Mitochondrial membrane permeabilization in neuronal injury
Abstract
Acute neurological conditions such as cerebrovascular diseases and trauma are associated with irreversible loss of neurons and glial cells. Severe or prolonged injury results in uncontrollable cell death within the core of lesions. Conversely, cells that are less severely damaged succumb in a relatively slow fashion, frequently via the intrinsic pathway of cell death, through the deterioration of mitochondrial functions. The permeabilization of mitochondrial membranes determines whether cells will succumb to or survive the injury, and represents a 'point of no return' in mitochondrial cell death. It is therefore an attractive target for the development of new neuroprotective interventions.
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RCD is a primary etiological determinant in diseases with irreversible loss of post-mitotic tissues such as myocardial infarction and neurodegeneration.
“On the one hand, RCD constitutes a primary etiological determinant in diseases associated with the irreversible loss of post-mitotic tissues (e.g., myocardial infarction, neurodegeneration) [687, 752, 851, 869, 1035, 1036].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [1035]
Cites
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673 · see citing works
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455 · see citing works
Mitochondrial membrane permeabilization in cell death
Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598 · see citing works
Self-citationClassification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., El-Deiry, W. S., Golstein, P., Green, D. R., et al. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.150 · Cited by 3,399 · see citing works
Self-citationBaines, C. P., Kaiser, R. A., Purcell, N. H., Blair, N. S., Osinska, H., Hambleton, M. A., Brunskill, E. W., Sayen, M. R., Gottlieb, R. A., Dorn, G. W., et al. (2005) · Nature · doi:10.1038/nature03434 · Cited by 2,280 · see citing works
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
Kuida, K., Zheng, T. S., Na, S., Kuan, C.-Y., Yang, D., Karasuyama, H., RAKIC, P. T., & Flavell, R. A. (1996) · Nature · doi:10.1038/384368a0 · Cited by 1,881 · see citing works
p53 Regulates Mitochondrial Respiration
Matoba, S., Kang, J.-G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., & Hwang, P. M. (2006) · Science · doi:10.1126/science.1126863 · Cited by 1,650 · see citing works
Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9
Kuida, K., Haydar, T. F., Kuan, C.-Y., Gu, Y., Taya, C., Karasuyama, H., Su, M. S.-S., Rakic, P., & Flavell, R. A. (1998) · Cell · doi:10.1016/s0092-8674(00)81476-2 · Cited by 1,643 · see citing works
Nakagawa, T., Shimizu, S., Watanabe, T., Yamaguchi, O., Otsu, K., Yamagata, H., Inohara, H., Kubo, T., & Tsujimoto, Y. (2005) · Nature · doi:10.1038/nature03317 · Cited by 1,635 · see citing works
Mechanisms of cytochrome c release from mitochondria
Garrido, C., Galluzzi, L., Brunet, M., Puig, P., Mirjolet, C., & Kroemer, G. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401950 · Cited by 1,394 · see citing works
Self-citationEssential role of the mitochondrial apoptosis-inducing factor in programmed cell death
Joza, N. A., Susín, S. A., Daugas, É., Stanford, W. L., Cho, S. K., Li, C. Y. J., Sasaki, T., Elia, A., Cheng, H.-Y. M., Ravagnan, L., et al. (2001) · Nature · doi:10.1038/35069004 · Cited by 1,365 · see citing works
Self-citationOxidative Phosphorylation at the fin de siècle
Saraste, M. (1999) · Science · doi:10.1126/science.283.5407.1488 · Cited by 1,318 · see citing works
Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development
Yoshida, H., Kong, Y., Yoshida, R., Elia, A., Hakem, A., Hakem, R., Penninger, J. M., & Mak, T. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81733-x · Cited by 1,138 · see citing works
Regulation of autophagy by cytoplasmic p53
Tasdemir, E., Maiuri, M. C., Galluzzi, L., Vitale, I., Djavaheri-Mergny, M., D'Amelio, M., Criollo, A., Morselli, E., Zhu, C., Harper, F., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1730 · Cited by 1,132 · see citing works
Self-citationS-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury
Cho, D.-H., Nakamura, T., Fang, J., Cieplak, P., Godzik, A., Gu, Z., & Lipton, S. A. (2009) · Science · doi:10.1126/science.1171091 · Cited by 1,092 · see citing works
The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
Kokoszka, J. E., Waymire, K. G., Levy, S. E., Sligh, J. E., Cai, J., Jones, D. P., MacGregor, G. R., & Wallace, D. C. (2004) · Nature · doi:10.1038/nature02229 · Cited by 1,086 · see citing works
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis
Lei, K., & Davis, R. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438011100 · Cited by 1,068 · see citing works
Potential therapeutic applications of autophagy
Rubinsztein, D. C., Gestwicki, J. E., Murphy, L. O., & Klionsky, D. J. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2272 · Cited by 1,004 · see citing works
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death
Baines, C. P., Kaiser, R. A., Sheiko, T., Craigen, W. J., & Molkentin, J. D. (2007) · Nature Cell Biology · doi:10.1038/ncb1575 · Cited by 971 · see citing works
The Fas Signaling Pathway: More Than a Paradigm
Wajant, H. (2002) · Science · doi:10.1126/science.1071553 · Cited by 957 · see citing works
Hara, H., Friedlander, R. M., Gagliardini, V., Ayata, C., Fink, K., Huang, Z., Shimizu‐Sasamata, M., Yuan, J., & Moskowitz, M. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.2007 · Cited by 835 · see citing works
Negative regulation of the Apaf-1 apoptosome by Hsp70
Saleh, A., Srinivasula, S. M., Balkir, L., Robbins, P. D., & Alnemri, E. S. (2000) · Nature Cell Biology · doi:10.1038/35019510 · Cited by 823 · see citing works
Schinzel, A. C., Takeuchi, O., Huang, Z., Fisher, J. K., Zhou, Z., Rubens, J., Hetz, C., Danial, N. N., Moskowitz, M. A., & Korsmeyer, S. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505294102 · Cited by 820 · see citing works
Effect of a Novel Free Radical Scavenger, Edaravone (MCI-186), on Acute Brain Infarction
(2003) · Cerebrovascular Diseases · doi:10.1159/000069318 · Cited by 659 · see citing works
AIF deficiency compromises oxidative phosphorylation
Vahsen, N., Candé, C., Brière, J.-J., Bénit, P., Joza, N. A., Larochette, N., Mastroberardino, P. G., Péquignot, M. O., Casares, N., Lazar, V., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600461 · Cited by 622 · see citing works
Self-citationMitochondrial creatine kinase in human health and disease
Schlattner, U., Tokarska-Schlattner, M., & Wallimann, T. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.09.004 · Cited by 617 · see citing works
The harlequin mouse mutation downregulates apoptosis-inducing factor
Klein, J. A., Longo-Guess, C. M., Rossmann, M. P., Seburn, K. L., Hurd, R. E., Frankel, W. N., Bronson, R. T., & Ackerman, S. L. (2002) · Nature · doi:10.1038/nature01034 · Cited by 605 · see citing works
Necroptosis: A Specialized Pathway of Programmed Necrosis
Galluzzi, L., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2008.12.004 · Cited by 561 · cited 1× · see citing works
“(see below) have led to the hypothesis that MPT and MOMP would preferentially regulate necrosis and apoptosis, respectivel”
BackgroundSelf-citationAstrocyte metabolism and signaling during brain ischemia
Rossi, D. J., Brady, J. D., & Mohr, C. (2007) · Nature Neuroscience · doi:10.1038/nn2004 · Cited by 558 · see citing works
Nitric oxide, cell bioenergetics and neurodegeneration
Moncada, S., & Bolaños, J. P. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03988.x · Cited by 556 · see citing works
Cleavage of the Plasma Membrane Na+/Ca2+ Exchanger in Excitotoxicity
