Visual experience is necessary for the development of multisensory integration
Open accessAbstract
Multisensory neurons and their ability to integrate multisensory cues develop gradually in the midbrain [i.e., superior colliculus (SC)]. To examine the possibility that early sensory experiences might play a critical role in these maturational processes, animals were raised in the absence of visual cues. As adults, the SC of these animals were found to contain many multisensory neurons, the large majority of which were visually responsive. Although these neurons responded robustly to each of their cross-modal inputs when presented individually, they were incapable of synthesizing this information. These observations suggest that visual experiences are critical for the SC to develop the ability to integrate multisensory information and lead to the prediction that, in the absence of such experience, animals will be compromised in their sensitivity to cross-modal events.
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Vision may be necessary for successful cross-calibration.
“Vision may be necessary for successful cross-calibration (Hötting & Röder, 2009; Occelli et al., 2013; Wallace et al., 2004).”
From Designing sensory-substitution devices: Principles, pitfalls and potential1 (2016) · cites this paper as Wallace et al., 2004
The Abstract says that visual experience is critical for developing multisensory integration in the superior colliculus, and the Results report reduced spatial fidelity of auditory and somatosensory receptive fields in dark-reared cats. These findings are consistent with a role for vision in cross-calibration, but the paper does not directly test whether vision calibrates one sense against another. (LLM, conf=0.78)
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Cites
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The role of visual experience for the neural basis of spatial cognition
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“Vision may be necessary for successful cross-calibration (Hötting & Röder, 2009; Occelli et al., 2013; Wallace et al., 2004).”
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- Authors
- Wallace, M. T., Perrault, T. J., Hairston, W. D., & Stein, B. E.
- Affiliations
- Wake Forest University Health Sciences (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-10-27
- Volume
- 24
- Issue
- 43
- Pages
- 9580-9584
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6730167
- OpenAlex
- W2092425177
- Cited by
- 183
- References
- 23
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 7 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 11 · 2016: 9 · 2015: 12 · 2014: 12 · 2013: 7 · 2012: 14
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (NS36916)
- National Institute of Mental Health (MH-63861, R01MH063861)
- National Institute of Neurological Disorders and Stroke (NS 36916, R01NS036916)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- multisensory integration, superior colliculus, visual experience, sensory deprivation, multisensory neurons, cross-modal integration, midbrain development, visual responsiveness
- MeSH terms
- Animals, Brain Mapping, Cats, Darkness, Sensation, Sensory Deprivation, Superior Colliculi, Vision, Ocular
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