Neuroinflammation in Alzheimer’s disease: Pleiotropic roles for cytokines and neuronal pentraxins

A synaptic model of memory: long-term potentiation in the hippocampus

Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566 · see citing works

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works

Glutamate neurotoxicity and diseases of the nervous system

Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works

2016 Alzheimer's disease facts and figures

Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069 · see citing works

C-reactive protein: a critical update

Pepys, M. B., & Hirschfield, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18921 · Cited by 4,576 · see citing works

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110 · see citing works

C-reactive protein: a critical update

Pepys, M. B., & Hirschfield, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318921 · Cited by 3,436 · see citing works

2013 Alzheimer's disease facts and figures

Thies, W. H., & Bleiler, L. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.02.003 · Cited by 3,331 · see citing works

Diagnosis of Alzheimer's Disease

Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499 · see citing works

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

Villemagne, V. L., Burnham, S., Bourgeat, P., Brown, B., Ellis, K. A., Salvado, O., Szoeke, C., Macaulay, S. L., Martins, R., Maruff, P., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70044-9 · Cited by 2,279 · see citing works

Microglial <scp>M1/M2</scp> polarization and metabolic states

Orihuela, R., McPherson, C. A., & Harry, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13139 · Cited by 2,070 · see citing works

Gene regulation and DNA damage in the ageing human brain

Lu, T., Pan, Y., Kao, S.-Y., Li, C., Kohane, I., Chan, J., & Yankner, B. A. (2004) · Nature · doi:10.1038/nature02661 · Cited by 1,874 · see citing works

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V, Perrot, L. J., White, C. L., & Araoz, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7611 · Cited by 1,777 · see citing works

Statins and the risk of dementia

Jick, H., Zornberg, G. L., Jick, S. S., Seshadri, S. S., & Drachman, D. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03155-x · Cited by 1,763 · see citing works

2015 Alzheimer's disease facts and figures

Alzheimer's Association (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.02.003 · Cited by 1,641 · see citing works

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

Sierra, A., Encinas, J. M., Deudero, J. J. P., Chancey, J. H., Enikolopov, G., Overstreet-Wadiche, L. S., Tsirka, S. E., & Maletic-Savatic, M. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.08.014 · Cited by 1,622 · see citing works

Microglial interactions with synapses are modulated by visual experience

Tremblay, M.-È., Lowery, R. L., & Majewska, A. K. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000527 · Cited by 1,542 · see citing works

Immune modulation of learning, memory, neural plasticity and neurogenesis

Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483 · see citing works

Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions

Peterson, J. W., Bö, L., Mörk, S., Chang, A., & Trapp, B. D. (2001) · Annals of Neurology · doi:10.1002/ana.1123 · Cited by 1,403 · see citing works

Mitochondrial abnormalities in Alzheimer's disease

Hirai, K., Aliev, G., Nunomura, A., Fujioka, H., Russell, R. L., Atwood, C. S., Johnson, A. B., Kress, Y., Vinters, H. V., Tabaton, M., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03017.2001 · Cited by 1,367 · see citing works

Neural mechanisms of ageing and cognitive decline

Bishop, N. A., Lu, T., & Yankner, B. A. (2010) · Nature · doi:10.1038/nature08983 · Cited by 1,323 · see citing works

Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein.

Pepys, M., & Baltz, M. (1983) · Advances in Immunology · doi:10.1016/s0065-2776(08)60379-x · Cited by 1,322 · see citing works

Advanced protein glycosylation in diabetes and aging

Brownlee, M. D. (1995) · Annual Review of Medicine · doi:10.1146/annurev.med.46.1.223 · Cited by 1,312 · see citing works

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

Lustbader, J. W., Cirilli, M., Lin, C., Xu, H. W., Takuma, K., Wang, N., Caspersen, C., Chen, X., Pollak, S., Chaney, M., et al. (2004) · Science · doi:10.1126/science.1091230 · Cited by 1,303 · see citing works

Untitled work

Wyss-Coray (2006) · doi:10.1038/nm1484 · Cited by 1,284 · see citing works

Inflammation in Neurodegenerative Disease—A Double-Edged Sword

Wyss-Coray, T., & Mucke, L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00794-8 · Cited by 1,235 · see citing works

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

Wang, X., Su, B., Lee, H.-G., Li, X., Perry, G., Smith, M. A., & Zhu, X. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1357-09.2009 · Cited by 1,224 · see citing works

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

Spires-Jones, T. L., & Hyman, B. T. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.004 · Cited by 1,201 · see citing works

Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

Manczak, M., Anekonda, T. S., Henson, E., Park, B. S., Quinn, J., & Reddy, P. H. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl066 · Cited by 1,104 · see citing works

Clinical trial of indomethacin in Alzheimer's disease

Rogers, J., Kirby, L., Hempelman, S. R., Berry, D. A., McGeer, P. L., Kaszniak, A. W., Zalinski, J., Cofield, M., Mansukhani, L., Willson, P., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1609 · Cited by 991 · see citing works

Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila

Yin, J. C. P., Wallach, J. S., Del Vecchio, M., Wilder, E. L., Zhou, H., Quinn, W. G., & Tully, T. (1994) · Cell · doi:10.1016/0092-8674(94)90399-9 · Cited by 959 · see citing works

Three-Dimensional Relationships between Hippocampal Synapses and Astrocytes

Ventura, R., & Harris, K. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-16-06897.1999 · Cited by 900 · see citing works

Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility.

Garlanda, C., Bottazzi, B., Bastone, A., & Mantovani, A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115756 · Cited by 885 · see citing works

Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis

Brown, J., Cooper‐Kuhn, C. M., Kempermann, G., Van Praag, H., Winkler, J., Gage, F. H., & Kuhn, H. G. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02647.x · Cited by 809 · see citing works

Advanced glycation end products contribute to amyloidosis in Alzheimer disease

Vitek, M. P., Bhattacharya, K., Glendening, J. M., Stopa, E., Vlassara, H., Bucala, R., Manogue, K., & Cerami, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4766 · Cited by 806 · see citing works

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

Kleinberger, G., Yamanishi, Y., Suárez-Calvet, M., Czirr, E., Lohmann, E., Cuyvers, E., Struyfs, H., Pettkus, N., Wenninger-Weinzierl, A., Mazaheri, F., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009093 · Cited by 798 · see citing works

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

Lee, J. W., Lee, Y. K., Yuk, D. Y., Choi, D. Y., Ban, S. B., Oh, K. W., & Hong, J. T. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-37 · Cited by 772 · see citing works

Molecular mechanisms of neurodegeneration in Alzheimer's disease

Crews, L., & Masliah, E. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq160 · Cited by 772 · see citing works

Microglia and neurodegeneration: The role of systemic inflammation

Cunningham, C. (2013) · Glia · doi:10.1002/glia.22350 · Cited by 769 · see citing works

The case for rejecting the amyloid cascade hypothesis

Herrup, K. (2015) · Nature Neuroscience · doi:10.1038/nn.4017 · Cited by 768 · see citing works

Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration

Cunningham, C., Wilcockson, D. C., Campion, S., Lunnon, K., & Perry, V. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2614-05.2005 · Cited by 768 · see citing works

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

Gupta, S. C., Sundaram, C., Reuter, S., & Aggarwal, B. B. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.05.004 · Cited by 762 · see citing works

Evidence for a cytokine model of cognitive function

McAfoose, J., & Baune, B. T. (2009) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.005 · Cited by 760 · see citing works

Mapping the evolution of regional atrophy in Alzheimer's disease: Unbiased analysis of fluid-registered serial MRI

Scahill, R. I., Schott, J. M., Stevens, J., Rossor, M. N., & Fox, N. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052587399 · Cited by 748 · see citing works

Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

Caspersen, C., Wang, N., Yao, J., Sosunov, A., Chen, X., Lustbader, J. W., Xu, H. W., Stern, D., McKhann, G., & Du Yan, S. (2005) · The FASEB Journal · doi:10.1096/fj.05-3735fje · Cited by 738 · see citing works

Detection of Abnormal Memory Decline in Mild Cases of Alzheimer's Disease Using CERAD Neuropsychological Measures

Welsh-Bohmer, K. A., Butters, N., Hughes, J. P., Mohs, R. C., & Heyman, A. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530150046016 · Cited by 721 · see citing works

Microdomains for neuron–glia interaction: parallel fiber signaling to Bergmann glial cells

Grosche, J., Matyash, V., Möller, T., Verkhratsky, A., Reichenbach, A., & Kettenmann, H. (1999) · Nature Neuroscience · doi:10.1038/5692 · Cited by 700 · see citing works

The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

Hansson Petersen, C. A., Alikhani, N., Behbahani, H., Wiehager, B., Pavlov, P. F., Alafuzoff, I., Leinonen, V., Ito, A., Winblad, B., Glaser, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806192105 · Cited by 693 · see citing works

Toward a molecular definition of long-term memory storage

Bailey, C. H., Bartsch, D., & Kandel, E. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13445 · Cited by 691 · see citing works

Microglia derived from aging mice exhibit an altered inflammatory profile

Sierra, A., Gottfried‐Blackmore, A. C., McEwen, B. S., & Bulloch, K. (2007) · Glia · doi:10.1002/glia.20468 · Cited by 688 · see citing works

Current and future treatments for Alzheimer's disease

Yiannopoulou, K. G., & Papageorgiou, S. G. (2013) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285612461679 · Cited by 677 · see citing works

Association of diabetes mellitus and dementia, the Rotterdam study

Ott, A., Stolk, R. P., Hofman, A., van Harskamp, F., Grobbee, D. E., & Breteler, M. M. B. (1996) · Diabetologia · doi:10.1007/s001250050588 · Cited by 677 · see citing works

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

Frakes, A. E., Ferraiuolo, L., Haidet-Phillips, A. M., Schmelzer, L., Braun, L., Miranda, C. J., Ladner, K. J., Bevan, A. K., Foust, K. D., Godbout, J. P., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.013 · Cited by 638 · see citing works

Gene expression changes in the course of normal brain aging are sexually dimorphic

Berchtold, N. C., Cribbs, D. H., Coleman, P. D., Rogers, J., Head, E., Kim, R., Beach, T., Miller, C., Troncoso, J., Trojanowski, J. Q., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806883105 · Cited by 626 · see citing works

Age-related inflammatory cytokines and disease

Brüünsgaard, H., & Pedersen, B. K. (2003) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(02)00056-5 · Cited by 608 · see citing works

An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm

Bottazzi, B., Doni, A., Garlanda, C., & Mantovani, A. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101305 · Cited by 592 · see citing works

Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive Impairment

Blalock, E. M., Chen, K.-C., Sharrow, K., Herman, J. P., Porter, N. M., Foster, T. C., & Landfield, P. W. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03807.2003 · Cited by 570 · see citing works

The Neuropsychological Profile of Alzheimer DiseasePreprint

Weıntraub, S., Wicklund, A. H., & Salmon, D. P. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006171 · Cited by 569 · see citing works

Alzheimer Disease

Castellani, R. J., Rolston, R. K., & Smith, M. A. (2010) · Disease-a-Month · doi:10.1016/j.disamonth.2010.06.001 · Cited by 561 · see citing works

Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity

Bickerstaff, M., Botto, M., Hutchinson, W., Herbert, J., Tennent, G., Bybee, A., Mitchell, D., Cook, H., Butler, P., Walport, M., et al. (1999) · Nature Medicine · doi:10.1038/9544 · Cited by 548 · see citing works

DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice

Meira, L. B., Bugni, J. M., Green, S. L., Lee, C., Pang, B., Borenshtein, D., Rickman, B. H., Rogers, A. B., Moroski-Erkul, C. A., McFaline‐Figueroa, J. L., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35073 · Cited by 548 · see citing works

Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions

Tynan, R. J., Naicker, S., Hinwood, M., Nalivaiko, E., Buller, K. M., Pow, D. V., Day, T. A., & Walker, F. R. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.02.001 · Cited by 531 · see citing works

YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease

Craig-Schapiro, R., Perrin, R. J., Roe, C. M., Xiong, C., Carter, D., Cairns, N. J., Mintun, M. A., Peskind, E. R., Li, G., Galasko, D. R., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.025 · Cited by 504 · see citing works

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches

Morales, I., Guzmán-Martínez, L., Cerda-Troncoso, C., Farías, G. A., & Maccioni, R. B. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00112 · Cited by 490 · see citing works

Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal β-Catenin Pathway Function in an Alzheimer’s Disease Model

Kitazawa, M., Cheng, D., Tsukamoto, M. R., Koike, M. A., Wes, P. D., Vasilevko, V., Cribbs, D. H., & LaFerla, F. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100620 · Cited by 473 · see citing works

Deciphering the mechanism underlying late-onset Alzheimer disease

Krstic, D., & Knuesel, I. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.236 · Cited by 457 · see citing works

The microglial "activation" continuum: from innate to adaptive responses

Town, T., Nikolic, V., & Tan, J. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-24 · Cited by 456 · see citing works

Microglia: actively surveying and shaping neuronal circuit structure and function

Wake, H., Moorhouse, A. J., Miyamoto, A., & Nabekura, J. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.11.007 · Cited by 448 · see citing works

Focal thinning of the cerebral cortex in multiple sclerosis.

Sailer, M., Fischl, B., Salat, D., Tempelmann, C., Schönfeld, M. A., Busa, E., Bodammer, N., Heinze, H., & Dale, A. (2003) · Brain : a journal of neurology · doi:10.1093/brain/awg175 · Cited by 445 · see citing works

Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3

Mantovani, A., Garlanda, C., Doni, A., & Bottazzi, B. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-007-9126-7 · Cited by 440 · see citing works

Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APP Sw,Ind ) mice

Jin, K., Galván, V., Xie, L., Mao, X. O., Gorostiza, O. F., Bredesen, D. E., & Greenberg, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403678101 · Cited by 433 · see citing works

Interleukin-1β (IL-1β) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro

Cunningham, A. J., Murray, C. A., O'Neill, L. A. J., Lynch, M. A., & O'Connor, J. J. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(95)12252-4 · Cited by 433 · see citing works

Sustained hippocampal IL-1β overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology

Shaftel, S. S., Kyrkanides, S., Olschowka, J. A., Miller, J.-N. H., Johnson, R. E., & O’Banion, M. K. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31450 · Cited by 433 · see citing works

Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study

Kuusisto, J., Koivisto, K. J., Mykkänen, L. M., Helkala, E.-L., Vanhanen, M., Hänninen, T., Kervinen, K., Kesäniemi, Y. A., Riekkinen, P. J., & Laakso, M. (1997) · BMJ · doi:10.1136/bmj.315.7115.1045 · Cited by 426 · see citing works

Interleukin-1 (IL-1): A central regulator of stress responses

Goshen, I., & Yirmiya, R. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.10.001 · Cited by 399 · see citing works

The Major Receptor for C-Reactive Protein on Leukocytes Is Fcγ Receptor II

Bharadwaj, D., Stein, M., Volzer, M. A., Mold, C., & Clos, T. W. D. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.4.585 · Cited by 391 · see citing works

Interleukin 1β inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus

Bellinger, F. P., Madamba, S. G., & Siggins, G. R. (1993) · Brain Research · doi:10.1016/0006-8993(93)90959-q · Cited by 388 · see citing works

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice

Sheng, J. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00069-x · Cited by 388 · see citing works

Plasma tau levels in Alzheimer's disease

Zetterberg, H., Wilson, D. H., Andréasson, U., Minthon, L., Blennow, K., Randall, J., & Hansson, O. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt163 · Cited by 385 · see citing works