Bano, D., Young, K. W., Guérin, C. J., Feuvre, R. A. L., Rothwell, N. J., Naldini, L., Rizzuto, R., Carafoli, E., & Nicotera, P. (2005) · Cell · doi:10.1016/j.cell.2004.11.049 · Cited by 532 · see citing works
Mattiasson, G., Shamloo, M., Gido, G., Mathi, K., Tomasevic, G., Yi, S., Warden, C. H., Castilho, R. F., Melcher, T., Gonzalez-Zulueta, M., et al. (2003) · Nature Medicine · doi:10.1038/nm903 · Cited by 515 · see citing works
Transcription-independent pro-apoptotic functions of p53
Moll, U. M., Wolff, S., Speidel, D., & Deppert, W. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.09.007 · Cited by 468 · see citing works
Synergistic Activation of Caspase-3 by m-Calpain after Neonatal Hypoxia-Ischemia
Blomgren, K., Zhu, C., Wang, X., Karlsson, J., Leverin, A., Bahr, B. A., Mallard, C. E., & Hagberg, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007807200 · Cited by 440 · see citing works
Self-citationInhibitory Phosphorylation of Glycogen Synthase Kinase-3 (GSK-3) in Response to Lithium
Zhang, F., Phiel, C. J., Spece, L. J., Gurvich, N., & Klein, P. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212635200 · Cited by 436 · see citing works
Shimizu, S., Konishi, A., Kodama, T. S., & Tsujimoto, Y. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3100 · Cited by 433 · see citing works
Kondo, T., Reaume, A. G., Huang, T., Carlson, E. J., Murakami, K., Chen, S. F., Hoffman, E. K., Scott, R. W., Epstein, C. J., & Chan, P. H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04180.1997 · Cited by 429 · see citing works
The transcriptional targets of p53 in apoptosis control
Yu, J., & Zhang, L. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.189 · Cited by 421 · see citing works
Structure, Activation, and Biology of Calpain
Suzuki, K., Hata, S., Kawabata, Y., & Sorimachi, H. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s12 · Cited by 417 · see citing works
A critical role of neural-specific JNK3 for ischemic apoptosis
Kuan, C.-Y., Whitmarsh, A. J., Yang, D. D., Liao, G., Schloemer, A. J., Dong, C., Bao, J., Banasiak, K. J., Haddad, G. G., Flavell, R. A., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336254100 · Cited by 410 · see citing works
The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia–ischemia
Zhu, C., Wang, X., Xu, F., Bahr, B. A., Shibata, M., Uchiyama, Y., Hagberg, H., & Blomgren, K. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401545 · Cited by 400 · see citing works
Self-citationMartins, L. M., Morrison, A., Klupsch, K., Fedele, V., Moisoi, N., Teismann, P., Abuin, A., Grau, E., Geppert, M., Livi, G. P., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.9848-9862.2004 · Cited by 395 · see citing works
Regulation of hexokinase binding to VDAC
Pastorino, J. G., & Hoek, J. B. (2008) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-008-9148-8 · Cited by 388 · see citing works
Weber, J. T., Slemmer, J. E., Shacka, J. J., & Sweeney, M. I. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708783497337 · Cited by 386 · see citing works
Mitochondrial uncoupling proteins in the cns: in support of function and survival
Andrews, Z., Diano, S., & Horvath, T. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1767 · Cited by 380 · see citing works
Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death
Morrison, R. S., Wenzel, H. J., Kinoshita, Y., Robbins, C. A., Donehower, L. A., & Schwartzkroin, P. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-04-01337.1996 · Cited by 370 · see citing works
Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage
Iadecola, C., Zhang, F., & Xu, X. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.268.1.r286 · Cited by 366 · see citing works
Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs.
Verhagen, A. M., Coulson, E. J., & Vaux, D. L. (2001) · Genome biology · doi:10.1186/gb-2001-2-7-reviews3009 · Cited by 363 · see citing works
Namura, S., Iihara, K., Takami, S., Nagata, I., Kikuchi, H., Matsushita, K., Moskowitz, M. A., Bonventre, J. V., & Alessandrini, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181213498 · Cited by 360 · see citing works
Rong, Y., & Distelhorst, C. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.021507.105852 · Cited by 357 · see citing works
Culmsee, C., Zhu, C., Landshamer, S., Becattini, B., Wagner, E., Pellecchia, M., Blomgren, K., & Plesnila, N. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2818-05.2005 · Cited by 339 · see citing works
Self-citationOverexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage
Takagi, Y., Mitsui, A., Nishiyama, A., Nozaki, K., Sono, H., Gon, Y., Hashimoto, N., & Yodoi, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.4131 · Cited by 337 · see citing works
Yang, Q.-H., Church-Hajduk, R., Ren, J., Newton, M. L., & Du, C. (2003) · Genes & Development · doi:10.1101/gad.1097903 · Cited by 332 · see citing works
Culmsee, C., Zhu, X., Yu, Q., Chan, S. L., Camandola, S., Guo, Z., Greig, N. H., & Mattson, M. P. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.t01-1-00220.x · Cited by 317 · see citing works
Cao, G., Xing, J., Xiao, X., Liou, A. K. F., Gao, Y., Yin, X., Clark, R. S. B., Graham, S. H., & Chen, J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2826-07.2007 · Cited by 304 · see citing works
Le, D. A., Wu, Y., Huang, Z., Matsushita, K., Plesnila, N., Augustinack, J. C., Hyman, B. T., Yuan, J., Kuida, K., Flavell, R. A., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232473399 · Cited by 303 · see citing works
Antiapoptotic and Anti-inflammatory Mechanisms of Heat-Shock Protein Protection
Yenari, M. A., Liu, J., Zheng, Z., Vexler, Z. S., Lee, J. E., & Giffard, R. G. (2005) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2005.tb00012.x · Cited by 299 · see citing works
Zhao, H., Yenari, M. A., Cheng, D., Sapolsky, R. M., & Steinberg, G. K. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01756.x · Cited by 290 · see citing works
Hao, Z., Duncan, G. S., Chang, C., Elia, A., Fang, M., Wakeham, A. C., Okada, H., Calzascia, T., Jang, Y., You-Ten, A. J., et al. (2005) · Cell · doi:10.1016/j.cell.2005.03.016 · Cited by 278 · see citing works
Abu-Hamad, S., Zaid, H., Israelson, A., Nahon, E., & Shoshan-Barmatz, V. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708216200 · Cited by 278 · see citing works
Caspase 3 activation is essential for neuroprotection in preconditioning
McLaughlin, B., Hartnett, K. A., Erhardt, J. A., Legos, J. J., White, R. F., Barone, F. C., & Aizenman, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0232966100 · Cited by 271 · see citing works
Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor
Gurbuxani, S. K., Schmitt, E., Candé, C., Parcellier, A., Hammann, A., Daugas, É., Kouranti, I., Spahr, C. S., Pance, A., Kroemer, G., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206794 · Cited by 266 · see citing works
Self-citationMitochondria in cell death: novel targets for neuroprotection and cardioprotection
Mattson, M. P., & Kroemer, G. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00046-7 · Cited by 264 · see citing works
Self-citationNo death without life: vital functions of apoptotic effectors
Galluzzi, L., Joza, N. A., Tasdemir, E., Maiuri, M. C., Hengartner, M. O., Abrams, J., Tavernarakis, N., Penninger, J. M., Madeo, F., & Kroemer, G. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.28 · Cited by 256 · see citing works
Self-citationYamashima, T., Kohda, Y., Tsuchiya, K., Ueno, T., Yamashita, J., Yoshioka, T., & Kominami, E. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00184.x · Cited by 254 · see citing works
BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia
