive DNA methylation patterns in neurons versus nonneurons. Here, we extracted nuclei from the mPFC of adult animals that had experienced maltreatment and used fluorescence-activated cell sorting to isolate cell types before performing bisulfite sequencing to estimate methylation of cytosine–guanine sites. Our data indicate that early-life stress induced methylation of DNA associated with Bdnf IV in a cell-type and sex-specific manner. Specifically, females that experienced early-life maltreatment exhibited greater neuronal cytosine–guanine methylation compared to controls, while no changes were detected in Bdnf methylation in males regardless of cell type. These changes localize the specificity of our previous findings to mPFC neurons and highlight the capacity of maltreatment to cause methylation changes that are likely to have functional consequences for neuronal function.

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In neurons, an adverse caregiving environment from PND1-7 led to increased Bdnf exon IV DNAm across 12 CpG sites in neurons isolated from the medial prefrontal cortex of adult female but not male rats.
“One study found that an adverse caregiving environment from PND1–7 led to increased brain-derived neurotrophic factor (Bdnf) exon IV DNAm across 12 CpG sites in neurons isolated from the medial prefrontal-cortex (PFC) of adult female but not in male rats [100]”
From Cell-type-specific epigenetic effects of early life stress on the brain (2022) · cites this paper as [100]

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Authors: Blaze, J., & Roth, T. L.
Affiliations: University of Delaware (US)
Corresponding author: Roth, Tania L.
ORCID: Blaze, Jennifer
Roth, Tania L.
Venue: Development and Psychopathology
Publisher: Cambridge University Press (CUP)
Published: 2017-04-12
Volume: 29
Issue: 2
Pages: 477-489
ISSN: 0954-5794 (ISSN-L)
1469-2198
DOI: 10.1017/s0954579417000128
PMC: PMC5508559
OpenAlex: W2607048366
Cited by: 48
References: 142
Citations by year: 2026: 4 · 2025: 1 · 2024: 7 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 8 · 2018: 7 · 2017: 6
FWCI: 8.48
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Development and Psychopathology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Delaware IDeA Network of Biomedical Research Excellence (P20‐GM103446)
National Institute of General Medical Sciences (GM103446, P20GM103653, P20GM103446)
Topics: Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: childhood adversity, DNA methylation, epigenetics, brain-derived neurotrophic factor, medial prefrontal cortex, neurons, sex differences, cell type specificity, early life stress
MeSH terms: Animals, Disease Models, Animal, Female, Humans, Male, Neurons, Sex Factors, Stress, Psychological, Prefrontal Cortex, DNA Methylation, Brain-Derived Neurotrophic Factor, Rats, Long-Evans, Rats, Adult Survivors of Child Abuse

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Caregiver maltreatment causes altered neuronal DNA methylation in female rodents

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