The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Interaction of Cellular Prion and Stress-Inducible Protein 1 Promotes Neuritogenesis and Neuroprotection by Distinct Signaling Pathways
Open accessAbstract
Understanding the physiological function of the cellular prion (PrP c) depends on the investigation of PrP c-interacting proteins. Stress-inducible protein 1 (STI1) is a specific PrP c ligand that promotes neuroprotection of retinal neurons through cAMP-dependent protein kinase A (PKA). Here, we examined the signaling pathways and functional consequences of the PrP c interaction with STI1 in hippocampal neurons. Both PrP c and STI1 are abundantly expressed and highly colocalized in the hippocampus in situ, indicating that they can interact in vivo. Recombinant STI1 (His 6-STI1) added to hippocampal cultures interacts with PrP c at the neuronal surface and elicits neuritogenesis in wild-type neurons but not in PrP c-null cells. This effect was abolished by antibodies against either PrP c or STI1 and was dependent on the STI1 domain that binds PrP c. Binding of these proteins induced the phosphorylation/activation of the mitogen-activated protein kinase, which was essential for STI1-promoted neuritogenesis. His 6-STI1, but not its counterpart lacking the PrP c binding site, prevented cell death via PKA activation. These results demonstrate that two parallel effects of the PrP c–STI1 interaction, neuritogenesis and neuroprotection, are mediated by distinct signaling pathways.
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Cites
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394
Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase
Favata, M. F., Horiuchi, K. Y., Manos, E. J., Daulerio, A. J., Stradley, D. A., Feeser, W. S., Van Dyk, D. E., Pitts, W. J., Earl, R. A., Hobbs, F., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18623 · Cited by 3,015
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Büeler, H., Fischer, M., Lang, Y., Bluethmann, H., Lipp, H.-P., DeArmond, S. J., Prusiner, S. B., Aguet, M., & Weissmann, C. (1992) · Nature · doi:10.1038/356577a0 · Cited by 1,655
Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases
Rüegg, U. T., & Gillian, B. (1989) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(89)90263-0 · Cited by 897
Signal Transduction Through Prion Protein
Mouillet-Richard, S., Ermonval, M., Chebassier, C., Laplanche, J. L., Lehmann, S., Launay, J. M., & Kellermann, O. (2000) · Science · doi:10.1126/science.289.5486.1925 · Cited by 805
Extracellular Matrix Molecules And Their Receptors: Functions In Neural Development
Reichardt, L. F., & Tomaselli, K. J. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002531 · Cited by 750
Shyng, S.-L., Lehmann, S., Moulder, K. L., & Harris, D. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.50.30221 · Cited by 704
The role of calcium in apoptosis
Nicotera, P., & Orrenius, S. (1998) · Cell Calcium · doi:10.1016/s0143-4160(98)90116-6 · Cited by 458
Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection
Zanata, S. M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf325 · Cited by 445
The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells
Rieger, R., Edenhofer, F., Lasmézas, C. I., & Weiss, S. (1997) · Nature Medicine · doi:10.1038/nm1297-1383 · Cited by 431
Cited by
Physiology of the prion protein
Linden, R., Martins, V. R., Prado, M. A. M., Cammarota, M., Izquierdo, I., & Brentani, R. R. (2008) · Physiological Reviews · doi:10.1152/physrev.00007.2007 · Cited by 617
Self-citationAstrogliosis: An integral player in the pathogenesis of Alzheimer's disease
Osborn, L. M., Kamphuis, W., Wadman, W. J., & Hol, E. M. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.001 · Cited by 312
Prions and their partners in crime
Caughey, B., & Baron, G. S. (2006) · Nature · doi:10.1038/nature05294 · Cited by 295
Upadhya, R., Zingg, W., Shetty, S., & Shetty, A. K. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.04.017 · Cited by 282
Steele, A. D., Emsley, J. G., Özdinler, P. H., Lindquist, S., & Macklis, J. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511290103 · Cited by 270
Metadata
- Authors
- Lopes, M. H., Hajj, G. N. M., Muras, A. G., Mancini, G. L., Castro, R. M. P. S., Ribeiro, K. C. B., Brentani, R. R., Linden, R., & Martins, V. R.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-12-07
- Volume
- 25
- Issue
- 49
- Pages
- 11330-11339
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2127981299
- Cited by
- 286
- References
- 44
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lopes, M. H., Hajj, G. N. M., Muras, A. G., Mancini, G. L., Castro, R. M. P. S., Ribeiro, K. C. B., Brentani, R. R., Linden, R., & Martins, V. R. (2005). Interaction of Cellular Prion and Stress-Inducible Protein 1 Promotes Neuritogenesis and Neuroprotection by Distinct Signaling Pathways. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.2313-05.2005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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