Neuronal Pentraxin 1 Negatively Regulates Excitatory Synapse Density and Synaptic Plasticity
Open accessAbstract
In mature neurons, the number of synapses is determined by a neuronal activity-dependent dynamic equilibrium between positive and negative regulatory factors. We hypothesized that neuronal pentraxin (NP1), a proapoptotic protein induced by low neuronal activity, could be a negative regulator of synapse density because it is found in dystrophic neurites in Alzheimer's disease-affected brains. Here, we report that knockdown of NP1 increases the number of excitatory synapses and neuronal excitability in cultured rat cortical neurons and enhances excitatory drive and long-term potentiation in the hippocampus of behaving mice. Moreover, we found that NP1 regulates the surface expression of the Kv7.2 subunit of the Kv7 family of potassium channels that control neuronal excitability. Furthermore, pharmacological activation of Kv7 channels prevents, whereas inhibition mimics, the increase in synaptic proteins evoked by the knockdown of NP1. These results indicate that NP1 negatively regulates excitatory synapse number by modulating neuronal excitability and show that NP1 restricts excitatory synaptic plasticity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
NPTXs play a role in synaptogenesis.
“NPTXs play a role in synaptogenesis (Farhy-Tselnicker et al. 2017; Figueiro-Silva et al. 2015; Sia et al. 2007)”
From Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration (2022) · cites this paper as Figueiro-Silva et al. 2015
NPTX1 negatively regulates excitatory synapse density through interaction with a subunit of slow-rectifying-gated Kv7 potassium channel.
“Moreover, NPTX1 negatively regulates excitatory synapse density through interaction with a subunit of slow-rectifying-gated Kv7 potassium channel (Figueiro-Silva et al. 2015).”
From Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration (2022) · cites this paper as Figueiro-Silva et al. 2015
NPTX2 promotes synaptic plasticity at excitatory synapses.
“While NPTX2 promotes synaptic plasticity at excitatory synapses, NPTX1 is part of the mechanism of neuronal apoptosis and negatively regulates synaptic plasticity at excitatory synapses (DeGregorio-Rocasolano et al. 2001; Figueiro-Silva et al. 2015; Tsui et al. 1996).”
From Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration (2022) · cites this paper as Figueiro-Silva et al. 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
Grynkiewicz, G., Poenie, M., & Tsien, R. Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83641-4 · Cited by 21,722 · see citing works
Abràmoff, M. D., Magalhães, P. J., & Ram, S. J. (2004) · Utrecht University Repository (Utrecht University) · Cited by 11,816 · see citing works
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,460 · see citing works
Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,497 · see citing works
Alzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420 · see citing works
Experience-dependent structural synaptic plasticity in the mammalian brain
Holtmaat, A., & Svoboda, K. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2699 · Cited by 1,934 · see citing works
Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images
Meijering, E. H. W., Jacob, M., Sarria, J. ‐. F., Steiner, P., Hirling, H., & Unser, M. A. (2004) · Cytometry Part A · doi:10.1002/cyto.a.20022 · Cited by 1,611 · see citing works
KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M-Channel
Wang, H. (1998) · Science · doi:10.1126/science.282.5395.1890 · Cited by 1,294 · see citing works
D'Mello, S. R., Galli, C., Ciotti, T., & Calissano, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.10989 · Cited by 892 · see citing works
Neural <i>KCNQ</i> (Kv7) channels
Brown, D. A., & Passmore, G. M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00111.x · Cited by 676 · see citing works
Molecular mechanisms of dendritic spine morphogenesis
Tada, T., & Sheng, M. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.12.001 · Cited by 615 · see citing works
Regulation of transcription factors by neuronal activity
West, A. E., Griffith, E. C., & Greenberg, M. E. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn987 · Cited by 604 · see citing works
Silent synapses and the emergence of a postsynaptic mechanism for LTP
Kerchner, G. A., & Nicoll, R. A. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2501 · Cited by 602 · see citing works
Structural plasticity upon learning: regulation and functions
Caroni, P., Donato, F., & Muller, D. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3258 · Cited by 491 · see citing works
Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product narp.