Plesnila, N., Zinkel, S. S., Le, D. A., Amin‐Hanjani, S., Wu, Y., Qiu, J., Chiarugi, A., Thomas, S. S., Kohane, D. S., Korsmeyer, S. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261323298 · Cited by 253 · see citing works
Kim, G. W., Kondo, T., Noshita, N., & Chan, P. H. (2002) · Stroke · doi:10.1161/hs0302.103745 · Cited by 251 · see citing works
Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus
Xu, D., Crocker, S. J., Doucet, J.-P., St-Jean, M., Tamai, K., Hakim, A. M., Ikeda, J., Liston, P., Thompson, C. S., Korneluk, R. G., et al. (1997) · Nature Medicine · doi:10.1038/nm0997-997 · Cited by 246 · see citing works
The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal
Vieira, H. L., Belzacq, A.-S., Haouzi, D., Bernassola, F., Cohen, I., Jacotot, E., Ferri, K. F., El Hamel, C., Bartle, L. M., Melino, G., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204575 · Cited by 244 · cited 1× · see citing works
“Both NO and peroxynitrites can directly activate MP”
BackgroundSelf-citationInactivation of Glycogen Synthase Kinase 3 Promotes Axonal Growth and Recovery in the CNS
Dill, J., Wang, H., Zhou, F., & Li, S. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1178-08.2008 · Cited by 229 · see citing works
Blockade of Electron Transport during Ischemia Protects Cardiac Mitochondria
Lesnefsky, E. J., Chen, Q., Moghaddas, S., Hassan, M. O., Tandler, B., & Hoppel, C. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409720200 · Cited by 229 · see citing works
The Novel Antioxidant Edaravone: From Bench to Bedside
Watanabe, T., Tahara, M., & Todo, S. (2008) · Cardiovascular Therapeutics · doi:10.1111/j.1527-3466.2008.00041.x · Cited by 228 · see citing works
Zhu, C., Wang, X., Deinum, J., Huang, Z., Gao, J.-F., Modjtahedi, N., Neagu, M. R., Nilsson, M., Eriksson, P. S., Hagberg, H., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070193 · Cited by 224 · see citing works
Self-citationGao, Y., Signore, A. P., Yin, W., Cao, G., Yin, X., Sun, F., Luo, Y., Graham, S. H., & Chen, J. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600062 · Cited by 220 · see citing works
Specific pathophysiological functions of JNK isoforms in the brain
Brecht, S., Kirchhof, R., Chromik, A. M., Willesen, M. G., Nicolaus, T., Raivich, G., Wessig, J., Waetzig, V., Goetz, M. E., Claussen, M. C., et al. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03857.x · Cited by 219 · see citing works
Zhu, D. Y., Liu, S. H., Sun, H., & Lu, Y. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00223.2003 · Cited by 216 · see citing works
Matsumoto, S., Friberg, H., Ferrand-Drake, M., & Wieloch, T. W. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199907000-00002 · Cited by 215 · see citing works
Zhu, C., Wang, X., Huang, Z., Qiu, L., Xu, F., Vahsen, N., Nilsson, M., Eriksson, P. S., Hagberg, H., Culmsee, C., et al. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402053 · Cited by 213 · see citing works
Self-citationCa2+-dependent proteases in ischemic neuronal death
Yamashima, T. (2004) · Cell Calcium · doi:10.1016/j.ceca.2004.03.001 · Cited by 213 · see citing works
Crack, P. J., Taylor, J. M., Flentjar, N. J., de Haan, J. B., Hertzog, P. J., Iannello, R. C., & Kola, I. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00535.x · Cited by 212 · see citing works
Rodrigues, C. M. P., Solá, S., Nan, Z., Castro, R. E., Ribeiro, P. S., Low, W. C., & Steer, C. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1031632100 · Cited by 210 · see citing works
Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death
Tajeddine, N., Galluzzi, L., Kepp, O., Hangen, E., Morselli, E., Senovilla, L., Araujo, N., Pinna, G., Larochette, N., Zamzami, N., et al. (2008) · Oncogene · doi:10.1038/onc.2008.63 · Cited by 207 · see citing works
Self-citation(1998) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1998.0er10.x · Cited by 206 · see citing works
Antiapoptotic and Anti-inflammatory Mechanisms of Heat-Shock Protein Protection
Yenari, M. A. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1344.007 · Cited by 204 · see citing works
Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury
Giffard, R. G., Xu, L., Zhao, H., Carrico, W., Ouyang, Y., Qiao, Y., Sapolsky, R. M., Steinberg, G. K., Hu, B. R., & Yenari, M. A. (2004) · Journal of Experimental Biology · doi:10.1242/jeb.01034 · Cited by 199 · see citing works
Kikuchi, M., Tenneti, L., & Lipton, S. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-13-05037.2000 · Cited by 197 · see citing works
Han, B. H., Xu, D., Choi, J., Han, Y., Xanthoudakis, S., Roy, S., Tam, J., Vaillancourt, J. P., Colucci, J. T., Siman, R. G., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202931200 · Cited by 178 · see citing works
Li, M., Ona, V. O., Chen, M., Kaul, M., Tenneti, L., Zhang, X., Stieg, P. E., Lipton, S. A., & Friedlander, R. M. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00173-1 · Cited by 178 · see citing works
Cheung, E. C., Melanson-Drapeau, L., Cregan, S. P., Vanderluit, J. L., Ferguson, K. L., McIntosh, W. C., Park, D. S., Bennett, S. A. L., & Slack, R. S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4261-04.2005 · Cited by 177 · see citing works
Hetz, C., Vitte, P.-A., Bombrun, A., Rostovtseva, T. K., Montessuit, S., Hiver, A., Schwarz, M. K., Church, D. J., Korsmeyer, S. J., Martinou, J.-C., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505843200 · Cited by 176 · see citing works
Generation and Characterization of Smac/DIABLO-Deficient Mice
Okada, H., Suh, W., Jin, J., Woo, M., Du, C., Elia, A., Duncan, G. S., Wakeham, A. C., Itié, A., Lowe, S. W., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3509-3517.2002 · Cited by 172 · see citing works
Mitogen-Activated Protein Kinase Inhibition in Traumatic Brain Injury: In Vitro and In Vivo Effects
Mori, T., Wang, X., Jung, J., Sumii, T., Singhal, A. B., Fini, M. E., Dixon, C. E., Alessandrini, A., & Lo, E. H. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200204000-00008 · Cited by 168 · see citing works
Intravenous TAT–Bcl‐Xl is protective after middle cerebral artery occlusion in mice
Kılıç, E., Dietz, G. P. H., Hermann, D. M., & Bähr, M. (2002) · Annals of Neurology · doi:10.1002/ana.10356 · Cited by 166 · see citing works
Endo, H., Kamada, H., Nito, C., Nishi, T., & Chan, P. H. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0897-06.2006 · Cited by 163 · see citing works
Ischemic neuronal death in the rat hippocampus: the calpain–calpastatin–caspase hypothesis
Rami, A. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00018-4 · Cited by 157 · see citing works
Chiang, C.-W., Harris, G., Ellig, C. L., Masters, S. C., Subramanian, R. R., Shenolikar, S., Wadzinski, B. E., & Yang, E. (2001) · Blood · doi:10.1182/blood.v97.5.1289 · Cited by 154 · see citing works
Higuchi, M., Tomioka, M., Takano, J., Shirotani, K., Iwata, N., Masumoto, H., Maki, M., Itohara, S., & Saido, T. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500939200 · Cited by 154 · see citing works
Gill, R., Soriano, M. A., Blomgren, K., Hagberg, H., Wybrect, R., Miss, M.-T., Hoefer, S., Adam, G., Niederhauser, O., Kemp, J. A., et al. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200204000-00006 · Cited by 152 · see citing works
Self-citationRegulation of Protein Phosphatase 2A Activity by Caspase-3 during Apoptosis
Santoro, M. F., Annand, R. R., Robertson, M. M., Peng, Y.-W., Brady, M., Mankovich, J. A., Hackett, M. C., Ghayur, T., Walter, G., Wong, W. W., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.13119 · Cited by 152 · see citing works
Mechanistic Role of Calpains in Postischemic Neurodegeneration
Bevers, M. B., & Neumar, R. W. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600595 · Cited by 150 · see citing works
The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin ?
