The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Distribution of Postsynaptic Density (PSD)-95 and Ca2+/Calmodulin-Dependent Protein Kinase II at the PSD
Open accessAbstract
Postsynaptic densities (PSDs) contain proteins that regulate synaptic transmission. We determined the positions of calcium/calmodulin-dependent protein kinase II (CaMKII) and PSD-95 within the three-dimensional structure of isolated PSDs using immunogold labeling, rotary shadowing, and electron microscopic tomography. The results show that all PSDs contain a central mesh immediately underlying the postsynaptic membrane. Label for PSD-95 is found on both the cytoplasmic and cleft sides of this mesh, averaging 12 nm from the cleft side. All PSDs label for PSD-95. The properties of CaMKII labeling are quite different. Label is virtually absent on the cleft sides of PSDs, but can be heavy on the cytoplasmic side at a mean distance of 25 nm from the cleft. In tomograms, CaMKII holoenzymes can be visualized directly, appearing as labeled, tower-like structures reflecting the 20 nm diameter of the holoenzyme. These towers protrude from the cytoplasmic side of the central mesh. There appears to be a local organization of CaMKII, as judged by fact that the nearest-neighbor distances are nearly invariant over a wide range of labeling density for CaMKII. The average density of CaMKII holoenzymes is highly variable, ranging from zero to values approaching a tightly packed state. This variability is significantly higher than that for PSD-95 and is consistent with an information storage role for CaMKII.
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Cites
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Cited by
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Self-citationThe Postsynaptic Organization of Synapses
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DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke
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“However, CaMK-II was found to become inactivated in the brain in response to ischemic insults (Hanson et al., 1994; Waxham et al., 1996; Petersen et al., 2003).”
Metadata
- Authors
- Petersen, J. D., Chen, X., Vinade, L., Dosemeci, A., Lisman, J. E., & Reese, T. S.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-12-03
- Volume
- 23
- Issue
- 35
- Pages
- 11270-11278
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1723799090
- Cited by
- 208
- References
- 17
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
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