NGF Is Essential for Hippocampal Plasticity and Learning

A synaptic model of memory: long-term potentiation in the hippocampus

Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566

Developments of a water-maze procedure for studying spatial learning in the rat

Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,015

Trk Receptors: Roles in Neuronal Signal Transduction

Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537

A rapid radiochemical method for the determination of choline acetyltransferase

Fonnum, F. (1975) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1975.tb11895.x · Cited by 2,358

The Neurobiology of Consolidations, Or, How Stable is the Engram?

Dudai, Y. (2004) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.142050 · Cited by 1,671

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

Hefti, F. F. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02155.1986 · Cited by 1,445

Retrograde amnesia and memory consolidation: a neurobiological perspective

Squire, L. R., & Alvarez, P. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80023-9 · Cited by 1,412

Long-Lasting Neurotrophin-Induced Enhancement of Synaptic Transmission in the Adult Hippocampus

Kang, H., & Schuman, E. M. (1995) · Science · doi:10.1126/science.7886457 · Cited by 1,354

Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.

Williams, L. R., Varon, S. S., Peterson, G. M., Wictorin, K., Fischer, W., Björklund, A., & Gage, F. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.23.9231 · Cited by 1,055

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

Fischer, W., Wictorin, K., Björklund, A., Williams, L., Varon, S. S., & Gage, F. H. (1987) · Nature · doi:10.1038/329065a0 · Cited by 1,024

NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms

Malenka, R. C., & Nicoll, R. A. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90197-t · Cited by 904

BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?

Lü, Y., Christian, K. M., & Lu, B. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.018 · Cited by 807

Heightened synaptic plasticity of hippocampal CA1 neurons during a Cholinergically induced rhythmic state

Huerta, P. T., & Lisman, J. E. (1993) · Nature · doi:10.1038/364723a0 · Cited by 564

Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system.

Whittemore, S. R., Ebendal, T., Lärkfors, L., Olson, L., Seiger, Å., Strömberg, I., & Persson, H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.3.817 · Cited by 522

Long-term potentiation in the dentate gyrus is induced preferentially on the positive phase of θ-rhythm

Pavlides, C., Greenstein, Y. J., Grudman, M., & Winson, J. (1988) · Brain Research · doi:10.1016/0006-8993(88)91499-0 · Cited by 485

Nerve Growth Factor Gene Expression in the Developing Rat Brain

Large, T. H., Bodary, S. C., Clegg, D., Weskamp, G., Otten, U., & Reichardt, L. F. (1986) · Science · doi:10.1126/science.3764415 · Cited by 435

Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor

Wiley, R. G., Oeltmann, T. N., & Lappi, D. A. (1991) · Brain Research · doi:10.1016/0006-8993(91)91199-b · Cited by 417

Nerve growth factor (NGF) in the rat CNS: Absence of specific retrograde axonal transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra

Schwab, M. E., Otten, U., Agid, Y., & Thoenen, H. (1979) · Brain Research · doi:10.1016/0006-8993(79)90303-2 · Cited by 416

Stimulation in Hippocampal Region CA1 in Behaving Rats Yields Long-Term Potentiation when Delivered to the Peak of Theta and Long-Term Depression when Delivered to the Trough

Hyman, J. M., Wyble, B., Goyal, V., Rossi, C. A., & Hasselmo, M. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-37-11725.2003 · Cited by 404

Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor

Heckers, S., Ohtake, T., Wiley, R. G., Lappi, D., Geula, C., & Mesulam, M. M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01271.1994 · Cited by 401

p140trk mRNA marks NGF-responsive forebrain neurons: Evidence that trk gene expression is induced by NGF

Holtzman, D. M., Li, Y., Parada, L. F., Kinsman, S. L., Chen, C.-K., Valletta, J. S., Zhou, J., Long, J. B., & Mobley, W. C. (1992) · Neuron · doi:10.1016/0896-6273(92)90184-f · Cited by 367