Medial temporal lobe atrophy on MRI differentiates Alzheimer's disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosis

Burton, E. J., Barber, R., Mukaetova‐Ladinska, E. B., Robson, J., Perry, R. H., Jaros, E., Kalaria, R. N., & O'Brien, J. T. (2008) · Brain · doi:10.1093/brain/awn298 · Cited by 373 · see citing works

Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease

Jarvik, G. P., Wijsman, E. M., Kukull, W. A., Schellenberg, G. D., Yu, C., & Larson, E. B. (1995) · Neurology · doi:10.1212/wnl.45.6.1092 · Cited by 371 · see citing works

Evidence That Increased Hippocampal Expression of the Cytokine Interleukin-1β Is a Common Trigger for Age- and Stress-Induced Impairments in Long-Term Potentiation

Murray, C. A., & Lynch, M. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-08-02974.1998 · Cited by 359 · see citing works

Microglia Function in Central Nervous System Development and Plasticity

Schafer, D. P., & Stevens, B. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020545 · Cited by 353 · see citing works

Neuroinflammation: Implications for the Pathogenesis and Molecular Diagnosis of Alzheimer's Disease

Rojo, L. E., Fernández, J. A., Maccioni, A. A., Jimenez, J. M., & Maccioni, R. B. (2008) · Archives of Medical Research · doi:10.1016/j.arcmed.2007.10.001 · Cited by 351 · see citing works

Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease

Donovan, M. H., Yazdani, U., Norris, R. D., Games, D., German, D. C., & Eisch, A. J. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20840 · Cited by 350 · see citing works

Interleukin-1β inhibits long-term potentiation in the CA3 region of mouse hippocampal slices

Katsuki, H., Nakai, S., Hirai, Y., Akaji, K., Kiso, Y., & Satoh, M. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90099-r · Cited by 331 · see citing works

Ineffective phagocytosis of amyloid-β by macrophages of Alzheimer's disease patients

Fiala, M., Lin, J., Ringman, J. M., Kermani-Arab, V., Tsao, G., Patel, A. J., Lossinsky, A. S., Graves, M. C., Gustavson, A. R., Sayre, J. W., et al. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-7304 · Cited by 328 · see citing works

β-Amyloid Activates the O⨪2 Forming NADPH Oxidase in Microglia, Monocytes, and Neutrophils

Della Bianca, V., Dusi, S., Bianchini, E., Dal Prà, I., & Rossi, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.22.15493 · Cited by 324 · see citing works

Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons

Chang, M. C., Park, J. M., Pelkey, K. A., Grabenstatter, H. L., Xu, D., Linden, D. J., Sutula, T. P., McBain, C. J., & Worley, P. F. (2010) · Nature Neuroscience · doi:10.1038/nn.2621 · Cited by 316 · see citing works

NPTX2 and cognitive dysfunction in Alzheimer’s Disease

Xiao, M.-F., Xu, D., Craig, M. T., Pelkey, K. A., Chien, C.-C., Shi, Y., Zhang, J., Resnick, S., Pletnikova, O., Salmon, D., et al. (2017) · eLife · doi:10.7554/elife.23798 · Cited by 316 · see citing works

Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity

Tsui, C., Copeland, N., Gilbert, D., Jenkins, N., Barnes, C., & Worley, P. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02463.1996 · Cited by 315 · see citing works

Demyelination Causes Synaptic Alterations in Hippocampi from Multiple Sclerosis Patients

Dutta, R., Chang, A., Doud, M., Kidd, G., Ribaudo, M. V., Young, E. A., Fox, R. J., Staugaitis, S., & Trapp, B. D. (2011) · Annals of Neurology · doi:10.1002/ana.22337 · Cited by 313 · see citing works

Amyloid Fibrils Activate Tyrosine Kinase-Dependent Signaling and Superoxide Production in Microglia

McDonald, D. R., Brunden, K. R., & Landreth, G. E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02284.1997 · Cited by 308 · see citing works

Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to β-amyloid deposition in APP/PS1 double transgenic Alzheimer mice

Malm, T. M., Koistinaho, M., Pärepalo, M., Vatanen, T., Ooka, A., Karlsson, S., & Koistinaho, J. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.09.009 · Cited by 301 · see citing works

Mitochondria: A therapeutic target in neurodegeneration

Moreira, P. I., Zhu, X., Wang, X., Lee, H., Nunomura, A., Petersen, R. B., Perry, G. L., & Smith, M. A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.10.007 · Cited by 286 · see citing works

Plasticity of perisynaptic astroglia during synaptogenesis in the mature rat hippocampus

Witcher, M. R., Kirov, S. A., & Harris, K. M. (2006) · Glia · doi:10.1002/glia.20415 · Cited by 281 · see citing works

Contribution of systemic inflammation to chronic neurodegeneration

Perry, V. H. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0722-x · Cited by 277 · see citing works

Characterization of microglial reaction after middle cerebral artery occlusion in rat brain

Morioka, T., Kalehua, A. N., & Streit, W. J. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903270110 · Cited by 272 · see citing works

Methylene Blue Delays Cellular Senescence and Enhances Key Mitochondrial Biochemical Pathways

Atamna, H., Nguyen, A., Schultz, C., Boyle, K., Newberry, J., Kato, H., & Ames, B. N. (2008) · The FASEB Journal · doi:10.1096/fj.07-9610com · Cited by 272 · see citing works

Narp and NP1 Form Heterocomplexes that Function in Developmental and Activity-Dependent Synaptic Plasticity

Xu, D., Hopf, C., Reddy, R., Cho, R. W., Guo, L., Lanahan, A., Petralia, R. S., Wenthold, R. J., O'Brien, R. J., & Worley, P. (2003) · Neuron · doi:10.1016/s0896-6273(03)00463-x · Cited by 265 · see citing works

INTERACTIONS OF C-REACTIVE PROTEIN WITH THE COMPLEMENT SYSTEM

Siegel, J. N., Rent, R., & Gewurz, H. (1974) · The Journal of Experimental Medicine · doi:10.1084/jem.140.3.631 · Cited by 259 · see citing works

Rodent models of neuroinflammation for Alzheimer’s disease

Nazem, A., Sankowski, R., Bacher, M., & Al‐Abed, Y. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0291-y · Cited by 249 · see citing works

The age-related attenuation in long-term potentiation is associated with microglial activation

Griffin, R., Nally, R., Nolan, Y., McCartney, Y., Linden, J., & Lynch, M. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04165.x · Cited by 246 · see citing works

The Inhibitory Effect of Interleukin-1β on Long-Term Potentiation Is Coupled with Increased Activity of Stress-Activated Protein Kinases

Vereker, E., O'Donnell, E., & Lynch, M. A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-18-06811.2000 · Cited by 242 · see citing works

Pathogenesis of Alzheimer's disease.