Leker, R. R. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.01.030 · Cited by 145 · see citing works
Respiratory Chain Inhibition Induces Tolerance to Focal Cerebral Ischemia
Wiegand, F., Liao, W., Busch, C., Castell, S., Knapp, F., Lindauer, U., Megow, D., Meisel, A., Redetzky, A., Ruscher, K., et al. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199911000-00007 · Cited by 144 · see citing works
Caspase-9: Involvement in secondary death of axotomized rat retinal ganglion cells in vivo
Kermer, P., Ankerhold, R., Klöcker, N., Krajewski, S., Reed, J. C., & Bähr, M. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00256-4 · Cited by 143 · see citing works
Protein Phosphatase 2A Enhances the Proapoptotic Function of Bax through Dephosphorylation
Xin, M., Xin, M., & Deng, X. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512543200 · Cited by 139 · see citing works
Gibson, M. E., Han, B. H., Choi, J., Knudson, C. M., Korsmeyer, S. J., Parsadanian, M., & Holtzman, D. M. (2001) · Molecular Medicine · doi:10.1007/bf03401871 · Cited by 132 · see citing works
Kelly, S., Zhang, Z. J., Zhao, H., Xu, L., Giffard, R. G., Sapolsky, R. M., Yenari, M. A., & Steinberg, G. K. (2002) · Annals of Neurology · doi:10.1002/ana.10264 · Cited by 127 · see citing works
Developmental Shift of Cyclophilin D Contribution to Hypoxic-Ischemic Brain Injury
Wang, X., Carlsson, Y., Basso, E., Zhu, C., Rousset, C. I., Rasola, A., Johansson, B. R., Blomgren, K., Mallard, C. E., Bernardi, P., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5832-08.2009 · Cited by 125 · see citing works
Self-citationDistinct hsp70 Domains Mediate Apoptosis-inducing Factor Release and Nuclear Accumulation
Ruchalski, K. L., Mao, H., Li, Z., Wang, Z., Gillers, S., Wang, Y., Mosser, D. D., Gabai, V. L., Schwartz, J. H., & Borkan, S. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513728200 · Cited by 125 · see citing works
Saito, A., Hayashi, T., Okuno, S., Ferrand-Drake, M., & Chan, P. H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01710.2003 · Cited by 121 · see citing works
Targeting post-mitochondrial effectors of apoptosis for neuroprotection
Galluzzi, L., Morselli, E., Kepp, O., & Kroemer, G. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.09.006 · Cited by 119 · see citing works
Self-citationProteome-wide Identification of HtrA2/Omi Substrates
Walle, L. V., Damme, P. V., Lamkanfi, M., Saelens, X., Vandekerckhove, J. S., Gevaert, K., & Vandenabeele, P. (2007) · Journal of Proteome Research · doi:10.1021/pr060510d · Cited by 119 · see citing works
Xu, Z., Wang, B., Wang, X., Kuang, F., Duan, X., Jiao, X., & Ju, G. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.06.023 · Cited by 116 · see citing works
De Bilbao, F., Arsenijevic, D., Vallet, P., Hjelle, O. P., Ottersen, O. P., Bouras, C., Raffin, Y., Abou, K., Langhans, W., Collins, S., et al. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02432.x · Cited by 108 · see citing works
Nonapoptotic Role for Apaf-1 in the DNA Damage Checkpoint
Zermati, Y., Mouhamad, S., Stergiou, L., Besse, B., Galluzzi, L., Boehrer, S., Pauleau, A., Rosselli, F., D’Amelio, M., Amendola, R., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.030 · Cited by 107 · see citing works
Self-citationTargeting p53 to mitochondria for cancer therapy
Galluzzi, L., Morselli, E., Kepp, O., Tajeddine, N., & Kroemer, G. (2008) · Cell Cycle · doi:10.4161/cc.7.13.6222 · Cited by 106 · see citing works
Self-citationWang, X., Zhu, C., Wang, X., Hagberg, H., Korhonen, L., Sandberg, M., Lindholm, D., & Blomgren, K. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.01.014 · Cited by 103 · see citing works
Self-citationCerebrovascular protection by various nitric oxide donors in rats after experimental stroke.
Khan, M., Jatana, M., Elango, C., Paintlia, A., Singh, A., & Singh, I. (2006) · Nitric oxide · doi:10.1016/j.niox.2006.01.008 · Cited by 102 · see citing works
Houde, C., Banks, K. G., Coulombe, N., Rasper, D., Grimm, E. L., Roy, S., Simpson, E. M., & Nicholson, D. W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3356-04.2004 · Cited by 101 · see citing works
SB 239063, a novel p38 inhibitor, attenuates early neuronal injury following ischemia
Legos, J. J., Erhardt, J. A., White, R. F., Lenhard, S. C., Chandra, S., Parsons, A. A., Tuma, R. F., & Barone, F. C. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03228-5 · Cited by 100 · see citing works
Zinc-Dependent Multi-Conductance Channel Activity in Mitochondria Isolated from Ischemic Brain
Bonanni, L., Chachar, M., Jover‐Mengual, T., Li, H., Jones, A., Yokota, H., Ofengeim, D., Flannery, R. J., Miyawaki, T., Cho, C.-H., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5444-05.2006 · Cited by 99 · see citing works
Zhao, X., Haensel, C., Araki, E., et al. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02459-8 · Cited by 98 · see citing works
EndoG is dispensable in embryogenesis and apoptosis
David, K. K., Sasaki, M., Yu, S.-W., Dawson, T. M., & Dawson, V. L. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401787 · Cited by 96 · see citing works
Wießner, C., ALLEGRINI, P. R., Rupalla, K., Sauer, D., Oltersdorf, T., McGregor, A. L., Bischoff, S. F., Böttiger, B. W., & van der Putten, H. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00392-4 · Cited by 95 · see citing works
Guan, Q.-H., Pei, D., Zong, Y.-Y., Xu, T., & Zhang, G.-Y. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.11.067 · Cited by 92 · see citing works
Pirianov, G., Brywe, K. G., Mallard, C. E., Edwards, A. D., Flavell, R. A., Hagberg, H., & Mehmet, H. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600413 · Cited by 92 · see citing works
Weaver, J., Tarze, A., Moffat, T. C., Bras, M. L., Deniaud, A., Brenner, C., Bren, G. D., Morin, M. Y., Phenix, B. N., Dong, L. M., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22954 · Cited by 91 · see citing works
Self-citationCritical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury
Zhang, Q., Dong-na, W. U., Han, D. K., & Zhang, G. (2007) · FEBS Letters · doi:10.1016/j.febslet.2006.12.055 · Cited by 90 · see citing works
Rodić, N., Oka, M., Hamazaki, T., Murawski, M. R., Jorgensen, M., Maatouk, D. M., Resnick, J. L., Li, E., & Terada, N. (2005) · STEM CELLS · doi:10.1634/stemcells.2005-0119 · Cited by 89 · see citing works
Receptors that mediate cellular dependence
Bredesen, D. E., Mehlen, P., & Rabizadeh, S. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401680 · Cited by 89 · see citing works
Miyawaki, T., Mashiko, T., Ofengeim, D., Flannery, R. J., Noh, K.-M., Fujisawa, S., Bonanni, L., Bennett, M. V. L., Zukin, R. S., & Jonas, E. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800628105 · Cited by 89 · see citing works
Chandrasekaran, K., Mehrabian, Z., Spinnewyn, B., Chinopoulos, C., Drieu, K., & Fiskum, G. M. (2003) · Pharmacopsychiatry · doi:10.1055/s-2003-40447 · Cited by 89 · see citing works
Causal Role of Apoptosis-Inducing Factor for Neuronal Cell Death Following Traumatic Brain Injury
Slemmer, J. E., Zhu, C., Landshamer, S., Trabold, R., Grohm, J., Ardeshiri, A., Wagner, E., Sweeney, M. I., Blomgren, K., Culmsee, C., et al. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080168 · Cited by 87 · see citing works
Self-citationThe X-linked inhibitor of apoptosis (XIAP) prevents cell death in axotomized CNS neurons in vivo
Kügler, S., Straten, G., Kreppel, F., Isenmann, S., Liston, P., & Bähr, M. (2000) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400712 · Cited by 84 · see citing works
IAP family proteins delay motoneuron cell death in vivo
Perrelet, D., Ferri, A., MacKenzie, A. E., Smith, G. M., Korneluk, R. G., Liston, P., Sagot, Y., Terrado, J., Monnier, D., & Kato, A. C. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00098.x · Cited by 83 · see citing works