O’Brien, R. J., Xu, D., Petralia, R. S., Steward, O., Huganir, R. L., & Worley, P. (1999) · Neuron · doi:10.1016/s0896-6273(00)80782-5 · Cited by 471 · see citing works
Involvement of the CA3–CA1 Synapse in the Acquisition of Associative Learning in Behaving Mice
Gruart, A., Muñoz, M.-D., & Delgado-Garcia, J. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2834-05.2006 · Cited by 460 · see citing works
Self-citationDevaux, J. J., Kleopa, K. A., Cooper, E. C., & Scherer, S. S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4512-03.2004 · Cited by 451 · see citing works
Structure and function of the pentraxins
Gewurz, H., Zhang, X.-H., & Lint, T. F. (1995) · Current Opinion in Immunology · doi:10.1016/0952-7915(95)80029-8 · Cited by 331 · see citing works
Tsui, C., Copeland, N., Gilbert, D., Jenkins, N., Barnes, C., & Worley, P. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02463.1996 · Cited by 315 · see citing works
Cooper, E. C., Harrington, E., Jan, Y. N., & Jan, L. Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09529.2001 · Cited by 305 · see citing works
Positive and negative regulatory mechanisms that mediate long-term memory storage
Abel, T. G., & Kandel, E. R. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00050-7 · Cited by 267 · see citing works
Xu, D., Hopf, C., Reddy, R., Cho, R. W., Guo, L., Lanahan, A., Petralia, R. S., Wenthold, R. J., O'Brien, R. J., & Worley, P. (2003) · Neuron · doi:10.1016/s0896-6273(03)00463-x · Cited by 265 · see citing works
Cooper, E. C., Aldape, K., Abosch, A., Barbaro, N. M., Berger, M. S., Peacock, W. S., Jan, Y. N., & Jan, L. Y. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090092797 · Cited by 217 · see citing works
Primary support cultures of hippocampal and substantia nigra neurons
Fath, T., Ke, Y. D., Gunning, P. W., Götz, J., & Ittner, L. M. (2008) · Nature Protocols · doi:10.1038/nprot.2008.199 · Cited by 210 · see citing works
Sia, G.-M., Béïque, J.-C., Rumbaugh, G., Cho, R., Worley, P. F., & Huganir, R. L. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.020 · Cited by 201 · see citing works
Neuronal Pentraxins Mediate Synaptic Refinement in the Developing Visual System
Bjartmar, L., Huberman, A. D., Ullian, E. M., Renteria, R. C., Liu, X., Xu, W., Prezioso, J., Susman, M. W., Stellwagen, D., Stokes, C. C., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4212-05.2006 · Cited by 179 · see citing works
Martire, M., Castaldo, P., D’Amico, M., Preziosi, P., Annunziato, L., & Taglialatela, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3143-03.2004 · Cited by 175 · see citing works
Kneussel, M., & Betz, H. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-4-00001.x · Cited by 169 · see citing works
Neuronal pentraxin, a secreted protein with homology to acute phase proteins of the immune system
Schlimgen, A. K., Helms, J. A., Vogel, H. S., & Perin, M. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90308-9 · Cited by 163 · see citing works
O'Brien, R., Xu, D., Mi, R., Tang, X., Hopf, C., & Worley, P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04487.2002 · Cited by 160 · see citing works
Contribution of KCNQ2 and KCNQ3 to the medium and slow afterhyperpolarization currents
Tzingounis, A. V., & Nicoll, R. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810535105 · Cited by 138 · see citing works
Lamas, J. A., Selyanko, A. A., & Brown, D. A. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01637.x · Cited by 135 · see citing works
Chapter 10 Synaptic remodeling, synaptic growth and the storage of long-term memory in Aplysia
Bailey, C. H., & Kandel, E. R. (2008) · Progress in brain research · doi:10.1016/s0079-6123(07)00010-6 · Cited by 130 · see citing works
Hadley, J. K., Passmore, G. M., Tatulian, L., AlQatari, M., Ye, F., Wickenden, A. D., & Brown, D. A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05012.2003 · Cited by 125 · see citing works
Normal induction but accelerated decay of LTP in APP + PS1 transgenic mice
Gureviciene, I., Ikonen, S., Gurevicius, K., Sarkaki, A., Groen, T. V., Pussinen, R., Ylinen, A., & Tanila, H. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.11.011 · Cited by 115 · see citing works