Swerdlow, R. H. (2007) · PubMed Central · Cited by 236 · see citing works

Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1β in the substantia nigra

Ferrari, C. C., Pott Godoy, M. C., Tarelli, R., Chertoff, M., Depino, A. M., & Pitossi, F. J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.06.013 · Cited by 235 · see citing works

Neurodegeneration by Activation of the Microglial Complement-Phagosome Pathway

Bodea, L.-G., Wang, Y., Linnartz-Gerlach, B., Kopatz, J., Sinkkonen, L., Musgrove, R., Kaoma, T., Muller, A., Vallar, L., Di Monte, D. A., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5002-13.2014 · Cited by 234 · see citing works

Age-Dependent Cognitive Deficits and Neuronal Apoptosis in Cyclooxygenase-2 Transgenic Mice

Andreasson, K. I., Savonenko, A. V., Vidensky, S., Goellner, J. J., Zhang, Y., Shaffer, A. F., Kaufmann, W. E., Worley, P. F., Isakson, P. C., & Markowska, A. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08198.2001 · Cited by 232 · see citing works

Glia: The many ways to modulate synaptic plasticity

Achour, S. B., & Pascual, O. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.02.013 · Cited by 232 · see citing works

The roles of inflammation and immune mechanisms in Alzheimer's disease

Eldik, L. J. V., Carrillo, M. C., Cole, P. E., Feuerbach, D., Greenberg, B., Hendrix, J. A., Kennedy, M. E., Kozauer, N., Margolin, R. A., Molinuevo, J. L., et al. (2016) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2016.05.001 · Cited by 226 · see citing works

Sustained hippocampal IL-1β overexpression impairs contextual and spatial memory in transgenic mice

Hein, A. M., Stasko, M. R., Matousek, S. B., Scott-McKean, J. J., Maier, S. F., Olschowka, J. A., Costa, A. C. S., & O’Banion, M. K. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.10.002 · Cited by 223 · see citing works

Role of complement and Fcγ receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus

Moalli, F., Doni, A., Deban, L., Zelante, T., Zagarella, S., Bottazzi, B., Romani, L., Mantovani, A., & Garlanda, C. (2010) · Blood · doi:10.1182/blood-2009-12-258376 · Cited by 205 · see citing works

Nitrative DNA damage in inflammation and its possible role in carcinogenesis

Sawa, T., & Ohshima, H. (2005) · Nitric Oxide · doi:10.1016/j.niox.2005.06.005 · Cited by 198 · see citing works

Synapse elimination in the central nervous system

Kano, M., & Hashimoto, K. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.05.002 · Cited by 191 · see citing works

Atypical inflammation in the central nervous system in prion disease

Perry, V. H., Cunningham, C. M., & Boche, D. (2002) · Current Opinion in Neurology · doi:10.1097/00019052-200206000-00020 · Cited by 180 · see citing works

Neuronal Pentraxins Mediate Synaptic Refinement in the Developing Visual System

Bjartmar, L., Huberman, A. D., Ullian, E. M., Renteria, R. C., Liu, X., Xu, W., Prezioso, J., Susman, M. W., Stellwagen, D., Stokes, C. C., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4212-05.2006 · Cited by 179 · see citing works

Synaptic plasticity in vitro: cell culture of identified Aplysia neurons mediating short-term habituation and sensitization

Rayport, S., & Schacher, S. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-03-00759.1986 · Cited by 177 · see citing works

Developing novel blood‐based biomarkers for Alzheimer's disease

Snyder, H. M., Carrillo, M. C., Grodstein, F., Henriksen, K., Jeromin, A., Lovestone, S., Mielke, M. M., O'Bryant, S., Sarasa, M., Sj⊘gren, M., et al. (2014) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2013.10.007 · Cited by 177 · see citing works

Randomized pilot study of nimesulide treatment in Alzheimer’s disease

Aisen, P. S. S., Schmeidler, J., & Pasinetti, G. M. (2002) · Neurology · doi:10.1212/wnl.58.7.1050 · Cited by 174 · see citing works

Circadian and Homeostatic Regulation of Structural Synaptic Plasticity in Hypocretin Neurons

Appelbaum, L., Wang, G. X., Yokogawa, T., Skariah, G. M., Smith, S. J., Mourrain, P., & Mignot, E. J.-M. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.006 · Cited by 172 · see citing works

Identification and Validation of Novel Cerebrospinal Fluid Biomarkers for Staging Early Alzheimer's Disease

Perrin, R. J., Craig‐Schapiro, R., Malone, J. P., Shah, A. R., Erdmann-Gilmore, P., Davis, A., Roe, C. M., Peskind, E. R., Li, G., Galasko, D. R., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016032 · Cited by 172 · see citing works

Selective activation of microglia facilitates synaptic strength

Clark, A. K., Gruber-Schoffnegger, D., Drdla-Schutting, R., Gerhold, K. J., Malcangio, M., & Sandkühler, J. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2061-14.2015 · Cited by 171 · see citing works

Neuronal Pentraxin Receptor, a Novel Putative Integral Membrane Pentraxin That Interacts with Neuronal Pentraxin 1 and 2 and Taipoxin-associated Calcium-binding Protein 49

Dodds, D. C., Omeis, I. A., Cushman, S. J., Helms, J. A., & Perin, M. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21488 · Cited by 170 · see citing works

Apolipoprotein E4 enhances brain inflammation by modulation of the NF-κB signaling cascade

Ophir, G., Amariglio, N., Jacob‐Hirsch, J., Elkon, R., Rechavi, G., & Michaelson, D. M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.05.002 · Cited by 166 · see citing works

<i><scp>APOE</scp></i>‐modulated Aβ‐induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective

Tai, L. M., Ghura, S., Koster, K. P., Liakaite, V., Maienschein‐Cline, M., Kanabar, P., Collins, N., Ben‐Aissa, M., Lei, A. Z., Bahroos, N., et al. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13072 · Cited by 165 · see citing works

Development and evaluation of a multiplexed mass spectrometry based assay for measuring candidate peptide biomarkers in Alzheimer's Disease Neuroimaging Initiative (ADNI) CSF

Spellman, D. S., Wildsmith, K. R., Honigberg, L. A., Tuefferd, M., Baker, D., Raghavan, N., Nairn, A. C., Croteau, P., Schirm, M., Allard, R., et al. (2015) · PROTEOMICS – Clinical Applications · doi:10.1002/prca.201400178 · Cited by 161 · see citing works

Sustained expression of interleukin-1β in mouse hippocampus impairs spatial memory

Moore, A. H., Wu, M., Shaftel, S. S., Graham, K. A., & O’Banion, M. K. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.073 · Cited by 159 · see citing works

Learning in Aplysia: looking at synaptic plasticity from both sides

Roberts, A. C., & Glanzman, D. L. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.09.014 · Cited by 157 · see citing works

C3-dependent mechanism of microglial priming relevant to multiple sclerosis

Ramaglia, V., Hughes, T. R., Donev, R., Ruseva, M. M., Wu, X., Huitinga, I., Baas, F., Neal, J., & Morgan, B. P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111924109 · Cited by 151 · see citing works

Inflammatory markers in AD and MCI patients with different biomarker profiles

Schuitemaker, A., Dik, M. G., Veerhuis, R., Scheltens, P., Schoonenboom, N. S. M., Hack, C. E., Blankenstein, M. A., & Jonker, C. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.01.014 · Cited by 149 · see citing works

Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline

VanGuilder, H. D., Farley, J. A., Han, Y., Kirk, C. A. V., Mitschelen, M. C., Sonntag, W. E., & Freeman, W. M. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.03.012 · Cited by 145 · see citing works

Neuronal pentraxin receptor in cerebrospinal fluid as a potential biomarker for neurodegenerative diseases

Yin, G. N., Lee, H. W., Cho, J.-Y., & Suk, K. (2009) · Brain Research · doi:10.1016/j.brainres.2009.01.058 · Cited by 143 · see citing works

Label-Free Quantitative LC–MS Proteomics of Alzheimer’s Disease and Normally Aged Human Brains

Andreev, V. P., Petyuk, V., Brewer, H. M., Karpievitch, Y. V., Xie, F., Clarke, J., Camp, D., Smith, R. D., Lieberman, A. P., Albin, R. L., et al. (2012) · Journal of Proteome Research · doi:10.1021/pr3001546 · Cited by 140 · see citing works

Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats

Nimmo, A. J., Černak, I., Heath, D. L., Hu, X., Bennett, C. J., & Vink, R. (2004) · Neuropeptides · doi:10.1016/j.npep.2003.12.003 · Cited by 136 · see citing works

Potential Inflammatory biomarkers in Alzheimer's disease

Mrak, R. E., & Griffin, W. S. T. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-8406 · Cited by 135 · see citing works

Serum Amyloid P Component and C-Reactive Protein Opsonize Apoptotic Cells for Phagocytosis through Fcγ Receptors