Lee, B. I., Lee, D. J., Cho, K. J., & Kim, G. W. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.05.058 · Cited by 81 · see citing works
Regulation of the human apoptotic DNase/RNase Endonuclease G: involvement of Hsp70 and ATP
Kalinowska, M., Garncarz, W., Pietrowska, M., Garrard, W. T., & Widłak, P. (2005) · APOPTOSIS · doi:10.1007/s10495-005-0410-9 · Cited by 81 · see citing works
Apaf-1 deficiency and neural tube closure defects are found in fog mice
Honarpour, N., Gilbert, S. L., Lahn, B. T., Wang, X., & Herz, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171283198 · Cited by 81 · see citing works
Matrone, C., Pignataro, G., Molinaro, P., Irace, C., Scorziello, A., Renzo, G. F. D., & Annunziato, L. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02483.x · Cited by 81 · see citing works
Zhu, C., Wang, X., Qiu, L., Peeters‐Scholte, C. M. P. C. D., Hagberg, H., & Blomgren, K. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02500.x · Cited by 80 · see citing works
Self-citationCésar, M. C., & Wilson, J. E. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.12.030 · Cited by 76 · see citing works
Activation of Proinflammatory Caspases by Cathepsin B in Focal Cerebral Ischemia
Benchoua, A., Braudeau, J., Reis, A., Couriaud, C., & Onténiente, B. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000140272.54583.fb · Cited by 76 · see citing works
Matsumori, Y., Northington, F. J., Hong, S. M., Kayama, T., Sheldon, R. A., Vexler, Z. S., Ferriero, D. M., Weinstein, P. R., & Liu, J. (2006) · Stroke · doi:10.1161/01.str.0000199057.00365.20 · Cited by 74 · see citing works
Lee, S., Kwon, H., Kim, Y., Lee, K.-M., Kim, M., & Yoon, B. (2004) · Stroke · doi:10.1161/01.str.0000136150.73891.14 · Cited by 71 · see citing works
Luo, J., Cen, L., Zhang, X., Chiang, S. W. Y., Huang, Y., Lin, D., Fan, Y., van Rooijen, N., Lam, D. S. C., Pang, C. P., et al. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05718.x · Cited by 69 · see citing works
Glutathione peroxidase inhibits cell death and glial activation following experimental stroke
Ishibashi, N., Prokopenko, O., Weisbrot-Lefkowitz, M., Reuhl, K. R., & Mirochnitchenko, O. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00459-x · Cited by 66 · see citing works
Pei, D., Song, Y., Yu, H., Hu, W., Du, Y., & Zhang, G. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05531.x · Cited by 64 · see citing works
Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia–ischemia
Ness, J., Harvey, C. R., Strasser, A., Bouillet, P., Klocke, B. J., & Roth, K. A. (2006) · Brain Research · doi:10.1016/j.brainres.2006.04.132 · Cited by 64 · see citing works
Hisatomi, T., Nakazawa, T., Noda, K., Almulki, L., Miyahara, S., Nakao, S., Ito, Y., She, H., Kohno, R.-I., Michaud, N. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34267 · Cited by 64 · see citing works
Self-citationWagstaff, M. J. D., Collaço‐Moraes, Y., Aspey, B. S., Coffin, R. S., Harrison, M. J., Latchman, D. S., & de Belleroche, J. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00127-1 · Cited by 62 · see citing works
Chaitanya, G. V., & Babu, P. P. (2008) · Neurochemical Research · doi:10.1007/s11064-007-9567-7 · Cited by 62 · see citing works
Protective effects of oral creatine supplementation on spinal cord injury in rats
Hausmann, O., Fouad, K., Wallimann, T., & Schwab, M. (2002) · Spinal Cord · doi:10.1038/sj.sc.3101330 · Cited by 61 · see citing works
Prevention of mitochondrial dysfunction in post‐traumatic mouse brain by superoxide dismutase
Xiong, Y., Shie, F., Zhang, J., Lee, C.-P., & Ho, Y. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03412.x · Cited by 61 · see citing works
Tehranian, R., Rose, M. E., Vagni, V., Pickrell, A. M., Griffith, R. P., Liu, H., Clark, R. S. B., Dixon, C. E., Kochanek, P. M., & Graham, S. H. (2008) · Journal of Neurotrauma · doi:10.1089/neu.2007.0441 · Cited by 60 · see citing works
AIF and EndoG in noise-induced hearing loss.
Yamashita, D., Miller, J. M., Jiang, H., Minami, S., & Schacht, J. (2004) · PubMed · Cited by 60 · see citing works
Mitochondria as Targets of Apoptosis Regulation by Nitric Oxide
Vieira, H. L. A., & Kroemer, G. (2003) · IUBMB Life · doi:10.1080/15216540310001639652 · Cited by 59 · see citing works
Self-citationMouw, G., Zechel, J. L., Zhou, Y., Lust, W. D., Selman, W. R., & Ratcheson, R. A. (2002) · Metabolic Brain Disease · doi:10.1023/a:1019921904378 · Cited by 57 · see citing works
Glycolysis and Perinatal Hypoxic-Ischemic Brain Damage
Vannucci, R. C., Brucklacher, R. M., & Vannucci, S. J. (2005) · Developmental Neuroscience · doi:10.1159/000085991 · Cited by 56 · see citing works
Neuroprotective Effects of Virally Delivered HSPs in Experimental Stroke
Badin, R. A., Lythgoe, M. F., van der Weerd, L., Thomas, D. L., Gadian, D. G., & Latchman, D. S. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600190 · Cited by 55 · see citing works
Jin, H., Park, I., An, S., Lee, H., Woo, S., Hong, Y., Lee, S., Park, K. H., Yoo, D., Rhee, C., et al. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20488 · Cited by 55 · see citing works
Higuchi, Y., Hattori, H., Hattori, R., & Furusho, K. (1996) · Brain and Development · doi:10.1016/0387-7604(96)00019-8 · Cited by 54 · see citing works
Sasaki, T., Han, F., Shioda, N., Moriguchi, S., Kasahara, J., Ishiguro, K., & Fukunaga, K. (2006) · Brain Research · doi:10.1016/j.brainres.2006.06.009 · Cited by 52 · see citing works
West, T., Atzeva, M., & Holtzman, D. M. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.12.017 · Cited by 51 · see citing works
Monoubiquitination and Cellular Distribution of XIAP in Neurons after Traumatic Brain Injury
Lotocki, G., Alonso, O. F., Frydel, B. R., Dietrich, W. D., & Keane, R. W. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000086938.68719.e0 · Cited by 50 · see citing works
Elibol, B., Söylemezoğlu, F., Ünal, I., Fujii, M., Hirt, L., Huang, P. L., Moskowitz, M. A., & Dalkara, T. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00159-2 · Cited by 49 · see citing works
Wáng, Q., Zhang, Q., Dong-na, W. U., Yin, X., & Zhang, G. (2007) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2007.00469.x · Cited by 46 · see citing works
p53 Potentiates Hippocampal Neuronal Death Caused by Global Ischemia
Yonekura, I., Takai, K., Asai, A., Kawahara, N., & Kirino, T. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600293 · Cited by 45 · see citing works
Saito, A., Hayashi, T., Okuno, S., Nishi, T., & Chan, P. H. (2004) · Stroke · doi:10.1161/01.str.0000128416.28778.7a · Cited by 45 · see citing works
Amplified expression of uncoupling proteins in human brain ischemic lesions
Nakase, T., Yoshida, Y., & Nagata, K. (2007) · Neuropathology · doi:10.1111/j.1440-1789.2007.00815.x · Cited by 44 · see citing works
Clark, R. S. B., Nathaniel, P. D., Zhang, X., Dixon, C. E., Alber, S. M., Watkins, S. C., Melick, J. A., Kochanek, P. M., & Graham, S. H. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600338 · Cited by 38 · see citing works
Expression of Cu/Zn SOD Protein Is Suppressed in hsp 70.1 Knockout Mice
Choi, S.-M., Park, K.-A., Lee, H.-J., Park, M.-S., Lee, J.-H., Park, K.-C., Kim, M., Lee, S., Seo, J., & Yoon, B. (2005) · BMB Reports · doi:10.5483/bmbrep.2005.38.1.111 · Cited by 35 · see citing works
Choi, J., Park, H.-J., Kim, H.-Y., Kim, S.-Y., Lee, J. E., Choi, Y., Chun, M., Chung, J.-W., & Lee, M. (2005) · Cell and Tissue Research · doi:10.1007/s00441-004-1033-0 · Cited by 33 · see citing works
Aggravation of brain injury after transient focal ischemia in p53-deficient mice
Maeda, K., Hata, R., Gillardon, F., & Hossmann, K. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00017-1 · Cited by 33 · see citing works
Bano, D., Munarriz, E. R., Chen, H., Ziviani, E., Lippi, G., Young, K. W., & Nicotera, P. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1387.006 · Cited by 32 · see citing works