Abad, M. A., Enguita, M., DeGregorio-Rocasolano, N., Ferrer, I., & Trullas, R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0575-06.2006 · Cited by 102 · see citing works
Self-citationThe calcium-activated slow AHP: cutting through the Gordian knot
Andrade, R., Foehring, R. C., & Tzingounis, A. V. (2012) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00047 · Cited by 101 · see citing works
Peretz, A. S., Sheinin, A., Yue, C., Degani-Katzav, N., Gibor, G., Nachman, R., Gopin, A., Tam, E., Shabat, D., Yaari, Y., et al. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00634.2006 · Cited by 78 · see citing works
Calmodulin Activation Limits the Rate of KCNQ2 K+ Channel Exit from the Endoplasmic Reticulum
Alaimo, A., Gómez-Posada, J. C., Aivar, P., Etxeberría, A., Rodrı́guez-Alfaro, J. A., Areso, P., & Villarroel, Á. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.019539 · Cited by 70 · see citing works
Diversity of potassium channels in neuronal dendrites
YUAN, L., & Chen, X. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.03.003 · Cited by 58 · see citing works
DeGregorio-Rocasolano, N., Gasull, T., & Trullas, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007967200 · Cited by 56 · see citing works
M‐type potassium channels modulate Schaffer collateral–CA1 glutamatergic synaptic transmission
Sun, J., & Kapur, J. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.235820 · Cited by 55 · see citing works
Shahidullah, M., Santarelli, L. C., Wen, H., & Levitan, I. B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503966102 · Cited by 43 · see citing works
Regev, N., Degani-Katzav, N., Korngreen, A., Etzioni, A., Siloni, S., Alaimo, A., Chikvashvili, D., Villarroel, Á., Attali, B., & Lotan, I. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006586 · Cited by 39 · see citing works
Tseng, L. A., & Bixby, J. L. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.04.005 · Cited by 29 · see citing works
Clayton, K. B., Podlesniy, P., Figueiro-Silva, J., López-Doménech, G., Benitez, L., Enguita, M., Abad, M. A., Soriano, E., & Trullas, R. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4604-11.2012 · Cited by 28 · see citing works
Self-citationChen, B., & Bixby, J. L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4365-04.2005 · Cited by 25 · see citing works
Tanaka, T., Saito, H., & Matsuki, N. (1996) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.70.89 · Cited by 24 · see citing works
Pérez‐Brangulí, F., Muhaisen, A., & Blasi, J. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1122 · Cited by 24 · see citing works
Kv7 (KCNQ) potassium channels that are mutated in human diseases
Brown, D. A. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.153007 · Cited by 21 · see citing works
Lampe, B. J., Gaskill, J. L., Keim, S. C., & Brown, B. S. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)13347-x · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS
Faust, T. E., Gunner, G., & Schafer, D. P. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00507-y · Cited by 440 · see citing works
Genetic architecture of subcortical brain structures in 38,851 individuals
Satizábal, C. L., Adams, H. H. H., Hibar, D. P., White, C. C., Knol, M. J., Stein, J. L., Scholz, M. R., Sargurupremraj, M., Jahanshad, N., Roshchupkin, G. V., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0511-y · Cited by 256 · see citing works
Tran, M. N., Maynard, K. R., Spangler, A., Huuki, L. A., Montgomery, K. D., Sadashivaiah, V., Tippani, M., Barry, B. K., Hancock, D. B., Hicks, S. C., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.001 · Cited by 219 · see citing works
Gómez de San José, N., Massa, F., Halbgebauer, S., Oeckl, P., Steinacker, P., & Otto, M. (2022) · Journal of Neural Transmission · doi:10.1007/s00702-021-02411-2 · Cited by 112 · see citing works
Brinkmalm, G., Sjödin, S., Simonsen, A. H., Hasselbalch, S. G., Zetterberg, H., Brinkmalm, A., & Blennow, K. (2018) · PROTEOMICS – Clinical Applications · doi:10.1002/prca.201700131 · Cited by 111 · see citing works
