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Characterization of Fear Memory Reconsolidation
Open accessAbstract
Reactivation of consolidated memories returns them to a protein synthesis-dependent state. One interpretation of these findings is that the memory reconsolidates after use. Two alternative interpretations are that protein synthesis inhibition facilitates extinction and that postreactivation protein synthesis inhibition leads to an inability to retrieve the consolidated memory. First, using two different approaches, we report that reconsolidation cannot be reduced down to facilitated extinction. We show that the reconsolidation deficit does not show renewal after a contextual shift, whereas an extinguished auditory fear memory does under the same conditions and the deficit occurs regardless of whether the memory is reactivated with an extinction [conditioned stimulus (CS) alone] or a reinforced trial (CS-unconditioned stimulus). To address the issue of whether postreactivation anisomycin leads to an inability to retrieve the consolidated memory, we used two traditional assays for retrieval deficits. First, we demonstrate that the amnesia induced by blockade of reconsolidation does not show any spontaneous recovery. Second, we show that application of reminder shock does not result in the reinstatement of the memory. These findings support the idea that reactivation of consolidated memories initiates a second time-dependent memory formation process.
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“Indeed, neuroscience has shown that re-accessing memories generally changes them, rather than enforces them.66,67”
From The overfitted brain: Dreams evolved to assist generalization (2021) · cites this paper as [66]
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Preventing the return of fear in humans using reconsolidation update mechanisms
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Background
Metadata
- Authors
- Duvarci, S., & Nader, K.
- Affiliations
- W. M. Keck Foundation (US)
- McGill University (CA)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-10-20
- Volume
- 24
- Issue
- 42
- Pages
- 9269-9275
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6730081
- OpenAlex
- W2018795098
- Cited by
- 379
- References
- 39
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 13 · 2022: 18 · 2021: 15 · 2020: 14 · 2019: 14 · 2018: 16 · 2017: 22 · 2016: 18 · 2015: 24 · 2014: 23 · 2013: 21 · 2012: 24
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alfred P. Sloan Foundation
- Volkswagen Foundation
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- fear memory reconsolidation, memory reactivation, protein synthesis inhibition, anisomycin, extinction, memory retrieval, memory consolidation, spontaneous recovery, reinstatement, auditory fear conditioning
- MeSH terms
- Amygdala, Animals, Anisomycin, Conditioning, Psychological, Extinction, Psychological, Fear, Male, Memory, Protein Synthesis Inhibitors, Time Factors, Rats, Sprague-Dawley, Rats
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