Mold, C., Baca, R., & Clos, T. W. D. (2002) · Journal of Autoimmunity · doi:10.1006/jaut.2002.0615 · Cited by 134 · see citing works

Disease-modifying treatments for Alzheimer’s disease

Galimberti, D., & Scarpini, E. A. (2011) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285611404470 · Cited by 128 · see citing works

Astrocytes support hippocampal-dependent memory and long-term potentiation via interleukin-1 signaling

Menachem-Zidon, O. B., Avital, A., Menahem, Y. B., Goshen, I., Kreisel, T., Shmueli, E., Segal, M., Hur, T. B., & Yirmiya, R. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.11.007 · Cited by 127 · see citing works

Studies on the interactions between C‐reactive protein and complement proteins

Bı́ró, A., Rovó, Z., Papp, D., Cervenak, L., Varga, L. Á., Füst, G., Thielens, N. M., Arlaud, G. J., & Prohászka, Z. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02535.x · Cited by 125 · see citing works

Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer’s disease

Berchtold, N. C., Sabbagh, M. N., Beach, T. G., Kim, R. C., Cribbs, D. H., & Cotman, C. W. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.031 · Cited by 124 · see citing works

Proteomic Changes in Cerebrospinal Fluid of Presymptomatic and Affected Persons Carrying Familial Alzheimer Disease Mutations

Ringman, J. M. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.642 · Cited by 124 · see citing works

CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid β‐peptide

Townsend, K. P., Town, T., Mori, T., Lue, L., Shytle, D., Sanberg, P. R., Morgan, D., Fernandez, F., Flavell, R. A., & Tan, J. (2005) · European Journal of Immunology · doi:10.1002/eji.200425585 · Cited by 121 · see citing works

Neuroinflammation‐induced acceleration of amyloid deposition in the APP^V717F transgenic mouse

Qiao, X., Cummins, D. J., & Paul, S. M. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01666.x · Cited by 119 · see citing works

Neurodegeneration and Alzheimer's disease (AD). What Can Proteomics Tell Us About the Alzheimer's Brain?

Moya‐Alvarado, G., Gershoni‐Emek, N., Perlson, E., & Bronfman, F. C. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r115.053330 · Cited by 119 · see citing works

Suppression of Nuclear Factor-κB Activation and Inflammation in Microglia by Physically Modified Saline

Khasnavis, S., Jana, A., Roy, A., Mazumder, M., Bhushan, B., Wood, T., Ghosh, S., Watson, R. L., & Pahan, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.338012 · Cited by 117 · see citing works

Brain injury, neuroinflammation and Alzheimer's disease

Breunig, J. J., Guillot‐Sestier, M., & Town, T. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00026 · Cited by 104 · see citing works

Human Neuronal Pentraxin II (NPTX2): Conservation, Genomic Structure, and Chromosomal Localization

Hsu, Y., & Perin, M. S. (1995) · Genomics · doi:10.1006/geno.1995.1134 · Cited by 103 · see citing works

Pathogenesis and Disease-modifying Therapy in Alzheimer's Disease: The Flat Line of Progress

Castellani, R. J., & Perry, G. L. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.09.009 · Cited by 103 · see citing works

Decreased C-Reactive Protein Levels in Alzheimer Disease

O'Bryant, S. E., Waring, S. C., Hobson, V., Hall, J. R., Moore, C. B., Bottiglieri, T., Massman, P., & Diaz-Arrastia, R. (2010) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988709351832 · Cited by 103 · see citing works

Quantification of the Brain Proteome in Alzheimer’s Disease Using Multiplexed Mass Spectrometry

Musunuri, S., Wetterhall, M., Ingelsson, M., Lannfelt, L., Artemenko, K. A., Bergquist, J., Kultima, K., & Shevchenko, G. (2014) · Journal of Proteome Research · doi:10.1021/pr401202d · Cited by 102 · see citing works

Microglia in Alzheimer's Disease: It's All About Context

Weitz, T. M., & Town, T. (2012) · International Journal of Alzheimer's Disease · doi:10.1155/2012/314185 · Cited by 95 · see citing works

Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication

Flannery, B. M., Bruun, D. A., Rowland, D. J., Banks, C. N., Austin, A. T., Kukis, D. L., Li, Y., Ford, B. D., Tancredi, D. J., Silverman, J. L., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0744-y · Cited by 93 · see citing works

Plasma Amyloid β-Protein and C-reactive Protein in Relation to the Rate of Progression of Alzheimer Disease

Locascio, J. J., Fukumoto, H., Yap, L., Bottiglieri, T., Growdon, J. H., Hyman, B. T., & Irizarry, M. C. (2008) · Archives of Neurology · doi:10.1001/archneur.65.6.776 · Cited by 92 · see citing works

Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease

Alcolea, D. A., Vilaplana, E., Pegueroles, J., Montal, V., Sánchez‐Juan, P., González‐Suárez, A., Pozueta, A., Rodríguez‐Rodríguez, E., Bartrés‐Faz, D., Dídac Vidal-piñeiro, A., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.03.001 · Cited by 89 · see citing works

Coagulation and inflammatory markers in Alzheimer's and vascular dementia

Gupta, A., Watkins, A., Thomas, P., Majer, R., Habubi, N., Morris, G., & Pansari, K. (2004) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2004.00143.x · Cited by 87 · see citing works

An update on clinical proteomics in Alzheimer’s research

Korolainen, M. A., Nyman, T. A., Aittokallio, T. A., & Pirttilä, T. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06558.x · Cited by 86 · see citing works

Modelling neuroinflammatory phenotypes in vivo.

Buckwalter, M. S., & Wyss‐Coray, T. (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-10 · Cited by 85 · see citing works

Microglia: Activation in acute and chronic inflammatory states and in response to cardiovascular dysfunction

Badoer, E. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.07.005 · Cited by 80 · see citing works

Neuronal Pentraxin 2 predicts medial temporal atrophy and memory decline across the Alzheimer’s disease spectrum

Swanson, A., & Willette, A. A. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.07.148 · Cited by 79 · see citing works

CHF5074 Reduces Biomarkers of Neuroinflammation in Patients with Mild Cognitive Impairment: A 12-Week, Double-Blind, Placebo- Controlled Study

Ross, J., Sharma, S., Winston, J., Nunez, M., Bottini, G., Franceschi, M., Scarpini, E. A., Frigerio, E., Fiorentini, F., Fernández, M., et al. (2013) · Current Alzheimer Research · doi:10.2174/13892037113149990144 · Cited by 78 · see citing works

Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination?

Gillmore, J., Hutchinson, W., Herbert, J., Bybee, A., Mitchell, D., Hasserjian, R., Yamamura, K., Suzuki, M., Sabin, C., & Pepys, M. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01860.x · Cited by 70 · see citing works

Neuronal pentraxin II is highly upregulated in Parkinson’s disease and a novel component of Lewy bodies

Moran, L. B., Hickey, L., Michael, G. J., Derkacs, M., Christian, L. M., Kalaitzakis, M. E., Pearce, R. K. B., & Graeber, M. B. (2008) · Acta Neuropathologica · doi:10.1007/s00401-007-0309-3 · Cited by 69 · see citing works

Interleukin-6 trans-signaling in the senescent mouse brain is involved in infection-related deficits in contextual fear conditioning

Burton, M. D., & Johnson, R. W. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.10.008 · Cited by 67 · see citing works

Pathogenesis of Alzheimer’s Disease

Castellani, R. J., & Perry, G. L. (2014) · Springer eBooks · doi:10.1007/978-1-4614-5836-4_162 · Cited by 67 · see citing works

Neuropathology and the Neuroinflammation Idea

Mrak, R. E. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1158 · Cited by 66 · see citing works

Gene expression parallels synaptic excitability and plasticity changes in Alzheimer’s disease