The Role of Kv7.2 in Neurodevelopment: Insights and Gaps in Our Understanding
Dirkx, N., Miceli, F., Taglialatela, M., & Weckhuysen, S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.570588 · Cited by 77 · see citing works
Neuroinflammation in Alzheimer’s disease: Pleiotropic roles for cytokines and neuronal pentraxins
Swanson, A., Wolf, T., Sitzmann, A., & Willette, A. A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.015 · Cited by 72 · see citing works
An Intrinsic Transcriptional Program Underlying Synaptic Scaling during Activity Suppression
Schaukowitch, K., Reese, A. L., Kim, S.-K., Kilaru, G., Joo, J., Kavalali, E. T., & Kim, T.-K. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.033 · Cited by 71 · see citing works
Acidification can directly affect olfaction in marine organisms
Porteus, C. S., Roggatz, C. C., Velez, Z., Hardege, J. D., & Hubbard, P. C. (2021) · Journal of Experimental Biology · doi:10.1242/jeb.237941 · Cited by 52 · see citing works
Spatiotemporal patterns of gene expression around implanted silicon electrode arrays
Thompson, C. H., Saxena, A., Heelan, N., Salatino, J. W., & Purcell, E. K. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/abf2e6 · Cited by 47 · see citing works
The Role of Neuronal Pentraxin 2 (NP2) in Regulating Glutamatergic Signaling and Neuropathology
Chapman, G., Shanmugalingam, U., & Smith, P. D. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00575 · Cited by 48 · see citing works
Kovács, R. Á., Vadászi, H., Bulyáki, É., Török, G., Tóth, V., Mátyás, D., Kun, J., Hunyadi-Gulyás, É., Fedor, F. Z., Csincsi, Á., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.599771 · Cited by 43 · see citing works
Cummings, D. M., Benway, T. A., Ho, H., Tedoldi, A., Freitas, M. M. F., Shahab, L., Murray, C. E., Richard-Loendt, A., Brandner, S., Lashley, T., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx046 · Cited by 43 · see citing works
Navakkode, S., Gaunt, J. R., Pavón, M. V., Bansal, V. A., Abraham, R. P., Chong, Y. S., Ch’ng, T. H., & Sajikumar, S. (2021) · Aging Cell · doi:10.1111/acel.13502 · Cited by 39 · see citing works
Biomarkers: Our Path Towards a Cure for Alzheimer Disease
Tarawneh, R. M. (2020) · Biomarker Insights · doi:10.1177/1177271920976367 · Cited by 37 · see citing works
Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease
Ma, Q., Teng, E., Zuo, X., Jones, M. R., Teter, B., Zhao, E. Y., Zhu, C., Bilousova, T. V., Gylys, K. H., Apostolova, L. G., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.02.014 · Cited by 32 · see citing works
NPTX1 mutations trigger endoplasmic reticulum stress and cause autosomal dominant cerebellar ataxia
Coutelier, M., Jacoupy, M., Janer, A., Renaud, F., Auger, N., Saripella, G. V., Ancien, F., Pucci, F., Rooman, M. J., Gilis, D., et al. (2021) · Brain · doi:10.1093/brain/awab407 · Cited by 29 · see citing works
Histone deacetylase-3: Friend and foe of the brain
D’Mello, S. R. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220928278 · Cited by 26 · see citing works
Biology of AMPA receptor interacting proteins - From biogenesis to synaptic plasticity
Matthews, P. M., Pinggera, A., Kampjut, D., & Greger, I. H. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108709 · Cited by 25 · see citing works
Blood-based Biomarkers of Alzheimer’s Disease: The Long and Winding Road
Manzine, P. R., Vatanabe, I. P., Peron, R., Grigoli, M. M., Pedroso, R. V., Nascimento, C. M. C., & Cominetti, M. R. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200114105515 · Cited by 21 · see citing works
Therapeutic role of voltage-gated potassium channels in age-related neurodegenerative diseases
Urrutia, J., Arrizabalaga-Iriondo, A., Sanchez-del-Rey, A., Martínez-Ibargüen, A., Gallego, M., Casis, Ó., & Revuelta, M. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1406709 · Cited by 19 · see citing works
Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals WorldwidePreprint
Satizábal, C. L., Adams, H. H. H., Hibar, D. P., White, C. C., Stein, J. L., Scholz, M. R., Sargurupremraj, M., Jahanshad, N., Smith, A. V., Bis, J. C., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/173831 · Cited by 18 · see citing works
