Cited by 613Memory and Neural MechanismsMemory Processes and InfluencesSleep and Wakefulness Research

The labile nature of consolidation theory

Nader, Karim, Schafe, Glenn E., LeDoux, Joseph E.·2000·Nature Reviews Neuroscience

Abstract

'Consolidation' has been used to describe distinct but related processes. In considering the implications of our recent findings on the lability of reactivated fear memories, we view consolidation and reconsolidation in terms of molecular events taking place within neurons as opposed to interactions between brain regions. Our findings open up a new dimension in the study of memory consolidation. We argue that consolidation is not a one-time event, but instead is reiterated with subsequent activation of the memories.

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Crossref · 10.1038/35044580

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49 of 49 references verified0 citation errors · 0 not checkable

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  • The re-stabilisation of a memory is a putative process termed memory reconsolidation, and requires de-novo protein synthesis.

    “The re-stabilisation of a memory is a putative process termed memory ‘reconsolidation’, and requires de-novo protein synthesis (Nader, Schafe, & LeDoux, 2000).”
  • Reactivation during wakefulness destabilized memories rendering them susceptible to interference learning, as indicated by impaired memory recall for the originally learned card-pair locations after interference learning.

    “As expected from reconsolidation studies (e.g., Refs.844, 845, 1043), reactivation during wakefulness destabilized memories rendering them susceptible to interference learning, as indicated by impaired memory recall for the originally learned card-pair locations after interference learning (FIGURE 4D).”

    From About Sleep's Role in Memory (2013) · cites this paper as [845]

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Authors
Nader, K., Schafe, G. E., & LeDoux, J. E.
Affiliations
New York University (US)
Corresponding author
Nader, Karim
Venue
Nature Reviews Neuroscience
Published
2000-12
Volume
1
Issue
3
Pages
216-219
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2784028944
Cited by
613
References
49
Citations by year
2026: 14 · 2025: 16 · 2024: 12 · 2023: 20 · 2022: 29 · 2021: 19 · 2020: 29 · 2019: 27 · 2018: 35 · 2017: 39 · 2016: 23 · 2015: 35 · 2014: 27 · 2013: 34 · 2012: 40
FWCI
0.55
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
W. M. Keck Foundation
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
memory consolidation, memory reconsolidation, fear memory, memory reactivation, molecular mechanisms of memory, neural mechanisms
MeSH terms
Amnesia, Animals, Brain, Conditioning, Psychological, Humans, Memory, Models, Neurological

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