DYRK1A Regulates the Bidirectional Axonal Transport of APP in Human-Derived Neurons

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

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Organogenesis in a dish: Modeling development and disease using organoid technologies

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Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer’s Disease

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Amyloid Precursor Protein Trafficking, Processing, and Function

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Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease

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Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

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Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

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APP processing is regulated by cytoplasmic phosphorylation

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Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo

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The role of DYRK1A in neurodegenerative diseases

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The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between β-amyloid production and tau phosphorylation in Alzheimer disease

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Axonal Membrane Proteins Are Transported in Distinct Carriers: A Two-Color Video Microscopy Study in Cultured Hippocampal Neurons

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Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

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The Mechanochemistry of Molecular Motors

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Amyloid precursor protein promotes post‐developmental neurite arborization in the Drosophila brain

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Dual‐specificity tyrosine(Y)‐phosphorylation regulated kinase 1A‐mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer’s disease

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Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells.

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Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation

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Force measurements on cargoes in living cells reveal collective dynamics of microtubule motors

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β-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites

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The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes

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A combinatorial MAP code dictates polarized microtubule transport

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Dyrk1A Overexpression Inhibits Proliferation and Induces Premature Neuronal Differentiation of Neural Progenitor Cells

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Microtubule Organization Determines Axonal Transport Dynamics

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DYRK1A haploinsufficiency causes a new recognizable syndrome with microcephaly, intellectual disability, speech impairment, and distinct facies

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Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system

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Dyrk1 inhibition improves Alzheimer's disease‐like pathology

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Chromatin-wide Profiling of DYRK1A Reveals a Role as a Gene-Specific RNA Polymerase II CTD Kinase

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Regulation of Axonal Transport by Protein Kinases

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Measuring Molecular Motor Forces In Vivo: Implications for Tug-of-War Models of Bidirectional Transport

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The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

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Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate

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Effects of harmine, an acetylcholinesterase inhibitor, on spatial learning and memory of APP/PS1 transgenic mice and scopolamine-induced memory impairment mice

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The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system

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Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis

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Normalizing the gene dosage of Dyrk1A in a mouse model of down syndrome rescues several Alzheimer’s disease phenotypes

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αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease

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Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A) Modulates Serine/Arginine-rich Protein 55 (SRp55)-promoted Tau Exon 10 Inclusion

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Dyrk1A Influences Neuronal Morphogenesis Through Regulation of Cytoskeletal Dynamics in Mammalian Cortical Neurons

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Harmine stimulates proliferation of human neural progenitors

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MAP7 regulates organelle transport by recruiting kinesin-1 to microtubules

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The down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4

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Tau pathology reduction with SM07883, a novel, potent, and selective oral DYRK1A inhibitor: A potential therapeutic for Alzheimer's disease

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Kinesin-1 Motors Can Circumvent Permanent Roadblocks by Side-Shifting to Neighboring Protofilaments

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The Drosophila Homologue of the Amyloid Precursor Protein Is a Conserved Modulator of Wnt PCP Signaling

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Kinesin and dynein use distinct mechanisms to bypass obstacles

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MNB/DYRK1A phosphorylation regulates the interactions of synaptojanin 1 with endocytic accessory proteins

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Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing

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Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function

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Phosphorylation of Amyloid Precursor Protein at Threonine 668 Is Essential for Its Copper-responsive Trafficking in SH-SY5Y Neuroblastoma Cells

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Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies

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Dyrk1A Binds to Multiple Endocytic Proteins Required for Formation of Clathrin-Coated Vesicles

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Chronic Dyrk1 Inhibition Delays the Onset of AD-Like Pathology in 3xTg-AD Mice

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Phosphorylation by Dyrk1A of Clathrin Coated Vesicle-Associated Proteins: Identification of the Substrate Proteins and the Effects of Phosphorylation

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Overexpression of Dyrk1A Causes the Defects in Synaptic Vesicle Endocytosis

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The Amyloid Precursor Protein Is a Conserved Receptor for Slit to Mediate Axon Guidance

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UV Irradiation Accelerates Amyloid Precursor Protein (APP) Processing and Disrupts APP Axonal Transport

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Neprilysin Is Suppressed by Dual-Specificity Tyrosine-Phosphorylation Regulated Kinase 1A (DYRK1A) in Down-Syndrome-Derived Fibroblasts

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Competition between microtubule-associated proteins directs motor transportPreprint

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Proteasome stress leads to APP axonal transport defects by promoting its amyloidogenic processing in lysosomes

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Down syndrome phenotype in a boy with a mosaic microduplication of chromosome 21q22

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Imaging Amyloid Precursor Protein In Vivo: An Axonal Transport Assay

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Increased activity of mitochondrial respiratory chain complex in noise-damaged rat cochlea

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Methods for Quantitative Analysis of Axonal Cargo Transport

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Tau Isoforms Imbalance Impairs the Axonal Transport of the Amyloid Precursor Protein in Human Neurons

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Proteomic changes induced by harmine in human brain organoids reveal signaling pathways related to neuroprotectionPreprint

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Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies.

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The Omnipresence of DYRK1A in Human Diseases

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Gene Dosage-Dependent Association of DYRK1A With the Cytoskeleton in the Brain and Lymphocytes of Down Syndrome Patients

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Overexpression of Dyrk1A contributes to neurofibrillary degeneration in down syndrome

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Systematic diversification of benzylidene heterocycles yields novel inhibitor scaffolds selective for Dyrk1A, Clk1 and CK2

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Targeting trisomic treatments: optimizing Dyrk1a inhibition to improve Down syndrome deficits

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Enhanced -secretase processing alters APP axonal transport and leads to axonal defects

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