The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
NGF Is Essential for Hippocampal Plasticity and Learning
Open accessAbstract
Nerve growth factor (NGF) is produced in the hippocampus throughout life and is retrogradely trafficked to septal cholinergic neurons, providing a potential mechanism for modulating cholinergic inputs and, thereby, hippocampal plasticity. To explore NGF modulation of hippocampal plasticity and function, NGF levels were augmented or blocked in intact adult rats, and subsequent in vivo effects on cholinergic neurons, hippocampal long-term potentiation (LTP), and learning were examined. NGF augmentation significantly enhanced cholinergic neuronal markers and facilitated induction of hippocampal LTP. Blockade of endogenous NGF significantly reduced hippocampal LTP and impaired retention of spatial memory. These findings reveal an essential role for NGF in regulating biological mechanisms related to plasticity and memory in the intact adult brain.
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“NGF has been implicated in proliferation and differentiation of neuronal stem cells (Cattaneo and McKay 1990) and more recently in neurogenesis in the striatum (Frielingsdorf et al. 2007; Zhu et al. 2011) and in regulating hippocampal plasticity (Conner et al. 2009).”
From Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression (2018) · cites this paper as Conner et al. 2009
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Metadata
- Authors
- Conner, J. M., Franks, K. M., Titterness, A. K., Russell, K., Merrill, D. A., Christie, B. R., Sejnowski, T. J., & Tuszynski, M. H.
- Affiliations
- University of California San Diego (US)
- Salk Institute for Biological Studies (US)
- University of British Columbia (CA)
- Corresponding author
- Tuszynski, Mark H.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-09-02
- Volume
- 29
- Issue
- 35
- Pages
- 10883-10889
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2765804
- OpenAlex
- W2069958148
- Cited by
- 189
- References
- 61
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 8 · 2023: 8 · 2022: 10 · 2021: 17 · 2020: 17 · 2019: 12 · 2018: 13 · 2017: 18 · 2016: 8 · 2015: 8 · 2014: 17 · 2013: 17 · 2012: 9
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Alzheimer's Association
- National Institutes of Health (5r01ns037083-03, AG05131, AG10435)
- Canadian Institutes of Health Research
- National Institute on Aging (P01AG010435, AG05131, P50AG005131, AG10435)
- National Institute of Neurological Disorders and Stroke (NS 37083)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nerve growth factor, hippocampal plasticity, hippocampal long-term potentiation, spatial memory, cholinergic neurons, learning, memory retention
- MeSH terms
- Animals, Female, Hippocampus, Learning, Memory, Synaptic Transmission, Neuronal Plasticity, Rats, Inbred F344, Long-Term Potentiation, Nerve Growth Factor, Rats
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