Lesions of the Basal Forebrain Cholinergic System Impair Task Acquisition and Abolish Cortical Plasticity Associated with Motor Skill Learning

Conner, J. M., Culberson, A., Packowski, C., Chiba, A. A., & Tuszynski, M. H. (2003) · Neuron · doi:10.1016/s0896-6273(03)00288-5 · Cited by 352

TrkA‐immunoreactive profiles in the central nervous system: Colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin

Sobreviela, T., Clary, D. O., Reichardt, L. F., Brandabur, M. M., Kordower, J. H., & Mufson, E. J. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903500407 · Cited by 324

Survival of Adult Basal Forebrain Cholinergic Neurons After Loss of Target Neurons

Sofroniew, M. V., Galletly, N. P., Ole Isacson, A., & Svendsen, C. N. (1990) · Science · doi:10.1126/science.1688664 · Cited by 284

Nerve growth factor infusion in the primate brain reduces lesion- induced cholinergic neuronal degeneration

Tuszynski, M. H., U, H., Amaral, D., & Gage, F. H. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-11-03604.1990 · Cited by 281

Agonists of cholinergic and noradrenergic receptors facilitate synergistically the induction of long-term potentiation in slices of rat visual cortex

Bröcher, S., Artola, A., & Singer, W. (1992) · Brain Research · doi:10.1016/0006-8993(92)90110-u · Cited by 272

NGF receptor reexpression and NGF-mediated cholinergic neuronal hypertrophy in the damaged adult neostriatum

Gage, F. H., Batchelor, P., Chen, K. S., Chin, D. E., Higgins, G. A., Koh, S., Deputy, S. R., Rosenberg, M. B., Fischer, W., & Björklund, A. (1989) · Neuron · doi:10.1016/0896-6273(89)90184-0 · Cited by 240

Cholinergic modulation of activity-dependent synaptic plasticity in the piriform cortex and associative memory function in a network biophysical simulation

Hasselmo, M. E., & Barkai, E. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06592.1995 · Cited by 215

Acute Intrahippocampal Infusion of BDNF Induces Lasting Potentiation of Synaptic Transmission in the Rat Dentate Gyrus

Messaoudi, E., Bårdsen, K., Srebro, B., & Bramham, C. R. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.1.496 · Cited by 208

Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus

Blitzer, R. D., Gil, O., & Landau, E. M. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90835-w · Cited by 192

Human nerve growth factor improves spatial memory in aged but not in young rats

Markowska, A. L., Koliatsos, V., Breckler, S., Price, D., & Olton, D. S. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-04815.1994 · Cited by 190

TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons

Holtzman, D. M., Kilbridge, J. F., Li, Y., Cunningham, E. T., Lenn, N., Clary, D. O., Reichardt, L. F., & Mobley, W. C. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-02-01567.1995 · Cited by 190

Muscarinic receptor activation facilitates the induction of long-term potentiation (LTP) in the rat dentate gyrus

Burgard, E. C., & Sarvey, J. M. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90382-j · Cited by 188

Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey

Koliatsos, V., Nauta, H. J. W., Clatterbuck, R. E., Holtzman, D. M., Mobley, W. C., & Price, D. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-12-03801.1990 · Cited by 170

A novel cholinergic induction of long-term potentiation in rat hippocampus

Auerbach, J. M., & Segal, M. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.4.2034 · Cited by 166 · cited 1×

Somatic gene transfer of NGF to the aged brain: behavioral and morphological amelioration

Chen, K., & Gage, F. H. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-04-02819.1995 · Cited by 165

Nerve growth factor-induced synaptogenesis and hypertrophy of cortical cholinergic terminals.