Saura, C. A., Parra‐Damas, A., & Enríquez-Barreto, L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00318 · Cited by 65 · see citing works

CSF YKL-40 and pTau181 are related to different cerebral morphometric patterns in early AD

Gispert, J. D., Monté, G. C., Falcón, C., Tucholka, A., Rojas, S., Sánchez‐Valle, R., Antonell, A., Lladó, A., Rami, L., & Molinuevo, J. L. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.10.022 · Cited by 62 · see citing works

Granins as disease-biomarkers: translational potential for psychiatric and neurological disorders

Bartolomucci, A., Pasinetti, G. M., & Salton, S. R. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.057 · Cited by 61 · see citing works

Overexpression of Neuronal Pentraxin 1 Is Involved in Neuronal Death Evoked by Low K+ in Cerebellar Granule Cells

DeGregorio-Rocasolano, N., Gasull, T., & Trullas, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007967200 · Cited by 56 · see citing works

Neuronal Pentraxin 1 Negatively Regulates Excitatory Synapse Density and Synaptic Plasticity

Figueiro-Silva, J., Gruart, A., Clayton, K. B., Podlesniy, P., Abad, M. A., Gasull, X., Delgado-García, J. M., & Trullas, R. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2548-14.2015 · Cited by 53 · see citing works

Targeted human cerebrospinal fluid proteomics for the validation of multiple Alzheimer's disease biomarker candidates

Choi, Y. S., Hou, S., Choe, L. H., & Lee, K. H. (2013) · Journal of Chromatography B · doi:10.1016/j.jchromb.2013.05.003 · Cited by 47 · see citing works

The soluble pattern recognition receptor pentraxin-3 in innate immunity, inflammation and fertility

Garlanda, C., Maina, V., Cotena, A., & Moalli, F. (2009) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2009.05.006 · Cited by 45 · see citing works

Explorative and targeted neuroproteomics in Alzheimer's disease

Brinkmalm, A., Portelius, E., Öhrfelt, A., Brinkmalm, G., Andréasson, U., Gobom, J., Blennow, K., & Zetterberg, H. (2015) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2015.01.009 · Cited by 45 · see citing works

Regional Differences in Neurotrophin Availability Regulate Selective Expression of VGF in the Developing Limbic Cortex

Eagleson, K. L., Fairfull, L. D., Salton, S. R., & Levitt, P. R. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09315.2001 · Cited by 39 · see citing works

Pentraxins and Alzheimer's disease: At the interface between biomarkers and pharmacological targets

Osera, C., Pascale, A., Amadio, M., Venturini, L., Govoni, S. M., & Ricevuti, G. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.004 · Cited by 30 · see citing works

Hippocampal neuroplasticity and inflammation: relevance for multiple sclerosis

Mancini, A., Gaetani, L., Gregorio, M. D., Tozzi, A., Ghiglieri, V., Calabresi, P., & Filippo, M. D. (2017) · Multiple Sclerosis and Demyelinating Disorders · doi:10.1186/s40893-017-0019-1 · Cited by 30 · see citing works

Reduced synaptic density and deficient locomotor response in neuronal activity‐regulated pentraxin 2a mutant zebrafish

Elbaz, I., Lerer‐Goldshtein, T., Okamoto, H., & Appelbaum, L. (2014) · The FASEB Journal · doi:10.1096/fj.14-258350 · Cited by 23 · see citing works

On the 150th Anniversary of Darwin's Submission of One of his “Five Great Books”, The Variation of Animals and Plants Under Domestication, to his publisher John Murray

(2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.12.004 · Cited by 18 · see citing works

Development and Plasticity

Schwartz, J. P. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60887-x · Cited by 6 · see citing works

Untitled work

Klegeris (1997) · doi:10.1002/(sici)1097-4547(19970715)49:2

Neuroinflammation, gut microbiome, and Alzheimer's disease

Lin, L., Zheng, L. J., & Zhang, L. J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0983-2 · Cited by 147 · see citing works

Mast Cells in Stress, Pain, Blood-Brain Barrier, Neuroinflammation and Alzheimer’s Disease

Kempuraj, D., Mentor, S., Thangavel, R., Ahmed, M. E., Selvakumar, G. P., Raikwar, S. P., Dubova, I., Zaheer, S. A., Iyer, S. S., & Zaheer, A. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00054 · Cited by 135 · see citing works

Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration

Gómez de San José, N., Massa, F., Halbgebauer, S., Oeckl, P., Steinacker, P., & Otto, M. (2022) · Journal of Neural Transmission · doi:10.1007/s00702-021-02411-2 · Cited by 112 · see citing works

Neuroinflammation in Gulf War Illness is linked with HMGB1 and complement activation, which can be discerned from brain-derived extracellular vesicles in the blood

Madhu, L. N., Attaluri, S., Kodali, M., Shuai, B., Upadhya, R., Gitaí, D. L. G., & Shetty, A. K. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.040 · Cited by 94 · see citing works

Ocular Manifestations of Alzheimer’s and Other Neurodegenerative Diseases: The Prospect of the Eye as a Tool for the Early Diagnosis of Alzheimer’s Disease

Colligris, P., de Lara, M. J. P., Colligris, B., & Pintor, J. J. (2018) · Journal of Ophthalmology · doi:10.1155/2018/8538573 · Cited by 84 · see citing works

The role of T cells in the pathogenesis of Parkinson’s disease

Chen, Z., Chen, S., & Liu, J. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.08.002 · Cited by 78 · see citing works

The intestinal microbiome and Alzheimer's disease: A review

Li, Z., Zhu, H., Zhang, L., & Qin, C. (2018) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12033 · Cited by 75 · see citing works

The neuroinflammatory role of microglia in Alzheimer's disease and their associated therapeutic targets

AmeliMojarad, M., & AmeliMojarad, M. (2024) · CNS Neuroscience &amp; Therapeutics · doi:10.1111/cns.14856 · Cited by 73 · see citing works

The role of natural flavonoids on neuroinflammation as a therapeutic target for Alzheimer’s disease: a narrative review

Zhang, Q., & Yan, Y. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.373680 · Cited by 72 · see citing works

The Role of Circular RNAs in Immune-Related Diseases

Xie, R., Zhang, Y., Zhang, J., Li, J., & Zhou, X. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00545 · Cited by 68 · see citing works

Polysaccharide of Schisandra Chinensis Fructus ameliorates cognitive decline in a mouse model of Alzheimer's disease

Xu, M., Yan, T., Fan, K., Wang, M., Yu, Q., Xiao, F., Bi, K., & Jia, Y. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.02.046 · Cited by 70 · see citing works

A comprehensive systematic review of CSF proteins and peptides that define Alzheimer’s disease

Pedrero-Prieto, C. M., García‐Carpintero, S., Frontiñán-Rubio, J., Llanos-González, E., García, C. A., Alcain, F. J., Lindberg, I., Durán‐Prado, M., Peinado, J. R., & Rabanal‐Ruiz, Y. (2020) · Clinical Proteomics · doi:10.1186/s12014-020-09276-9 · Cited by 65 · see citing works

Targeting Microglia-Synapse Interactions in Alzheimer’s Disease

Piccioni, G., Mango, D., Saidi, A., Corbo, M., & Nisticò, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052342 · Cited by 62 · see citing works

Torularhodin from Sporidiobolus pararoseus Attenuates d -galactose/AlCl3-Induced Cognitive Impairment, Oxidative Stress, and Neuroinflammation via the Nrf2/NF-κB Pathway

Zhang, W., Hua, H., Guo, Y., Cheng, Y., Pi, F., Yao, W., Xie, Y., & He, Q. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c01892 · Cited by 55 · see citing works

Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer’s disease

Moreno‐Rodríguez, M., Perez, S. E., Nadeem, M., Malek‐Ahmadi, M. H., & Mufson, E. J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1723-x · Cited by 52 · see citing works