Mondragón, L., Galluzzi, L., Mouhamad, S., Orzáez, M., Vicencio, J. M., Vitale, I., Moure, A., Messeguer, Á., Pérez‐Payá, E., & Kroemer, G. (2009) · APOPTOSIS · doi:10.1007/s10495-008-0310-x · Cited by 31 · see citing works
Self-citationHo, Y., Logue, E. S., Callaway, C. W., & DeFranco, D. B. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.039 · Cited by 30 · see citing works
Saito, A., Hayashi, T., Okuno, S., Nishi, T., & Chan, P. H. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.05.012 · Cited by 28 · see citing works
Di‐Pietro, P. B., Dias, M. L., Scaini, G., Búrigo, M., Constantino, L. D. S., Machado, R. A., Dal‐Pizzol, F., & STRECK, E. L. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.01.051 · Cited by 28 · see citing works
Apoptosis inhibition in ischemic brain by intraperitoneal PTD-BIR3-RING (XIAP)
Fan, Y., Lü, C., Xie, J., Zhao, Y., & Yang, G. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.07.008 · Cited by 28 · see citing works
Role of EndoG in development and cell injury
Apostolov, E. O., Wang, X., Shah, S. V., & Basnakian, A. G. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402217 · Cited by 26 · see citing works
The nitric oxide donor LA 419 decreases brain damage in a focal ischemia model
Martínez‐Murillo, R., Fernández, A. P., Serrano, J., Rodrigo, J., Salas, E., Mourelle, M., & Martı́nez, A. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.01.011 · Cited by 26 · see citing works
Enhanced expression of p53 in reactive astrocytes following transient focal ischemia
Chung, Y. H., Shin, C. M., Kim, M. J., Lee, E. Y., Kim, G., & Ik, C. (2002) · Neurological Research · doi:10.1179/016164102101199828 · Cited by 25 · see citing works
Wingrave, J. M., Sribnick, E. A., Wilford, G. G., Matzelle, D. D., Mou, J. A., Ray, S. K., Hogan, E. L., & Banik, N. L. (2004) · Journal of Neurotrauma · doi:10.1089/neu.2004.21.1240 · Cited by 24 · see citing works
Yu, F., Sugawara, T., Nishi, T., Liu, J., & Chan, P. H. (2006) · Journal of Neurotrauma · doi:10.1089/neu.2006.23.595 · Cited by 23 · see citing works
Two caspase‐2 transcripts are expressed in rat hippocampus after global cerebral ischemia
Jin, K., Nagayama, T., Mao, X., Kawaguchi, K., Hickey, R. W., Greenberg, D. A., Simon, R. P., & Graham, S. H. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00781.x · Cited by 23 · see citing works
Hwang, I. K., Ahn, H. C., Yoo, K., Lee, J., Suh, H., Kwon, Y., Cho, J. H., & Won, M. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.08.017 · Cited by 23 · see citing works
Inhibition of Apoptosome Activation Protects Injured Motor Neurons from Cell Death
Kanungo, A., Hao, Z., Elia, A., Mak, T. W., & Henderson, J. T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800988200 · Cited by 14 · see citing works
Chaperonin GroEL and its mutant D87K protect from ischemia in vivo and in vitro
Xu, L., Dayal, M., Ouyang, Y., Sun, Y., Yang, C. F., Frydman, J., & Giffard, R. G. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.032 · Cited by 13 · see citing works
Tamura, M., Nakamura, M., Ogawa, Y., Toyama, Y., Miura, M., & Okano, H. (2005) · Glia · doi:10.1002/glia.20212 · Cited by 12 · see citing works
Hexokinase Binding in Ischemic and Reperfused Piglet Brain
Gray, S. M., Adams, V., Yamashita, Y., Le, S.-P., Goddard‐Finegold, J., & McCabe, E. R. B. (1994) · Biochemical Medicine and Metabolic Biology · doi:10.1006/bmmb.1994.1070 · Cited by 8 · see citing works
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Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works
Self-citationMolecular mechanisms of necroptosis: an ordered cellular explosion
Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2970 · Cited by 2,382 · see citing works
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Wilson, D. M., Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. (2023) · Cell · doi:10.1016/j.cell.2022.12.032 · Cited by 1,789 · see citing works
Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms
Anjum, A., Yazid, M. D., Daud, M., Idris, J., Ng, M. H., Naicker, A. S., Ismail, O. H. R., Kumar, R., & Lokanathan, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207533 · Cited by 1,327 · see citing works
Fricker, M., Tolkovsky, A. M., Borutaitė, V., Coleman, M. P., & Brown, G. C. (2018) · Physiological Reviews · doi:10.1152/physrev.00011.2017 · Cited by 1,122 · see citing works
Consensus guidelines for the detection of immunogenic cell death
Kepp, O., Senovilla, L., Vitale, I., Vacchelli, E., Adjemian, S., Agostinis, P., Apetoh, L., Aranda, F., Barnaba, V., Bloy, N., et al. (2014) · OncoImmunology · doi:10.4161/21624011.2014.955691 · Cited by 832 · see citing works
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Galluzzi, L., Vitale, I., Michels, J., Brenner, C., Szabadkai, G., Harel-Bellan, A., Castedo, M., & Kroemer, G. (2014) · Cell Death & Disease · doi:10.1038/cddis.2013.428 · Cited by 782 · see citing works
Self-citationZinc in the physiology and pathology of the CNS
Sensi, S. L., Paoletti, P., Bush, A. I., & Sekler, I. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2734 · Cited by 759 · see citing works
Zündorf, G., & Reiser, G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3359 · Cited by 482 · see citing works
Motor Neuron Diversity in Development and Disease
Kanning, K. C., Kaplan, A., & Henderson, C. E. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135722 · Cited by 472 · see citing works
Necrotic, apoptotic and autophagic cell fates triggered by nanoparticles
Mohammadinejad, R., Moosavi, M. A., Tavakol, S., Vardar, D. Ö., Hosseini, A., Rahmati, M., Dini, L., Hussain, S., Mandegary, A., & Klionsky, D. J. (2018) · Autophagy · doi:10.1080/15548627.2018.1509171 · Cited by 464 · see citing works
Role of the c subunit of the F O ATP synthase in mitochondrial permeability transition
Bonora, M., Bononi, A., Marchi, E. D., Giorgi, C., Lebiedzińska, M., Marchi, S., Patergnani, S., Rimessi, A., Suski, J. M., Wojtala, A., et al. (2013) · Cell Cycle · doi:10.4161/cc.23599 · Cited by 454 · see citing works
Self-citationMitochondrial dysfunction and pathology in bipolar disorder and schizophrenia
Clay, H. B., Daws, S., & Konradi, C. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.08.007 · Cited by 399 · see citing works
Development of a Highly Sensitive Fluorescence Probe for Hydrogen Peroxide
Abo, M., Urano, Y., Hanaoka, K., Terai, T., Komatsu, T., & Nagano, T. (2011) · Journal of the American Chemical Society · doi:10.1021/ja203521e · Cited by 393 · see citing works
Cheng, A., Yang, Y., Zhou, Y., Maharana, C., Lu, D., Peng, W., Liu, Y., Wan, R., Marosi, K., Misiak, M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.013 · Cited by 371 · see citing works
BID links ferroptosis to mitochondrial cell death pathways
Neitemeier, S., Jelinek, A., Laino, V., Hoffmann, L., Eisenbach, I., Eying, R., Ganjam, G. K., Dolga, A. M., Oppermann, S., & Culmsee, C. (2017) · Redox Biology · doi:10.1016/j.redox.2017.03.007 · Cited by 366 · see citing works
Mitochondria: The calcium connection
Contreras, L., Drago, I., Zampese, E., & Pozzan, T. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.05.005 · Cited by 349 · see citing works
Bell's palsy: aetiology, clinical features and multidisciplinary care
Eviston, T. J., Croxson, G. R., Kennedy, P. G. E., Hadlock, T. A., & Krishnan, A. V. (2015) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-309563 · Cited by 334 · see citing works
Bonora, M., Wieckowski, M. R., Chinopoulos, C., Kepp, O., Kroemer, G., Galluzzi, L., & Pinton, P. (2015) · Oncogene · doi:10.1038/onc.2014.96 · Cited by 330 · see citing works
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Perier, C., & Vila, M. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a009332 · Cited by 304 · see citing works
Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders?
