Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
Open accessAbstract
Human-derived neurons provide the answers: Pathways involved in energy metabolism and removal of cellular debris by lysosomes play an important role in protecting our brain from degeneration in Parkinson's disease. Burbulla et al. identified a toxic cascade of mitochondrial and lysosomal dysfunction in human neurons derived from patients with Parkinson's. The dysfunction was mediated by accumulation of oxidized dopamine and α-synuclein, but it was not found in Parkinson's mouse models, owing to species-specific differences in dopamine metabolism. Inherent species-specific differences between human and mouse neurons emphasize the value of studying human neurons to identify relevant targets for treatment of Parkinson's disease and related synucleinopathies. Science , this issue p. 1255
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Human dopaminergic neurons contain substantially higher dopamine levels than mouse dopaminergic neurons, and some cellular disease processes have been proposed to depend on high dopamine found only in human dopaminergic neurons.
“dopaminergic neurons, which are selectively vulnerable in Parkinson’s Disease, contain substantially higher levels of dopamine in humans compared to mice, and some cellular disease processes have been proposed to depend on the high levels of dopamine found only in human dopaminergic neurons18.”
From CRISPR-based functional genomics for neurological disease (2020) · cites this paper as [18]
There are differences between disease-relevant cell types such as neurons and glia between humans and mice.
“First, there are differences between disease-relevant cell types, such as neurons and glia, between humans and mice.”
From CRISPR-based functional genomics for neurological disease (2020) · cites this paper as [18]
iPSC-derived dopaminergic neurons recapitulate Parkinson's disease molecular processes in a dopamine-dependent manner.
“iPSC-derived dopaminergic neurons recapitulate molecular processes characteristic of Parkinson’s Disease, dependent on dopamine levels18.”
From CRISPR-based functional genomics for neurological disease (2020) · cites this paper as [18]
DAQ has been found in human induced pluripotent stem cell-derived dopaminergic neurons that carry mutations associated with PD.
“DAQ has been found in human induced pluripotent stem cell-derived dopaminergic neurons that carry mutations associated with PD269.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [269]
Mitochondrial stress promotes the accumulation of oxidized dopamine, consequently increasing α-synuclein aggregates in neurons derived from patients with Parkinson's disease, an effect selective to human neurons.
“This study demonstrates that mitochondrial stress promotes the accumulation of oxidized dopamine, consequently increasing α-synuclein aggregates in neurons derived from patients with PD, an effect selective to human neurons.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [269]
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- Authors
- Burbulla, L. F., Song, P., Mazzulli, J. R., Zampese, E., Wong, Y. C., Jeon, S., Santos, D. P., Blanz, J., Obermaier, C. D., Strojny, C., Savas, J. N., Kiskinis, E., Zhuang, X., Krüger, R., Surmeier, D. J., & Krainc, D.
- Affiliations
- Northwestern University (US)
- University of Luxembourg (LU)
- University of Chicago (US)
- Centre Hospitalier de Luxembourg (LU)
- Corresponding author
- Krainc, Dimitri
- ORCID
- Venue
- Science
- Published
- 2017-09-22
- Volume
- 357
- Issue
- 6357
- Pages
- 1255-1261
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6021018
- OpenAlex
- W2752710053
- Cited by
- 874
- References
- 37
- Citations by year
- 2026: 83 · 2025: 99 · 2024: 110 · 2023: 93 · 2022: 100 · 2021: 98 · 2020: 108 · 2019: 91 · 2018: 76 · 2017: 16
- FWCI
- 54.93
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Open Repository and Bibliography (University of Luxembourg) (submittedVersion)
- DZNE Pub (submittedVersion)
- Funders
- NIH Office of the Director (award301003, R01NS076054, award301024, R00DC013805-02, award346646, T32NS041234, award346647, F32NS101778, award346648, R01NS092823)
- IDP Foundation (award346545)
- Michael J. Fox Foundation for Parkinson’s Research (award346546)
- JPB Foundation (award346543)
- NIH (award346544, NS047085)
- German Academic Exchange Service (award301004)
- Spinal Muscular Atrophy Foundation (award301007)
- Les Turner ALS Foundation (award301005)
- Target ALS (award301006)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- Parkinson's disease, dopamine oxidation, mitochondrial dysfunction, lysosomal dysfunction, dopaminergic neurons, substantia nigra, glucocerebrosidase, alpha-synuclein, oxidative stress, familial Parkinson's disease, neurodegeneration
- MeSH terms
- Protein Deglycase DJ-1, Animals, Antioxidants, Cell Line, Disease Models, Animal, Dopamine, Glucosylceramidase, Humans, Lysosomes, Melanins, Mesencephalon, Mitochondria, Oxidation-Reduction, Parkinson Disease, Substantia Nigra, Tacrolimus, Mice, Knockout, Oxidative Stress, Mice, alpha-Synuclein, Dopaminergic Neurons, Calcineurin Inhibitors
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