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Ortiz‐Guerrero, G., González-Reyes, R. E., de‐la‐Torre, A., Medina-Rincón, G. J., & Nava-Mesa, M. O. (2020) · Brain Sciences · doi:10.3390/brainsci10060369 · Cited by 46 · see citing works

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Keymoradzadeh, A., Hedayati, M., Abedinzade, M., Gazor, R., Rostampour, M., & Taleghani, B. K. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112814 · Cited by 43 · see citing works

Cellular and molecular influencers of neuroinflammation in Alzheimer's disease: Recent concepts & roles

Ghosh, P., Singh, R. B., Ganeshpurkar, A., Pokle, A. V., Singh, R. B., Singh, S. K., & Kumar, A. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105212 · Cited by 44 · see citing works

Bioactivity-guided isolation of the major anthocyanin from Lycium ruthenicum Murr. fruit and its antioxidant activity and neuroprotective effects in vitro and in vivo

Chen, S., Hu, N., Wang, H., Wu, Y., & Li, G. (2022) · Food & Function · doi:10.1039/d1fo04095b · Cited by 41 · see citing works

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Shin, H. J., Kim, I. S., Choi, S. G., Lee, K., Park, H., Shin, J., Kim, D., Beom, J., Yi, Y. Y., Gupta, D. P., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00715-x · Cited by 42 · see citing works

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Rujeedawa, T., Félez, E. C., Clare, I. C. H., Fortea, J., Strydom, A., Rebillat, A., Coppus, A. M. W., Levin, J., & Zaman, S. H. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10194582 · Cited by 40 · see citing works

TLR7/8 in the Pathogenesis of Parkinson’s Disease

Campolo, M., Filippone, A., Biondo, C., Mancuso, G., Casili, G., Lanza, M., Cuzzocrea, S., Esposito, E., & Paterniti, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249384 · Cited by 36 · see citing works

A Combination of Neurofilament Light, Glial Fibrillary Acidic Protein, and Neuronal Pentraxin-2 Discriminates Between Frontotemporal Dementia and Other Dementias

Bolsewig, K., Hok-A-Hin, Y. S., Sepe, F. N., Boonkamp, L., Jacobs, D., Bellomo, G., Paoletti, F. P., Vanmechelen, E., Teunissen, C. E., Parnetti, L., et al. (2022) · Journal of Alzheimer's Disease · doi:10.3233/jad-220318 · Cited by 36 · see citing works

Circulating microRNAs as novel biomarkers of Alzheimer's disease

Zendjabil, M. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.05.039 · Cited by 36 · see citing works

The emerging role of brain neuroinflammatory responses in Alzheimer’s disease

AmeliMojarad, M., AmeliMojarad, M., & Cui, X. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1391517 · Cited by 33 · see citing works

Aging-related changes in fluid intelligence, muscle and adipose mass, and sex-specific immunologic mediation: A longitudinal UK Biobank study

Klinedinst, B. S., Pappas, C. A., Le, S. T., Yu, S., Wang, Q., Wang, L., Allenspach‐Jorn, K., Mochel, J. P., & Willette, A. A. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.09.008 · Cited by 27 · see citing works

Imidazolylacetophenone oxime-based multifunctional neuroprotective agents: Discovery and structure-activity relationships

Ren, B., Guo, C., Liu, R., Bian, Z.-Y., Liu, R.-C., Huang, L.-F., & Tang, J. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.114031 · Cited by 26 · see citing works

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Xu, G., Fan, L., Zhao, S., & Ouyang, C. (2021) · Bioengineered · doi:10.1080/21655979.2021.1915658 · Cited by 24 · see citing works

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Huang, L., Li, B., Li, X., Liu, G., Liu, R., Guo, J., Xu, B., Li, Y., & Fang, W. (2019) · Current Drug Targets · doi:10.2174/1389450120666190308144448 · Cited by 24 · see citing works

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Guo, T., Zhou, D., Yang, Y., Zhang, X., Chen, G., Lin, B., Sun, Y., Ni, H., Liu, J., Hou, Y., et al. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104338 · Cited by 23 · see citing works

Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience

Walker, K. A., An, Y., Moghekar, A., Moaddel, R., Duggan, M. R., Peng, Z., Tian, Q., Pilling, L. C., Drouin, S. M., Espeland, M. A., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00772-2 · Cited by 21 · see citing works

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Li, J.-G., Chu, J., & Praticò, D. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0268-1 · Cited by 21 · see citing works

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Yang, W., Zhang, Y., Li, Y., Nie, Y., Liang, J., Liu, Y., Liu, J., Zhang, Y., Song, C., Qian, Z., et al. (2020) · Chemistry & Biodiversity · doi:10.1002/cbdv.202000055 · Cited by 18 · see citing works

Common cytokine receptor gamma chain family cytokines activate MAPK, PI3K, and JAK/STAT pathways in microglia to influence Alzheimer’s Disease

Zuppe, H. T., & Reed-Geaghan, E. G. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1441691 · Cited by 20 · see citing works

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Podvin, S., Jones, A. C., Liu, Q., Aulston, B. D., Mosier, C., Ames, J., Winston, C. N., Lietz, C. B., Jiang, Z., O’Donoghue, A. J., et al. (2021) · ACS Omega · doi:10.1021/acsomega.1c00660 · Cited by 16 · see citing works

Hippocampal but Not Serum Cytokine Levels Are Altered by Traffic-Related Air Pollution in TgF344-AD and Wildtype Fischer 344 Rats in a Sex- and Age-Dependent Manner

Patten, K. T., Valenzuela, A. E., Wallis, C., Harvey, D. J., Bein, K. J., Wexler, A. S., Gorin, F. A., & Lein, P. J. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.861733 · Cited by 16 · see citing works

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Liu, H., Reynolds, G. P., & Wei, X. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-191111 · Cited by 15 · see citing works

Neuroprotective effect of tormentic acid against memory impairment and neuro‑inflammation in an Alzheimer's disease mouse model

Cui, W., Sun, C., Ma, Y., Wang, S., Wang, X., & Zhang, Y. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11154 · Cited by 13 · see citing works

Isoflurane preconditioning ameliorates electromagnetic pulse-induced neural damage by shifting microglia polarization toward anti-inflammatory phenotype via upregulation of SOCS1

Zhang, X., Lv, M., Zhu, X., Tian, L., Li, J., Shao, Y., Gao, C., & Sun, X. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2018.12.064 · Cited by 13 · see citing works

TIAM2S ‐positive microglia enhance inflammation and neurotoxicity through soluble ICAM ‐1‐mediated immune priming

Chu, C., Chen, J., Chan, Y., Lu, W., Huang, Y.-T., Mao, P., Sze, C., & Sun, H. S. (2023) · The FASEB Journal · doi:10.1096/fj.202300462rr · Cited by 12 · see citing works

An interventional study of baicalin on neuronal pentraxin-1, neuronal pentraxin-2, and C-reactive protein in Alzheimer’s disease rat model

Zhao, J., Hou, S.-J., Zhao, J., Yu, H., & Duan, S.-R. (2023) · Translational Neuroscience · doi:10.1515/tnsci-2022-0298 · Cited by 8 · see citing works

Inflammatory Cytokines and Cognition in Alzheimer’s Disease and Its Prodrome

Seong, S. J., Kim, K. W., Song, J. Y., Park, K. J., Jo, Y. T., Han, J. H., Yoo, K. H., Jo, H. J., & Hwang, J. Y. (2024) · Psychiatry Investigation · doi:10.30773/pi.2024.0071 · Cited by 8 · see citing works

The Impact of the Exposome on Alzheimer’s Disease: The Influence of Nutrition

Monaco, M., Torazza, C., Fedele, E., & Grilli, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073015 · Cited by 7 · see citing works

Effect of total flavonoids of Dracocephalum moldavica L . On neuroinflammation in Alzheimer's disease model amyloid-β (Aβ1-42)-peptide-induced astrocyte activation

