The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Cell-Autonomous β-Catenin Signaling Regulates Cortical Precursor Proliferation
Open accessAbstract
Overexpression of β-catenin, a protein that functions in both cell adhesion and signaling, causes expansion of the cerebral cortical precursor population and cortical surface area enlargement. Here, we find that focal elimination of β-catenin from cortical neural precursors in vivo causes premature neuronal differentiation. Precursors within the cerebral cortical ventricular zone exhibit robust β-catenin-mediated transcriptional activation, which is downregulated as cells exit the ventricular zone. Targeted inhibition of β-catenin signaling during embryonic development causes cortical precursor cells to prematurely exit the cell cycle, differentiate into neurons, and migrate to the cortical plate. These results show that β-catenin-mediated transcriptional activation functions in the decision of cortical ventricular zone precursors to proliferate or differentiate during development, and suggest that the cell-autonomous signaling activity of β-catenin can control the production of cortical neurons and thus regulate cerebral cortical size.
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Citations
Cites
Specification of Cerebral Cortical Areas
Rakic, P. (1988) · Science · doi:10.1126/science.3291116 · Cited by 3,127 · cited 1×
“…in the developing cerebral cortex is coupled closely to terminal cell cycle exit (Takahashi et al., 1996), with the time of cell cycle exit (or “birthdate”) correlating with the final laminar position of cortical neurons (McConnell, 1988; Rakic, 1988; Caviness et al., 1995; Takahashi et al., 1999).”
BackgroundNoctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R. (2004) · Nature Neuroscience · doi:10.1038/nn1172 · Cited by 2,229
Cox, R. T., Kirkpatrick, C., & Peifer, M. (1996) · The Journal of cell biology · doi:10.1083/jcb.134.1.133 · Cited by 300 · cited 4×
“Although reduction of total -catenin immunofluorescence is modest ( 43% reduction) even after 48 h, relatively small changes in total -catenin can have dramatic phenotypic consequences (Cox et al., 1996; Sanson et al., 1996), likely because -catenin resides in two distinct pools in cells (Nelson and Nusse, 2004).”
BackgroundInfluentialDorsky, R. I., Sheldahl, L. C., & Moon, R. T. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0515 · Cited by 287 · cited 1×
“-catenin signaling in developing cerebral cortex To examine -catenin-mediated transcriptional signaling in the ventricular zone (VZ), we used a reporter construct that expresses a destabilized GFP variant under the control of a -catenin responsive promoter (TOPdGFP) (Dorsky et al., 2002).”
Method
Cited by
Development and Evolution of the Human Neocortex
Lui, J. H., Hansen, D. V., & Kriegstein, A. R. (2011) · Cell · doi:10.1016/j.cell.2011.06.030 · Cited by 1,342
Neural stem cells: balancing self-renewal with differentiation
Doe, C. Q. (2008) · Development · doi:10.1242/dev.014977 · Cited by 420
GSK-3 is a master regulator of neural progenitor homeostasis
Kim, W.-Y., Wang, X., Wu, Y., Doble, B. W., Patel, S., Woodgett, J. R., & Snider, W. D. (2009) · Nature Neuroscience · doi:10.1038/nn.2408 · Cited by 399
Cerebral cortex expansion and folding: what have we learned?
Fernández, V., Llinares‐Benadero, C., & Borrell, V. (2016) · The EMBO Journal · doi:10.15252/embj.201593701 · Cited by 361
Wnt Signaling Regulates Neuronal Differentiation of Cortical Intermediate Progenitors
Munji, R. N., Choe, Y., Li, G., Siegenthaler, J. A., & Pleasure, S. J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5404-10.2011 · Cited by 275
Metadata
- Authors
- Woodhead, G. J., Mutch, C. A., Olson, E. C., & Chenn, A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-11-29
- Volume
- 26
- Issue
- 48
- Pages
- 12620-12630
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2044181030
- Cited by
- 216
- References
- 4
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Woodhead, G. J., Mutch, C. A., Olson, E. C., & Chenn, A. (2006). Cell-Autonomous β-Catenin Signaling Regulates Cortical Precursor Proliferation. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.3180-06.2006
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
