The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Retrograde Regulation of GABA Transmission by the Tonic Release of Oxytocin and Endocannabinoids Governs Postsynaptic Firing
Open accessAbstract
The probability of neurotransmitter release at the nerve terminal is an important determinant of synaptic efficacy. At some central synapses, the postsynaptic, or target, neuron determines neurotransmitter release probability (Pr) at the presynaptic terminal. The mechanisms responsible for this target-cell dependent control of Pr have not been elucidated. Using whole-cell patch-clamp recordings from magnocellular neurosecretory cells in the paraventricular and supraoptic nuclei of the hypothalamus, we demonstrate that inhibitory, GABA synapses specifically onto oxytocin (OT)-producing neurosecretory cells exhibit a low Pr that is relatively uniform at multiple synapses onto the same cell. This low Pr results from a two-step process that requires the tonic release of OT from the postsynaptic cell. The ambient extracellular levels of neuropeptide are sufficient to activate postsynaptic OT receptors and trigger the Ca 2+-dependent production of endocannabinoids, which act in a retrograde manner at presynaptic cannabinoid CB 1 receptors to decrease GABA release. The functional consequence of this tonic inhibition of GABA release is that all inhibitory inputs facilitate uniformly when activated at high rates of activity. This causes inhibition in the postsynaptic cell that is sufficiently powerful to disrupt firing. Blockade of CB 1 receptors increases Pr at these synapses, resulting in a rapid depression of IPSCs at high rates of activity, thereby eliminating the ability of afferent inputs to inhibit postsynaptic firing. By playing a deterministic role in GABA release at the afferent nerve terminal, the postsynaptic OT neuron effectively filters synaptic signals and thereby modulates its own activity patterns.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“oxytocin signalling controls the probability of presynaptic GABA release through the postsynaptic release of endocannabinoids and the activation of presynaptic CB1 receptors50.”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
Synaptic depression and cortical gain control
Abbott, L. F., Varela, J. A., Sen, K., & Nelson, S. B. (1997) · Science · doi:10.1126/science.275.5297.221 · Cited by 1,690
Abbott, L. F., & Regehr, W. G. (2004) · Nature · doi:10.1038/nature03010 · Cited by 1,684
Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
Wilson, R. I., & Nicoll, R. A. (2001) · Nature · doi:10.1038/35069076 · Cited by 1,607
Tsodyks, M. V., & Markram, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.719 · Cited by 1,607
Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex
Gupta, A., Wang, Y., & Markram, H. (2000) · Science · doi:10.1126/science.287.5451.273 · Cited by 1,036
Ohno‐Shosaku, T., Maejima, T., & Kano, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00247-1 · Cited by 874
Redistribution of synaptic efficacy between neocortical pyramidal neurons
Markram, H., & Tsodyks, M. V. (1996) · Nature · doi:10.1038/382807a0 · Cited by 857
Target-cell-specific facilitation and depression in neocortical circuits
Reyes, A., Lujan, R., Rozov, A., Burnashev, N., Somogyi, P., & Sakmann, B. (1998) · Nature Neuroscience · doi:10.1038/1092 · Cited by 716 · cited 2×
“Although targetcell-dependent modulation of GABA release probability has been reported previously (Reyes et al., 1998; Gupta et al., 2000; Rozov et al., 2001; Koester and Johnston, 2005), there have been few descriptions of the mechanisms used by individual postsynaptic neurons to regulate Pr.”
BackgroundHeterosynaptic LTD of Hippocampal GABAergic Synapses
Chevaleyre, V., & Castillo, P. E. (2003) · Neuron · doi:10.1016/s0896-6273(03)00235-6 · Cited by 647
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–106 of 106
Effect of Cannabinoids and Stress on Motor Maps and Behaviour
Scullion, K. (2015) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/25792
The Cell Biology of Oxytocin and Vasopressin Cells
Theodosis, D. T., Voisin, D. L., Poulain, D. A., & Tasker, J. G. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00050-4
Liu, X., Huang, H., Feng, X., Li, X., Ye, J., Yang, H. M., Liu, J., Liang, Z., Guo, Z., Cai, R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.23.677968
Endocannabinoid regulation of hippocampal circuits
Berthoux, C., & Castillo, P. E. (2025) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-443-13908-6.00009-8
Acquired transient vasopressin deficiency by cannabinoids and other substances
Vijayan, M., & Rein, J. L. (2026) · Endocrinology · doi:10.1210/endocr/bqag014
New regulators in oxytocin and vasopressin release : role of the endolysosomal two-pore channels
Martucci, L. L. (2021) · theses.fr (ABES) · doi:10.70675/027d1ae2zd2ebz4677za019ze6ccd94cafe9
Metadata
- Authors
- Oliet, S. H. R., Baimoukhametova, D. V., Piet, R., & Bains, J. S.
- Affiliations
- Inserm (FR)
- University of Calgary (CA)
- Université Bordeaux Segalen (FR)
- Corresponding author
- Bains, Jaideep S.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-02-07
- Volume
- 27
- Issue
- 6
- Pages
- 1325-1333
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673587
- OpenAlex
- W2091992063
- Cited by
- 107
- References
- 64
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 3 · 2015: 7 · 2014: 9 · 2013: 7 · 2012: 8
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fondation pour la Recherche Médicale
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- retrograde regulation, oxytocin, endocannabinoids, CB1 receptor, postsynaptic inhibition, presynaptic inhibition, magnocellular neurosecretory cells, paraventricular nucleus, supraoptic nucleus, hypothalamus, inhibitory synapses
- MeSH terms
- Animals, Calcium, Egtazic Acid, Female, gamma-Aminobutyric Acid, Hypothalamus, Anterior, Male, Morpholines, Naphthalenes, Oxytocin, Paraventricular Hypothalamic Nucleus, Piperidines, Pyrazoles, Rats, Sprague-Dawley, Rats, Wistar, Presynaptic Terminals, Patch-Clamp Techniques, 6-Cyano-7-nitroquinoxaline-2,3-dione, Receptor, Cannabinoid, CB1, Extracellular Fluid, Benzoxazines, Rats, Cannabinoid Receptor Modulators, Endocannabinoids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