Garofalo, L., Ribeiro‐da‐Silva, A., & Cuello, A. C. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.2639 · Cited by 163

Endogenous acetylcholine lowers the threshold for long‐term potentiation induction in the CA1 area through muscarinic receptor activation: in vivo study

Ovsepian, S. V., Anwyl, R., & Rowan, M. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03582.x · Cited by 154

Systemic Administration of a Nerve Growth Factor Conjugate Reverses Age-Related Cognitive Dysfunction and Prevents Cholinergic Neuron Atrophy

Bäckman, C. M., Rose, G. M., Hoffer, B. J., Henry, M. A., Bartus, R. T., Friden, P. M., & Granholm, A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-17-05437.1996 · Cited by 140

Muscarinic receptors involved in hippocampal plasticity

Segal, M., & Auerbach, J. M. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00051-9 · Cited by 107

Effect of anticholinergic drug on long-term potentiation in rat hippocampal slices

Hirotsu, I., Hori, N., Katsuda, N., & Ishihara, T. (1989) · Brain Research · doi:10.1016/0006-8993(89)90561-1 · Cited by 107

192 IgG-saporin : I. Specific Lethality for Cholinergic Neurons in the Basal Forebrain of the Rat

Book, A. A., Wiley, R. G., & Schweitzer, J. B. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199401000-00012 · Cited by 105

The substrates of memory: Defects, treatments, and enhancement

LYNCH, G. S., Rex, C. S., Chen, L. Y., & Gall, C. M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.082 · Cited by 103

Acetylcholine synthesis and release following continuous intracerebral administration of NGF in adult and aged Fischer-344 rats

Rylett, R. J., Goddard, S., Schmidt, B., & Williams, L. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03956.1993 · Cited by 101

Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery.

Tuszynski, M. H., & Gage, F. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4621 · Cited by 99

Exogenous Nerve Growth Factor Increases the Activity of High‐Affinity Choline Uptake and Choline Acetyltransferase in Brain of Fisher 344 Male Rats

Williams, L. R., & Rylett, R. J. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04594.x · Cited by 95

Nerve growth factor increases extracellular acetylcholine levels in the parietal cortex and hippocampus of aged rats and restores object recognition

Scali, C., Casamenti, F., Pazzagli, M., Bartolini, L., & Pepeu, G. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90253-4 · Cited by 78

Distribution of nerve growth factor‐like immunoreactive neurons in the adult rat brain following colchicine treatment

Conner, J. M., & Varon, S. S. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903260304 · Cited by 76

Elevation of Nerve Growth Factor and Antisense Knockdown of TrkA Receptor during Contextual Memory Consolidation

Woolf, N. J., Milov, A. M., Schweitzer, E. S., & Roghani, A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-03-01047.2001 · Cited by 68

NGF Deprivation of Adult Rat Brain Results in Cholinergic Hypofunction and Selective Impairments in Spatial Learning

der Zee, C. E. E. M. V., Lourenssen, S. R., Stanisz, J., & Diamond, J. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01030.x · Cited by 59

Activation of TrkA by nerve growth factor upregulates expression of the cholinergic gene locus but attenuates the response to ciliary neurotrophic growth factor

Berse, B., López-Coviella, I., & Blusztajn, J. K. (1999) · Biochemical Journal · doi:10.1042/bj3420301 · Cited by 50

Evidence that nerve growth factor plays a role in long-term potentiation in the rat dentate gyrus

Kelly, A. M., Conroy, S., & Lynch, M. A. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00048-3 · Cited by 39

Gene-experience interaction alters the cholinergic septohippocampal pathway of mice

Brooks, A. I., Cory‐Slechta, D. A., & Federoff, H. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.230169397 · Cited by 32

Memory impairment and neural dysfunction after continuous infusion of anti-nerve growth factor antibody into the septum in adult rats

Nitta, A., Murase, K., Furukawa, Y., Hayashi, K., Hasegawa, T., & Nabeshima, T. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90001-v · Cited by 31

Chronic intraventricular infusion with NGF improves LTP in old cognitively-impaired rats

Bergado, J. A., Fernández, C. I., Gómez-Soria, A. A., & González, O. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00610-0 · Cited by 29

