The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Apoptosis-Inducing Factor Triggered by Poly(ADP-Ribose) Polymerase and Bid Mediates Neuronal Cell Death after Oxygen-Glucose Deprivation and Focal Cerebral Ischemia
Open accessAbstract
Delayed neuronal cell death occurring hours after reperfusion is a hallmark of ischemic stroke and a primary target for neuroprotective strategies. In the present study, we investigated whether apoptosis-inducing factor (AIF), a caspase-independent proapoptotic protein, is responsible for neuronal cell death after glutamate toxicity and oxygen-glucose deprivation (OGD)in vitro and after experimental stroke in vivo. AIF translocated to the nucleus in which it colocalized with DNA fragmentation and nuclear apoptotic morphology after exposure to glutamate or OGD in cultured neurons or after transient middle cerebral artery occlusion (MCAo) in mice. Small inhibitory RNA-mediated downregulation of AIF reduced glutamate- and OGD-induced neuronal apoptosis by 37 and 60%, respectively (p< 0.01). Moreover, Harlequin mutant mice, which express AIF at low levels (∼20% of wild-type mice), displayed smaller infarct volumes (-43%;p< 0.03) and showed dramatically reduced cell death in the ischemic penumbra after 45 min of MCAo compared with wild-type littermates. Inhibition of poly(ADP-ribose) polymerase and Bid reduced nuclear AIF translocation. These results provide the first evidence for a causal role of AIF in ischemic neuronal cell death. Therefore, caspase-independent cell death signaling may provide a promising novel target for therapeutic interventions in cerebrovascular diseases.
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Cites
Molecular characterization of mitochondrial apoptosis-inducing factor
Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., et al. (1999) · Nature · doi:10.1038/17135 · Cited by 4,060
Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor
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Apoptotic and antiapoptotic mechanisms in stroke
Mattson, M. P., Culmsee, C., & Yu, Z. F. (2000) · Cell and Tissue Research · doi:10.1007/s004419900154 · Cited by 318
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Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2970 · Cited by 2,382
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Self-citationParthanatos: mitochondrial‐linked mechanisms and therapeutic opportunities
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Wang, Y., Kim, N. S., Haince, J.-F., Kang, H. C., David, K. K., Andrabi, S. A., Poirier, G. G., Dawson, V. L., & Dawson, T. M. (2011) · Science Signaling · doi:10.1126/scisignal.2000902 · Cited by 476
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“AIF is a key in neuronal cell death paradigms, since mice with reduced levels of AIF through siRNA or through the Hq mutation have reduced levels of AIF have decreased infarct size after ischemic injury (51, 56, 65).”
BackgroundMitochondrial membrane permeabilization in neuronal injury
Galluzzi, L., Blomgren, K., & Kroemer, G. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2665 · Cited by 418
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Poly(ADP-ribose) signaling in cell death
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Molecular mechanisms of regulated necrosis
Galluzzi, L., Kepp, O., Krautwald, S., Kroemer, G., & Linkermann, A. (2014) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.02.006 · Cited by 258
Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivo
Lanza, C., Morando, S., Voci, A., Canesi, L., Principato, M. C., Serpero, L. D., Mancardi, G., Uccelli, A., & Vergani, L. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06268.x · Cited by 175
Xu, Z., Zhang, J., David, K. K., Yang, Z.-J., Li, X., Dawson, T. M., Dawson, V. L., & Koehler, R. C. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00747.2009 · Cited by 20
Ryanodine receptor inhibitor dantrolene reduces hypoxic-ischemic brain injury in neonatal mice
Ovcjak, A., Xiao, A., Kim, J.-S., Xu, B., Szeto, V., Turlova, E., Abussaud, A., Chen, N.-H., Miller, S. P., Sun, H.-S., et al. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.113985 · Cited by 16
Metadata
- Authors
- Culmsee, C., Zhu, C., Landshamer, S., Becattini, B., Wagner, E., Pellecchia, M., Blomgren, K., & Plesnila, N.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-11-02
- Volume
- 25
- Issue
- 44
- Pages
- 10262-10272
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2074194694
- Cited by
- 339
- References
- 3
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
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