van Horssen, J., van Schaik, P. E. M., & Witte, M. E. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.06.050 · Cited by 289 · see citing works
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration
Kerur, N., Fukuda, S., Banerjee, D., Kim, Y., Fu, D., Apicella, I., Varshney, A., Yasuma, R., Fowler, B. J., Baghdasaryan, E., et al. (2017) · Nature Medicine · doi:10.1038/nm.4450 · Cited by 285 · see citing works
Metabolic Dysfunction and Oxidative Stress in Epilepsy
Pearson-Smith, J. N., & Patel, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112365 · Cited by 277 · see citing works
Gong, L., Tang, Y., An, R., Lin, M., Chen, L., & Du, J. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.465 · Cited by 260 · see citing works
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Galluzzi, L., Kepp, O., Krautwald, S., Kroemer, G., & Linkermann, A. (2014) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.02.006 · Cited by 258 · see citing works
Self-citationCaspase-3 in the central nervous system: beyond apoptosis
D’Amelio, M., Sheng, M., & Cecconi, F. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.06.004 · Cited by 255 · see citing works
Alternative Mitochondrial Electron Transfer as a Novel Strategy for Neuroprotection
Wen, Y., Li, W., Poteet, E. C., Xie, L., Tan, C., Yan, L., Ju, X., Liu, R., Qian, H., Marvin, M. A., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.208447 · Cited by 251 · see citing works
Organelle-specific initiation of cell death
Galluzzi, L., Bravo-San Pedro, J. M., & Kroemer, G. (2014) · Nature Cell Biology · doi:10.1038/ncb3005 · Cited by 239 · see citing works
Self-citationAutophagy in acute brain injury
Galluzzi, L., Bravo-San Pedro, J. M., Blomgren, K., & Kroemer, G. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.51 · Cited by 234 · see citing works
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Zischka, H., Lichtmannegger, J., Schmitt, S., Jägemann, N., Schulz, S., Wartini, D., Jennen, L., Rust, C., Larochette, N., Galluzzi, L., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45401 · Cited by 214 · see citing works
Self-citationPedrós, I., Petrov, D., Allgaier, M., Sureda, F. X., Barroso, E., Beas‐Zárate, C., Auladell, C., Pallàs, M., Vázquez‐Carrera, M., Casadesús, G., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.025 · Cited by 203 · see citing works
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Hagberg, H., Mallard, C. E., Rousset, C. I., & Thornton, C. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70261-8 · Cited by 194 · see citing works
Novak, C. M., Özen, M., & Burd, I. D. (2018) · Clinics in Perinatology · doi:10.1016/j.clp.2018.01.015 · Cited by 186 · see citing works
Mature neurons: equipped for survival
Kole, A. J., Annis, R. P., & Deshmukh, M. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.220 · Cited by 180 · see citing works
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Summers, D. W., DiAntonio, A., & Milbrandt, J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0877-14.2014 · Cited by 176 · see citing works
ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2
Pedrini, S., Sau, D., Guareschi, S., Bogush, M., Brown, R. H., Naniche, N., Kia, A., Trotti, D., & Pasinelli, P. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq202 · Cited by 166 · see citing works
Cell Death in the Developing Brain after Hypoxia-Ischemia
Thornton, C., Leaw, B., Mallard, C. E., Nair, S., Jinnai, M., & Hagberg, H. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00248 · Cited by 163 · see citing works
Low-level laser therapy for beta amyloid toxicity in rat hippocampus
Lu, Y., Wang, R., Dong, Y., Tucker, D., Zhao, N., Ahmed, M. E., Zhu, L., Liu, T. C., Cohen, R. M., & Zhang, Q. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.10.003 · Cited by 162 · see citing works
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Perier, C., Bové, J., & Vila, M. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4074 · Cited by 159 · see citing works
Tan, A. C. S., Pilgrim, M. G., Fearn, S., Bertazzo, S., Tsolaki, E., Morrell, A. P., Li, M., Messinger, J. D., Dolz‐Marco, R., Lei, J., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat4544 · Cited by 157 · see citing works
Galluzzi, L., Berghe, T. V., Vanlangenakker, N., Büttner, S., Eisenberg, T., Vandenabeele, P., Madeo, F., & Kroemer, G. (2011) · International review of cytology · doi:10.1016/b978-0-12-386039-2.00001-8 · Cited by 150 · see citing works
Self-citationBerberine as a potential autophagy modulator
Mohammadinejad, R., Ahmadi, Z., Tavakol, S., & Ashrafizadeh, M. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28325 · Cited by 147 · see citing works
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Vastegani, S. M., Nasrolahi, A., Ghaderi, S., Belali, R., Rashno, M., Farzaneh, M., & Khoshnam, S. E. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03904-0 · Cited by 145 · see citing works
Gigante, A. D., Young, L. T., Yatham, L. N., Andreazza, A. C., Nery, F. G., Grinberg, L. T., Heinsen, H., & Lafer, B. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571000146x · Cited by 143 · see citing works
Reconceptualization of translocator protein as a biomarker of neuroinflammation in psychiatry
Notter, T., Coughlin, J. M., Sawa, A., & Meyer, U. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.232 · Cited by 142 · see citing works
Srivastava, R. K., Pant, A. B., Kashyap, M. P., Kumar, V., Lohani, M., Jonas, L., & Rahman, Q. (2010) · Nanotoxicology · doi:10.3109/17435390.2010.503944 · Cited by 138 · see citing works
Eisenberg, T., Carmona‐Gutiérrez, D., Büttner, S., Tavernarakis, N., & Madeo, F. (2010) · APOPTOSIS · doi:10.1007/s10495-009-0453-4 · Cited by 137 · see citing works
Deoxynivalenol, gut microbiota and immunotoxicity: A potential approach?
Liao, Y., Peng, Z., Chen, L., Nussler, A. K., Liu, L., & Yang, W. Q. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.01.013 · Cited by 136 · see citing works
Queiroga, C. S. F., Almeida, A. S., Martel, C., Brenner, C., Alves, P. M., & Vieira, H. L. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.065052 · Cited by 133 · see citing works
Development or disease: duality of the mitochondrial permeability transition pore
Maria Jose Perez, J., & Quintanilla, R. A. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.04.018 · Cited by 131 · see citing works
Hormesis, cell death and aging
Martins, I., Galluzzi, L., & Kroemer, G. (2011) · Aging · doi:10.18632/aging.100380 · Cited by 128 · see citing works
Self-citationAcute pathophysiological processes after ischaemic and traumatic brain injury
Kunz, A. B., Dirnagl, U., & Mergenthaler, P. (2010) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2010.10.001 · Cited by 128 · see citing works
Gong, Y., Yu, B., Yang, W. J., & Zhang, X. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.01.022 · Cited by 128 · see citing works
Anti-Apoptotic Effects of Carotenoids in Neurodegeneration
Park, H., Hayden, M. M., Bannerman, S., Jansen, J., & Crowe-White, K. M. (2020) · Molecules · doi:10.3390/molecules25153453 · Cited by 125 · see citing works
A Bcl-xL–Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis
Li, H., Alavian, K. N., Lazrove, E., Mehta, N., Jones, A., Zhang, P., Licznerski, P., Graham, M. M., Uo, T., Guo, J., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2791 · Cited by 123 · see citing works
The H+-ATP synthase: A gate to ROS-mediated cell death or cell survival
Martínez‐Reyes, I., & Cuezva, J. M. (2014) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2014.03.010 · Cited by 123 · see citing works
Valerio, A., Bertolotti, P., Delbarba, A., Perego, C., Dossena, M., Ragni, M., Spano, P., Carruba, M. O., Simoni, M. G. D., & Nisoli, E. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07171.x · Cited by 123 · see citing works
Wang, L., Li, Y., Zhao, L., Qi, Z., Gou, J., Zhang, S., & Zhang, J. Z. (2020) · Nanoscale · doi:10.1039/d0nr05746k · Cited by 123 · see citing works
He, B., Shi, Y., Liang, Y., Yang, A., Fan, Z., Yuan, L., Zou, X., Chang, X. Y., Zhang, H., Wang, X., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04700-z · Cited by 122 · see citing works
Methamphetamine-Induced Neuronal Damage: Neurotoxicity and Neuroinflammation
Kim, B., Yun, J., & Park, B. (2020) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2020.044 · Cited by 116 · see citing works
Mitochondrial Abnormalities in a Streptozotocin-Induced Rat Model of Sporadic Alzheimer's Disease
Correia, S. C., Santos, R. X., Santos, M. S., Casadesús, G., LaManna, J. C., Perry, G. L., Smith, M. A., & Moreira, P. I. (2013) · Current Alzheimer Research · doi:10.2174/1567205011310040006 · Cited by 116 · see citing works
Brown, M. R. D., Ramirez, J. D., & Farquhar-Smith, P. W. (2014) · British Journal of Pain · doi:10.1177/2049463714542605 · Cited by 114 · see citing works
Zinc deficiency and neurodevelopment: The case of neurons
Adamo, A. M., & Oteiza, P. I. (2010) · BioFactors · doi:10.1002/biof.91 · Cited by 113 · see citing works
Perinatal brain damage: The term infant
Hagberg, H., Edwards, A. D., & Groenendaal, F. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.09.011 · Cited by 109 · see citing works
Formentini, L., Pereira, M. P., Sánchez-Cenizo, L., Santacatterina, F., Lucas, J. J., Fernández-Balbuena, C. N., Martı́nez-Serrano, A., & Cuezva, J. M. (2014) · The EMBO Journal · doi:10.1002/embj.201386392 · Cited by 108 · see citing works
Shin, E., Tran, H., Nguyen, P. T., Jeong, J. H., Nah, S.-Y., Jang, C., Nabeshima, T., & Kim, H. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2318-5 · Cited by 108 · see citing works
Mitochondrial regulation of cell death: a phylogenetically conserved control
Galluzzi, L., Kepp, O., & Kroemer, G. (2016) · Microbial Cell · doi:10.15698/mic2016.03.483 · Cited by 106 · see citing works
Self-citationOncosuppressive Functions of Autophagy
Morselli, E., Galluzzi, L., Kepp, O., Mariño, G., Michaud, M., Vitale, I., Maiuri, M. C., & Kroemer, G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3478 · Cited by 104 · see citing works
Self-citationHow do reactive oxygen species and calcium trigger mitochondrial membrane permeabilisation?