Modulation of long‐term potentiation by individual subtypes of muscarinic acetylcholine receptor in the rat dentate gyrus

Luo, L., Chen, W., Wang, M., Zhu, D., She, J., & Ruan, D. (2008) · Hippocampus · doi:10.1002/hipo.20461 · Cited by 29

Dose-dependent responses to nerve growth factor by adult rat cholinergic medial septum and neostriatum neurons

Vahlsing, H. L., Hagg, T., Spencer, M., Conner, J. M., Manthorpe, M., & Varon, S. S. (1991) · Brain Research · doi:10.1016/0006-8993(91)90098-g · Cited by 28

Characterization of antibodies to nerve growth factor: assay-dependent variability in the cross-reactivity with other neurotrophins

Conner, J., & Varon, S. (1996) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(95)00151-4 · Cited by 26

Activation of TrkA by nerve growth factor upregulates expression of the cholinergic gene locus but attenuates the response to ciliary neurotrophic growth factor

Berse, B., López-Coviella, I., & Blusztajn, J. K. (1999) · Biochemical Journal · doi:10.1042/0264-6021:3420301 · Cited by 21

Memory Impairment and Neural Dysfunction after Continuous Infusion of Anti-Nerve Growth Factor Antibody into the Septum in Adult Rats.

Nitta, Atsumi, Murase, Katsuhito, Furukawa, Yoshiko, Hayashi, K., Kyozo, Hasegawa, Takaaki, et al. (1994) · 岐阜藥科大學紀要 = The annual proceedings of Gifu College of Pharmacy · Cited by 10

Cholinergic Lesions as a Model of Alzheimer’s Disease

Conner, J. M., & Tuszynski, M. H. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-691-1_3 · Cited by 2

Immune modulation of learning, memory, neural plasticity and neurogenesis

Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483

Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

Agrawal, M., Saraf, S., Saraf, S., Antimisiaris, S. G., Chougule, M. B., Shoyele, S. A., & Alexander, A. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.05.011 · Cited by 630

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

Levy, M. J. F., Boulle, F., Steinbusch, H. W., van den Hove, D. L. A., Kenis, G., & Lanfumey, L. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4950-4 · Cited by 308

The role of cytokines in modulating learning and memory and brain plasticity

Bourgognon, J.-M., & Cavanagh, J. (2020) · Brain and Neuroscience Advances · doi:10.1177/2398212820979802 · Cited by 262

Encephalopathies: the emerging diabetic complications

Sima, A. A. F. (2010) · Acta Diabetologica · doi:10.1007/s00592-010-0218-0 · Cited by 189

Development/Plasticity/Repair NGF Is Essential for Hippocampal Plasticity and Learning

Conner, J. M., Franks, K. M., Titterness, A. K., Russell, K., Merrill, D. A., Christie, B. R., B, T. J. S. A., & Tuszynski, M. H. (2009)

Nerve growth factor inhibits the expression of long-term potentiation in hippocampal slices

Tancredi, V., D’Arcangelo, G., Mercanti, D., & Calissano, P. (1993) · Neuroreport · doi:10.1097/00001756-199302000-00008 · Cited by 17

Protective Effect of Nerve Growth Factor in the Hippocampus against Disturbances in Synaptic Plasticity Caused by Cholinergic Deficit

Volobueva, Y. E., Dobryakova, Y. V., Bolshakov, A. P., & Markevich, V. A. (2022) · Neurochemical Journal · doi:10.1134/s1819712422020155 · Cited by 1

Short- and Long-term Memory are Differentialy Modulated by Hippocampal Nerve Growth Factor and Fibroblast Growth Factor

Walz, R., Roesler, R., Reinke, A., Martins, M. R., Quevedo, J., & Izquierdo, I. (2005) · Neurochemical Research · doi:10.1007/s11064-004-2440-z · Cited by 11

Chronic intracerebroventricular infusion of nerve growth factor improves recognition memory in the rat

Birch, A. M., & Kelly, A. M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.023 · Cited by 38