Alterations in Ion Channel Expression Surrounding Implanted Microelectrode Arrays in the BrainPreprint
Salatino, J. W., Kale, A. P., & Purcell, E. K. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/518811 · Cited by 16 · see citing works
A human in vitro neuronal model for studying homeostatic plasticity at the network level
Yuan, X., Puvogel, S., van Rhijn, J.-R., Ciptasari, U., Esteve‐Codina, A., Meijer, M., Rouschop, S., van Hugte, E., Oudakker, A. R., Schoenmaker, C., et al. (2023) · Stem Cell Reports · doi:10.1016/j.stemcr.2023.09.011 · Cited by 14 · see citing works
Swaro, A., Bristow, B. N., Anwer, M., Zhang, A. A., Kraus, L., Gandhi, R. K., Erwin, S. R., Stach, T. R., Sullivan, K. E., Fan, J., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115795 · Cited by 13 · see citing works
Warpechowski, M., Warpechowski, J. J., Kulczyńska‐Przybik, A., & Mroczko, B. (2022) · Medical Science Monitor · doi:10.12659/msm.938826 · Cited by 11 · see citing works
Diaz, J. R., Martá-Ariza, M., Khodadadi‐Jamayran, A., Heguy, A., Tsirigos, A., Pankiewicz, J. E., Sullivan, P. M., & Sadowski, M. J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.845291 · Cited by 10 · see citing works
Arias, C. C. W. P., Silbern, I., Gomes, L. C., Wartmann, H., Dambeck, V., Fanz, J., Neuenroth, L., Bähr, M., Outeiro, T. F., Bonn, S., et al. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15924 · Cited by 9 · see citing works
Pan, A. L., Audrain, M., Sakakibara, E., Joshi, R., Zhu, X., Wang, Q., Wang, M., Beckmann, N. D., Schadt, E. E., Gandy, S., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1400447 · Cited by 9 · see citing works
Tao, J., Yang, Y., Guo, Y. X., Zhang, Y., Le, Q., Huang, N., Liu, X., Yu, J., Ma, L., & Wang, F. (2025) · Cell Research · doi:10.1038/s41422-025-01157-w · Cited by 8 · see citing works
Olğun, Y., Poyraz, C. A., Bozluolçay, M., Konukoğlu, D., & Poyraz, B. Ç. (2024) · Current Alzheimer Research · doi:10.2174/0115672050313419240520051751 · Cited by 8 · see citing works
Monitoring of activity-driven trafficking of endogenous synaptic proteins through proximity labeling
Pascual-Caro, C., & de Juan‐Sanz, J. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002860 · Cited by 7 · see citing works
Greco, L. A., Reay, W. R., Dayas, C. V., & Cairns, M. J. (2023) · Addiction Biology · doi:10.1111/adb.13313 · Cited by 7 · see citing works
Wang, J., Wu, W., Wan, J., Zhan, L., Chen, Y., Yun, F., Ji, Y., Suo, G., Zheng, Y., Shen, D., et al. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116449 · Cited by 6 · see citing works
Dowling, P., Zweyer, M., Sabir, H., Henry, M., Meleady, P., Swandulla, D., & Ohlendieck, K. (2023) · European Journal of Translational Myology · doi:10.4081/ejtm.2023.11553 · Cited by 5 · see citing works
Guo, Z., Hong, X., Wang, X., Chen, W., & Guo, Z. (2024) · Aging Clinical and Experimental Research · doi:10.1007/s40520-023-02670-x · Cited by 5 · see citing works
Knorr, U. B., Simonsen, A. H., Nilsson, J., Brinkmalm, A., Zetterberg, H., Blennow, K., Knudsen, M. B., Forman, J. L., Hasselbalch, S. G., & Kessing, L. V. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.05.034 · Cited by 5 · see citing works
Potential Protein Blood-based Biomarkers in Different Types of Dementia: A Therapeutic Overview
Manzine, P. R., Vatanabe, I. P., Grigoli, M. M., Pedroso, R. V., Monteiro, M. P. A. O., de Oliveira, D. D. S. M. S., Nascimento, C. M. C., Peron, R., Orlandi, F. D. S., & Cominetti, M. R. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220408124809 · Cited by 4 · see citing works
Inhibition of neuronal pentraxin 2 relieved epileptic seizure via reducing GluA1 phosphorylation
Xing, M., Yang, X., Jin, S., & Xu, X. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4003 · Cited by 4 · see citing works
Turner, N. P., Bajo, M., Roberts, A. J., Roberto, M., & Yates, J. R. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107254 · Cited by 2 · see citing works
[Expression and Diagnostic Value of NPTX1 in Thymoma Patients].
