Cited by 418Cell death mechanisms and regulationMitochondrial Function and PathologyPharmacological Receptor Mechanisms and Effects

Mitochondrial membrane permeabilization in neuronal injury

Galluzzi, Lorenzo, Blomgren, Klas, Kroemer, Guido·2009·Nature Reviews Neuroscience

Abstract

Acute neurological conditions such as cerebrovascular diseases and trauma are associated with irreversible loss of neurons and glial cells. Severe or prolonged injury results in uncontrollable cell death within the core of lesions. Conversely, cells that are less severely damaged succumb in a relatively slow fashion, frequently via the intrinsic pathway of cell death, through the deterioration of mitochondrial functions. The permeabilization of mitochondrial membranes determines whether cells will succumb to or survive the injury, and represents a 'point of no return' in mitochondrial cell death. It is therefore an attractive target for the development of new neuroprotective interventions.

Integrity signals

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Crossref · 10.1038/nrn2665

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189 of 189 references verified0 citation errors · 0 not checkable

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  • RCD is a primary etiological determinant in diseases with irreversible loss of post-mitotic tissues such as myocardial infarction and neurodegeneration.

    “On the one hand, RCD constitutes a primary etiological determinant in diseases associated with the irreversible loss of post-mitotic tissues (e.g., myocardial infarction, neurodegeneration) [687, 752, 851, 869, 1035, 1036].”

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Authors
Galluzzi, L., Blomgren, K., & Kroemer, G.
Affiliations
  • Inserm (FR)
  • Drottning Silvias barn- och ungdomssjukhus (SE)
  • Université Paris-Sud (FR)
Corresponding author
Kroemer, Guido
Venue
Nature Reviews Neuroscience
Published
2009-07
Volume
10
Issue
7
Pages
481-494
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2002091021
Cited by
418
References
188
Citations by year
2026: 8 · 2025: 13 · 2024: 12 · 2023: 18 · 2022: 12 · 2021: 12 · 2020: 18 · 2019: 21 · 2018: 23 · 2017: 33 · 2016: 27 · 2015: 29 · 2014: 34 · 2013: 25 · 2012: 35
FWCI
3.37
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pharmacological Receptor Mechanisms and Effects
Keywords
mitochondrial membrane permeabilization, neuronal injury, neuronal cell death, mitochondrial apoptosis, neuroprotection, cerebrovascular disease, traumatic brain injury, mitochondrial dysfunction
MeSH terms
Animals, Electron Transport, Mitochondria, Necrosis, Neurons, Oxidation-Reduction, Peptide Hydrolases, Permeability, Apoptosis, Molecular Chaperones, Proto-Oncogene Proteins c-bcl-2, Mitogen-Activated Protein Kinases, Mitochondrial Membranes

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