Tajeddine, N. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.02.013 · Cited by 101 · see citing works
Madhu, V., Hernandez-Meadows, M., Boneski, P. K., Qiu, Y., Guntur, A. R., Kurland, I. J., Barve, R. A., & Risbud, M. V. (2023) · Autophagy · doi:10.1080/15548627.2022.2162245 · Cited by 96 · see citing works
Palasz, E., Niewiadomski, W., Gasiorowska, A., Wysocka, A., Stepniewska, A., & Niewiadomska, G. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01143 · Cited by 95 · see citing works
Nutraceuticals against Neurodegeneration: A Mechanistic Insight
Dadhania, V. P., Trivedi, P. P., Vikram, A., & Tripathi, D. N. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160104142223 · Cited by 92 · see citing works
BAX channel activity mediates lysosomal disruption linked to Parkinson disease
Bové, J., Martínez-Vicente, M., Dehay, B., Perier, C., Recasens, A., Bombrun, A., Antonsson, B., & Vila, M. (2014) · Autophagy · doi:10.4161/auto.28286 · Cited by 89 · see citing works
Ebrahimi‐Fakhari, D., Saidi, L.-J., & Wahlster, L. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-79 · Cited by 86 · see citing works
Organellar Dysfunction in the Pathogenesis of Pancreatitis
Gukovsky, I., Pandol, S. J., & Gukovskaya, A. S. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4068 · Cited by 84 · see citing works
Meena, R., Rani, M., Pal, R., & Rajamani, P. (2012) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-012-9699-3 · Cited by 82 · see citing works
Autophagy of Mitochondria: A Promising Therapeutic Target for Neurodegenerative Disease
Kamat, P. K., Kalani, A., Kyles, P., Tyagi, S. C., & Tyagi, N. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-014-0006-5 · Cited by 82 · see citing works
Nano-titanium dioxide induces genotoxicity and apoptosis in human lung cancer cell line, A549
Srivastava, R., Rahman, Q., Kashyap, M., Singh, A. K., Jain, G., Jahan, S., Lohani, M., Lantow, M., & Pant, A. B. (2012) · Human & Experimental Toxicology · doi:10.1177/0960327112462725 · Cited by 82 · see citing works
Cannabidiol induces intracellular calcium elevation and cytotoxicity in oligodendrocytes
Mato, S., Sánchez‐Gómez, M. V., & Matute, C. (2010) · Glia · doi:10.1002/glia.21044 · Cited by 79 · see citing works
Caspase Cascade Regulated Mitochondria Mediated Apoptosis in Monocrotophos Exposed PC12 Cells
Kashyap, M. P., Singh, A. K., Siddiqui, M. A., Kumar, V., Tripathi, V., Khanna, V. K., Yadav, S., Jain, S., & Pant, A. B. (2010) · Chemical Research in Toxicology · doi:10.1021/tx100234m · Cited by 79 · see citing works
Henshall, D. C., & Engel, T. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00110 · Cited by 78 · see citing works
Hsp70.1 and related lysosomal factors for necrotic neuronal death
Yamashima, T. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07596.x · Cited by 78 · see citing works
Involvement of mitochondria-mediated apoptosis in deoxynivalenol cytotoxicity
Bensassi, F., Gallerne, C., Dein, O. S. E., Lemaire, C., Hajlaoui, M. R., & Bacha, H. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.01.015 · Cited by 78 · see citing works
ERK signaling leads to mitochondrial dysfunction in extracellular zinc‐induced neurotoxicity
He, K., & Aizenman, E. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06762.x · Cited by 77 · see citing works
Neuroprotective Effect of Bax-Inhibiting Peptide on Neonatal Brain Injury
Wang, X., Han, W., Du, X., Zhu, C., Carlsson, Y., Mallard, C. E., Jacotot, E. D., & Hagberg, H. (2010) · Stroke · doi:10.1161/strokeaha.110.589051 · Cited by 76 · see citing works
Jonas, E. A., Porter, G. A., Beutner, G., Mnatsakanyan, N., & Alavian, K. N. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.04.013 · Cited by 76 · see citing works
Caspase-3 and prostaglandins signal for tumor regrowth in cancer therapy
Galluzzi, L., Kepp, O., & Kroemer, G. (2011) · Oncogene · doi:10.1038/onc.2011.459 · Cited by 75 · see citing works
Self-citationBarateiro, A. P., Vaz, A. R., Silva, S. L., Fernandes, A. M. A., & Brites, D. M. T. O. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8187-9 · Cited by 74 · see citing works
Mitochondrial damage & lipid signaling in traumatic brain injury
Lamade, A. M., Anthonymuthu, T. S., Hier, Z. E., Gao, Y., Kagan, V. E., & Bayır, H. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113307 · Cited by 74 · see citing works
Abnormal Mitochondrial Quality Control in Neurodegenerative Diseases
Yan, X., Wang, B., Hu, Y., Wang, S., & Zhang, X. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00138 · Cited by 74 · see citing works
Soft materials as biological and artificial membranes
Tang, S., Davoudi, Z., Wang, G., Xu, Z., Rehman, T. U., Promiński, A., Tian, B., Bratlie, K. M., Peng, H., & Wang, Q. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00029b · Cited by 72 · see citing works
Gao, Y., Zhuang, Z., Gao, S., Li, X., Zhang, Z., Ye, Z.-N., Li, L., Tang, C., Zhou, M., Han, X., et al. (2017) · PubMed Central · Cited by 70 · see citing works
Bhalla, V., Roopa, & Kumar, M. (2012) · Dalton Transactions · doi:10.1039/c2dt31341c · Cited by 70 · see citing works
Nair, S., Rocha‐Ferreira, E., Fleiss, B., Nijboer, C. H. A., Gressèns, P., Mallard, C. E., & Hagberg, H. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15267 · Cited by 69 · see citing works
An Antiapoptotic Neuroprotective Role for Neuroglobin
Brittain, T., Skommer, J., Raychaudhuri, S., & Birch, N. P. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11062306 · Cited by 69 · see citing works
Dar, N. J., Bhat, J. A., Satti, N. K., Sharma, P. R., Hamid, A., & Ahmad, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0044-7 · Cited by 69 · see citing works
Kulbe, J. R., & Hall, E. D. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.08.003 · Cited by 69 · see citing works
Gu, T., Mo, S., Mu, Y., Huang, X., & Hu, L. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.127731 · Cited by 67 · see citing works
Kulbe, J. R., Hill, R. L., Singh, I. N., Wang, J. A., & Hall, E. D. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4628 · Cited by 67 · see citing works
Salvi, A., Liu, H., & Salim, S. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100205 · Cited by 67 · see citing works
- Authors
- Galluzzi, L., Blomgren, K., & Kroemer, G.
- Affiliations
- Inserm (FR)
- Drottning Silvias barn- och ungdomssjukhus (SE)
- Université Paris-Sud (FR)
- Corresponding author
- Kroemer, Guido
- Venue
- Nature Reviews Neuroscience
- Published
- 2009-07
- Volume
- 10
- Issue
- 7
- Pages
- 481-494
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2002091021
- Cited by
- 418
- References
- 188
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 12 · 2023: 18 · 2022: 12 · 2021: 12 · 2020: 18 · 2019: 21 · 2018: 23 · 2017: 33 · 2016: 27 · 2015: 29 · 2014: 34 · 2013: 25 · 2012: 35
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pharmacological Receptor Mechanisms and Effects
- Keywords
- mitochondrial membrane permeabilization, neuronal injury, neuronal cell death, mitochondrial apoptosis, neuroprotection, cerebrovascular disease, traumatic brain injury, mitochondrial dysfunction
- MeSH terms
- Animals, Electron Transport, Mitochondria, Necrosis, Neurons, Oxidation-Reduction, Peptide Hydrolases, Permeability, Apoptosis, Molecular Chaperones, Proto-Oncogene Proteins c-bcl-2, Mitogen-Activated Protein Kinases, Mitochondrial Membranes
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