The labile nature of consolidation theory
Abstract
'Consolidation' has been used to describe distinct but related processes. In considering the implications of our recent findings on the lability of reactivated fear memories, we view consolidation and reconsolidation in terms of molecular events taking place within neurons as opposed to interactions between brain regions. Our findings open up a new dimension in the study of memory consolidation. We argue that consolidation is not a one-time event, but instead is reiterated with subsequent activation of the memories.
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The re-stabilisation of a memory is a putative process termed memory reconsolidation, and requires de-novo protein synthesis.
“The re-stabilisation of a memory is a putative process termed memory ‘reconsolidation’, and requires de-novo protein synthesis (Nader, Schafe, & LeDoux, 2000).”
From Intrusive memories of trauma: A target for research bridging cognitive science and its clinical application (2019) · cites this paper as Nader, Schafe, & LeDoux, 2000
Reactivation during wakefulness destabilized memories rendering them susceptible to interference learning, as indicated by impaired memory recall for the originally learned card-pair locations after interference learning.
“As expected from reconsolidation studies (e.g., Refs.844, 845, 1043), reactivation during wakefulness destabilized memories rendering them susceptible to interference learning, as indicated by impaired memory recall for the originally learned card-pair locations after interference learning (FIGURE 4D).”
From About Sleep's Role in Memory (2013) · cites this paper as [845]
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- Authors
- Nader, K., Schafe, G. E., & LeDoux, J. E.
- Affiliations
- New York University (US)
- Corresponding author
- Nader, Karim
- Venue
- Nature Reviews Neuroscience
- Published
- 2000-12
- Volume
- 1
- Issue
- 3
- Pages
- 216-219
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2784028944
- Cited by
- 613
- References
- 49
- Citations by year
- 2026: 14 · 2025: 16 · 2024: 12 · 2023: 20 · 2022: 29 · 2021: 19 · 2020: 29 · 2019: 27 · 2018: 35 · 2017: 39 · 2016: 23 · 2015: 35 · 2014: 27 · 2013: 34 · 2012: 40
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- W. M. Keck Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- memory consolidation, memory reconsolidation, fear memory, memory reactivation, molecular mechanisms of memory, neural mechanisms
- MeSH terms
- Amnesia, Animals, Brain, Conditioning, Psychological, Humans, Memory, Models, Neurological
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