The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Robust Pacemaking in Substantia Nigra Dopaminergic Neurons
Open accessAbstract
Dopaminergic neurons of the substantia nigra pars compacta are autonomous pacemakers. This activity is responsible for the sustained release of dopamine necessary for the proper functioning of target structures, such as the striatum. Somatodendritic L-type Ca 2+channels have long been viewed as important, if not necessary, for this activity. The studies reported here challenge this viewpoint. Using a combination of optical and electrophysiological approaches in brain slices, it was found that antagonism of L-type Ca 2+channel effectively stopped dendritic Ca 2+oscillations but left autonomous pacemaking unchanged. Moreover, damping intracellular Ca 2+oscillations with exogenous buffer had little effect on pacemaking rate. Although not necessary for pacemaking, L-type channels helped support pacemaking when challenged with cationic channel blockers. Simulations suggested that the insensitivity to antagonism of L-type channels reflected the multichannel nature of the pacemaking process. The robustness of pacemaking underscores its biological importance and provides a framework for understanding how therapeutics targeting L-type Ca 2+channels might protect dopaminergic neurons in Parkinson's disease without compromising their function.
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Cites
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‘Rejuvenation’ protects neurons in mouse models of Parkinson’s disease
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Self-citationThe control of firing pattern in nigral dopamine neurons: single spike firing
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Neuron: A Tool for Neuroscientists
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α1D (Cav1.3) Subunits Can Form L-type Ca2+ Channels Activating at Negative Voltages
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Cited by
Kriks, S., Shim, J.-W., Piao, J., Ganat, Y. M., Wakeman, D. R., Xie, Z., Carrillo-Reid, L., Auyeung, G., Antonacci, C., Buch, A., et al. (2011) · Nature · doi:10.1038/nature10648 · Cited by 1,907
Self-citationSelective neuronal vulnerability in Parkinson disease
Surmeier, D. J., Obeso, J. A., & Halliday, G. M. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.178 · Cited by 1,116
Self-citationDopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
Burbulla, L. F., Song, P., Mazzulli, J. R., Zampese, E., Wong, Y. C., Jeon, S., Santos, D. P., Blanz, J., Obermaier, C. D., Strojny, C., et al. (2017) · Science · doi:10.1126/science.aam9080 · Cited by 874
Self-citationSchöndorf, D. C., Aureli, M., McAllister, F. E., Hindley, C. J., Mayer, F., Schmid, B., Sardi, S. P., Valsecchi, M., Hoffmann, S., Schwarz, L. K., et al. (2014) · Nature Communications · doi:10.1038/ncomms5028 · Cited by 543
Determinants of dopaminergic neuron loss in Parkinson's disease
Surmeier, D. J. (2018) · The FEBS Journal · doi:10.1111/febs.14607 · Cited by 444
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Metadata
- Authors
- Guzman, J. N., Sánchez-Padilla, J., Chan, C. S., & Surmeier, D. J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-09-02
- Volume
- 29
- Issue
- 35
- Pages
- 11011-11019
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2006200262
- Cited by
- 411
- References
- 31
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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