Ren, W., Yan, X.-S., Fan, J.-C., Huo, D.-S., Wang, X., Jia, J., & Yang, Z.-J. (2024) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2024.2336570 · Cited by 7 · see citing works

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Sevilla, R. M. R., López‐Espuela, F., Fuentes, J. M., Juan, B. D. D. S., Portilla-Cuenca, J. C., Hijón, C. C., & Naranjo, I. C. (2022) · Current Alzheimer Research · doi:10.2174/1567205019666220127102640 · Cited by 6 · see citing works

Inhibition of neuronal pentraxin 2 relieved epileptic seizure via reducing GluA1 phosphorylation

Xing, M., Yang, X., Jin, S., & Xu, X. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4003 · Cited by 4 · see citing works

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Jiménez-Pareyón, G. R., Cristóbal-Luna, J. M., García-Martínez, Y., Garfias-Noguez, C., Damián, M. R., Torres-Maravilla, E., & Sánchez-Pardo, M. E. (2025) · Microorganisms · doi:10.3390/microorganisms13122718 · Cited by 3 · see citing works

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Zou, W., & Li, J. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020602 · Cited by 3 · see citing works

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Wu, M., Chen, Y., Yao, W., Zhou, S., Xie, Z., Tao, Y., Zhong, Y., & Ma, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-91785-4 · Cited by 3 · see citing works

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AmeliMojarad, M., AmeliMojarad, M., & Cui, X. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102615 · Cited by 4 · see citing works

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Zhou, J., Li, X., Wang, X., Yang, Y., Nai, A., Shi, H., Zhao, J., Zhang, J., Ding, S., Han, Y. K., et al. (2024) · Psychopharmacology · doi:10.1007/s00213-023-06515-3 · Cited by 2 · see citing works

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Li, J., Ma, W., & Gu, S. (2025) · Brain and Behavior · doi:10.1002/brb3.70305 · Cited by 2 · see citing works

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Berg, A. P., Tariq, S. H., Flores, C. C., Lefton, M., Owada, Y., Davis, C. J., Ferraro, T. N., Jacobs, J., Gritsenko, M. A., Lee, Y., et al. (2025) · Neuroglia · doi:10.3390/neuroglia6030033 · Cited by 1 · see citing works

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Jiangping, W., & Shijun, X. (2019) · International Journal of Neurology and Neurotherapy · doi:10.23937/2378-3001/1410084

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Ayala, D. (2019) · UA Campus Repository (The University of Arizona)

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Lim, B. (2020) · TSpace (University of Toronto)

Síntese e avaliação da citotoxicidade de chalconas e derivados com efeito inibitório sobre acetilcolinesterase e beta-secretase (BACE-1)ß

Antoniolli, G. (2018) · doi:10.47749/t/unicamp.2018.1126989

Investigation and description of the New Brain and New Mind hypotheses

Klinedinst, B. S. (2021) · doi:10.31274/td-20240329-457

Induction of endogenous IL-10 promotes resolution and tolerance of nitric oxide in microglia

Kuo, H., Chen, J., Chao, C., Lee, K.-F., Huang, Y.-T., Mao, P., Lin, T.-C., Chiu, S.-C., Huang, Y.-L., & Chu, C. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101094

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Guimarães, G. M., Cazarin, C. A., Bernadina, J. G., Eisendecker, H. I., dos Santos, A. C., Dalmagro, A. P., Harle, M., Vieira, M. E., Malheiros, Â., Filho, V. C., et al. (2025) · Exploration of neuroscience · doi:10.37349/en.2025.1006109

Additional file 2 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease

Shin, H. J., Kim, I. S., Choi, S. G., Lee, K., Park, H., Shin, J., Kim, D., Beom, J., Yi, Y. Y., Gupta, D. P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25424802

Additional file 9 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease

Shin, H. J., Kim, I. S., Choi, S. G., Lee, K., Park, H., Shin, J., Kim, D., Beom, J., Yi, Y. Y., Gupta, D. P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26694294

Additional file 3 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease

Shin, H. J., Kim, I. S., Choi, S. G., Lee, K., Park, H., Shin, J., Kim, D., Beom, J., Yi, Y. Y., Gupta, D. P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26694276

Additional file 1 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease

Shin, H. J., Kim, I. S., Choi, S. G., Lee, K., Park, H., Shin, J., Kim, D., Beom, J., Yi, Y. Y., Gupta, D. P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25424750

Additional file 6 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease

Shin, H. J., Kim, I. S., Choi, S. G., Lee, K., Park, H., Shin, J., Kim, D., Beom, J., Yi, Y. Y., Gupta, D. P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26694285

Additional file 4 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease

Shin, H. J., Kim, I. S., Choi, S. G., Lee, K., Park, H., Shin, J., Kim, D., Beom, J., Yi, Y. Y., Gupta, D. P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26694279

Additional file 8 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease

Shin, H. J., Kim, I. S., Choi, S. G., Lee, K., Park, H., Shin, J., Kim, D., Beom, J., Yi, Y. Y., Gupta, D. P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26694291

Additional file 5 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease

Shin, H. J., Kim, I. S., Choi, S. G., Lee, K., Park, H., Shin, J., Kim, D., Beom, J., Yi, Y. Y., Gupta, D. P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26694282

Additional file 7 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease

Shin, H. J., Kim, I. S., Choi, S. G., Lee, K., Park, H., Shin, J., Kim, D., Beom, J., Yi, Y. Y., Gupta, D. P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26694288

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Mierzwa, N., & Wężyk, M. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106858

Effects on cognition of regional astrogliosis assessed by 18F-SMBT-1 PET in non- demented individualsPreprint

Tirado, L. A. R., Cohen, A. D., Lopresti, B. J., Ikonomović, M. D., Gogola, A., Matan, C., Zeng, X., Karikari, T. K., López, O. L., Snitz, B. E., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10449518/v1

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Wu, D., Lin, Y., Guo, W., Wang, Z., Chang, Y., Yan, J., Han, D., Xiang, K., & Yang, Z. (2026) · Experimental Brain Research · doi:10.1007/s00221-026-07364-0

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Feng, J., Xie, W., Lu, H., Tian, L., Shi, X., Huang, J., Zeng, X., Yichi, Z., Zhao, M., Cheng, B., et al. (2026) · Current Microbiology · doi:10.1007/s00284-026-05170-z

BindingDB Entry 50017548: Imidazolylacetophenone oxime-based multifunctional neuroprotective agents: Discovery and structure-activity relationships.

BindingDB (2023) · UC San Diego · doi:10.7270/q21g0rbb

Pentraxins and Alzheimer's disease: At the interface between biomarkers and pharmacological targets

Osera, C., Pascale, A., Amadio, M., Venturini, L., Govoni, S. M., & Ricevuti, G. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.004 · Cited by 30 · see citing works

The potential role of proinflammatory and antiinflammatory cytokines in Alzheimer disease pathogenesis

Azizi, G., & Mirshafiey, A. (2012) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2012.705292 · Cited by 72 · see citing works

The dual roles of cytokines in Alzheimer’s disease: update on interleukins, TNF-α, TGF-β and IFN-γ

Zheng, C., Zhou, X.-W., & Wang, J.-Z. (2016) · Translational Neurodegeneration · doi:10.1186/s40035-016-0054-4 · Cited by 292 · see citing works

Characterization of inflammatory biomarkers and candidates for diagnosis of Alzheimer’s disease

Bagyinszky, E., Youn, Y. C., An, S. S. A., & Kim, S. (2014) · BioChip Journal · doi:10.1007/s13206-014-8301-1 · Cited by 12 · see citing works

Cytokines as messengers of neuroimmune interactions

Luheshi, G. N., Hammond, E., & van Dam, A. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)89618-4 · Cited by 9 · see citing works