The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Dichotomous Anatomical Properties of Adult Striatal Medium Spiny Neurons
Open accessAbstract
Principal medium spiny projection neurons (MSNs) of the striatum have long been thought to be homogeneous in their somatodendritic morphology and physiology. Recent work using transgenic mice, in which the two major classes of MSN are labeled, has challenged this assumption. To explore the basis for this difference, D 1 and D 2 receptor-expressing MSNs (D 1 and D 2 MSNs) in brain slices from adult transgenic mice were characterized electrophysiologically and anatomically. These studies revealed that D 1 MSNs were less excitable than D 2 MSNs over a broad range of developmental time points. Although M 1 muscarinic receptor signaling was a factor, it was not sufficient to explain the dichotomy between D 1 and D 2 MSNs. Reconstructions of biocytin-filled MSNs revealed that the physiological divergence was paralleled by a divergence in total dendritic area. Experimentally grounded simulations suggested that the dichotomy in MSN dendritic area was a major contributor to the dichotomy in electrophysiological properties. Thus, rather than being an intrinsically homogenous population, striatal MSNs have dichotomous somatodendritic properties that mirror differences in their network connections and biochemistry.
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BackgroundSelf-citationEndocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models
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Cited by
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Dopaminergic modulation of synaptic transmission in cortex and striatum
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Distinct Roles of GABAergic Interneurons in the Regulation of Striatal Output Pathways
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The Basal Ganglia Over 500 Million Years
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Metadata
- Authors
- Gertler, T. S., Chan, C. S., & Surmeier, D. J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-10-22
- Volume
- 28
- Issue
- 43
- Pages
- 10814-10824
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2020887697
- Cited by
- 471
- References
- 9
- FWCI
- 11.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gertler, T. S., Chan, C. S., & Surmeier, D. J. (2008). Dichotomous Anatomical Properties of Adult Striatal Medium Spiny Neurons. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.2660-08.2008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
