The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Toll-Like Receptor Signaling Is Critical for Wallerian Degeneration and Functional Recovery after Peripheral Nerve Injury
Open accessAbstract
Toll-like receptors (TLRs) bind specific components conserved among microorganisms as well as endogenous ligands produced by necrotic cells, injured axons, and the extracellular matrix. Here, we investigated whether TLRs are involved in regulating the immune response, Wallerian degeneration (WD), and nerve regeneration after sciatic nerve lesion. Early expression of interleukin-1β and monocyte chemoattractant protein-1 was compromised in the sciatic nerve distal stump of mice deficient in TLR signaling. In addition, significantly fewer macrophages were recruited and/or activated in the sciatic nerve distal stump of TLR2-, TLR4-, and MyD88-deficient mice compared with wild-type littermates, whereas WD, axonal regeneration, and recovery of locomotor function were impaired. In contrast, animals that received a single microinjection of TLR2 and TLR4 ligands at the site of sciatic nerve lesion had faster clearance of the degenerating myelin and recovered earlier than saline-injected control rats. Finally, rats that had altered innate immune response through dexamethasone treatment exhibited three times more myelin debris in their sciatic nerve distal stump and a significant delay in recovery of locomotor function. Our results provide strong evidence that TLR signaling plays a critical role in orchestrating the innate immune response leading to efficient and rapid clearance of inhibitory myelin debris and nerve regeneration.
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ATP mediates rapid microglial response to local brain injury in vivo
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The P2Y12 receptor regulates microglial activation by extracellular nucleotides
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Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve
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Self-citationInflammaging impairs peripheral nerve maintenance and regeneration
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Laflamme, N., Cisbani, G., Préfontaine, P., Srour, Y., Bernier, J., St-Pierre, M.-K., Tremblay, M.-È., & Rivest, S. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00178 · Cited by 55
Self-citationEffects of Immunomodulatory Substances on Phagocytosis of A by Human Microglia
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Toll-Like Receptors in Neurodegeneration
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Metadata
- Authors
- Boivin, A., Pineau, I., Barrette, B., Filali, M., Vallières, N., Rivest, S., & Lacroix, S.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-11-14
- Volume
- 27
- Issue
- 46
- Pages
- 12565-12576
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2019919875
- Cited by
- 259
- References
- 8
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
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