Du, X., Yu, L., Yang, L., Cao, D., & Zhang, Y. (2021) · PubMed Central · doi:10.3779/j.issn.1009-3419.2021.102.03 · Cited by 2 · see citing works
Liu, E., Hang, Z., Liu, M., Mu, S., Han, W., Fan, S., Shi, Z. S., Yue, Q., & Sun, J. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111483 · Cited by 1 · see citing works
Kara, B., Beck, J. S., Fu, Z., Hickey, S. L., Kanaan, N. M., Mufson, E. J., Ginsberg, S. D., & Counts, S. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02080-2 · Cited by 1 · see citing works
Ha, T.-Y., Lim, S. M., Park, H., & Chang, K. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01769-9 · Cited by 1 · see citing works
Potential prognostic value of CSF-targeted proteomics across the Alzheimer’s disease continuum
Xu, B., Ling, Y., Liu, L., Liu, Y., Lin, Y., Lyu, J., & Zhang, Y. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-05104-z · Cited by 1 · see citing works
Clinical Validation of Neuronal Pentraxin Receptor as a Candidate Biomarker for Alzheimer’s Disease
Lim, B. (2020) · TSpace (University of Toronto)
Activity-driven trafficking of endogenous synaptic proteins through proximity labelingPreprint
Pascual-Caro, C., & de Juan‐Sanz, J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.19.590083
Disturbed engram network caused by NPTXs downregulation underlies aging-related memory deficitsPreprint
Tao, J., Yang, Y., Guo, Y. X., Zhang, Y., Le, Q., Huang, N., Liu, X., Yu, J., Ma, L., & Wang, F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.19.654996
Fluid and Imaging Markers of Synaptic Injury
Tarawneh, R. M. (2025) · Springer eBooks · doi:10.1007/978-3-031-80849-4_4
Xu, B., Ling, Y., Liu, L., Liu, Y., Lin, Y., Lyu, J., & Zhang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.25989206
Williams, C. R., Gallagher, E. P., McElhany, P., Busch, D. S., Maher, M. T., & Dittman, A. H. (2026) · Journal of Comparative Physiology A · doi:10.1007/s00359-026-01801-9
Mao, F., Yang, Y., Jiang, Z., Le, Q., & Jin, T. (2026) · Neuroreport · doi:10.1097/wnr.0000000000002272
The neuroimmune system and cognition
Klein, R. S. (2026) · Nature Immunology · doi:10.1038/s41590-026-02560-0 · Cited by 1 · see citing works
- Authors
- Figueiro-Silva, J., Gruart, A., Clayton, K. B., Podlesniy, P., Abad, M. A., Gasull, X., Delgado-García, J. M., & Trullas, R.
- Affiliations
- Universidad Pablo de Olavide (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2015-04-08
- Volume
- 35
- Issue
- 14
- Pages
- 5504-5521
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6605318
- OpenAlex
- W2077160832
- Cited by
- 53
- References
- 55
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 11 · 2023: 4 · 2022: 3 · 2021: 10 · 2020: 6 · 2019: 2 · 2018: 2 · 2017: 4
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (publishedVersion, other-oa)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by-nc-sa)
- Funders
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- synaptic plasticity, long-term potentiation, neuronal excitability, Kv7 channels, pro-apoptotic proteins, Alzheimer's disease, cortical neurons, hippocampus, synaptic proteins
- MeSH terms
- Pentraxins, Animals, C-Reactive Protein, Cells, Cultured, Cerebral Cortex, Female, Gene Expression Regulation, Hippocampus, Humans, Male, Mice, Inbred C57BL, Nerve Net, Nerve Tissue Proteins, Neuronal Plasticity, Neurons, Synapses, Wakefulness, Rats, Sprague-Dawley, Receptors, AMPA, Excitatory Amino Acid Antagonists, Mice, Rats, GABA-A Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
